MASTER CHEMISTRY

- Thermodynamics of single-component systems.

- Basic thermodynamics of multicomponent systems. Chemical potential, Gibbs-Duhem relationship, variance.

- Thermal analysis techniques used to construct binary/ternary diagrams: ATG, ATD and DSC

- Construction and interpretation of binary phase diagrams based on thermodynamic quantities. Diagrams of Gibbs free enthalpy, pressure and temperature as a function of binary mixture composition. Liquid-liquid, liquid-vapor, solid-liquid mixtures.

- Phase transformation: first- and second-order transitions, critical points. Examples.

- The supercritical state: definition, thermodynamic properties, wide-ranging industrial applications.

- Construction and interpretation of ternary phase diagrams: variance, definitions of ternary eutectic, first- and second-order peritectic, isothermal section, study of alloy cooling.

Hourly volumes* :

CM :13

TD:7

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The aim of this solution chemistry course is to introduce the various concepts needed to study the complex liquid mixtures used in separative chemistry. The proposed approach is mainly thermodynamic. In particular, we explain the role of concentration effects, beyond the ideal laws valid only for dilute solutions.

CM: 12 H

TD: 8 H

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This lecture, entirely provided in English, gives a basic introduction into crystallography and electron diffraction for beginners. X-ray diffraction is an important characterization technique in modern chemistry the majority of crystalline structures in inorganic and organic solids have been solved by this method. It is therefore of importance for all students to have an understanding of its basic concepts and instrumentation. The course provides explanations and principles of X-ray diffraction together with the geometry and symmetry of X-ray patterns. Beside interaction principles of X-rays and matter, it treats how to obtain quantitative intensities for single crystal and powder diffraction patterns. It naturally includes the understanding of lattice planes and the reciprocal lattice concept together with the Ewald sphere construction. Further on it gives a basic understanding of the Fourier transform relation between the crystalline structure and the diffracted intensities as well as the reciprocal lattice concept.

Electron diffraction is a complementary technique to X-rays that provides information in terms of symmetry and geometry on the materials studied. In this course, we will therefore approach the description of the method for obtaining electron diffraction pattern and their interpretation. We will be able to obtain the lattice parameters, the reflection conditions as well as the groups of possible spaces.

This lecture also serves as the introductory part to the lecture Electron Microscopy and Crystallography II

CM:14

TD :6

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Knowledge of the latest mass spectrometry techniques for the qualitative analysis of organic molecules and biomolecules.

1) Description of fundamental principles (Ion Science and Technology) :

- Ionization techniques

- Analysis techniques

- Tandem mass spectrometry (MS/MS)

- LC/MS and LC/MS/MS couplings

2) Application in biomolecule analysis and organic chemistry reaction monitoring.

Hourly volumes* :

CM: 15 H

TD: 5 H

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Polymers are all around us: we eat them, we wear them, we build extremely complex structures from them. From mature technologies to the most innovative materials, polymers are a crucial building block in the construction of tomorrow's world. In this course, we will look at a number of aspects, including the controlled synthesis of polymers and cross-linked materials, surface modification by polymers, a number of characterization tools adapted to polymers and, finally, a final section developing the latest advances involving polymers.

Hourly volumes* :

            CM: 13h

            TD: 7h

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Module HAC720C covers "advanced inorganic materials" in 5 main parts. Part¹ is dedicated to general information on inorganic materials, covering structure-properties relationships; particular attention is paid to chemical bonding, the real crystal and the polycrystalline solid; the different classes of inorganic materials are described. Part ² covers ceramic materials (definitions and properties) and their synthesis (raw materials including clays, shaping, drying and debinding, sintering); a distinction is made between traditional ceramics and technical ceramics (synthesis routes for oxide and non-oxide ceramics). Part³ deals with glasses (classification and synthesis routes) and glass ceramics (devitrification and soft chemistry); their properties and applications are also covered. Part⁴ is devoted to metals: properties of metals and metal alloys; metal nanoparticles; and catalytic materials. Part ⁵ is devoted to inorganic materials developed for energy; ceramics (oxides and non-oxides; nanostructured) and metal hydrides are described (properties and synthesis) through several examples and in the context of their applications (accumulators, hydrogen storage and carbon dioxide capture).

Hourly volumes* :

CM: 13h

TD: 7h

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This course provides basic knowledge and cross-disciplinary skills in the field of colloids and interfaces, which are common to the various courses in the Chemistry Master's program (Chemistry of Materials, Separative Chemistry, Materials and Processes, ICAP Cosmetics Engineering, Chemistry of Biomolecules). It is also offered to international students enrolled in the SFRI program at the University of Montpellier, where the course is taught in English. An introductory presentation covering the basic concepts and notions will enable students to discover and better understand the main physico-chemical properties of colloidal dispersions, associative colloids and solutions of macromolecules, as well as the parameters and phenomena governing stability in colloidal dispersions and mixed solution-colloid systems. This will be followed by interdisciplinary hands-on teaching based on the flipped classroom principle, to help students build and deepen their knowledge through individual and group analysis of various applications of colloidal and interfacial phenomena and systems.

Hourly volumes* :

CM: 7

TD : 13

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RMN :

Liquid-phase NMR (Nuclear Magnetic Resonance) is an essential spectroscopic analysis method for chemists, enabling them to determine the structure of small organic molecules or macromolecules in solution, to study dynamic phenomena... The aim of this course is to understand the phenomena involved in this technique and to relate them to the different structural information accessible by this method. The aim is to be able to exploit the spectral data obtained from this analysis to elucidate the structure and stereochemistry of organic molecules or polymer structures, or to monitor reactions.

X-ray diffraction :

X-ray diffraction is a powerful, non-destructive technique not only for characterizing the crystalline structure of materials, but also for providing crystallographic and structural information such as lattice parameters and atomic positions. This includes all crystallized materials such as ceramics, materials for the storage and transformation of energy and information, as well as organic molecules and metal complexes (interatomic distances and angles, stereochemistry (chirality, stereoisomerism...), intra- and intermolecular bonds...). The aim of this course is to provide an introduction to crystallography and diffraction, with the aim of understanding the operation and characteristics of an X-ray diffractometer, as well as interpreting diffraction patterns (structural analysis, lattice parameters).

Hourly volumes* :

            CM: 10

            TD : 10

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This course covers the fundamental concepts and practical tools of chemometrics through : - statistical data analysis ;

• probability laws ;
• confidence interval estimation ;
• parametric and non-parametric tests.

An introduction to experimental design will be offered at the end of the module.

Hourly volumes* :

CM: 7h

TD: 13h

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The first part of the course introduces the fundamentals of transition metal organometallic chemistry. It begins with a description of the Metal-C bond, enabling us to understand its stability and chemical reactivity. Secondly, the power of this synthesis tool for the formation of C-H, C-C, etc. bonds will be demonstrated. Examples of their applications in various fields will enable the acquisition of these reactions and their fields of application: fine chemistry, catalytic transformations of industrial importance, synthesis of natural products, preparation of materials.

The second part of this course is dedicated to hetero-element chemistry, focusing on the elements Silicon, Tin and Boron. The aim of this part is to present the various methods for preparing boron-, tin- and silicon-based reagents, as well as the main transformations carried out with these compounds, with applications in organic synthesis and materials synthesis.

CM: 13 H 

TD: 7 H

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The program focuses on describing the principles and applications of the main methods for structural characterization of solids, thin films, surfaces and interfaces, as well as several examples of applications in materials chemistry. It includes the following techniques.

• Introduction to solid-state NMR (NMR signal, Interactions in solid-state NMR, Magic angle rotation, NMR sequences, Cross-polarization, Instrumentation, etc.).
• Electron microscopy: principles and applications of scanning and transmission electron microscopy and correlated techniques (EDS microanalysis).
• Spectroscopic methods: Raman spectroscopy, photoelectron spectroscopy, X-ray spectroscopy (XAS, XRF, etc.), Mössbauer spectrometry.

Hourly volumes* :

            CM: 10 h

            TD: 10 h

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This teaching unit is dedicated to deepening the foundations of organic chemistry and coordination chemistry covered in L3, and acquiring notions linked to molecular engineering and molecular chemistry. The course comprises lectures and tutorials. Students will work in advance of certain lectures and tutorials, with course documents provided, to ensure that the lectures and tutorials enable them to play a full part in the course, understand the concepts presented and the skills to be acquired. A progression program and activities will be proposed. For students who have not seen the basics of coordination chemistry and organic chemistry, documents will be made available.

Coordination chemistry: The course will cover various aspects of transition metal and lanthanide complexes, molecular materials (polynuclear complexes and coordination polymers with extended structures (MOFs, etc.)), their properties and applications. Structural aspects, bonding description, properties, as well as stability and reactivity aspects will be covered. Emphasis will be placed on the complexation effect and stability of metal, lanthanide and actinide complexes with certain ligands, with a view to applications in the biomedical field (imaging and therapy), decontamination (nuclear field), etc. The electronic (relaxivity, magnetism) and optical (absorption, luminescence) properties of these complexes will be discussed and put into the context of applications in various fields, such as imaging, electronics, sensors, etc.

Organic Chemistry: This course builds on the knowledge acquired in the Bachelor's degree, and will involve a reasoned study of the main reaction mechanisms in organic chemistry, providing a common foundation for all students in the Chemistry Master's program. The main processes (substitution, addition, elimination, transposition...) and their essential characteristics and applications to mechanistic sequences will be examined. The course is designed to provide students with general tools for analyzing mechanisms (ionic, radical, concerted) in order to grasp their variety.

Hourly volumes* :

CM: 13 H

TD: 7 H

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The professional project bridges the gap between traditional practical work and the internship in a laboratory or company. It is carried out in the form of a tutored project, which puts students in a professional situation through collaborative (group) work based on the realization of a project in response to a problem set by a company, community, association or academic. It is part of the Chemistry Master's core curriculum, and is carried out under the responsibility of a member of the teaching team (academic or industrial). Carried out throughout the semester, this project aims to link and anchor the knowledge and know-how acquired during the Bachelor's degree and the early Master's program, through a professional setting. These situations will be directly linked to the Master's course chosen by the students. In addition to their chemistry-disciplinary skills, students will also acquire the interpersonal, organizational and communication skills intrinsically linked to project management, which will equip them for their future professional life.

Responding to a research problem: example of the synthesis of new phosphorescent materials.

Hourly volumes* :

CM: 5h

TD: 5h

Practical work: 40h

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The internship in semester 8 of the Master 1 Chemistry of Biomolecules is designed to familiarize students with research careers in life chemistry. Students will have the opportunity to carry out this introductory research internship in academic or private laboratories. Subject to prior approval by the teaching staff (internship subject in line with the Master's courses and suitable environment/means), students can look for a host team in an academic environment in the University of Montpellier's Chemistry Pole institutes (IBMM, ICGM, etc.), in academic laboratories outside the University of Montpellier (in France or abroad) or in the private sector (chemical, pharmaceutical and agri-food industries, biotechnology laboratories, etc.).

Fieldwork: 2 to 4 months' internship

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The goal of this course is to enable students with a chemistry background to understand the fundamentals of process engineering.

The course consists on two main parts that are illustrated by the same process.

In the first part of the course, a drying process will be used to introduce the most common heat and mass transfer phenomena found in process engineering, from which the dimensionless numbers can be derived. In the second part, the thermodynamic properties of the air/water vapour mixtures will be used to derive basic dimensioning rules for the same drying process.

This course will be entirely taught in English.

Hourly volumes* :

CM: 10

TD : 10

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The following topics will be covered:

- Biobased solvents

- Biomass fuels

- Antioxidants derived from lignin

- Metal catalysts from plants

- Surfactants obtained from renewable resources

- Examples of industrial applications of enzymatic synthesis

Hourly volumes* :

CM: 15

TD : 5

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A general approach to liquid-liquid extraction will be developed through notions of thermodynamics and kinetics, with a view to understanding the mechanisms responsible for extraction as well as the processes taking place at the liquid-liquid interface. Fundamental aspects of other types of extraction (liquid-solid, supercritical fluid, distillation) will also be covered.

Hourly volumes* :

            CM: 12h

            TD : 8h

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The aim of the medicinal chemistry course is to introduce students to the key stages in the process of developing molecules with biological activity. In particular, a description of the interactions involved, the notion of pharmocophores, bio-isosteria, etc., as well as structure-activity relationship studies will be covered, enabling students to envisage appropriate strategies and structural modifications.

Hourly volumes* :

WC: 3 p.m.

TD: 5 h

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This teaching unit is shared with MI students in the Chemistry Master's courses: ICAP P1, ICAP P2, MAT P1, MAT P2, BM (semester S2). The following topics will be covered:

• The 12 Principles of Green Chemistry and units of measurement in Green Chemistry ;
• Synthesis strategies for sustainable chemistry ;
• Alternative or eco-compatible solvents for synthesis and extraction;
• Non-conventional activation techniques and applications.

CM: 13

TD: 7 H

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The mechanical and thermal properties of materials are at the heart of many applications in the field of materials for energy. After an introduction to these different fields of application, this course aims to define the different concepts needed to master both the mechanical and thermal properties of materials, with a focus on bulk materials.

Hourly volumes* :

            CM: 11H

            TD : 9H

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General presentation of the most commonly used calculation and modelling methods in the field of solid state chemistry according to the spatial and temporal scales that can be studied with them:

(1) Quantum calculations (Hartree Fock, Post-Hartree Fock methods, DFT),

(2) Force-field modeling (atomistic and coarse-grained),

(3) Hybrid QMM and AACG modeling.

Overview of different calculation techniques: static and optimization calculations, molecular dynamics and Monte Carlo.

The UE will include lectures and practical work. Two practical modeling exercises will be offered: modeling techniques in classical mechanics and quantum calculations.

            CM: 11H

            TD : 9H

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This teaching unit is dedicated to the presentation of inorganic materials and nanomaterials for use in the biomedical field (imaging, therapy, implants). It builds on the knowledge acquired in UE HAC930C (Development of materials for health). The aim is to develop health issues and inorganic materials and nanomaterials in diagnostics, therapy and wellness. Strategies for developing the inorganic materials and nanomaterials of the future based on therapeutics and multifunctionality, and intelligent materials will also be addressed.

The course comprises lectures and tutorials. Students will be offered a group project on the (theoretical) study of an inorganic material or nanomaterials for health.    

CM: 11

 TD : 9

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In small groups or on a one-to-one basis, this course will cover pedagogical tools and best practices relating to communication and professional integration, through :

• assessments of knowledge, skills, competencies, attitudes and motivations;
• awareness of job search techniques ;
• CV and cover letter writing ;
• rules of oral and written communication ;
• mock job interviews.

Students will be able to take part in role-playing exercises directly linked to the sectors targeted by their career paths.

Practical work: 20h

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The electronic and optical properties of solids are at the heart of numerous applications in the fields of energy (photovoltaic panels, passive coolants, etc.), light production (white diodes, lasers, etc.) and electronics (components, microprocessors, etc.). After an introduction to these different fields of application, this course aims to define the different concepts needed to master both the electronic and optical properties of materials, which are essential for understanding the most modern technologies.

Hourly volumes* :

            CM: 11H

            TD : 9H

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Hybrid" materials are a new family of materials, combining organic ligands with inorganic entities, and are increasingly being studied at both fundamental and application levels.

In this course, two main categories of hybrid materials will be discussed:

• Coordination Networks and Metal-Organic Frameworks
• Organosilicon/carbon materials

CM: 10 h

TD: 10 h

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The theoretical knowledge required to understand, formulate and implement dispersed systems will be detailed in this module. The physico-chemical principles governing the preparation and stability of solid-liquid and liquid-liquid dispersions will be detailed, in line with the specifications and expected properties of use. Topics covered include powder dispersibility, modification of the solid/liquid interface to control zeta potential and colloidal interactions (extended DLVO), and the rheology of dispersed systems in relation to the state of dispersion. Liquid-liquid dispersion: emulsification, Winsor's R ratio, HLD formulation and formulation maps.

Introduction to synthetic techniques in dispersed media: emulsion synthesis of nanoparticles, latexes, microcapsules...

CM: 11

TD : 9

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The substitution of petroleum-based materials is an increasingly important issue, both technologically and economically. This module provides skills in agropolymers, biobased polymers, degradable materials and biocomposites. New, more environmentally-friendly synthesis routes will be presented, enabling the preparation of synthetic degradable polymers.

The degradation, biodegradation and recyclability of polymers will also be discussed.

Hourly volumes* :

            CM: 11CM

            TD : 9 TD

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The development of materials involves numerous coupled phenomena, some of which are linked to the nature of the materials and their intrinsic properties, others to the processes involved in the transformation of matter and/or energy. Morphogenesis is therefore the result of interdependent, coupled mechanisms whose relative kinetics will lead to one structure or another. Mastering and controlling these coupled mechanisms requires a good understanding of the transformation dynamics of the materials themselves, as well as a precise description of the transfer and transport phenomena involved in the process. Integration into the reactive environment will be covered at the end of the course.

Hourly volumes* :

            CM: 11

            TD : 9

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One of the major problems linked to the use of various materials in our daily lives is their durability and therefore their degradation. In this course, we'll look at the issues surrounding the durability of materials (resources, reserves, criticality of materials, etc.) as well as the methodologies for studying durability (types of surface/volume aging, temporal extrapolation, multi-scale, combination of effects, experimental representation and industrial validation). This will then enable aging kinetics to be modeled using different models.

The different types of degradation affecting polymers will then be analyzed.

Finally, the ageing of different types of materials will be illustrated by various concrete case studies (concrete, ceramics, metals and elastomers).

Timetable*: 11h CM :

                                    9h TD

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Materials used in housing and road construction have a wide range of characteristics and properties (durability, mechanical strength, thermal and acoustic insulation), enabling them to be adapted to the characteristics, implementation conditions and cost set by specific specifications. This course provides a basic understanding of the preparation, formulation and application of different types of materials used in housing (concrete, plaster, paints, adhesives, etc.) and road construction (bitumen). For each of the materials presented, innovative approaches to reducing their ecological footprint while maintaining their performance will also be described.

Hourly volumes* :

            CM: 11

            TD : 9

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This course covers the principles governing the exploitation of thermal energy. After a presentation of the technological challenges and prospects associated with thermoelectric conversion and thermochemical storage, particular emphasis is placed on the design and development of functional materials for the direct conversion of thermal energy into electricity and for the storage of thermal energy by sorption.

Hourly volumes* :

            CM: 11 H

            TD: 9 H

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This teaching unit is dedicated to the presentation of materials and nanomaterials intended for use in the biomedical field (imaging, therapy, implants, etc.). The aim is to give a representative picture of healthcare issues, where materials and nanomaterials play an indispensable role in diagnosis, therapy and well-being. Strategies for developing the materials and nanomaterials of the future will also be discussed.

The prerequisites for the development of health-related materials and their behavior/interaction with a living organism will be explained. Examples of inorganic (inorganic nanoparticles, various materials for implants...), organic (polymers, liposomes, etc.) and biologically derived materials and nanomaterials used as contrast agents for various types of imaging, as therapeutic agents, or as implants will be presented.

The course includes both lectures and tutorials. 

Hourly volumes* :

            CM: 11

            TD : 9

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This teaching unit covers the various aspects of the current fuel cycle and future nuclear cycles. Concepts relating to the upstream part of the cycle (mineral resources, uranium extraction and purification, isotopic enrichment), the passage of fuel through nuclear reactors and then the downstream part of the cycle (reprocessing of spent fuel, recycling of recoverable materials and remanufacturing of fuel, management of ultimate nuclear waste) will be covered. This will be followed by several aspects of future nuclear fuel cycles, including the use of non-conventional resources, advanced separation concepts and the development of fourth-generation reactors.

Hourly volumes* :

            CM: 15h

            TD: 5h

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Metallurgy encompasses all the industries and techniques involved in metal processing.

Hourly volumes* :

            CM: 11

            TD : 9

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This course covers the main conventional membrane technologies for liquid and gas media. With regard to liquid media, baromembrane technologies such as microfiltration, ultrafiltration, nanofiltration and reverse osmosis will be described, as well as technologies based on electrochemical potential gradients (electrodeionization) or temperature gradients (membrane distillation). Gas permeation and pervaporation for gas and/or vapor separation will also be presented. For all technologies, the question of the choice of suitable membrane materials will be addressed, and representative examples of appropriate fields of use (in line with current environmental and energy issues) will be given.

Hourly volumes* :

            CM : 11h

            TD: 9h

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The course will focus on the energy context and energy conversion and storage methods, the historical development of electrochemical energy conversion and storage technologies and modern applications, and electrochemical mechanisms. Finally, links will be made between modern energy conversion and storage technologies and current societal issues.

Hourly volumes* :

            CM: 11

            TD : 9

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This course consists of an in-depth study of a chosen problem or topic related to materials chemistry for the three targeted orientations of the pathway: sustainable development, health and membrane engineering. This may take the form of a research, development or analysis study at laboratory or company level. Students work in small project groups. They will choose their subject, define the aim, objectives and means under the guidance of a tutor. The final aim is to develop a product/methodology using the knowledge of synthesis and analysis already acquired, in preparation for the internships that will take place in S8.  

Hourly volumes* :

            CM: 6h

            TD : 6h

            Practical work: 16h

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Membrane materials are usually divided into two families: polymeric membranes and inorganic (or ceramic) membranes. Each of these families will make up a part of this course. The first part will be devoted to the design of polymer membranes. In this section, we will focus mainly on phase inversion preparation techniques (NIPS, VIPS, TIPS), with a focus on research and innovation (SNIPS, aquaporin, etc.). Additives (especially pore-forming and hydrophilizing agents), which play an important role in phase inversion approaches, will also be described, as well as the various routes for chemical modification of post-synthesis membranes. The second part will focus on the design of inorganic membranes. In this part, we will present both wet processes, i.e. the main methods of liquid film deposition (dip-coating, spin-coating, sputtering, tape-casting, silk-screen printing) and deposition from solutions (electrolytic or chemical processes) or suspensions (electrophoresis, Langmuir-Blodgett), and dry processes (PVD techniques (evap. and spray), CVD techniques (thermal, PECVD and ALD), MBE, surface treatment). Finally, as an illustration of the two membrane families, we will discuss case studies of membrane applications, notably in the packaging field.

Hourly volumes* :

            CM : 11h

            TD: 9h

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Today, it is essential to design products that respect the environment throughout their entire life cycle. It is widely recognized that, as a product progresses through the various stages of production, the technical choices available become narrower, and the opportunities for reducing environmental impact are correspondingly reduced. So it's right from the start, at the product design stage, that the environment must be taken into account.

The method is based on a product life cycle analysis. It takes into account factors such as :

• Choice of materials and raw materials
• The technologies used to manufacture, use and maintain the product, and to dispose of it as waste.
• The product's lifespan and the possibility of recovering materials at end-of-life (recycling, etc.).
• User behavior analysis.

Hourly volumes* :

            CM :11h

            TD :9h

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This is a lecture course, intended mainly for students in the Materials and Sustainable Development program. It presents the role played by heterogeneous catalysis in the development of clean chemistry and in the depollution of gas/liquid effluents. Basic notions of heterogeneous catalysis and the main families of catalytic materials will be discussed.  

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• Transport mechanisms in solids,
• Complex impedance spectroscopy
• Solid electrolyte electrochemical systems,
• Solid electrochemistry applications: energy and environment (batteries, accumulators, sensors, electrochromes, etc.)

Hourly volumes* :

            CM: 11H

            TD : 9H

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This end-of-studies Master 2 internship is designed to place students in a pre-professional situation, in an academic research laboratory or an industrial R&D laboratory, in France or abroad.  

The student will be looking for a host team in an academic environment in the institutes of the Chemistry Pole of the University of Montpellier (ICGM, IEM, IBMM...), in academic laboratories outside the University of Montpellier (in France or abroad) or in the private sector working in the materials field. The research project on which the student will be working will have been validated beforehand by the teaching team, to ensure that the internship subject is in line with the Master's courses, the skills and expertise acquired in previous semesters and the teaching units taken, particularly in semester 9, depending on the orientation chosen. The teaching team will also ensure that the internship takes place in an appropriate environment and with adequate resources.

This 5 to 6 month internship may start in mid-January after the exam session, and may not exceed 6 months in semester 10.

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The substitution of petroleum-based materials is an increasingly important issue, both technologically and economically. This module provides skills in agropolymers, biobased polymers, degradable materials and biocomposites. New, more environmentally-friendly synthesis routes will be presented, enabling the preparation of synthetic degradable polymers.

The degradation, biodegradation and recyclability of polymers will also be discussed.

Hourly volumes* :

            CM: 11CM

            TD : 9 TD

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Knowledge of the main polymer families used in the biomedical field.

1) Specificity of polymers for biomedical applications and the main polymer families used

2) Description of application families

3) Discussion of the concept of synthesis and the relationship between structure/properties and specifications

Hourly volumes* :

CM: 15 H

TD: 5 H

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This teaching unit is dedicated to the presentation of materials and nanomaterials intended for use in the biomedical field (imaging, therapy, implants, etc.). The aim is to give a representative picture of healthcare issues, where materials and nanomaterials play an indispensable role in diagnosis, therapy and well-being. Strategies for developing the materials and nanomaterials of the future will also be discussed.

The prerequisites for the development of health-related materials and their behavior/interaction with a living organism will be explained. Examples of inorganic (inorganic nanoparticles, various materials for implants...), organic (polymers, liposomes, etc.) and biologically derived materials and nanomaterials used as contrast agents for various types of imaging, as therapeutic agents, or as implants will be presented.

The course includes both lectures and tutorials. 

Hourly volumes* :

            CM: 11

            TD : 9

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This course covers the various molecular and supramolecular tools available for the vectorization and delivery of active ingredients, depending on the type of cells or intracellular organelles targeted. Ligand-receptor interactions are covered, as are methods for preparing and activating conjugates. Examples of drugs will be presented.

Hourly volumes* :

CM: 15 H

TD: 5 H

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This teaching unit is dedicated to the presentation of inorganic materials and nanomaterials for use in the biomedical field (imaging, therapy, implants). It builds on the knowledge acquired in UE HAC930C (Development of materials for health). The aim is to develop health issues and inorganic materials and nanomaterials in diagnostics, therapy and wellness. Strategies for developing the inorganic materials and nanomaterials of the future based on therapeutics and multifunctionality, and intelligent materials will also be addressed.

The course comprises lectures and tutorials. A group project on the (theoretical) study of an inorganic material or nanomaterials for health will be proposed to students.

Hourly volumes* :

            CM: 11

            TD : 9

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This teaching unit is dedicated to the acquisition of concepts related to medical devices and biomaterials. The course includes traditional lectures and tutorials, as well as interactive Learning Lab sessions on innovation in medical devices. 

CM: 3 HCM

TD : 5HTD

12H CM-TD Learning Lab

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This course consists of an in-depth study of a chosen problem or topic related to materials chemistry for the three targeted orientations of the pathway: sustainable development, health and membrane engineering. This may take the form of a research, development or analysis study at laboratory or company level. Students work in small project groups. They will choose their subject, define the aim, objectives and means under the guidance of a tutor. The final aim is to develop a product/methodology using the knowledge of synthesis and analysis already acquired, in preparation for the internships that will take place in S8.  

Hourly volumes* :

            CM: 6h

            TD : 6h

            Practical work: 16h

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Membrane materials are usually divided into two families: polymeric membranes and inorganic (or ceramic) membranes. Each of these families will make up a part of this course. The first part will be devoted to the design of polymer membranes. In this section, we will focus mainly on phase inversion preparation techniques (NIPS, VIPS, TIPS), with a focus on research and innovation (SNIPS, aquaporin, etc.). Additives (especially pore-forming and hydrophilizing agents), which play an important role in phase inversion approaches, will also be described, as well as the various routes for chemical modification of post-synthesis membranes. The second part will focus on the design of inorganic membranes. In this part, we will present both wet processes, i.e. the main methods of liquid film deposition (dip-coating, spin-coating, sputtering, tape-casting, silk-screen printing) and deposition from solutions (electrolytic or chemical processes) or suspensions (electrophoresis, Langmuir-Blodgett), and dry processes (PVD techniques (evap. and spray), CVD techniques (thermal, PECVD and ALD), MBE, surface treatment). Finally, as an illustration of the two membrane families, we will discuss case studies of membrane applications, notably in the packaging field.

Hourly volumes* :

            CM : 11h

            TD: 9h

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This course covers the main conventional membrane technologies for liquid and gas media. With regard to liquid media, baromembrane technologies such as microfiltration, ultrafiltration, nanofiltration and reverse osmosis will be described, as well as technologies based on electrochemical potential gradients (electrodeionization) or temperature gradients (membrane distillation). Gas permeation and pervaporation for gas and/or vapor separation will also be presented. For all technologies, the question of the choice of suitable membrane materials will be addressed, and representative examples of appropriate fields of use (in line with current environmental and energy issues) will be given.

Hourly volumes* :

            CM : 11h

            TD: 9h

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This end-of-studies Master 2 internship is designed to place students in a pre-professional situation, in an academic research laboratory or an industrial R&D laboratory, in France or abroad.  

The student will be looking for a host team in an academic environment in the institutes of the Chemistry Pole of the University of Montpellier (ICGM, IEM, IBMM...), in academic laboratories outside the University of Montpellier (in France or abroad) or in the private sector working in the materials field. The research project on which the student will be working will have been validated beforehand by the teaching team, to ensure that the internship subject is in line with the Master's courses, the skills and expertise acquired in previous semesters and the teaching units taken, particularly in semester 9, depending on the orientation chosen. The teaching team will also ensure that the internship takes place in an appropriate environment and with adequate resources.

This 5 to 6 month internship may start in mid-January after the exam session, and may not exceed 6 months in semester 10.

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This teaching unit is dedicated to the acquisition of concepts related to pigments, dyes and adsorbents, from the point of view of their structures and applications. Emphasis is placed on applications in the fields of flavors & fragrances (food colorants, perfumery) and cosmetics (hair dyes, powders, toothpastes, etc.). Some sessions are specific to each of the two pathways (P1, Cosmetics Engineering; P2, Flavors & Fragrances) of the Master's degree in Chemistry specializing in Cosmetics, Flavors and Fragrances Engineering (ICAP). The course comprises lectures and tutorials.

Hourly volumes* :

CM: 10 h

TD: 10 h

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Some basic microbiological principles will be covered, giving students an overview of the diversity of microorganisms. Bacteria's mode of nutrition and multiplication as a function of physico-chemical environmental parameters will be studied.

The composition and role of skin and digestive microbiota will be discussed.

The microbiological criteria used for quality control of cosmetics and food products will be defined.

Physical and chemical antimicrobial agents to control microbial development will be examined.

On a practical level, students will be expected to know how to handle bacteria and be familiar with microbiological safety rules. Usual microbiological control techniques and preservative efficacy tests will be carried out on cosmetic products.

Hourly volumes* :

CM: 12h

Practical work: 8h

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This module covers all the raw materials knowledge you need to work in the cosmetics industry.

These are :

• describe the different chemical classes of raw materials, understand structure/activity relationships and sensory rendering.
• Study of documents relating to the marketing of cosmetic raw materials

Hourly volumes* :

            CM: 18

            TD : 6

            TP: 16

The course is based on case studies of ingredients in aqueous or fatty phases, and both polymers and polymerization processes will be developed.

The practical part of the module will involve the use of major categories of raw materials:

Use of gelling agents: application, study of their properties, sensory evaluation

Surfactant application: Formulation of a foaming product, including ingredient identification, formula design and sensory evaluation.

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This UE covers :

- the fundamentals of colorimetry, which defines an unambiguous measure of color based on psychophysical experiments.

- the principle and practical use of color measuring devices (colorimeters and spectro-colorimeters).

- the principles of color reproduction, particularly in the context of perfumes and cosmetics.

Theoretical ideas are complemented by a significant amount of observation and experimentation in the short practical sessions.

Hourly volumes* :

CM: 12h

Practical work: 8h

See full page

Study of the entire development of a cosmetic product

• Definition of a cosmetic product
• Launching development, interactions between the development department and marketing, industry and regulatory departments: needs, expectations, operations and procedures
• Study of all possible tests: sensory analysis, physico-chemical stability, health and safety, efficacy.
• Study of industrial transposition
• Study of interactions with packaging and associated tests
• Description of the product information file or legal cosmetics file

Study of emulsions, definitions, characteristics and formulation

Study of instability phenomena in emulsions and stabilization solutions

Practical part :

Formulation of water-in-oil, oil-in-water and gel-cream emulsions

Study of ingredients, chemical nature, physical behavior and formulation

Study of formulation equipment

Set up sensory, physicochemical and stability tests.

Development of a formula in several stages with imposed constraints.

Critical analysis of the results obtained.

For the introduction to chemical engineering applied to the field of cosmetics, students will work on a case study that describes the laboratory-scale production of a cosmetic product, and then find a way to produce it on a larger scale.

Hourly volumes* :

 CM :15

TP: 25

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This course provides basic knowledge and cross-disciplinary skills in the field of colloids and interfaces, which are common to the various courses in the Chemistry Master's program (Chemistry of Materials, Separative Chemistry, Materials and Processes, ICAP Cosmetics Engineering, Chemistry of Biomolecules). It is also offered to international students enrolled in the SFRI program at the University of Montpellier, where the course is taught in English. An introductory presentation covering the basic concepts and notions will enable students to discover and better understand the main physico-chemical properties of colloidal dispersions, associative colloids and solutions of macromolecules, as well as the parameters and phenomena governing stability in colloidal dispersions and mixed solution-colloid systems. This will be followed by interdisciplinary hands-on teaching based on the flipped classroom principle, to help students build and deepen their knowledge through individual and group analysis of various applications of colloidal and interfacial phenomena and systems.

Hourly volumes* :

CM: 7

TD : 13

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Knowledge and ability to apply the various regulations relating to the cosmetics industry (Regulation 1223/2009, REACH, CLP, etc.).

Learn more about the key articles of European cosmetics regulations - Regulation 1223/2009

Learn how to create a DIP

Focus on the safety report using an example

Hourly volumes* :

            CM: 10

            TD : 10

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This course covers the fundamental concepts and practical tools of chemometrics through : - statistical data analysis ;

• probability laws ;
• confidence interval estimation ;
• parametric and non-parametric tests.

An introduction to experimental design will be offered at the end of the module.

Hourly volumes* :

CM: 7h

TD: 13h

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This course is designed to teach liquid and gas chromatography.

Hourly volumes* :

            CM :15h

            TD: 5h

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The professional project bridges the gap between traditional practical work and the internship in a laboratory or company. It is carried out in the form of a tutored project, which puts students in a professional situation through collaborative (group) work based on the realization of a project in response to a problem set by a company, community, association or academic. It is part of the Chemistry Master's core curriculum, and is carried out under the responsibility of a member of the teaching team (academic or industrial). Carried out throughout the semester, this project aims to link and anchor the knowledge and know-how acquired during the Bachelor's degree and the early Master's program, through a professional setting. These situations will be directly linked to the Master's course chosen by the students. In addition to their chemistry-disciplinary skills, students will also acquire the interpersonal, organizational and communication skills intrinsically linked to project management, which will equip them for their future professional life.

Responding to a research problem: example of the synthesis of new phosphorescent materials.

Hourly volumes* :

CM: 5h

TD: 5h

Practical work: 40h

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This module focuses on R&D in the cosmetics industry, with an emphasis on scientific expertise and innovation, through courses and lectures. There will also be hands-on experience in the design and development of cosmetics and wellness products.

The practical part will focus on the development of make-up products:

Review of the composition of make-up products

Natural and synthetic coloring raw materials. Know the different galenic formulas used in make-up and how to select raw materials.

Know how to select pigments according to the desired target. Know how to disperse them and surface treatment.

Marketing study on defined make-up galenics

Theoretical courses on raw materials and galenics used in make-up, manufacturing processes, market trends and possible tests (claims, physico-chemical tests, efficacy tests, etc.).

In practice :

Practical courses on pigment premixes, foundations and lipsticks, combined with sensorial evaluations

Application to the formulation of various make-up products (foundation, lipstick, mascara, etc.) and quality control of finished products.

Hourly volumes* :

            CM: 20

            TD : 5

            TP: 15

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This teaching unit is shared with MI students in the Chemistry Master's courses: ICAP P1, ICAP P2, MAT P1, MAT P2, BM (semester S2). The following topics will be covered:

• The 12 Principles of Green Chemistry and units of measurement in Green Chemistry ;
• Synthesis strategies for sustainable chemistry ;
• Alternative or eco-compatible solvents for synthesis and extraction;
• Non-conventional activation techniques and applications.

CM: 13

TD: 7 H

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This 4-6 month internship will be carried out in an R&D laboratory in the cosmetics and well-being industries.

The tasks entrusted by the company to the student trainee will be in line with the objectives of the Master's program.

The internship can start in February/March and can be carried out in France or abroad.

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In small groups or on a one-to-one basis, this course will cover pedagogical tools and best practices relating to communication and professional integration, through :

• assessments of knowledge, skills, competencies, attitudes and motivations;
• awareness of job search techniques ;
• CV and cover letter writing ;
• rules of oral and written communication ;
• mock job interviews.

Students will be able to take part in role-playing exercises directly linked to the sectors targeted by their career paths.

Practical work: 20h

See full page

This module focuses on :

• Tools and sources of information (patents, databases, journals, trade fairs and scientific days, etc.) and communication: identifying relevant sources of information, analyzing and using them, communicating internally and externally.
• What business intelligence is, and how to understand and use it
• Marketing fundamentals: presentation of what marketing does, presentation of tools that can help students in their future work, detailed explanation of the development process of a cosmetic product in marketing, and the different careers available to students.

A project will be developed by the students.

Hourly volumes* :

CM :15h

TD: 5h

Practical: 10h

Exit: 10 a.m.

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A design of experiments is the ordered sequence of trials in an experiment, the aim of which is to test the validity of a hypothesis by reproducing a phenomenon and varying one or more parameters. Each trial produces data, and all the data produced during an experiment must be analyzed using rigorous methods to validate or invalidate the hypothesis. This experimental approach makes it possible to acquire new knowledge by confirming a model with a good economy of means (the lowest possible number of trials, for example).

Starting with a simple problem, the module develops the methodological and statistical tools needed to support increasingly complex hypotheses as optimally as possible. These methodologies are implemented using the R statistical language.

Hourly volumes* :

            CM: 15h

            Practical: 5h

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Provide students with the theoretical understanding of inferential statistics needed for the statistical analysis of sensory test data. General problem: extract interpretable regularities from sensory measurements in order to make the right decisions.

The lessons will cover the needs of each pathway, using appropriate examples and applications.

Hourly volumes* :

            CM: 10 H

            PRACTICAL WORK: 10H

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Polymers are used in a large number of cosmetic formulations for a variety of functions, the main ones being rheology control, formulation stabilization and conditioning. It is therefore important to know how they behave in these complex environments, in particular by studying polymer-surfactant interactions, since these two constituents are often present together in these media, as well as interactions with solid surfaces (suspensions, applications on hair or skin) or liquids (emulsions).

The course describes: (1) the different types of polymers used: water-soluble, synthetic, natural and semi-natural, amphiphilic and structure-property relationships, (2) principle of thickening formulas or gelling using polymers, (3) interactions with surfactants, presentation of the different types of surfactants and their physico-chemical properties, in particular polymeric surfactants, (4) interactions with surfaces (skin, hair) and all types of solid surfaces, (5) principle of stabilizing emulsions and suspensions using polymers.

The second part of this module is devoted to silicones and their use in cosmetics:

Silicone chemistry, silicones for cosmetics: categories, uses and sensory effects, with application examples.

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Basic knowledge of skin structure and physiology: skin structure; sensory receptors; mechanical and thermal sensitivity.

Skin penetration; skin hydration and moisturizing products; seborrhea, acne; Dermocosmetics typologies: skin penetration; skin aging, infant skin; cellulite

Hourly volumes* :

            CM: 16

            TD : 4

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This module is dedicated to the study of the main classes of cosmetic additives, as well as natural, biotechnological and synthetic active ingredients.

The first part of this course will focus on marine flora, with particular emphasis on the general composition and specific characteristics of different algae. What is the role and effectiveness of marine flora in cosmetics?

The course will conclude with case studies and perspectives.

A second part will focus on the plant world, enabling formulators and those in charge of regulatory affairs to understand how plant molecules are used for their beneficial effects in relation to the main cosmetic indications. Essential oils: what are their production techniques, chemical compositions, cosmetic properties, formulation and safety of use?

The third part of the module will focus on the different classes of additives used in cosmetics.

Emphasis will be placed on the chemical and organoleptic study of the main raw materials (synthetic or natural) used in cosmetics perfuming, and the regulatory constraints linked to their use (cosmetics directives on allergen dosage).

The families of fragrance molecules used in cosmetics (molecules with no organic function or containing alcohol, aldehyde, ketone or ester functions) will be studied:
- molecules with an aromatic ring
- phenol-type molecules
- cyclic and acyclic aliphatic molecules.
- acyclic and cyclic terpene molecules
- odor field.

-Notions of stability and volatility of molecules.

The course concludes with an apprenticeship in the formulation of fragrance compositions for cosmetic products.

Hourly volumes* :

            CM: 20

            TD : 10

            TP: 10

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What is eco-design? 

Product Life Cycle Assessment (LCA)
Who certifies?
Eco-design & raw materials
Biodiversity and the Nagoya Protocol.
Reminder of the principles of Green Chemistry
Eco-toxicology and biodegradability
Eco-design cosmetics manufacturing
Eco-design trends

What is the impact of eco-design packaging?

Notion of ecotoxicology: environmental impact/biodegradability

Information on ecodesign measurement: what tools are available/impact measurement Recylability of packaging: measurement and analysis (raw materials/formulas/ecotoxicology).

Students will be given the opportunity to put their work into practice.

Hourly volumes* :

            CM: 20

            TD : 10

            TP: 10

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The aim of this course is to understand and apply the principles of color formulation as practiced in the color industry. To achieve this, the basics of spectrophotometry, light-matter interactions and the simplest formulation models (Beer-Lambert and Kubelka-Munk) are studied and used in practical work.

Hourly volumes :

            CM : 12

            TP: 8

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European legislation and its hierarchy: regulations, directives, decisions, resolutions, national laws, institutions and authorities in charge of the regulatory system.

Description of the main regulations around the world and a global view of progress.

Institutions and authorities in charge of the regulatory system

Regulatory framework for cosmetics packaging

The compliance process for cosmetic packaging and its main difficulties

New requirements for cosmetics packaging under European and French laws on the circular economy

The course will cover Good Manufacturing Practices (GMP) designed to ensure reproducibility and quality in the manufacture of cosmetic products.

It will provide an understanding of the measures to be adopted with regard to production, control, storage and shipping processes, and to ensure the conformity of cosmetic products with current regulations (CE 1223/2009, ISO 22716, etc.).

Hourly volumes* :

            CM: 15

            TD : 15

            Land : 10

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This module covers all aspects of photoprotection:

It will begin with a review of solar radiation and the skin, focusing on natural melanin and non-melanin photoprotection. The skin's reaction to the sun will be discussed, with a focus on the benefits of the sun and its harmful side-effects. What are the cosmetics industry's protection options? How can we analyze the effectiveness of suncare products? What impact do filters have on the environment?

• Study of the development of suncare formulas: raw materials, chemical and physical filters, formulation techniques, regulations, the sun's relationship with the skin.

• Use of software to calculate theoretical SPFs

• Acquire knowledge of suncare product formulation
• Manufacturing processes
• Detailed analysis of INCI formulas

• Microemulsion formulation by phase inversion

Hourly volumes* :

            CM: 15

            TP: 25

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This teaching unit covers several areas:

• The lessons will show that chemistry opens the door to a wide range of professions in the cosmetics industry, not just formulation.

• Know how to reflect on the scientific method in order to avoid errors of judgment, and know how to reflect scientifically on all information. Teaching will be based on concrete examples linked to cosmetics (difference between risk and danger, reflection on various applications/consumer information, etc.).

• A real-life situation allows us to work on concrete marketing projects, from market research to the formalization of a cosmetics marketing concept.

Hourly volumes* :

            CM : 12

            TD : 8

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In-depth study of different cosmetic galenic formulations: composition, description of main components, formulation, principle, galenic forms

Study of ingredient families including emollients, esters, emulsifiers, sunscreens, preservatives and innovation in skincare and make-up products.

Study of INCI formulations and nomenclatures

Study of the different types of cosmetics companies

Study of manufacturing processes (agitation equipment, complementary manufacturing processes, impact of physico-chemical parameters on manufacturing)

It will be applied in a variety of fields.

For example: formulation of moisturizing emulsions with electrolytes (stability-disturbing elements), formulation of cleansing milk and cleansing lotion and setting up tests to measure cleansing effectiveness, formulation of make-up products.

Hourly volumes* :

            CM: 15

            TP: 25

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This module places students in a professional context, working with a cosmetics development and production company or raw materials supplier. The module will be organized in the form of industrial projects:

Students are divided into groups, as would be a scientific team. They must apply their theoretical knowledge in close collaboration with the industrialist. The industrialist can guide or help them to contact new suppliers, produce a cosmetics dossier, carry out a market study, etc., depending on the project assigned.

Activity reports will be produced via the sharing networks commonly used in the industry. Groups are expected to work independently, following specifications defined by the industrial company, in line with the diploma program.

This could involve, for example, the development of an innovative product, in compliance with French and European regulations, or countertyping.

Hourly volumes* :

            CM: 10

            TP: 30

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This module will help students understand the importance of innovation in a sector as dynamic as cosmetics.

This environment is governed by regulatory constraints, innovations in packaging, formulation and ingredients.

All this is also governed by the expectations of increasingly demanding consumers.

It is therefore essential for these future graduates to understand the ins and outs of innovation in cosmetics, and to know how to implement it while respecting certain criteria.

A project will be proposed to the students: Group presentation of the project and instructions for its implementation.

Hourly volumes* :

            CM: 20

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This 5-6 month internship, or work-study assignment, will be carried out in an R&D laboratory in the cosmetics and well-being industries.

The missions entrusted by the company to the student trainee/alternate will be in line with the objectives of the Master's program.

This internship or work-study assignment will be carried out in France or abroad.

See full page

This teaching unit is dedicated to the acquisition of concepts related to pigments, dyes and adsorbents, from the point of view of their structures and applications. Emphasis is placed on applications in the fields of flavors & fragrances (food colorants, perfumery) and cosmetics (hair dyes, powders, toothpastes, etc.). Some sessions are specific to each of the two pathways (P1, Cosmetics Engineering; P2, Flavors & Fragrances) of the Master's degree in Chemistry specializing in Cosmetics, Flavors and Fragrances Engineering (ICAP). The course comprises lectures and tutorials.

Hourly volumes* :

CM: 10 h

TD: 10 h

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Some basic microbiological principles will be covered, giving students an overview of the diversity of microorganisms. Bacteria's mode of nutrition and multiplication as a function of physico-chemical environmental parameters will be studied.

The composition and role of skin and digestive microbiota will be discussed.

The microbiological criteria used for quality control of cosmetics and food products will be defined.

Physical and chemical antimicrobial agents to control microbial development will be examined.

On a practical level, students will be expected to know how to handle bacteria and be familiar with microbiological safety rules. Usual microbiological control techniques and preservative efficacy tests will be carried out on cosmetic products.

Hourly volumes* :

CM: 12h

Practical work: 8h

See full page

This module covers all the raw materials knowledge you need to work in the cosmetics industry.

These are :

• describe the different chemical classes of raw materials, understand structure/activity relationships and sensory rendering.
• Study of documents relating to the marketing of cosmetic raw materials

Hourly volumes* :

            CM: 18

            TD : 6

            TP: 16

The course is based on case studies of ingredients in aqueous or fatty phases, and both polymers and polymerization processes will be developed.

The practical part of the module will involve the use of major categories of raw materials:

Use of gelling agents: application, study of their properties, sensory evaluation

Surfactant application: Formulation of a foaming product, including ingredient identification, formula design and sensory evaluation.

See full page

This UE covers :

- the fundamentals of colorimetry, which defines an unambiguous measure of color based on psychophysical experiments.

- the principle and practical use of color measuring devices (colorimeters and spectro-colorimeters).

- the principles of color reproduction, particularly in the context of perfumes and cosmetics.

Theoretical ideas are complemented by a significant amount of observation and experimentation in the short practical sessions.

Hourly volumes* :

CM: 12h

Practical work: 8h

See full page

Study of the entire development of a cosmetic product

• Definition of a cosmetic product
• Launching development, interactions between the development department and marketing, industry and regulatory departments: needs, expectations, operations and procedures
• Study of all possible tests: sensory analysis, physico-chemical stability, health and safety, efficacy.
• Study of industrial transposition
• Study of interactions with packaging and associated tests
• Description of the product information file or legal cosmetics file

Study of emulsions, definitions, characteristics and formulation

Study of instability phenomena in emulsions and stabilization solutions

Practical part :

Formulation of water-in-oil, oil-in-water and gel-cream emulsions

Study of ingredients, chemical nature, physical behavior and formulation

Study of formulation equipment

Set up sensory, physicochemical and stability tests.

Development of a formula in several stages with imposed constraints.

Critical analysis of the results obtained.

For the introduction to chemical engineering applied to the field of cosmetics, students will work on a case study that describes the laboratory-scale production of a cosmetic product, and then find a way to produce it on a larger scale.

Hourly volumes* :

 CM :15

TP: 25

See full page

This course provides basic knowledge and cross-disciplinary skills in the field of colloids and interfaces, which are common to the various courses in the Chemistry Master's program (Chemistry of Materials, Separative Chemistry, Materials and Processes, ICAP Cosmetics Engineering, Chemistry of Biomolecules). It is also offered to international students enrolled in the SFRI program at the University of Montpellier, where the course is taught in English. An introductory presentation covering the basic concepts and notions will enable students to discover and better understand the main physico-chemical properties of colloidal dispersions, associative colloids and solutions of macromolecules, as well as the parameters and phenomena governing stability in colloidal dispersions and mixed solution-colloid systems. This will be followed by interdisciplinary hands-on teaching based on the flipped classroom principle, to help students build and deepen their knowledge through individual and group analysis of various applications of colloidal and interfacial phenomena and systems.

Hourly volumes* :

CM: 7

TD : 13

See full page

Knowledge and ability to apply the various regulations relating to the cosmetics industry (Regulation 1223/2009, REACH, CLP, etc.).

Learn more about the key articles of European cosmetics regulations - Regulation 1223/2009

Learn how to create a DIP

Focus on the safety report using an example

Hourly volumes* :

            CM: 10

            TD : 10

See full page

This course covers the fundamental concepts and practical tools of chemometrics through : - statistical data analysis ;

• probability laws ;
• confidence interval estimation ;
• parametric and non-parametric tests.

An introduction to experimental design will be offered at the end of the module.

Hourly volumes* :

CM: 7h

TD: 13h

See full page

This course is designed to teach liquid and gas chromatography.

Hourly volumes* :

            CM :15h

            TD: 5h

See full page

The M1 ICAP student apprentice is placed in a professional situation to carry out a project in response to an industrial problem. This project will be carried out under the responsibility of a member of the teaching team (academic or industrial). Carried out throughout the semester, this project aims to put into practice the knowledge and skills acquired during the Bachelor's and early Master's courses. In addition to their chemistry-disciplinary skills, students will also acquire the interpersonal, organizational and communication skills intrinsically linked to project management, preparing them for their future professional life.

Example of an industrial problem: assessing the oxidative stability of fragrance ingredients in the presence of antioxidants.

Example of an industrial problem: analysis of allergens in perfumes: headspace (HS) solid phase microextraction (SPME) technique followed by gas chromatography-mass spectrometry (GC-MS) analysis.

Examples of industrial problems: detection and identification of compounds responsible for off-flavours using gas chromatography coupled with olfactometry.

Examples of industrial problems: Know and know how to use the essential physico-chemical analysis techniques used to control a finished product.

Hourly volumes* :

            CM: 5h

            TD: 5h

            Practical work: 40h

See full page

This module focuses on R&D in the cosmetics industry, with an emphasis on scientific expertise and innovation, through courses and lectures. There will also be hands-on experience in the design and development of cosmetics and wellness products.

The practical part will focus on the development of make-up products:

Review of the composition of make-up products

Natural and synthetic coloring raw materials. Know the different galenic formulas used in make-up and how to select raw materials.

Know how to select pigments according to the desired target. Know how to disperse them and surface treatment.

Marketing study on defined make-up galenics

Theoretical courses on raw materials and galenics used in make-up, manufacturing processes, market trends and possible tests (claims, physico-chemical tests, efficacy tests, etc.).

In practice :

Practical courses on pigment premixes, foundations and lipsticks, combined with sensorial evaluations

Application to the formulation of various make-up products (foundation, lipstick, mascara, etc.) and quality control of finished products.

Hourly volumes* :

            CM: 20

            TD : 5

            TP: 15

See full page

This teaching unit is shared with MI students in the Chemistry Master's courses: ICAP P1, ICAP P2, MAT P1, MAT P2, BM (semester S2). The following topics will be covered:

• The 12 Principles of Green Chemistry and units of measurement in Green Chemistry ;
• Synthesis strategies for sustainable chemistry ;
• Alternative or eco-compatible solvents for synthesis and extraction;
• Non-conventional activation techniques and applications.

CM: 13

TD: 7 H

See full page

This UE corresponds to the work-study assignment carried out in an R&D laboratory in the cosmetics and well-being industries.

The assignments entrusted by the company to the work-study student will be in line with the objectives of the Master's program.

The duration of the work-study placement follows the work-study schedule offered to partner companies.

See full page

In small groups or on a one-to-one basis, this course will cover pedagogical tools and best practices relating to communication and professional integration, through :

• assessments of knowledge, skills, competencies, attitudes and motivations;
• awareness of job search techniques ;
• CV and cover letter writing ;
• rules of oral and written communication ;
• mock job interviews.

Students will be able to take part in role-playing exercises directly linked to the sectors targeted by their career paths.

Practical work: 20h

See full page

This module focuses on :

• Tools and sources of information (patents, databases, journals, trade fairs and scientific days, etc.) and communication: identifying relevant sources of information, analyzing and using them, communicating internally and externally.
• What business intelligence is, and how to understand and use it
• Marketing fundamentals: presentation of what marketing does, presentation of tools that can help students in their future work, detailed explanation of the development process of a cosmetic product in marketing, and the different careers available to students.

A project will be developed by the students.

Hourly volumes* :

CM :15h

TD: 5h

Practical: 10h

Exit: 10 a.m.

See full page

A design of experiments is the ordered sequence of trials in an experiment, the aim of which is to test the validity of a hypothesis by reproducing a phenomenon and varying one or more parameters. Each trial produces data, and all the data produced during an experiment must be analyzed using rigorous methods to validate or invalidate the hypothesis. This experimental approach makes it possible to acquire new knowledge by confirming a model with a good economy of means (the lowest possible number of trials, for example).

Starting with a simple problem, the module develops the methodological and statistical tools needed to support increasingly complex hypotheses as optimally as possible. These methodologies are implemented using the R statistical language.

Hourly volumes* :

            CM: 15h

            Practical: 5h

See full page

Provide students with the theoretical understanding of inferential statistics needed for the statistical analysis of sensory test data. General problem: extract interpretable regularities from sensory measurements in order to make the right decisions.

The lessons will cover the needs of each pathway, using appropriate examples and applications.

Hourly volumes* :

            CM: 10 H

            PRACTICAL WORK: 10H

See full page

Polymers are used in a large number of cosmetic formulations for a variety of functions, the main ones being rheology control, formulation stabilization and conditioning. It is therefore important to know how they behave in these complex environments, in particular by studying polymer-surfactant interactions, since these two constituents are often present together in these media, as well as interactions with solid surfaces (suspensions, applications on hair or skin) or liquids (emulsions).

The course describes: (1) the different types of polymers used: water-soluble, synthetic, natural and semi-natural, amphiphilic and structure-property relationships, (2) principle of thickening formulas or gelling using polymers, (3) interactions with surfactants, presentation of the different types of surfactants and their physico-chemical properties, in particular polymeric surfactants, (4) interactions with surfaces (skin, hair) and all types of solid surfaces, (5) principle of stabilizing emulsions and suspensions using polymers.

The second part of this module is devoted to silicones and their use in cosmetics:

Silicone chemistry, silicones for cosmetics: categories, uses and sensory effects, with application examples.

See full page

Basic knowledge of skin structure and physiology: skin structure; sensory receptors; mechanical and thermal sensitivity.

Skin penetration; skin hydration and moisturizing products; seborrhea, acne; Dermocosmetics typologies: skin penetration; skin aging, infant skin; cellulite

Hourly volumes* :

            CM: 16

            TD : 4

See full page

This module is dedicated to the study of the main classes of cosmetic additives, as well as natural, biotechnological and synthetic active ingredients.

The first part of this course will focus on marine flora, with particular emphasis on the general composition and specific characteristics of different algae. What is the role and effectiveness of marine flora in cosmetics?

The course will conclude with case studies and perspectives.

A second part will focus on the plant world, enabling formulators and those in charge of regulatory affairs to understand how plant molecules are used for their beneficial effects in relation to the main cosmetic indications. Essential oils: what are their production techniques, chemical compositions, cosmetic properties, formulation and safety of use?

The third part of the module will focus on the different classes of additives used in cosmetics.

Emphasis will be placed on the chemical and organoleptic study of the main raw materials (synthetic or natural) used in cosmetics perfuming, and the regulatory constraints linked to their use (cosmetics directives on allergen dosage).

The families of fragrance molecules used in cosmetics (molecules with no organic function or containing alcohol, aldehyde, ketone or ester functions) will be studied:
- molecules with an aromatic ring
- phenol-type molecules
- cyclic and acyclic aliphatic molecules.
- acyclic and cyclic terpene molecules
- odor field.

-Notions of stability and volatility of molecules.

The course concludes with an apprenticeship in the formulation of fragrance compositions for cosmetic products.

Hourly volumes* :

            CM: 20

            TD : 10

            TP: 10

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What is eco-design? 

Product Life Cycle Assessment (LCA)
Who certifies?
Eco-design & raw materials
Biodiversity and the Nagoya Protocol.
Reminder of the principles of Green Chemistry
Eco-toxicology and biodegradability
Eco-design cosmetics manufacturing
Eco-design trends

What is the impact of eco-design packaging?

Notion of ecotoxicology: environmental impact/biodegradability

Information on ecodesign measurement: what tools are available/impact measurement Recylability of packaging: measurement and analysis (raw materials/formulas/ecotoxicology).

Students will be given the opportunity to put their work into practice.

Hourly volumes* :

            CM: 20

            TD : 10

            TP: 10

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The aim of this course is to understand and apply the principles of color formulation as practiced in the color industry. To achieve this, the basics of spectrophotometry, light-matter interactions and the simplest formulation models (Beer-Lambert and Kubelka-Munk) are studied and used in practical work.

Hourly volumes :

            CM : 12

            TP: 8

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European legislation and its hierarchy: regulations, directives, decisions, resolutions, national laws, institutions and authorities in charge of the regulatory system.

Description of the main regulations around the world and a global view of progress.

Institutions and authorities in charge of the regulatory system

Regulatory framework for cosmetics packaging

The compliance process for cosmetic packaging and its main difficulties

New requirements for cosmetics packaging under European and French laws on the circular economy

The course will cover Good Manufacturing Practices (GMP) designed to ensure reproducibility and quality in the manufacture of cosmetic products.

It will provide an understanding of the measures to be adopted with regard to production, control, storage and shipping processes, and to ensure the conformity of cosmetic products with current regulations (CE 1223/2009, ISO 22716, etc.).

Hourly volumes* :

            CM: 15

            TD : 15

            Land : 10

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This module covers all aspects of photoprotection:

It will begin with a review of solar radiation and the skin, focusing on natural melanin and non-melanin photoprotection. The skin's reaction to the sun will be discussed, with a focus on the benefits of the sun and its harmful side-effects. What are the cosmetics industry's protection options? How can we analyze the effectiveness of suncare products? What impact do filters have on the environment?

• Study of the development of suncare formulas: raw materials, chemical and physical filters, formulation techniques, regulations, the sun's relationship with the skin.

• Use of software to calculate theoretical SPFs

• Acquire knowledge of suncare product formulation
• Manufacturing processes
• Detailed analysis of INCI formulas

• Microemulsion formulation by phase inversion

Hourly volumes* :

            CM: 15

            TP: 25

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This teaching unit covers several areas:

• The lessons will show that chemistry opens the door to a wide range of professions in the cosmetics industry, not just formulation.

• Know how to reflect on the scientific method in order to avoid errors of judgment, and know how to reflect scientifically on all information. Teaching will be based on concrete examples linked to cosmetics (difference between risk and danger, reflection on various applications/consumer information, etc.).

• A real-life situation allows us to work on concrete marketing projects, from market research to the formalization of a cosmetics marketing concept.

Hourly volumes* :

            CM : 12

            TD : 8

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In-depth study of different cosmetic galenic formulations: composition, description of main components, formulation, principle, galenic forms

Study of ingredient families including emollients, esters, emulsifiers, sunscreens, preservatives and innovation in skincare and make-up products.

Study of INCI formulations and nomenclatures

Study of the different types of cosmetics companies

Study of manufacturing processes (agitation equipment, complementary manufacturing processes, impact of physico-chemical parameters on manufacturing)

It will be applied in a variety of fields.

For example: formulation of moisturizing emulsions with electrolytes (stability-disturbing elements), formulation of cleansing milk and cleansing lotion and setting up tests to measure cleansing effectiveness, formulation of make-up products.

Hourly volumes* :

            CM: 15

            TP: 25

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This module will help students understand the importance of innovation in a sector as dynamic as cosmetics.

This environment is governed by regulatory constraints, innovations in packaging, formulation and ingredients.

All this is also governed by the expectations of increasingly demanding consumers.

It is therefore essential for these future graduates to understand the ins and outs of innovation in cosmetics, and to know how to implement it while respecting certain criteria.

A project will be proposed to the students: Group presentation of the project and instructions for its implementation.

Hourly volumes* :

            CM: 20

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This 5-6 month internship, or work-study assignment, will be carried out in an R&D laboratory in the cosmetics and well-being industries.

The missions entrusted by the company to the student trainee/alternate will be in line with the objectives of the Master's program.

This internship or work-study assignment will be carried out in France or abroad.

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The aims of the course are to explain the macroscopic behavior of systems through their microscopic description, and to present the universal characteristics in the study of thermodynamic systems.

1. Thermodynamics reminder
2. A more general approach to statistical thermodynamics

III. General information on systems of identical particles without interaction

1. Applications of Boltzmann statistics
2. An example of the use of another statistic: blackbody radiation.

Hourly volumes* :

CM: 30

TD : 10

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RMN :

Liquid-phase NMR (Nuclear Magnetic Resonance) is an essential spectroscopic analysis method for chemists, enabling them to determine the structure of small organic molecules or macromolecules in solution, to study dynamic phenomena... The aim of this course is to understand the phenomena involved in this technique and to relate them to the different structural information accessible by this method. The aim is to be able to exploit the spectral data obtained from this analysis to elucidate the structure and stereochemistry of organic molecules or polymer structures, or to monitor reactions.

X-ray diffraction :

X-ray diffraction is a powerful, non-destructive technique not only for characterizing the crystalline structure of materials, but also for providing crystallographic and structural information such as lattice parameters and atomic positions. This includes all crystallized materials such as ceramics, materials for the storage and transformation of energy and information, as well as organic molecules and metal complexes (interatomic distances and angles, stereochemistry (chirality, stereoisomerism...), intra- and intermolecular bonds...). The aim of this course is to provide an introduction to crystallography and diffraction, with the aim of understanding the operation and characteristics of an X-ray diffractometer, as well as interpreting diffraction patterns (structural analysis, lattice parameters).

Hourly volumes* :

            CM: 10

            TD : 10

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Module HAC720C covers "advanced inorganic materials" in 5 main parts. Part¹ is dedicated to general information on inorganic materials, covering structure-properties relationships; particular attention is paid to chemical bonding, the real crystal and the polycrystalline solid; the different classes of inorganic materials are described. Part ² covers ceramic materials (definitions and properties) and their synthesis (raw materials including clays, shaping, drying and debinding, sintering); a distinction is made between traditional ceramics and technical ceramics (synthesis routes for oxide and non-oxide ceramics). Part³ deals with glasses (classification and synthesis routes) and glass ceramics (devitrification and soft chemistry); their properties and applications are also covered. Part⁴ is devoted to metals: properties of metals and metal alloys; metal nanoparticles; and catalytic materials. Part ⁵ is devoted to inorganic materials developed for energy; ceramics (oxides and non-oxides; nanostructured) and metal hydrides are described (properties and synthesis) through several examples and in the context of their applications (accumulators, hydrogen storage and carbon dioxide capture).

Hourly volumes* :

CM: 13h

TD: 7h

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- Thermodynamics of single-component systems.

- Basic thermodynamics of multicomponent systems. Chemical potential, Gibbs-Duhem relationship, variance.

- Thermal analysis techniques used to construct binary/ternary diagrams: ATG, ATD and DSC

- Construction and interpretation of binary phase diagrams based on thermodynamic quantities. Diagrams of Gibbs free enthalpy, pressure and temperature as a function of binary mixture composition. Liquid-liquid, liquid-vapor, solid-liquid mixtures.

- Phase transformation: first- and second-order transitions, critical points. Examples.

- The supercritical state: definition, thermodynamic properties, wide-ranging industrial applications.

- Construction and interpretation of ternary phase diagrams: variance, definitions of ternary eutectic, first- and second-order peritectic, isothermal section, study of alloy cooling.

Hourly volumes* :

CM :13

TD:7

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This course covers the fundamental concepts and practical tools of chemometrics through : - statistical data analysis ;

• probability laws ;
• confidence interval estimation ;
• parametric and non-parametric tests.

An introduction to experimental design will be offered at the end of the module.

Hourly volumes* :

CM: 7h

TD: 13h

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The first part of the course introduces the fundamentals of transition metal organometallic chemistry. It begins with a description of the Metal-C bond, enabling us to understand its stability and chemical reactivity. Secondly, the power of this synthesis tool for the formation of C-H, C-C, etc. bonds will be demonstrated. Examples of their applications in various fields will enable the acquisition of these reactions and their fields of application: fine chemistry, catalytic transformations of industrial importance, synthesis of natural products, preparation of materials.

The second part of this course is dedicated to hetero-element chemistry, focusing on the elements Silicon, Tin and Boron. The aim of this part is to present the various methods for preparing boron-, tin- and silicon-based reagents, as well as the main transformations carried out with these compounds, with applications in organic synthesis and materials synthesis.

CM: 13 H 

TD: 7 H

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The program focuses on describing the principles and applications of the main methods for structural characterization of solids, thin films, surfaces and interfaces, as well as several examples of applications in materials chemistry. It includes the following techniques.

• Introduction to solid-state NMR (NMR signal, Interactions in solid-state NMR, Magic angle rotation, NMR sequences, Cross-polarization, Instrumentation, etc.).
• Electron microscopy: principles and applications of scanning and transmission electron microscopy and correlated techniques (EDS microanalysis).
• Spectroscopic methods: Raman spectroscopy, photoelectron spectroscopy, X-ray spectroscopy (XAS, XRF, etc.), Mössbauer spectrometry.

Hourly volumes* :

            CM: 10 h

            TD: 10 h

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This lecture, entirely provided in English, gives a basic introduction into crystallography and electron diffraction for beginners. X-ray diffraction is an important characterization technique in modern chemistry the majority of crystalline structures in inorganic and organic solids have been solved by this method. It is therefore of importance for all students to have an understanding of its basic concepts and instrumentation. The course provides explanations and principles of X-ray diffraction together with the geometry and symmetry of X-ray patterns. Beside interaction principles of X-rays and matter, it treats how to obtain quantitative intensities for single crystal and powder diffraction patterns. It naturally includes the understanding of lattice planes and the reciprocal lattice concept together with the Ewald sphere construction. Further on it gives a basic understanding of the Fourier transform relation between the crystalline structure and the diffracted intensities as well as the reciprocal lattice concept.

Electron diffraction is a complementary technique to X-rays that provides information in terms of symmetry and geometry on the materials studied. In this course, we will therefore approach the description of the method for obtaining electron diffraction pattern and their interpretation. We will be able to obtain the lattice parameters, the reflection conditions as well as the groups of possible spaces.

This lecture also serves as the introductory part to the lecture Electron Microscopy and Crystallography II

CM:14

TD :6

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This teaching unit is dedicated to deepening the foundations of organic chemistry and coordination chemistry covered in L3, and acquiring notions linked to molecular engineering and molecular chemistry. The course comprises lectures and tutorials. Students will work in advance of certain lectures and tutorials, with course documents provided, to ensure that the lectures and tutorials enable them to play a full part in the course, understand the concepts presented and the skills to be acquired. A progression program and activities will be proposed. For students who have not seen the basics of coordination chemistry and organic chemistry, documents will be made available.

Coordination chemistry: The course will cover various aspects of transition metal and lanthanide complexes, molecular materials (polynuclear complexes and coordination polymers with extended structures (MOFs, etc.)), their properties and applications. Structural aspects, bonding description, properties, as well as stability and reactivity aspects will be covered. Emphasis will be placed on the complexation effect and stability of metal, lanthanide and actinide complexes with certain ligands, with a view to applications in the biomedical field (imaging and therapy), decontamination (nuclear field), etc. The electronic (relaxivity, magnetism) and optical (absorption, luminescence) properties of these complexes will be discussed and put into the context of applications in various fields, such as imaging, electronics, sensors, etc.

Organic Chemistry: This course builds on the knowledge acquired in the Bachelor's degree, and will involve a reasoned study of the main reaction mechanisms in organic chemistry, providing a common foundation for all students in the Chemistry Master's program. The main processes (substitution, addition, elimination, transposition...) and their essential characteristics and applications to mechanistic sequences will be examined. The course is designed to provide students with general tools for analyzing mechanisms (ionic, radical, concerted) in order to grasp their variety.

Hourly volumes* :

CM: 13 H

TD: 7 H

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The professional project bridges the gap between traditional practical work and the internship in a laboratory or company. It is carried out in the form of a tutored project, which puts students in a professional situation through collaborative (group) work based on the realization of a project in response to a problem set by a company, community, association or academic. It is part of the Chemistry Master's core curriculum, and is carried out under the responsibility of a member of the teaching team (academic or industrial). Carried out throughout the semester, this project aims to link and anchor the knowledge and know-how acquired during the Bachelor's degree and the early Master's program, through a professional setting. These situations will be directly linked to the Master's course chosen by the students. In addition to their chemistry-disciplinary skills, students will also acquire the interpersonal, organizational and communication skills intrinsically linked to project management, which will equip them for their future professional life.

Responding to a research problem: example of the synthesis of new phosphorescent materials.

Hourly volumes* :

CM: 5h

TD: 5h

Practical work: 40h

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The aim of this teaching module is to provide and understand the theoretical foundations associated with certain modeling methods found in various fields, from "small molecules" to living organisms and materials. This module aims to answer, in part, three questions: 1) Why model? 2) What model? 3) How to model?

Hourly volumes* :

CM: 14

TP: 6

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An internship lasting 2 to 4 months must be carried out in a research or R&D laboratory specializing in theoretical chemistry. Students will have the opportunity to carry out this internship in academic or private research laboratories. Subject to the prior approval of the teaching staff (internship subject in line with the Master's courses and suitable environment/means), students may seek a host team in an academic environment in the institutes of the Pôle Chimie of the University of Montpellier, in academic laboratories outside the University of Montpellier (in France or abroad) or in the private sector (chemical, pharmaceutical industries, etc.).

This 2 to 4 month internship can start as early as mid-May after the exam session, and cannot exceed 4 months.

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This course provides the theoretical basis for analyzing the microscopic origin of unusual physico-chemical properties.

The focus is on properties that are crucial in terms of the intensity of the research they generate and their technological applications: electron transfer, magnetism, photomagnetism, bistability, conduction, and so on. Several types of compounds will be studied: molecular switches, mono- and multi-radical aromatic molecules and strategies for assembling ordered high-spin organic structures, spin-transition compounds, magnet molecules, ferro-, antiferro- or ferrimagnetically-coupled poly-metallic complexes.

1. Derivation of simple models for highly correlated systems (Heisenberg).
2. Hydrocarbon compounds: aromaticity and magnetic properties of polyradical cyclic and polycyclic systems.
3. Monometallic complexes: spin-transition compounds (crystal field and ligand field theories, bistability concept). Magnetically anisotropic compounds (spin-orbit coupling), towards molecular magnets (hysteresis)...
4. Bimetallic complexes: electron transfer (molecular switches) in mixed-valence compounds and spin exchange in magnetic compounds (ferro- and antiferromagnetic couplings), photomagnetism.

Hourly volumes* :

CM: 24

TP: 8

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The aim of this course is to deepen and complement the theoretical knowledge acquired in
spectroscopy by students during their undergraduate studies.

Hourly volumes* :

CM: 15

TD : 9

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In small groups or on a one-to-one basis, this course will cover pedagogical tools and best practices relating to communication and professional integration, through :

• assessments of knowledge, skills, competencies, attitudes and motivations;
• awareness of job search techniques ;
• CV and cover letter writing ;
• rules of oral and written communication ;
• mock job interviews.

Students will be able to take part in role-playing exercises directly linked to the sectors targeted by their career paths.

Practical work: 20h

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The electronic and optical properties of solids are at the heart of numerous applications in the fields of energy (photovoltaic panels, passive coolants, etc.), light production (white diodes, lasers, etc.) and electronics (components, microprocessors, etc.). After an introduction to these different fields of application, this course aims to define the different concepts needed to master both the electronic and optical properties of materials, which are essential for understanding the most modern technologies.

Hourly volumes* :

            CM: 11H

            TD : 9H

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A general approach to the coordination chemistry of f-elements will be developed through the concepts of atomistics, oxidation state and coordination polyhedra, with the aim of highlighting the specific characteristics of f-elements. Direct comparisons will be made with the coordination chemistry of transition elements, and applications to nuclear chemistry will be discussed.

Hourly volumes* :

            CM: 12h

            TD : 8h

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Examples of homogeneous catalysis reactions will be presented, highlighting the underlying concepts and limitations of theoretical approaches (mainly DFT). Olein metathesis and polymerization examples will illustrate supported catalysis, with emphasis on the influence of the support.

Various examples will illustrate the specificity of nanocatalysts, distinguishing between the respective roles of electronic and geometric factors.

Hourly volumes* :

CM: 20

TD : 10

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The aim is to acquire strong skills in theoretical chemistry through the discovery or deepening of various themes.

This module is organized in two phases: (i) online courses and seminars, delivered throughout the first semester; (ii) a week of intensive training in early January, at one of the sites of the South-West pole of the French Theoretical Chemistry Network (Bordeaux, Montpellier, Pau, Toulouse).

Topics covered include :

- quantum chemistry and relativity

- Monte Carlo methods

- exploring potential energy surfaces

- calculation of the electronic structure of periodic systems

- quantum dynamics

- calculation of spectroscopic properties

Hourly volumes* :

CM: 40

TD : 20

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This module is a preparation for doctoral studies in the field of theoretical chemistry, especially quantum chemistry. Recent methodological developments and the development of increasingly powerful software have democratized the use of quantum chemistry software.

The module covers electronic structure and molecular dynamics. The formalism of the various methods and their field of application will be detailed to enable the informed use of theoretical chemistry software, particularly quantum chemistry.

(1) electronic structure

- Hartree-Fock

- electronic correlation, configuration interaction, coupled cluster

- Density Functional Theory (DFT)

(2) nuclear dynamics

- classical and ab initio dynamics (Car Parrinello, Born-Oppenheimer, propagators, thermodynamic sets, free-energy calculations)

- quantum dynamics of photo-induced processes (wave packet, adiabatic and non-adiabatic dynamics, link with absorption spectrum, diabatic representation, mixed classical-quantum dynamics)

Hourly volumes* :

CM: 10

TD : 20

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Introduce the methods used to explore the physico-chemical properties of materials using numerical computation. To provide a mathematical foundation for the numerical tools presented in the "Modeling" course in M1, and to complement the applications covered in this course.

Hourly volumes* :

CM: 28

TD : 12

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In this course, students will learn about the main numerical methods used in scientific software, particularly in theoretical chemistry programs.

Hourly volumes* :

CM: 21

TD : 9

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Present the methods used to explore the physico-chemical properties of materials using numerical computation. Give the mathematical foundations of the associated numerical tools.

I- Introduction

II- Quantum approach: molecular methods: quantum mechanics, Schrödinger equation, DFT methods.

III- Quantum approach: periodic systems

IV- Molecular dynamics: classical approach

Hourly volumes* :

CM: 30

TD : 10

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An internship lasting 5 to 6 months must be carried out in a research or R&D laboratory specializing in theoretical chemistry. Students will have the opportunity to carry out this end-of-study internship in academic or private research laboratories. Subject to prior approval by the teaching staff (internship subject in line with Master's courses and suitable environment/means), students may seek a host team in an academic environment in the institutes of the Pôle Chimie of the University of Montpellier, in academic laboratories outside the University of Montpellier (in France or abroad) or in the private sector (chemical, pharmaceutical industries, etc.).

This 5 to 6 month internship may start in mid-January after the exam session and may not exceed 6 months for a period in semester 10 within the validity of the university registration.

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Fluorinated biomolecules. Current developments in fluorinated molecules. Fluorination methods: nucleophilic or electrophilic mono-fluorination, introduction of difluoromethyl or trifluoromethyl groups. Contribution of fluorine atoms to the activity of these compounds. Examples of the synthesis of fluorinated compounds used as antitumoral agents, antiviral agents, antidepressants, anxiolytics, anti-inflammatories, etc.

Phosphorus biomolecules. Structure, nomenclature, reactivity, structural analysis and applications.

A number of synthesis routes for compounds in each of the families covered will be discussed, highlighting unconventional activation methods where appropriate. Biomedical applications will be targeted, as well as other applications in agrochemistry, optoelectronics, nanomaterials, etc.

Hourly volumes* :

CM: 15 h (7.5h Fluorinated biomolecules and 7.5h Phosphorus biomolecules)

TD: 5 h

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This course provides basic knowledge and cross-disciplinary skills in the field of colloids and interfaces, which are common to the various courses in the Chemistry Master's program (Chemistry of Materials, Separative Chemistry, Materials and Processes, ICAP Cosmetics Engineering, Chemistry of Biomolecules). It is also offered to international students enrolled in the SFRI program at the University of Montpellier, where the course is taught in English. An introductory presentation covering the basic concepts and notions will enable students to discover and better understand the main physico-chemical properties of colloidal dispersions, associative colloids and solutions of macromolecules, as well as the parameters and phenomena governing stability in colloidal dispersions and mixed solution-colloid systems. This will be followed by interdisciplinary hands-on teaching based on the flipped classroom principle, to help students build and deepen their knowledge through individual and group analysis of various applications of colloidal and interfacial phenomena and systems.

Hourly volumes* :

CM: 7

TD : 13

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This course is designed to teach liquid and gas chromatography.

Hourly volumes* :

            CM :15h

            TD: 5h

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Knowledge of gas chromatography and mass spectrometry techniques with electron impact ionization and quadrupole mass analyzer for the analysis of volatile organic molecules.

1) GC-MS analysis of volatile organic compounds :

• Electron impact ionization (EI) techniques
• Chemical ionization (CI) techniques
• Quadrupole (Q) analysis techniques
• GC/MS coupling

2) Applications in organic chemistry analysis and characterization of volatile samples.

Hourly volumes* :

CM: 15 H

TD: 5 H

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Knowledge of the main polymer families used in the biomedical field.

1) Specificity of polymers for biomedical applications and the main polymer families used

2) Description of application families

3) Discussion of the concept of synthesis and the relationship between structure/properties and specifications

Hourly volumes* :

CM: 15 H

TD: 5 H

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This course deals concisely and systematically with all aspects of heterocycle chemistry, from nomenclature to applications such as the principles of action of medicines, toxins or drugs, pigments, food colorants etc...

Hourly volumes* :

CM: 15 H

TD: 5 H

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Natural products play a major role in biomolecular chemistry. They represent an important source of bioactive compounds for medicinal chemistry. This teaching unit provides a comprehensive overview of secondary metabolism and the origin of natural products from plants. Emphasis will be placed on the organic chemistry behind the various biotransformations that occur during the biosynthesis of each major class of molecules. A mechanistic approach will be used to understand the chemical basis of each transformation.

Hourly volumes* :

CM: 13 

TD : 7

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RMN :

Liquid-phase NMR (Nuclear Magnetic Resonance) is an essential spectroscopic analysis method for chemists, enabling them to determine the structure of small organic molecules or macromolecules in solution, to study dynamic phenomena... The aim of this course is to understand the phenomena involved in this technique and to relate them to the different structural information accessible by this method. The aim is to be able to exploit the spectral data obtained from this analysis to elucidate the structure and stereochemistry of organic molecules or polymer structures, or to monitor reactions.

X-ray diffraction :

X-ray diffraction is a powerful, non-destructive technique not only for characterizing the crystalline structure of materials, but also for providing crystallographic and structural information such as lattice parameters and atomic positions. This includes all crystallized materials such as ceramics, materials for the storage and transformation of energy and information, as well as organic molecules and metal complexes (interatomic distances and angles, stereochemistry (chirality, stereoisomerism...), intra- and intermolecular bonds...). The aim of this course is to provide an introduction to crystallography and diffraction, with the aim of understanding the operation and characteristics of an X-ray diffractometer, as well as interpreting diffraction patterns (structural analysis, lattice parameters).

Hourly volumes* :

            CM: 10

            TD : 10

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Knowledge of the latest mass spectrometry techniques for the qualitative analysis of organic molecules and biomolecules.

1) Description of fundamental principles (Ion Science and Technology) :

- Ionization techniques

- Analysis techniques

- Tandem mass spectrometry (MS/MS)

- LC/MS and LC/MS/MS couplings

2) Application in biomolecule analysis and organic chemistry reaction monitoring.

Hourly volumes* :

CM: 15 H

TD: 5 H

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This course covers the fundamental concepts and practical tools of chemometrics through : - statistical data analysis ;

• probability laws ;
• confidence interval estimation ;
• parametric and non-parametric tests.

An introduction to experimental design will be offered at the end of the module.

Hourly volumes* :

CM: 7h

TD: 13h

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The first part of the course introduces the fundamentals of transition metal organometallic chemistry. It begins with a description of the Metal-C bond, enabling us to understand its stability and chemical reactivity. Secondly, the power of this synthesis tool for the formation of C-H, C-C, etc. bonds will be demonstrated. Examples of their applications in various fields will enable the acquisition of these reactions and their fields of application: fine chemistry, catalytic transformations of industrial importance, synthesis of natural products, preparation of materials.

The second part of this course is dedicated to hetero-element chemistry, focusing on the elements Silicon, Tin and Boron. The aim of this part is to present the various methods for preparing boron-, tin- and silicon-based reagents, as well as the main transformations carried out with these compounds, with applications in organic synthesis and materials synthesis.

CM: 13 H 

TD: 7 H

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This teaching unit is dedicated to deepening the foundations of organic chemistry and coordination chemistry covered in L3, and acquiring notions linked to molecular engineering and molecular chemistry. The course comprises lectures and tutorials. Students will work in advance of certain lectures and tutorials, with course documents provided, to ensure that the lectures and tutorials enable them to play a full part in the course, understand the concepts presented and the skills to be acquired. A progression program and activities will be proposed. For students who have not seen the basics of coordination chemistry and organic chemistry, documents will be made available.

Coordination chemistry: The course will cover various aspects of transition metal and lanthanide complexes, molecular materials (polynuclear complexes and coordination polymers with extended structures (MOFs, etc.)), their properties and applications. Structural aspects, bonding description, properties, as well as stability and reactivity aspects will be covered. Emphasis will be placed on the complexation effect and stability of metal, lanthanide and actinide complexes with certain ligands, with a view to applications in the biomedical field (imaging and therapy), decontamination (nuclear field), etc. The electronic (relaxivity, magnetism) and optical (absorption, luminescence) properties of these complexes will be discussed and put into the context of applications in various fields, such as imaging, electronics, sensors, etc.

Organic Chemistry: This course builds on the knowledge acquired in the Bachelor's degree, and will involve a reasoned study of the main reaction mechanisms in organic chemistry, providing a common foundation for all students in the Chemistry Master's program. The main processes (substitution, addition, elimination, transposition...) and their essential characteristics and applications to mechanistic sequences will be examined. The course is designed to provide students with general tools for analyzing mechanisms (ionic, radical, concerted) in order to grasp their variety.

Hourly volumes* :

CM: 13 H

TD: 7 H

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The professional project bridges the gap between traditional practical work and the internship in a laboratory or company. It is carried out in the form of a tutored project, which puts students in a professional situation through collaborative (group) work based on the realization of a project in response to a problem set by a company, community, association or academic. It is part of the Chemistry Master's core curriculum, and is carried out under the responsibility of a member of the teaching team (academic or industrial). Carried out throughout the semester, this project aims to link and anchor the knowledge and know-how acquired during the Bachelor's degree and the early Master's program, through a professional setting. These situations will be directly linked to the Master's course chosen by the students. In addition to their chemistry-disciplinary skills, students will also acquire the interpersonal, organizational and communication skills intrinsically linked to project management, which will equip them for their future professional life.

Responding to a research problem: example of the synthesis of new phosphorescent materials.

Hourly volumes* :

CM: 5h

TD: 5h

Practical work: 40h

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The internship in semester 8 of the Master 1 Chemistry of Biomolecules is designed to familiarize students with research careers in life chemistry. Students will have the opportunity to carry out this introductory research internship in academic or private laboratories. Subject to prior approval by the teaching staff (internship subject in line with the Master's courses and suitable environment/means), students can look for a host team in an academic environment in the University of Montpellier's Chemistry Pole institutes (IBMM, ICGM, etc.), in academic laboratories outside the University of Montpellier (in France or abroad) or in the private sector (chemical, pharmaceutical and agri-food industries, biotechnology laboratories, etc.).

Fieldwork: 2 to 4 months' internship

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Nucleosides are the basic building blocks of nucleic acids (DNA and RNA). As such, they play an essential role in many biological processes. In this course, the structure and biological role of natural nucleosides will be presented. It will also cover the main routes to synthesis and characterization of these compounds and their analogues (glycosylation reactions, structural modifications of the furanose ring, substitution and introduction of heteroatoms, configuration inversion, etc.). The use of nucleoside analogues in the treatment of viral pathologies and cancers will also be addressed.

Hourly volumes* :

WC: 3 p.m.

TD: 5 h

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This teaching unit is shared with MI students in the Chemistry Master's courses: ICAP P1, ICAP P2, MAT P1, MAT P2, BM (semester S2). The following topics will be covered:

• The 12 Principles of Green Chemistry and units of measurement in Green Chemistry ;
• Synthesis strategies for sustainable chemistry ;
• Alternative or eco-compatible solvents for synthesis and extraction;
• Non-conventional activation techniques and applications.

CM: 13

TD: 7 H

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The aim of the medicinal chemistry course is to introduce students to the key stages in the process of developing molecules with biological activity. In particular, a description of the interactions involved, the notion of pharmocophores, bio-isosteria, etc., as well as structure-activity relationship studies will be covered, enabling students to envisage appropriate strategies and structural modifications.

Hourly volumes* :

WC: 3 p.m.

TD: 5 h

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After a general introduction to the concepts of prochirality and stereochemistry, this course will present the tools needed to master diastereoselective and enantioselective syntheses. The different approaches will be presented in a detailed and rational manner. Examples of industrial syntheses of chiral bioactive molecules will be discussed.

Hourly volumes* :

CM: 15 H

TD: 5 H

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This course covers synthetic methods for obtaining enantiopure amino acids, as well as the use of chiral amino acids for the synthesis of other enantiopure compounds.

These amino acids are the building blocks of peptides. The different physico-chemical properties induced by the nature of these amino acids will enable us to define strategies for the synthesis and characterization of peptides of interest.

Hourly volumes* :

CM: 15 H

TD: 5 H

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The following topics will be covered:

- Biobased solvents

- Biomass fuels

- Antioxidants derived from lignin

- Metal catalysts from plants

- Surfactants obtained from renewable resources

- Examples of industrial applications of enzymatic synthesis

Hourly volumes* :

CM: 15

TD : 5

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In small groups or on a one-to-one basis, this course will cover pedagogical tools and best practices relating to communication and professional integration, through :

• assessments of knowledge, skills, competencies, attitudes and motivations;
• awareness of job search techniques ;
• CV and cover letter writing ;
• rules of oral and written communication ;
• mock job interviews.

Students will be able to take part in role-playing exercises directly linked to the sectors targeted by their career paths.

Practical work: 20h

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