This could be, for example, the development of an innovative product, in compliance with French and European regulations, or countertyping.

Activity reports will be produced via the sharing networks commonly used in the field. The groups will be asked to work independently, following a set of specifications defined by the industrialist, in line with the diploma programme.

            TP: 30
  • Examples of industrial problems: Know and know how to use the essential physico-chemical analysis techniques implemented during the control of a finished product

                CM: 5h

  •             Practical work: 40h

    Industrial internship

  • This UE corresponds to the work-study assignment carried out in an R&D laboratory in the cosmetics and well-being industries.

    The tasks entrusted by the company to the work-study student will be in line with the objectives of the Master's programme.

  • The duration of the work-study student's assignment follows the work-study schedule offered to partner companies.

    Industrial apprentice projects

This module consists of placing students in a professional context, in relation with a cosmetics development and production company or raw material supplier. The module will be organised in the form of industrial projects.

- Introduction to basic concepts in quantum physics and its relation to chemistry, modern materials science and engineering of nanodevices.
- To achieve the goals of this course, a mathematically-rigorous approach is combined with the physical interpretation of the concepts, and the application of the most important QM models to electronic and magnetic spectroscopies and chemistry is illustrated.

            CM (Readings): 24H
  •             Tutorials: 12H

    Statistical Mechanics (UE Toulouse 3)

The objectives of the course are to explain the macroscopic behaviour of systems through their microscopic description and to present the universal characteristics in the study of thermodynamic systems.

Reminder of thermodynamics

  • A more general approach to statistical thermodynamics
  • III. Generalities on systems of identical particles without interaction
  • Applications of Boltzmann statistics
            CM (Readings): 24H

An example of the use of another statistic: blackbody radiation.

CM: 30

Materials with outstanding electronic properties

  • This course provides the theoretical basis for analysing the microscopic origin of unusual physico-chemical properties.
  • The tasks entrusted by the company to the student trainee/intern will be in line with the objectives of the Master's programme.
  • The properties that are crucial for the intensity of the research they generate and their technological applications are addressed: electronic transfer, magnetism, photomagnetism, bistability, conduction, etc. Several types of compounds will be studied: molecular switches, mono- and multi-radical aromatic molecules and strategies for assembling ordered high-spin organic structures, spin-transition compounds, magnet molecules, ferro-, antiferro- or ferrimagnetically coupled poly-metallic complexes.
  • Derivation of simple models for highly correlated systems (Heisenberg).
  • Hydrocarbon compounds: aromaticity and magnetic properties of polyradical cyclic and polycyclic systems.
  • Monometallic complexes: spin transition compounds (crystal field and ligand field theories, bistability concept). Magnetically anisotropic compounds (spin-orbit coupling), towards molecular magnets (hysteresis)...
  • Bimetallic complexes: electronic transfer (molecular switches) in mixed valence compounds and spin exchange in magnetic compounds (ferro- and antiferromagnetic couplings), photomagnetism.

CM: 24

            CM (Readings): 24H

TP: 8

Internship 2-4 months

An internship of 2 to 4 months must be carried out in a research or research and development laboratory specialising in theoretical chemistry. Thus, students will have the opportunity to do this internship in academic or private research laboratories. Subject to prior acceptance by the teaching staff (internship subject related to the Master's courses and adequate environment/means), the student will be able to look for a host team in an academic environment in the institutes of the Chemistry Pole of the University of Montpellier, in academic laboratories outside the University of Montpellier (in France or abroad) or in the private sector (chemical, pharmaceutical industries, etc.).

  • This traineeship of 2 to 4 months' duration may start from mid-May after the examination session and may not exceed 4 months.
  • Quantum Mechanics and Modelling II
  • In this course a complete description of the structural, electronic and vibrational properties of molecules is given together with the quantum treatment of these properties in computer simulations.
  • In parallel the structural and electronic properties of solids is addressed with an emphasis on the properties of metals and semiconductors.
  •             CM: 42H
  •             TD: 21H
            CM (Readings): 24H

The students are divided into groups, such as a scientific team. They will have to apply their theoretical knowledge in close collaboration with the industrialist.

An internship of 5 to 6 months must be carried out in a research or research and development laboratory specialising in theoretical chemistry. Thus, students will have the opportunity to carry out this end-of-study internship in academic or private research laboratories. Subject to prior acceptance by the teaching staff (internship subject related to the Master's courses and adequate environment/means), the student may look for a host team in an academic environment in the institutes of the Chemistry Pole of the University of Montpellier, in academic laboratories outside the University of Montpellier (in France or abroad) or in the private sector (chemical, pharmaceutical industries, etc.).

This internship of 5 to 6 months duration may start in mid-January after the examination session and may not exceed 6 months for a period in semester 10 during the validity of the university registration.

            CM (Readings): 24H

Heterocyclic chemistry

This course deals in a concise and systematic way with all aspects of heterocycle chemistry, from nomenclature to applications such as the principles of action of drugs, toxins or medicines, pigments, food colorants etc...

Fluorinated and phosphorated biomolecules: synthesis and application

Fluorinated biomolecules. Current developments in fluorinated molecules. Fluorination methods: nucleophilic or electrophilic mono-fluorination, introduction of difluoromethyl or trifluoromethyl groups. Contribution of the fluorine atom(s) to the activity of these compounds. Examples of syntheses of fluorinated compounds used as antitumour agents, antiviral agents, antidepressants, anxiolytics, anti-inflammatories...

Phosphorus biomolecules. Structure, nomenclature, reactivity, structural analysis and applications.

Some synthetic routes of compounds from each of the families treated will be discussed, highlighting, where appropriate, non-conventional activation methods. Biomedical applications will be targeted, as well as other applications in agrochemistry, optoelectronics, nanomaterials, etc.

            CM (Readings): 24H

The projects will be applied in particular to make-up products.

CM: 15 h (7.5h Fluorinated Biomolecules and 7.5h Phosphorus Biomolecules)

Chemistry of natural products

Natural products play a major role in the field of biomolecular chemistry. They represent an important source of bioactive compounds for medicinal chemistry. This course provides a comprehensive overview of the secondary metabolism and origin of natural products from plants. The emphasis in this unit will be on the organic chemistry behind the different biotransformations that occur during the biosynthesis of each major class of molecules. A mechanistic approach will be used to understand the chemical basis of each transformation.

CM: 13 

TD: 7

Analysis of volatile molecules

Knowledge of gas chromatography and mass spectrometry techniques with electron impact ionisation and quadrupole mass analyser for the analysis of volatile organic molecules.

1) GC-MS analyses of volatile organic compounds:

            CM (Readings): 24H

Electron impact ionisation (EII) techniques

This 5 to 6 month internship, or work-study assignment, will be carried out in an R&D laboratory in the cosmetics and well-being industries.

The teaching of the organic synthesis strategies and tools module focuses on the development of strategies for the elaboration of molecules from the natural environment or not, using organic chemistry tools.

Amino acids and derivatives

This course discusses synthetic methods applied to obtain enantiopure amino acids as well as the use of chiral amino acids for the synthesis of other enantiopure compounds.

These amino acids are the building blocks of peptides. The different physico-chemical properties induced by the nature of these amino acids will allow the definition of strategies for the synthesis of peptides of interest and their characterisation.

Lipid compounds

- Triglycerides

- Phospholipids and sphingolipids



Strategy and tools in organic synthesis

The tasks entrusted by the company to the student trainee/intern will be in line with the objectives of the Master's programme.

- Glycolipids

Strategy and tools in organic synthesis

This internship or work-study assignment will be carried out in France or abroad.

- Fat-soluble vitamins

 

Strategy and tools in organic synthesis

Professional projects - follow-up of apprentice projects

- Steroid hormones

- Bile salts

Strategy and tools in organic synthesis

The student apprentice in M1 ICAP will be placed in a professional situation and will carry out a project in response to an industrial problem. This project will be carried out under the responsibility of a member of the teaching team (academic or industrial). Carried out throughout the semester, this project aims to put into practice the knowledge/know-how acquired during the Bachelor's and early Master's degree. In addition to the disciplinary skills of chemistry, other relational, organisational and communication skills, intrinsically linked to project management, will also be acquired and will prepare the students for their future professional life.

- Structure and synthesis of prostaglandins and leukotrienes

Drugs/bioprecursors

Strategy and tools in organic synthesis

Example of an industrial problem: evaluation of the oxidative stability of perfumed ingredients in the presence of antioxidants

Knowledge of the limitations associated with the administration of an active ingredient (solubility, bioavailability, etc.).

Strategy and tools in organic synthesis

Example of an industrial problem: analysis of allergens in perfumes: headspace (HS) solid phase microextraction (SPME) technique followed by gas chromatography-mass spectrometry (GC-MS) analysis

General description of the enzymatic systems involved in the biotransformation of nutrients and exogenous compounds.

Description of the main modes of membrane passage and transport systems for fundamental biomolecules (sugars, amino acids, nucleosides, etc.).

Examples of prodrug and bioprecursor design.

NMR

 Deepening of knowledge in 1H, 13C, 19F, 29Si, 31PNMR, as well as two-dimensional methods. EPR concepts will also be covered (principle and applications).

Glycochemistry

Strategy and tools in organic synthesis