Examples of industrial problems: Know and know how to use the essential physico-chemical analysis techniques implemented during the control of a finished product
CM: 5h
Practical work: 40h
Industrial internship
This UE corresponds to the work-study assignment carried out in an R&D laboratory in the cosmetics and well-being industries.
The tasks entrusted by the company to the work-study student will be in line with the objectives of the Master's programme.
The duration of the work-study student's assignment follows the work-study schedule offered to partner companies.
Industrial apprentice projects
This module consists of placing students in a professional context, in relation with a cosmetics development and production company or raw material supplier. The module will be organised in the form of industrial projects.
- Introduction to basic concepts in quantum physics and its relation to chemistry, modern materials science and engineering of nanodevices.
- To achieve the goals of this course, a mathematically-rigorous approach is combined with the physical interpretation of the concepts, and the application of the most important QM models to electronic and magnetic spectroscopies and chemistry is illustrated.
Tutorials: 12H
Statistical Mechanics (UE Toulouse 3)
The objectives of the course are to explain the macroscopic behaviour of systems through their microscopic description and to present the universal characteristics in the study of thermodynamic systems.
Reminder of thermodynamics
- A more general approach to statistical thermodynamics
- III. Generalities on systems of identical particles without interaction
- Applications of Boltzmann statistics
An example of the use of another statistic: blackbody radiation.
CM: 30
Materials with outstanding electronic properties
- This course provides the theoretical basis for analysing the microscopic origin of unusual physico-chemical properties.
- The tasks entrusted by the company to the student trainee/intern will be in line with the objectives of the Master's programme.
- The properties that are crucial for the intensity of the research they generate and their technological applications are addressed: electronic transfer, magnetism, photomagnetism, bistability, conduction, etc. Several types of compounds will be studied: molecular switches, mono- and multi-radical aromatic molecules and strategies for assembling ordered high-spin organic structures, spin-transition compounds, magnet molecules, ferro-, antiferro- or ferrimagnetically coupled poly-metallic complexes.
- Derivation of simple models for highly correlated systems (Heisenberg).
- Hydrocarbon compounds: aromaticity and magnetic properties of polyradical cyclic and polycyclic systems.
- Monometallic complexes: spin transition compounds (crystal field and ligand field theories, bistability concept). Magnetically anisotropic compounds (spin-orbit coupling), towards molecular magnets (hysteresis)...
- Bimetallic complexes: electronic transfer (molecular switches) in mixed valence compounds and spin exchange in magnetic compounds (ferro- and antiferromagnetic couplings), photomagnetism.
CM: 24
TP: 8
Internship 2-4 months
An internship of 2 to 4 months must be carried out in a research or research and development laboratory specialising in theoretical chemistry. Thus, students will have the opportunity to do this internship in academic or private research laboratories. Subject to prior acceptance by the teaching staff (internship subject related to the Master's courses and adequate environment/means), the student will be able to look for a host team in an academic environment in the institutes of the Chemistry Pole of the University of Montpellier, in academic laboratories outside the University of Montpellier (in France or abroad) or in the private sector (chemical, pharmaceutical industries, etc.).
- This traineeship of 2 to 4 months' duration may start from mid-May after the examination session and may not exceed 4 months.
- Quantum Mechanics and Modelling II
- In this course a complete description of the structural, electronic and vibrational properties of molecules is given together with the quantum treatment of these properties in computer simulations.
- In parallel the structural and electronic properties of solids is addressed with an emphasis on the properties of metals and semiconductors.
- CM: 42H
- TD: 21H
The students are divided into groups, such as a scientific team. They will have to apply their theoretical knowledge in close collaboration with the industrialist.
An internship of 5 to 6 months must be carried out in a research or research and development laboratory specialising in theoretical chemistry. Thus, students will have the opportunity to carry out this end-of-study internship in academic or private research laboratories. Subject to prior acceptance by the teaching staff (internship subject related to the Master's courses and adequate environment/means), the student may look for a host team in an academic environment in the institutes of the Chemistry Pole of the University of Montpellier, in academic laboratories outside the University of Montpellier (in France or abroad) or in the private sector (chemical, pharmaceutical industries, etc.).
This internship of 5 to 6 months duration may start in mid-January after the examination session and may not exceed 6 months for a period in semester 10 during the validity of the university registration.
Heterocyclic chemistry
This course deals in a concise and systematic way with all aspects of heterocycle chemistry, from nomenclature to applications such as the principles of action of drugs, toxins or medicines, pigments, food colorants etc... | Fluorinated and phosphorated biomolecules: synthesis and application |
|---|---|
Fluorinated biomolecules. Current developments in fluorinated molecules. Fluorination methods: nucleophilic or electrophilic mono-fluorination, introduction of difluoromethyl or trifluoromethyl groups. Contribution of the fluorine atom(s) to the activity of these compounds. Examples of syntheses of fluorinated compounds used as antitumour agents, antiviral agents, antidepressants, anxiolytics, anti-inflammatories... | Phosphorus biomolecules. Structure, nomenclature, reactivity, structural analysis and applications. |
Some synthetic routes of compounds from each of the families treated will be discussed, highlighting, where appropriate, non-conventional activation methods. Biomedical applications will be targeted, as well as other applications in agrochemistry, optoelectronics, nanomaterials, etc.
The projects will be applied in particular to make-up products.
CM: 15 h (7.5h Fluorinated Biomolecules and 7.5h Phosphorus Biomolecules)
Chemistry of natural products
Natural products play a major role in the field of biomolecular chemistry. They represent an important source of bioactive compounds for medicinal chemistry. This course provides a comprehensive overview of the secondary metabolism and origin of natural products from plants. The emphasis in this unit will be on the organic chemistry behind the different biotransformations that occur during the biosynthesis of each major class of molecules. A mechanistic approach will be used to understand the chemical basis of each transformation.
CM: 13
TD: 7
Analysis of volatile molecules
Knowledge of gas chromatography and mass spectrometry techniques with electron impact ionisation and quadrupole mass analyser for the analysis of volatile organic molecules.
1) GC-MS analyses of volatile organic compounds:
Electron impact ionisation (EII) techniques
This 5 to 6 month internship, or work-study assignment, will be carried out in an R&D laboratory in the cosmetics and well-being industries.
The teaching of the organic synthesis strategies and tools module focuses on the development of strategies for the elaboration of molecules from the natural environment or not, using organic chemistry tools.
Amino acids and derivatives
This course discusses synthetic methods applied to obtain enantiopure amino acids as well as the use of chiral amino acids for the synthesis of other enantiopure compounds.
These amino acids are the building blocks of peptides. The different physico-chemical properties induced by the nature of these amino acids will allow the definition of strategies for the synthesis of peptides of interest and their characterisation.
Lipid compounds
- Triglycerides
- Phospholipids and sphingolipids
The tasks entrusted by the company to the student trainee/intern will be in line with the objectives of the Master's programme.
- Glycolipids
This internship or work-study assignment will be carried out in France or abroad.
- Fat-soluble vitamins
Professional projects - follow-up of apprentice projects
- Steroid hormones
- Bile salts
The student apprentice in M1 ICAP will be placed in a professional situation and will carry out a project in response to an industrial problem. This project will be carried out under the responsibility of a member of the teaching team (academic or industrial). Carried out throughout the semester, this project aims to put into practice the knowledge/know-how acquired during the Bachelor's and early Master's degree. In addition to the disciplinary skills of chemistry, other relational, organisational and communication skills, intrinsically linked to project management, will also be acquired and will prepare the students for their future professional life.
- Structure and synthesis of prostaglandins and leukotrienes
Drugs/bioprecursors
Example of an industrial problem: evaluation of the oxidative stability of perfumed ingredients in the presence of antioxidants
Knowledge of the limitations associated with the administration of an active ingredient (solubility, bioavailability, etc.).
Example of an industrial problem: analysis of allergens in perfumes: headspace (HS) solid phase microextraction (SPME) technique followed by gas chromatography-mass spectrometry (GC-MS) analysis
General description of the enzymatic systems involved in the biotransformation of nutrients and exogenous compounds.
Description of the main modes of membrane passage and transport systems for fundamental biomolecules (sugars, amino acids, nucleosides, etc.).
Examples of prodrug and bioprecursor design.
NMR
Deepening of knowledge in 1H, 13C, 19F, 29Si, 31PNMR, as well as two-dimensional methods. EPR concepts will also be covered (principle and applications).
Glycochemistry
- General mechanism of glycosylation
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
TD: 5 H
Chemoinformatics
The themes of the EU are the following:
A theoretical part dedicated to chemoinformatics
A theoretical part dedicated more specifically to modelling tools for drug design
CM: 15 H
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
TD: 5 H
A part dedicated to the practical aspect with work on computers
Mass spectrometry
Knowledge of the latest mass spectrometry techniques for the detection, identification and structural characterisation of organic and biomolecules.
A theoretical part dedicated more specifically to modelling tools for drug design
Applications in chemistry (pharmaceutical industry) and biology (Omics approaches).
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
1) Structural elucidation (Ion characterisation technologies) :
A part dedicated to the practical aspect with work on computers
LC/MS/MS and exact mass measurements
Isotope labelling, H/D exchange
A theoretical part dedicated more specifically to modelling tools for drug design
Ion mobility
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
Practical work: 40h
2) Surface analysis and imaging (molecular mapping)
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
3) Application in chemistry and biology: characterisation of small organic molecules and biomolecules.
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Peptides and proteins
Peptides and proteins are made up of a sequence of amino acid residues that give them particular properties. Their functionality depends on their sequence and thus the chemical functions they carry, and is also greatly modulated by their structure. In addition to conventional peptide synthesis, advanced functional modification options, structures, and properties that can significantly modify or improve the properties of the resulting peptide will be developed. Significant biotechnological developments in both the chemical and biological fields will be discussed leading to a wide range of applications in which peptides and proteins are successfully used.
Hourly volumes*:
A theoretical part dedicated more specifically to modelling tools for drug design
CM :15
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
TD :5
Receptology
Receptors are of major interest in medicinal chemistry and constitute more than 40% of current therapeutic targets. This course is an interdisciplinary approach to provide the basic concepts and fundamentals of receptology necessary for students pursuing their training in biomolecular chemistry at the chemistry-biology interface.
Chemobiology (67% ENSCM)
The course will focus on organic chemistry and post-functionalization of biomolecules applied to peptides, proteins and nucleic acids (DNA and RNA) with applications in gene therapy, biosensing and design of probes for biological studies.
A theoretical part dedicated more specifically to modelling tools for drug design
5 credits
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
25 credits
An internship of 5 to 6 months duration must be carried out in a research or R&D laboratory specialised in organic chemistry, biomolecular chemistry, life chemistry, analytical instrumentation or analytical analysis/development. Thus, students will have the opportunity to carry out this end-of-study internship in academic or private research laboratories. Subject to prior acceptance by the teaching staff (internship subject in line with the Master's courses and adequate environment/means), the student will be able to look for a host team in an academic environment in the institutes of the Chemistry Pole of the University of Montpellier (IBMM, ICGM, IEM), in academic laboratories outside the University of Montpellier (in France or abroad) or in the private sector (chemical, pharmaceutical, agri-food, cosmetic industries, biotechnology laboratories, etc.) as well as in research structures such as proteomic/metabolomic/flowomic platforms.
The research project entrusted to the students must be related to the skills and expertise acquired during the previous semesters and the teaching units followed, in particular in semester 9 according to the chosen orientation.
This internship of 5 to 6 months duration can start from mid-January after the examination session and cannot exceed 6 months for a period in semester 10 included during the validity of the university registration. The teaching staff of the Master in Biomolecular Chemistry will advise students to find an internship corresponding to their aspirations and abilities.
Bibliographic project/Scientific information
Scientific information: The aim of this course is to familiarise students with the search for and management of scientific information. In this context, recent bibliographic research tools will be explained and used during the course (electronic documentation: Scifinder / Isis / Belstein). Training in the functionalities of the Zotero tool and in the use of the electronic laboratory notebook will also be provided. The writing and use of scientific publications will be covered.
Bibliographic project: The tools for researching scientific information will be applied to a concrete case. The student will be proposed a bibliographic subject by the teaching team in relation to the orientation he/she has chosen. This bibliographic subject may, if necessary, be defined in agreement with the host organisation where the internship will be carried out.
For this personal project, the student will have access to all the bibliographic sources of the university or the company hosting him/her. The bibliographical work may be combined with the English teaching unit in order to prepare an oral presentation at an international conference.
Green chemistry
The principles of Green Chemistry provide a basis for the evaluation and design of new chemical products and processes that minimise negative impacts on human health and the environment. In this teaching unit, offered to M2 students of the Master of Biomolecular Chemistry (BM), Orientation 2 (O2), the basic principles and concepts of Green Chemistry will be discussed, and their applications in the field of non-conventional activation methods and the use of alternative media in organic synthesis.
A theoretical part dedicated more specifically to modelling tools for drug design
CM: 9 H
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Field: 11 a.m.
Multi-step synthesis
The aim of this course is to describe the synthesis tools applied to complex and polyfunctional molecules. Retrosynthetic and stereocontrolled approaches will be discussed as well as the rational use of protective groups.
Field: 11 H
Extraction and separation of biomolecules
This course will teach techniques for the extraction of biomolecules (protein precipitation, SPE), as well as techniques for the separation of biomolecules (chromatography, electrophoresis).
A theoretical part dedicated more specifically to modelling tools for drug design
CM: 9 h
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Field: 11 a.m.
- Supported syntheses
- In chemistry, solid phase synthesis is a method in which molecules are covalently bonded to a solid support and synthesised step by step using selective protecting groups. This applied course aims to provide a comprehensive understanding of this field and to examine supported strategies for the practical preparation of polypeptides and oligonucleotides.
- CM: 9 H
Biotechnology and applications
A part dedicated to the practical aspect with work on computers
The aim of this course is to highlight biological processes at the cellular level or even in living subjects. Different molecular imaging approaches will be discussed (fluorescent probes, radiolabelling).
CM: 9 H
A theoretical part dedicated more specifically to modelling tools for drug design
Field: 11 H
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Functionalisation/Bioconjugation
A part dedicated to the practical aspect with work on computers
Bioconjugation reactions are of major interest in the biomedical sciences and allow chemists to modify biomolecules to confer new functions or properties. In this course, bioconjugation and biomolecule labelling strategies will be discussed to explore complex biological systems. The practical sessions will illustrate these concepts through examples of bioconjugation of osidic and nucleotidic platforms.
LC-MS, MS/MS
A theoretical part dedicated more specifically to modelling tools for drug design
Knowledge of LC/MS and LC/MS/MS techniques for the characterisation of organic molecules and biomolecules in complex media.
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Description of the instruments and acquisition modes that will be used in the lab.
- 1) Analytical Chromatography coupled with Ambient Ionisation Mass Spectrometry techniques:
- LC/MS type instrumentation,
- LC/MS/MS type instrumentation.
A part dedicated to the practical aspect with work on computers
2) Coupled spectral data acquisition devices.
CM: 9 H
A theoretical part dedicated more specifically to modelling tools for drug design
Bioanalysis
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Description of the most recent mass spectrometry techniques for analyses in the pharmaceutical industry (drug development : Drug discovery and pre-clinical analysis).
Mass spectrometry instrumentation and acquisition methods in the pharmaceutical industry for the following applications:
Analyses in the various stages of drug development,
Qualitative analyses in metabolism,
Quantitative analyses in pharmacokinetics.
CM: 15 H
Land: 5 H
A part dedicated to the practical aspect with work on computers
Screening
Understanding of screening techniques for bioactive molecules, and more generally in vitro tests used to measure a biological event in the perspective of drug discovery or diagnosis.
A theoretical part dedicated more specifically to modelling tools for drug design
1) Pharmacological and biophysical fundamentals describing a biological event, target of biological tests:
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
2) Biological tests for the development of medicines or diagnostics
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
3) Applications, case studies, critical analyses.
Separation/Purification
A part dedicated to the practical aspect with work on computers
The objective of this course is to provide students with theoretical and practical training in the fundamental techniques of separation and purification of biomolecules
Hourly volumes*:
CM: 9 hours
Field: 11 hours
Thermodynamics and defects of solids
A theoretical part dedicated more specifically to modelling tools for drug design
This module is devoted to deliver basic knowledge on the thermodynamics of defects. The understanding and basic concepts of defects in stoichiometric and non-stoichiometric solids is an important aspect to better understand and design materials for ionic and electronic conductivity with a specific relevance for energy materials. The lecture introduces and discusses the nature of point defects which intrude upon the perfect geometry of ideal crystal structures:
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Introduction into point defects (missing or misplaced atoms, ions or electrons)
Discussion of thermodynamic concepts of order-disorder phenomena in solid solutions
Understanding of Brouwer diagrams for oxides in order to emphasise the role of surrounding atmosphere onto the defect equilibrium at high temperature.
Understanding of diffusion pathways and energies of ions and electrons, as a major consequence of point defects, giving rise to electrical transport is investigated for ionic conductors.
A part dedicated to the practical aspect with work on computers
Experimental investigations of measuring the ionic conductivity versus the temperature are described. The method of Impedance Spectroscopy Measurements is discussed.
Presentation of the Kröger-Vink Notation of defects
A theoretical part dedicated more specifically to modelling tools for drug design
Mott-Hubbard insulators
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Crystallography II and Electron Microscopy
A part dedicated to the practical aspect with work on computers
The structural characterization of Materials is a mandatory prerequisite to develop functional materials and an absolute must for materials science researchers and engineers. For the interpretation of diffraction patterns, structures, microstructures etc., a detailed knowledge in crystallography, structure analysis but equally of the instruments used is necessary. The necessary knowledge is developed from the scratch, progressively yielding an understanding on how to characterize materials by standard and sophisticated diffraction methods. The lecture also includes lab work on powder and single crystal diffractometers, allowing to acquire the competencies to correctly use and interpret diffraction data. The lecture during the1st semester involves essentially X-ray diffraction as well as electron microscopy, while the crystallography part continues during the2nd semester with symmetry, structure solution and structure refinements as well as neutron scattering and magnetic structure analysis.
This lecture contains 2 parts:
A theoretical part dedicated more specifically to modelling tools for drug design
(1): Crystallography: Simple inorganic structures: basics & concepts, Fractional atomic coordinates and projections, Bravais lattices, Crystal systems, Lattice points, lines and planes, Miller indices, Zone equation, Wulff net, orienting matrix, Crystal growth and morphology, X-ray sources, interaction of X-rays, electrons and neutrons with matter, scattering lengths, structure factor, systematic extinctions, Debye-Waller factor, principles of scattering, reciprocal lattice, concept of Ewald sphere, Laue diffraction, Debye Scherrer camera, powder diffractometers, single crystal diffractometers, monochromators, detectors, resolution, stereographic projection, peak intensities, reflection profile broadening and grain size
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
(2): Electron microscopy:
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
In this part, we will be interested in electron microscopy through flipped classes. We will discuss the following topics: Electron sources, lens and aberrations, sample preparation, electron diffraction, Structural and chemical analysis, Imaging techniques.
CM: 34
TD:18
A part dedicated to the practical aspect with work on computers
The structural characterization of Materials is a mandatory prerequisite to develop functional materials and an absolute must for materials science researchers and engineers. For the interpretation of diffraction patterns, structures, microstructures etc., a detailed knowledge in crystallography, structure analysis but equally of the instruments used is necessary. The necessary knowledge is developed from the scratch, progressively yielding an understanding on how to characterize materials by standard and sophisticated diffraction methods. The lecture also includes lab work on powder and single crystal diffractometers, allowing to acquire the competencies to correctly use and interpret diffraction data. The lecture during the1st semester involves essentially X-ray diffraction as well as electron microscopy, while the crystallography part continues during the2nd semester with symmetry, structure solution and structure refinements as well as neutron scattering and magnetic structure analysis.
This lecture contains 2 parts:
A theoretical part dedicated more specifically to modelling tools for drug design
Inorganic materials
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
Practical work: 40h
2) Surface analysis and imaging (molecular mapping)
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
This module will be divided into 3 parts:
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
- General introduction: main classes of materials, relation properties-structure of materials
- Construction and interpretation of phase diagrams: binary (e.g. with metallic and ceramic alloys)
- Construction and interpretation of ternary phase diagrams: variance, ternary eutectic definitions, first and second order peritectic, isothermal section, study of alloy cooling.
CM: 17:00
A part dedicated to the practical aspect with work on computers
TD: 8h
Materials for catalysis M1
A theoretical part dedicated more specifically to modelling tools for drug design
Thermodynamic and kinetic bases to understand the optimal conditions for catalytic reactions and the requirement of activity and accessibility of catalysts.
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Methods for the preparation of porous and dispersed catalysts by nucleation-growth, aggregation and templating mechanisms.
Correlations between structural properties and activity of heterogeneous catalysts.
Examples of applications of heterogeneous catalysts to processes of refining and industrial chemistry.
Further on basic concepts of photocatalysis and electrocatalysis are explored
CM: 17:00
TD: 8 h
Surface properties M1
For this personal project, the student will have access to all the bibliographic sources of the university or the company hosting him/her. The bibliographical work may be combined with the English teaching unit in order to prepare an oral presentation at an international conference.
This course provides a comprehensive knowledge and tools that relate to surface properties and interfacial behaviour of crystalline and amorphous solids in different media. It contains two parts: (1) Fundamentals of Colloid and Surface Science, divided and porous solids
(2) Surface characterisation techniques and surface analysis
A theoretical part dedicated more specifically to modelling tools for drug design
Thin films and extreme conditions M1
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
This course consists of a series of different lectures in the field of synthesis and characterization of thin films for technological applications or academic research. It is completed by an introduction into synthesis techniques of compounds stabilized under high pressure or only available under special conditions.
A part dedicated to the practical aspect with work on computers
Physics of Low-dimensional systems
Quantum containment
A theoretical part dedicated more specifically to modelling tools for drug design
Quantum Wells, 1D Quantum-wire, 0D Quantum dots
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Electron confinement and Density of States (DoS) formalism
A part dedicated to the practical aspect with work on computers
Epitaxial films
Microstructure
A theoretical part dedicated more specifically to modelling tools for drug design
Dislocations and grain boundaries
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Coatings and applications
Diffusion barriers
Photo optical devices
Vacuum technology
High pressure synthesis
Synthesis of compounds with unusual valence and coordination states
CM: 17
TD: 8
A theoretical part dedicated more specifically to modelling tools for drug design
Project internship
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Preparation of the 3 months research internship, exploring the state of art of the project, preparing optimum experimental conditions, and to present it in front of a jury.
Internship research
- This module is devoted to an internship of 3 months minimum in a research laboratory or industry.
- Crystallography, crystal chemistry, Large scale facilities
This lecture is the continuation of the crystallography lecture of the1st semester and will give an advanced insight into structural characterization and structure refinements. It involves classical X-ray laboratory data collection and analysis, completed by synchrotron and neutron diffraction data analysis (powder and single crystal). The goal is to get familiar with the general principles of structure analysis, tanking advantage of the complementarity of X-ray and neutron diffraction. The lecture provides a detailed knowledge on how to understand and analyze phase transitions and how to deal with respective changes in the metric and associated data and structural transformations.
This lecture contains the following topics:
A theoretical part dedicated more specifically to modelling tools for drug design
Symmetry and space groups
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Introduction into structure refinement (single crystal and powder methods)
- Neutron and synchrotron facilities
- Magnetic structures with neutron diffraction
- Structure determination from single crystals (experiment and theory)
- Structure determination from powder diffraction data (experiment and theory)
The applications of Fourier series for structure solution and refinements: from the Patterson Method to difference Fourier analysis
Crystal twinning,
A theoretical part dedicated more specifically to modelling tools for drug design
Phase transitions
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Anomalous scattering and absolute structure determination
- TD:15
- Metallurgy and electronics properties
- This teaching unit is devoted to give an introduction to the electronic properties in the solid state of bulk and/or nano-materials, magnetic properties in transition metal oxides, etc.... This unit is given by different, alternating external teachers to UM and the topics may vary with respect to the respective area of expertise of the teaching stuff.
- Students should get familiarized not only with the electronic properties and ordering of materials, but also with respect to ionic and mixed electronic ionic conductors, materials for spintronics. Another aspect concerns here their specific characterizations using neutron/synchrotron diffraction as well as complementary macroscopic characterization methods for magnetism, permeability, etc
- CM: 30 h
TD: 15 h
Materials for catalysis M2
A theoretical part dedicated more specifically to modelling tools for drug design
Project preparation Master Thesis
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
The aim of this module is to prepare the master thesis project which will last six months during S4.
The thesis project involves the use of large scale facilities (preparation and obtention of the beam time access for neutron/synchrotron radiation). You will have to explore the state of art of the master thesis project and prepare optimum experimental conditions (optimization of experiments on light lines or neutron).
This module will help to develop 'transversal' skills such as the development and organization of a scientific project (organization between universities and different EU research centres)
as well as communication skills.
A theoretical part dedicated more specifically to modelling tools for drug design
Summer School: Large Scale Facilities
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
7 credits
72h
This module will help to develop 'transversal' skills such as the development and organization of a scientific project (organization between universities and different EU research centres)
The objective is to provide second year students master a good introduction in the use of "Large Scale Facilities" for the study and characterization of materials. In particular, we focus on the use of neutron scattering and 3rd generation synchrotron sources for the study of materials. Indeed, to date, the development and optimization of materials often require sophisticated methods, sometimes accessible only at Large Scale Facilities. This presents a major challenge for basic research and applied. The courses, which take place over two consecutive weeks, give basic instruction on the production of neutrons and synchrotron radiation as well as their specific applications and complementarity. The course content is as follows:
A theoretical part dedicated more specifically to modelling tools for drug design
- Neutron and synchrotron sources
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
- Interaction neutrons/synchrotron radiation with matter
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
- Diffraction methods and instrumentation for neutron and X-ray (synchrotron) scattering
- Spectroscopy: inelastic neutron scattering and X-ray absorption spectroscopy
A theoretical part dedicated more specifically to modelling tools for drug design
- Magnetic neutron scattering
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
- Presentation of neutron and synchrotron beamlines
A theoretical part dedicated more specifically to modelling tools for drug design
Surface properties M2
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
CM: 17:00
TD: 8 h
Electron Microscopy, Crystallography
A part dedicated to the practical aspect with work on computers
(1): Crystallography:
This part is essentially dedicated o get familiar with structure analysis and its application. After a brief introduction of the reciprocal lattice concept and the use of space groups in crystallography, the lecture focusses on structure analysis by diffraction methods using powder and single crystal X-ray and neutron scattering methods. This concerns an understanding into related techniques, i.e. the use of powder and single crystal diffractometers, as well as the techniques and programs used today for structure refinements. The concept of the lecture is to introduce into a basic understanding of what is behind the programs, rather than to use them blindly. Students will also collect single crystal diffraction data on a performant 4 cycle diffractometer with a 2D area detector, as well as magnetic structure analysis using neutron diffraction methods.
A theoretical part dedicated more specifically to modelling tools for drug design
Ion mobility
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Simple inorganic structures: Space groups, X-ray/neutron and synchrotron sources, interaction of X-rays, electrons and neutrons with matter, reciprocal lattice, concept of Ewald sphere, powder diffractometers, single crystal diffractometers, orienting matrix, Patterson method, structure refinement from powder or single crystal data, magnetic structure analysis, magnetic space groups
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
CM: 33 h
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
TD: 18 h
A part dedicated to the practical aspect with work on computers
Master thesis
The4th semester of the Master Course is entirely dedicated to the 5 months (minimum) master thesis project in Materials Science. Students get enrolled in a research topic, and to contribute to a scientific problem in a research team. It allows to apply acquired and to learn new scientific skills in order to identify the problem and to proceed for a (possible) solution. The topic is analysed and described in the written Master thesis memory and presented orally in from of a jury. It should allow the candidate to show his ability to conduct a scientific problem and to present it in an analytical way.
A theoretical part dedicated more specifically to modelling tools for drug design
Chemistry of synthetic odorant molecules 1
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Fragrance molecules are the raw materials necessary for the development of a perfume. This course provides the necessary fundamentals in this field for all students pursuing their training in fragrance and flavour engineering.
A part dedicated to the practical aspect with work on computers
(1): Crystallography:
This part is essentially dedicated o get familiar with structure analysis and its application. After a brief introduction of the reciprocal lattice concept and the use of space groups in crystallography, the lecture focusses on structure analysis by diffraction methods using powder and single crystal X-ray and neutron scattering methods. This concerns an understanding into related techniques, i.e. the use of powder and single crystal diffractometers, as well as the techniques and programs used today for structure refinements. The concept of the lecture is to introduce into a basic understanding of what is behind the programs, rather than to use them blindly. Students will also collect single crystal diffraction data on a performant 4 cycle diffractometer with a 2D area detector, as well as magnetic structure analysis using neutron diffraction methods.
A theoretical part dedicated more specifically to modelling tools for drug design
Natural aromatic raw materials: control and application
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Inorganic materials
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
- International market of natural aromatic raw materials, Main productions
- Main olfactory families
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
- Study of natural aromatic raw materials: chemical and olfactory characteristics
- Control of essential oils according to AFNOR standards
A part dedicated to the practical aspect with work on computers
Natural aromatic raw materials: obtaining
- Terms and definition of natural raw materials (ISO/TC54 "Essential oil")
A theoretical part dedicated more specifically to modelling tools for drug design
- Extraction methods for volatile constituents: obtaining essential oils, flavour extraction, supercritical CO2 extraction, ESAM process, VMHD extraction, headspace extraction techniques, SPME...
- Characterisation of volatile constituents: Gas Chromatography (GC), Ultra Fast Gas Chromatography (UFGC), Flame Ionization Detector (FID), Gas Chromatography-Mass Spectrometry (GC-MS), GC-FTIR, Comprehensive two-dimensional gas chromatography (GC-GC), chiral chromatographic analysis, GC-olfactometry, electronic nose.
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
CM: 12h
A part dedicated to the practical aspect with work on computers
(1): Crystallography:
This part is essentially dedicated o get familiar with structure analysis and its application. After a brief introduction of the reciprocal lattice concept and the use of space groups in crystallography, the lecture focusses on structure analysis by diffraction methods using powder and single crystal X-ray and neutron scattering methods. This concerns an understanding into related techniques, i.e. the use of powder and single crystal diffractometers, as well as the techniques and programs used today for structure refinements. The concept of the lecture is to introduce into a basic understanding of what is behind the programs, rather than to use them blindly. Students will also collect single crystal diffraction data on a performant 4 cycle diffractometer with a 2D area detector, as well as magnetic structure analysis using neutron diffraction methods.
A theoretical part dedicated more specifically to modelling tools for drug design
Practical work: 8 hours
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Physiology and practice of sensory analysis
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Course: Study of gustation and olfaction (reception and transmission of messages, coding of information, psychophysiological importance), notions of sensory analysis.
Practical work: Learning of referents used in perfumery and aromatics. Description, comparison, memorization, determination of recognition thresholds, application of the notion of olfactory power and volatility to the search for agreements.
- Regulation and formulation in aromatics and perfumery
- - Presentation of the main families of perfumes (SFP Classification)
- - Perfumery regulations.
- - Learning to formulate "typical" bases for perfumery or aromatics.
A part dedicated to the practical aspect with work on computers
CM: 10h
Chemistry of synthetic odorant molecules 2
A theoretical part dedicated more specifically to modelling tools for drug design
Study the major chemical families of odorant molecules from a chemical and olfactory point of view.
Acquire fundamental knowledge in the field of industrial synthesis and hemisynthesis of odorant molecules, their olfactory characteristics and their applications in Aromatics and/or Perfumery
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Formulation of ingredients for aromatics
A part dedicated to the practical aspect with work on computers
Evaluation of the aromatic power of the main aromatic ingredients.
Direct and retronasal olfactory comparison.
Influence of the support on perception.
Formulation of flavourings and applications on food supports with the intervention of a flavourist. Regulatory constraints.
CM: 12h
A theoretical part dedicated more specifically to modelling tools for drug design
TD: 8h
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
- Formulation of ingredients for perfumery
- Fragrance formulation
- Study of the constraints linked to the targeted application (stability, physico-chemical properties, cost, regulations...)
- Application
A part dedicated to the practical aspect with work on computers
End of year course
A 4-6 month work placement in a research laboratory or in R&D in the flavour or fragrance sector.
A theoretical part dedicated more specifically to modelling tools for drug design
The student trainee will be given assignments related to the theoretical and practical knowledge acquired during semesters S1 and S2 of the Master.
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
This course can start on1 March.
A part dedicated to the practical aspect with work on computers
(1): Crystallography:
This part is essentially dedicated o get familiar with structure analysis and its application. After a brief introduction of the reciprocal lattice concept and the use of space groups in crystallography, the lecture focusses on structure analysis by diffraction methods using powder and single crystal X-ray and neutron scattering methods. This concerns an understanding into related techniques, i.e. the use of powder and single crystal diffractometers, as well as the techniques and programs used today for structure refinements. The concept of the lecture is to introduce into a basic understanding of what is behind the programs, rather than to use them blindly. Students will also collect single crystal diffraction data on a performant 4 cycle diffractometer with a 2D area detector, as well as magnetic structure analysis using neutron diffraction methods.
A theoretical part dedicated more specifically to modelling tools for drug design
Evaluation of the course: writing a report, oral presentation and evaluation by the course supervisor are the three elements of the course evaluation.
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
(2): Electron microscopy:
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
In this part, we will be interested in electron microscopy through flipped classes. We will discuss the following topics: Electron sources, lens and aberrations, sample preparation, electron diffraction, Structural and chemical analysis, Imaging techniques.
CM: 34
Additives - encapsulation
Food additives play an increasingly important role in today's food processing industries. In addition, the development of new technologies in the field of food additives has a further impact on the evolution of food processing methods. This course provides students with knowledge of the different types of food additives currently available in the food industry.
CM: 14h
Practical work: 6h
Sensory analysis
A theoretical part dedicated more specifically to modelling tools for drug design
The most common sensory tests are described and applied to different matrices (comparative, descriptive, hedonic). The approach used in sensory analysis is examined, focusing on the choice of tests appropriate to the type of results expected and the material conditions of the study. The development of protocols highlights the critical points in the performance of the analyses. The interpretation of the test results is discussed during the practical exercises.
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
CM: 8h
A part dedicated to the practical aspect with work on computers
(1): Crystallography:
This part is essentially dedicated o get familiar with structure analysis and its application. After a brief introduction of the reciprocal lattice concept and the use of space groups in crystallography, the lecture focusses on structure analysis by diffraction methods using powder and single crystal X-ray and neutron scattering methods. This concerns an understanding into related techniques, i.e. the use of powder and single crystal diffractometers, as well as the techniques and programs used today for structure refinements. The concept of the lecture is to introduce into a basic understanding of what is behind the programs, rather than to use them blindly. Students will also collect single crystal diffraction data on a performant 4 cycle diffractometer with a 2D area detector, as well as magnetic structure analysis using neutron diffraction methods.
A theoretical part dedicated more specifically to modelling tools for drug design
TP: 12 hours
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
Practical work: 40h
2) Surface analysis and imaging (molecular mapping)
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Biopolymères et polymères dégradables pour le DD
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
In this part, we will be interested in electron microscopy through flipped classes. We will discuss the following topics: Electron sources, lens and aberrations, sample preparation, electron diffraction, Structural and chemical analysis, Imaging techniques.
CM: 34
La substitution des matériaux d’origine pétrolière est un enjeu de plus en plus important tant au point de vue technologique qu’économique. Ce module permet d’acquérir des compétences dans le domaine des agropolymères, des polymères biosourcés, des matériaux dégradables et des biocomposites. Les nouvelles voies de synthèse plus respectueuses de l’environnement seront présentées de manière à préparer des polymères dégradables synthétiques
La dégradation, la biodégradation et la recyclabilité de polymères seront également abordées
A part dedicated to the practical aspect with work on computers
CM : 11CM
TD : 9 TD
A theoretical part dedicated more specifically to modelling tools for drug design
Conception de matériaux membranaires
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Les matériaux membranaires se divisent usuellement en deux familles que sont d’une part les membranes polymères, et d’autre part les membranes inorganiques (ou céramiques). Chacune de ces familles constituera une partie de cette UE. La première partie sera consacrée à la conception de membranes polymères. Dans cette partie, nous aborderons principalement les techniques de préparation par inversion de phase (NIPS, VIPS, TIPS) avec une ouverture sur la recherche et l’innovation (SNIPS, aquaporine…). En complément, seront décrits les additifs (notamment les agents porogènes et hydrophilisants), qui jouent un rôle important dans les approches par inversion de phase, et seront présentées les différentes voies de modifications chimiques des membranes post-synthèses. La seconde partie sera consacrée à la conception de membranes inorganiques. Dans cette partie, nous présenterons d'une part les procédés en voie humide, à savoir les principales méthodes de dépôt de films liquides (dip-coating, spin-coating, pulvérisation, tape-casting, sérigraphie-sérigravure) et de dépôt à partir de solutions (procédés électrolytiques ou chimiques) ou de suspensions (électrophorèse, Langmuir-Blodgett), et d'autre part les procédés en voie sèche (techniques PVD (évap. et pulvé.), techniques CVD (thermique, PECVD et ALD), MBE, traitement de surface). Enfin, comme illustration des deux familles de membranes, nous traiterons d'études de cas sur des applications membranaires, dans le domaine de l'emballage notamment.
A part dedicated to the practical aspect with work on computers
Natural aromatic raw materials: obtaining
- Terms and definition of natural raw materials (ISO/TC54 "Essential oil")
A theoretical part dedicated more specifically to modelling tools for drug design
Etude thématique
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
2) Surface analysis and imaging (molecular mapping)
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Cet enseignement consiste en une étude approfondie d'un problème ou d'un sujet choisi qui est lié à la chimie des matériaux pour les trois orientations ciblées du parcours : développement durable, santé et ingénierie des membranes. Cela peut prendre la forme d'une étude en recherche, développement ou analyse à l’échelle du laboratoire ou dans une entreprise. Les étudiants vont travailler en petits groupes – projets. Ils vont choisir leur sujet, définir le but, les objectifs et les moyens sous la direction d’un tuteur. Le but final est de développer un produit/méthodologie en utilisant les connaissances de synthèse et analyses déjà acquise pour préparer les stages qui auront lieu en S8.
A part dedicated to the practical aspect with work on computers
CM : 6h
TD : 6h
TP : 16h
A theoretical part dedicated more specifically to modelling tools for drug design
Anglais avancé
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
This course deals in a concise and systematic way with all aspects of heterocycle chemistry, from nomenclature to applications such as the principles of action of drugs, toxins or medicines, pigments, food colorants etc...
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
28 crédits
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Ce stage de fin d’études en Master 2 est destiné à mettre l'étudiant dans une situation préprofessionnelle, dans un laboratoire de recherche académique ou un laboratoire de recherche et développement industriel, en France ou à l'étranger.
L’étudiant recherchera une équipe d’accueil en milieu académique dans les instituts du Pôle Chimie de l’Université de Montpellier (ICGM, IEM, IBMM…), dans des laboratoires académiques hors de l’Université de Montpellier (en France ou à l’étranger) ou en secteur privé travaillant dans le domaine des matériaux. Le projet de recherche sur lequel travaillera l’étudiant aura été au préalable validé par l’équipe pédagogique de manière à s’assurer que le sujet de stage est en lien avec les enseignements du master, les compétences et expertises acquises lors des semestres antérieurs et des unités d’enseignement suivis en particulier au semestre 9 selon l’orientation choisie. Par ailleurs, l’équipe pédagogique s’assurera que le stage se déroulera dans un environnement et avec des moyens adéquats.
Ce stage d’une durée de 5 à 6 mois pourra débuter à partir de mi-janvier après la session d’examen et ne pourra excéder 6 mois au semestre 10.
A theoretical part dedicated more specifically to modelling tools for drug design
(Nano)matériaux inorganiques pour la santé
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
7 credits
L’UE comporte des enseignements dispensés en cours magistraux, et en travaux dirigés. Un projet en groupe sur l’étude (théorique) d’un matériau ou de nanomatériaux inorganiques pour la santé sera proposé aux étudiants
A part dedicated to the practical aspect with work on computers
(1): Crystallography:
This part is essentially dedicated o get familiar with structure analysis and its application. After a brief introduction of the reciprocal lattice concept and the use of space groups in crystallography, the lecture focusses on structure analysis by diffraction methods using powder and single crystal X-ray and neutron scattering methods. This concerns an understanding into related techniques, i.e. the use of powder and single crystal diffractometers, as well as the techniques and programs used today for structure refinements. The concept of the lecture is to introduce into a basic understanding of what is behind the programs, rather than to use them blindly. Students will also collect single crystal diffraction data on a performant 4 cycle diffractometer with a 2D area detector, as well as magnetic structure analysis using neutron diffraction methods.
A theoretical part dedicated more specifically to modelling tools for drug design
Surface properties M2
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
CM: 17:00
TD: 8 h
Electron Microscopy, Crystallography
A part dedicated to the practical aspect with work on computers
(1): Crystallography:
This part is essentially dedicated o get familiar with structure analysis and its application. After a brief introduction of the reciprocal lattice concept and the use of space groups in crystallography, the lecture focusses on structure analysis by diffraction methods using powder and single crystal X-ray and neutron scattering methods. This concerns an understanding into related techniques, i.e. the use of powder and single crystal diffractometers, as well as the techniques and programs used today for structure refinements. The concept of the lecture is to introduce into a basic understanding of what is behind the programs, rather than to use them blindly. Students will also collect single crystal diffraction data on a performant 4 cycle diffractometer with a 2D area detector, as well as magnetic structure analysis using neutron diffraction methods.
A theoretical part dedicated more specifically to modelling tools for drug design
Inorganic materials
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Structure-based drug design
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
Faculté de pharmacie
Délivrance ciblée
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
In this part, we will be interested in electron microscopy through flipped classes. We will discuss the following topics: Electron sources, lens and aberrations, sample preparation, electron diffraction, Structural and chemical analysis, Imaging techniques.
CM: 34
Dans cet enseignement sont abordés les différents outils moléculaires ou supramoléculaires permettant la vectorisation et la délivrance de principes actifs selon le type de cellules ou d’organites intracellulaires ciblés. Les interactions ligands récepteurs seront traitées de même que les méthodes de préparation et d’activation des conjugués. Des exemples de médicaments seront présentés.
For this personal project, the student will have access to all the bibliographic sources of the university or the company hosting him/her. The bibliographical work may be combined with the English teaching unit in order to prepare an oral presentation at an international conference.
CM : 15 H
TD : 5 H
A theoretical part dedicated more specifically to modelling tools for drug design
Structure-based drug design
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
Faculté de pharmacie
Ion mobility
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
- International market of natural aromatic raw materials, Main productions
- Main olfactory families
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
- Study of natural aromatic raw materials: chemical and olfactory characteristics
- Control of essential oils according to AFNOR standards
A part dedicated to the practical aspect with work on computers
Natural aromatic raw materials: obtaining
- Terms and definition of natural raw materials (ISO/TC54 "Essential oil")
A theoretical part dedicated more specifically to modelling tools for drug design
Practical work: 8 hours
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
TP: 12 hours
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
Practical work: 40h
2) Surface analysis and imaging (molecular mapping)
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Innovation et besoins cliniques
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
Faculté de pharmacie
Cette unité d’enseignement est dédiée à l’acquisition de notions liées aux dispositifs médicaux et les biomatériaux. L’UE comporte les enseignements dispensés de manière classique en cours magistraux et en travaux dirigés ainsi que les enseignements interactifs en Learning Lab pour les problématiques de l’innovation dans les dispositifs médicaux.
CM : 3 HCM
TD : 5HTD
12H CM-TD Learning Lab
A theoretical part dedicated more specifically to modelling tools for drug design
Polymères pour la santé
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Connaissance des grandes familles de polymères utilisés dans le domaine biomédical.
1) Spécificité des polymères pour applications biomédicales et grandes familles de polymères utilisés
2) Description des familles d’applications
3) Discussion sur la notion de synthèse et relation structure/propriétés/cahier des charges
For this personal project, the student will have access to all the bibliographic sources of the university or the company hosting him/her. The bibliographical work may be combined with the English teaching unit in order to prepare an oral presentation at an international conference.
CM : 15 H
TD : 5 H
A theoretical part dedicated more specifically to modelling tools for drug design
Biopolymères et polymères dégradables pour le DD
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
In this part, we will be interested in electron microscopy through flipped classes. We will discuss the following topics: Electron sources, lens and aberrations, sample preparation, electron diffraction, Structural and chemical analysis, Imaging techniques.
CM: 34
La substitution des matériaux d’origine pétrolière est un enjeu de plus en plus important tant au point de vue technologique qu’économique. Ce module permet d’acquérir des compétences dans le domaine des agropolymères, des polymères biosourcés, des matériaux dégradables et des biocomposites. Les nouvelles voies de synthèse plus respectueuses de l’environnement seront présentées de manière à préparer des polymères dégradables synthétiques
La dégradation, la biodégradation et la recyclabilité de polymères seront également abordées
A part dedicated to the practical aspect with work on computers
CM : 11CM
TD : 9 TD
A theoretical part dedicated more specifically to modelling tools for drug design
Conception de matériaux membranaires
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Les matériaux membranaires se divisent usuellement en deux familles que sont d’une part les membranes polymères, et d’autre part les membranes inorganiques (ou céramiques). Chacune de ces familles constituera une partie de cette UE. La première partie sera consacrée à la conception de membranes polymères. Dans cette partie, nous aborderons principalement les techniques de préparation par inversion de phase (NIPS, VIPS, TIPS) avec une ouverture sur la recherche et l’innovation (SNIPS, aquaporine…). En complément, seront décrits les additifs (notamment les agents porogènes et hydrophilisants), qui jouent un rôle important dans les approches par inversion de phase, et seront présentées les différentes voies de modifications chimiques des membranes post-synthèses. La seconde partie sera consacrée à la conception de membranes inorganiques. Dans cette partie, nous présenterons d'une part les procédés en voie humide, à savoir les principales méthodes de dépôt de films liquides (dip-coating, spin-coating, pulvérisation, tape-casting, sérigraphie-sérigravure) et de dépôt à partir de solutions (procédés électrolytiques ou chimiques) ou de suspensions (électrophorèse, Langmuir-Blodgett), et d'autre part les procédés en voie sèche (techniques PVD (évap. et pulvé.), techniques CVD (thermique, PECVD et ALD), MBE, traitement de surface). Enfin, comme illustration des deux familles de membranes, nous traiterons d'études de cas sur des applications membranaires, dans le domaine de l'emballage notamment.
A part dedicated to the practical aspect with work on computers
Natural aromatic raw materials: obtaining
- Terms and definition of natural raw materials (ISO/TC54 "Essential oil")
A theoretical part dedicated more specifically to modelling tools for drug design
Etude thématique
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
2) Surface analysis and imaging (molecular mapping)
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Cet enseignement consiste en une étude approfondie d'un problème ou d'un sujet choisi qui est lié à la chimie des matériaux pour les trois orientations ciblées du parcours : développement durable, santé et ingénierie des membranes. Cela peut prendre la forme d'une étude en recherche, développement ou analyse à l’échelle du laboratoire ou dans une entreprise. Les étudiants vont travailler en petits groupes – projets. Ils vont choisir leur sujet, définir le but, les objectifs et les moyens sous la direction d’un tuteur. Le but final est de développer un produit/méthodologie en utilisant les connaissances de synthèse et analyses déjà acquise pour préparer les stages qui auront lieu en S8.
A part dedicated to the practical aspect with work on computers
CM : 6h
TD : 6h
TP : 16h
A theoretical part dedicated more specifically to modelling tools for drug design
Structures et Problématiques de Santé
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
Practical work: 40h
2) Surface analysis and imaging (molecular mapping)
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Nanotechnologies et systèmes multifonctionnels à visée théra
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
Faculté de pharmacie
Anglais avancé
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
This course deals in a concise and systematic way with all aspects of heterocycle chemistry, from nomenclature to applications such as the principles of action of drugs, toxins or medicines, pigments, food colorants etc...
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
28 crédits
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Ce stage de fin d’études en Master 2 est destiné à mettre l'étudiant dans une situation préprofessionnelle, dans un laboratoire de recherche académique ou un laboratoire de recherche et développement industriel, en France ou à l'étranger.
L’étudiant recherchera une équipe d’accueil en milieu académique dans les instituts du Pôle Chimie de l’Université de Montpellier (ICGM, IEM, IBMM…), dans des laboratoires académiques hors de l’Université de Montpellier (en France ou à l’étranger) ou en secteur privé travaillant dans le domaine des matériaux. Le projet de recherche sur lequel travaillera l’étudiant aura été au préalable validé par l’équipe pédagogique de manière à s’assurer que le sujet de stage est en lien avec les enseignements du master, les compétences et expertises acquises lors des semestres antérieurs et des unités d’enseignement suivis en particulier au semestre 9 selon l’orientation choisie. Par ailleurs, l’équipe pédagogique s’assurera que le stage se déroulera dans un environnement et avec des moyens adéquats.
Ce stage d’une durée de 5 à 6 mois pourra débuter à partir de mi-janvier après la session d’examen et ne pourra excéder 6 mois au semestre 10.
A theoretical part dedicated more specifically to modelling tools for drug design
- International market of natural aromatic raw materials, Main productions
- Main olfactory families
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
- Study of natural aromatic raw materials: chemical and olfactory characteristics
- Control of essential oils according to AFNOR standards
A part dedicated to the practical aspect with work on computers
Natural aromatic raw materials: obtaining
- Terms and definition of natural raw materials (ISO/TC54 "Essential oil")
A theoretical part dedicated more specifically to modelling tools for drug design
Surface properties M2
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
CM: 17:00
TD: 8 h
Electron Microscopy, Crystallography
A part dedicated to the practical aspect with work on computers
(1): Crystallography:
This part is essentially dedicated o get familiar with structure analysis and its application. After a brief introduction of the reciprocal lattice concept and the use of space groups in crystallography, the lecture focusses on structure analysis by diffraction methods using powder and single crystal X-ray and neutron scattering methods. This concerns an understanding into related techniques, i.e. the use of powder and single crystal diffractometers, as well as the techniques and programs used today for structure refinements. The concept of the lecture is to introduce into a basic understanding of what is behind the programs, rather than to use them blindly. Students will also collect single crystal diffraction data on a performant 4 cycle diffractometer with a 2D area detector, as well as magnetic structure analysis using neutron diffraction methods.
A theoretical part dedicated more specifically to modelling tools for drug design
Physiology and practice of sensory analysis
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Course: Study of gustation and olfaction (reception and transmission of messages, coding of information, psychophysiological importance), notions of sensory analysis.
Practical work: Learning of referents used in perfumery and aromatics. Description, comparison, memorization, determination of recognition thresholds, application of the notion of olfactory power and volatility to the search for agreements.
- Regulation and formulation in aromatics and perfumery
- - Presentation of the main families of perfumes (SFP Classification)
- - Perfumery regulations.
- - Learning to formulate "typical" bases for perfumery or aromatics.
A part dedicated to the practical aspect with work on computers
CM: 10h
Chemistry of synthetic odorant molecules 2
A theoretical part dedicated more specifically to modelling tools for drug design
Evaluation of the course: writing a report, oral presentation and evaluation by the course supervisor are the three elements of the course evaluation.
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
(2): Electron microscopy:
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
In this part, we will be interested in electron microscopy through flipped classes. We will discuss the following topics: Electron sources, lens and aberrations, sample preparation, electron diffraction, Structural and chemical analysis, Imaging techniques.
CM: 34
Additives - encapsulation
Food additives play an increasingly important role in today's food processing industries. In addition, the development of new technologies in the field of food additives has a further impact on the evolution of food processing methods. This course provides students with knowledge of the different types of food additives currently available in the food industry.
CM: 14h
Practical work: 6h
Sensory analysis
A theoretical part dedicated more specifically to modelling tools for drug design
The most common sensory tests are described and applied to different matrices (comparative, descriptive, hedonic). The approach used in sensory analysis is examined, focusing on the choice of tests appropriate to the type of results expected and the material conditions of the study. The development of protocols highlights the critical points in the performance of the analyses. The interpretation of the test results is discussed during the practical exercises.
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
CM: 8h
A part dedicated to the practical aspect with work on computers
(1): Crystallography:
This part is essentially dedicated o get familiar with structure analysis and its application. After a brief introduction of the reciprocal lattice concept and the use of space groups in crystallography, the lecture focusses on structure analysis by diffraction methods using powder and single crystal X-ray and neutron scattering methods. This concerns an understanding into related techniques, i.e. the use of powder and single crystal diffractometers, as well as the techniques and programs used today for structure refinements. The concept of the lecture is to introduce into a basic understanding of what is behind the programs, rather than to use them blindly. Students will also collect single crystal diffraction data on a performant 4 cycle diffractometer with a 2D area detector, as well as magnetic structure analysis using neutron diffraction methods.
A theoretical part dedicated more specifically to modelling tools for drug design
Modélisation et simulations numériques
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Le « design by modeling », également appelé « material by design » occupe une place de plus en plus prégnante dans la recherche académique et industrielle. Il s’agit d’allier les disciplines de la fabrication des matériaux et de la modélisation numérique pour optimiser l’élaboration des matériaux par des approches top-down ou bottom-up.
Cette UE vise ainsi à donner aux étudiants en Master 2 de Chimie des outils leur permettant d’appréhender les notions de modélisation et de simulation numériques à différentes échelles et à des niveaux de complexité croissante.
A part dedicated to the practical aspect with work on computers
(1): Crystallography:
This part is essentially dedicated o get familiar with structure analysis and its application. After a brief introduction of the reciprocal lattice concept and the use of space groups in crystallography, the lecture focusses on structure analysis by diffraction methods using powder and single crystal X-ray and neutron scattering methods. This concerns an understanding into related techniques, i.e. the use of powder and single crystal diffractometers, as well as the techniques and programs used today for structure refinements. The concept of the lecture is to introduce into a basic understanding of what is behind the programs, rather than to use them blindly. Students will also collect single crystal diffraction data on a performant 4 cycle diffractometer with a 2D area detector, as well as magnetic structure analysis using neutron diffraction methods.
A theoretical part dedicated more specifically to modelling tools for drug design
Phénomènes de transport
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
L’étude des phénomènes de transport de matière et de chaleur est importante dans les disciplines de la chimie en général. L’approche et le vocabulaire qui sont proposés dans cette UE sont communes à la chimie-physique et au génie de procédés.
A part dedicated to the practical aspect with work on computers
Natural aromatic raw materials: obtaining
- Terms and definition of natural raw materials (ISO/TC54 "Essential oil")
A theoretical part dedicated more specifically to modelling tools for drug design
Ion mobility
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Study the major chemical families of odorant molecules from a chemical and olfactory point of view.
Acquire fundamental knowledge in the field of industrial synthesis and hemisynthesis of odorant molecules, their olfactory characteristics and their applications in Aromatics and/or Perfumery
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Formulation of ingredients for aromatics
A part dedicated to the practical aspect with work on computers
Evaluation of the aromatic power of the main aromatic ingredients.
Direct and retronasal olfactory comparison.
Influence of the support on perception.
Formulation of flavourings and applications on food supports with the intervention of a flavourist. Regulatory constraints.
CM: 12h
A theoretical part dedicated more specifically to modelling tools for drug design
The student trainee will be given assignments related to the theoretical and practical knowledge acquired during semesters S1 and S2 of the Master.
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
This course can start on1 March.
A part dedicated to the practical aspect with work on computers
(1): Crystallography:
This part is essentially dedicated o get familiar with structure analysis and its application. After a brief introduction of the reciprocal lattice concept and the use of space groups in crystallography, the lecture focusses on structure analysis by diffraction methods using powder and single crystal X-ray and neutron scattering methods. This concerns an understanding into related techniques, i.e. the use of powder and single crystal diffractometers, as well as the techniques and programs used today for structure refinements. The concept of the lecture is to introduce into a basic understanding of what is behind the programs, rather than to use them blindly. Students will also collect single crystal diffraction data on a performant 4 cycle diffractometer with a 2D area detector, as well as magnetic structure analysis using neutron diffraction methods.
A theoretical part dedicated more specifically to modelling tools for drug design
Practical work: 8 hours
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Caractérisation des matériaux poreux
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Dans cette UE, après une présentation du milieu poreux, il sera abordé la description des phénomènes et du principe de chaque mesure conduisant à la caractérisation des matériaux poreux et pulvérulents.
Volumes horaires* :
CM : 11h
TD : 9h
A theoretical part dedicated more specifically to modelling tools for drug design
TP: 12 hours
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
Practical work: 40h
2) Surface analysis and imaging (molecular mapping)
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Biopolymères et polymères dégradables pour le DD
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
In this part, we will be interested in electron microscopy through flipped classes. We will discuss the following topics: Electron sources, lens and aberrations, sample preparation, electron diffraction, Structural and chemical analysis, Imaging techniques.
CM: 34
La substitution des matériaux d’origine pétrolière est un enjeu de plus en plus important tant au point de vue technologique qu’économique. Ce module permet d’acquérir des compétences dans le domaine des agropolymères, des polymères biosourcés, des matériaux dégradables et des biocomposites. Les nouvelles voies de synthèse plus respectueuses de l’environnement seront présentées de manière à préparer des polymères dégradables synthétiques
La dégradation, la biodégradation et la recyclabilité de polymères seront également abordées
A part dedicated to the practical aspect with work on computers
CM : 11CM
TD : 9 TD
A theoretical part dedicated more specifically to modelling tools for drug design
Conception de matériaux membranaires
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Les matériaux membranaires se divisent usuellement en deux familles que sont d’une part les membranes polymères, et d’autre part les membranes inorganiques (ou céramiques). Chacune de ces familles constituera une partie de cette UE. La première partie sera consacrée à la conception de membranes polymères. Dans cette partie, nous aborderons principalement les techniques de préparation par inversion de phase (NIPS, VIPS, TIPS) avec une ouverture sur la recherche et l’innovation (SNIPS, aquaporine…). En complément, seront décrits les additifs (notamment les agents porogènes et hydrophilisants), qui jouent un rôle important dans les approches par inversion de phase, et seront présentées les différentes voies de modifications chimiques des membranes post-synthèses. La seconde partie sera consacrée à la conception de membranes inorganiques. Dans cette partie, nous présenterons d'une part les procédés en voie humide, à savoir les principales méthodes de dépôt de films liquides (dip-coating, spin-coating, pulvérisation, tape-casting, sérigraphie-sérigravure) et de dépôt à partir de solutions (procédés électrolytiques ou chimiques) ou de suspensions (électrophorèse, Langmuir-Blodgett), et d'autre part les procédés en voie sèche (techniques PVD (évap. et pulvé.), techniques CVD (thermique, PECVD et ALD), MBE, traitement de surface). Enfin, comme illustration des deux familles de membranes, nous traiterons d'études de cas sur des applications membranaires, dans le domaine de l'emballage notamment.
A part dedicated to the practical aspect with work on computers
Natural aromatic raw materials: obtaining
- Terms and definition of natural raw materials (ISO/TC54 "Essential oil")
A theoretical part dedicated more specifically to modelling tools for drug design
Etude thématique
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
2) Surface analysis and imaging (molecular mapping)
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Cet enseignement consiste en une étude approfondie d'un problème ou d'un sujet choisi qui est lié à la chimie des matériaux pour les trois orientations ciblées du parcours : développement durable, santé et ingénierie des membranes. Cela peut prendre la forme d'une étude en recherche, développement ou analyse à l’échelle du laboratoire ou dans une entreprise. Les étudiants vont travailler en petits groupes – projets. Ils vont choisir leur sujet, définir le but, les objectifs et les moyens sous la direction d’un tuteur. Le but final est de développer un produit/méthodologie en utilisant les connaissances de synthèse et analyses déjà acquise pour préparer les stages qui auront lieu en S8.
A part dedicated to the practical aspect with work on computers
CM : 6h
TD : 6h
TP : 16h
A theoretical part dedicated more specifically to modelling tools for drug design
Anglais avancé
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
This course deals in a concise and systematic way with all aspects of heterocycle chemistry, from nomenclature to applications such as the principles of action of drugs, toxins or medicines, pigments, food colorants etc...
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
28 crédits
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Ce stage de fin d’études en Master 2 est destiné à mettre l'étudiant dans une situation préprofessionnelle, dans un laboratoire de recherche académique ou un laboratoire de recherche et développement industriel, en France ou à l'étranger.
L’étudiant recherchera une équipe d’accueil en milieu académique dans les instituts du Pôle Chimie de l’Université de Montpellier (ICGM, IEM, IBMM…), dans des laboratoires académiques hors de l’Université de Montpellier (en France ou à l’étranger) ou en secteur privé travaillant dans le domaine des matériaux. Le projet de recherche sur lequel travaillera l’étudiant aura été au préalable validé par l’équipe pédagogique de manière à s’assurer que le sujet de stage est en lien avec les enseignements du master, les compétences et expertises acquises lors des semestres antérieurs et des unités d’enseignement suivis en particulier au semestre 9 selon l’orientation choisie. Par ailleurs, l’équipe pédagogique s’assurera que le stage se déroulera dans un environnement et avec des moyens adéquats.
Ce stage d’une durée de 5 à 6 mois pourra débuter à partir de mi-janvier après la session d’examen et ne pourra excéder 6 mois au semestre 10.
A theoretical part dedicated more specifically to modelling tools for drug design
Applications in chemistry (pharmaceutical industry) and biology (Omics approaches).
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
1) Structural elucidation (Ion characterisation technologies) :
A part dedicated to the practical aspect with work on computers
LC/MS/MS and exact mass measurements
Isotope labelling, H/D exchange
A theoretical part dedicated more specifically to modelling tools for drug design
Microbiologie
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Quelques bases fondamentales de la microbiologie seront traitées de façon à ce que les étudiants aient un aperçu de la diversité des microorganismes. Le mode de nutrition et de multiplication des bactéries en fonction des paramètres physico-chimiques de l’environnement seront étudiés.
On abordera la composition et le rôle des microbiotes cutané et digestif.
Les critères microbiologiques utilisés pour le contrôle qualité des produits cosmétiques et agroalimentaires seront définis.
Les agents antimicrobiens physiques et chimiques permettant de contrôler le développement microbien seront examinés.
Au niveau pratique, on s’attachera à ce que l’étudiant sache manipuler des bactéries et connaisse les règles de sécurité microbiologique. Des techniques usuelles de contrôles microbiologiques et d’efficacité des conservateurs seront effectuées sur des produits cosmétiques.
A part dedicated to the practical aspect with work on computers
CM : 12h
TP : 8h
A theoretical part dedicated more specifically to modelling tools for drug design
Affaires reglementaires
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Connaitre et savoir appliquer les divers règlements en lien avec l’industrie de la cosmétique (Règlement 1223/2009, REACH, CLP, etc..)
Approfondir les articles importants de la réglementation européenne en cosmétique - Règlement 1223/2009
Apprendre à réaliser un DIP
Se focaliser sur le rapport de sécurité à partir d'un exemple
A part dedicated to the practical aspect with work on computers
Experimental investigations of measuring the ionic conductivity versus the temperature are described. The method of Impedance Spectroscopy Measurements is discussed.
Presentation of the Kröger-Vink Notation of defects
A theoretical part dedicated more specifically to modelling tools for drug design
Pigments, colorants et adsorbant: Structures et caractérisat
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Cette unité d’enseignement est dédiée à l’acquisition de notions liées aux pigments, colorants, et adsorbants, du point de vue de leurs structures et de leurs applications. L’accent sera mis sur les applications dans le domaine des arômes & parfums (colorants alimentaires, parfumerie) et celui des cosmétiques (coloration capillaire, poudres, dentifrices…). Certaines séances sont spécifiques à chacun des deux parcours (P1, Ingénierie des cosmétiques ; P2, Arômes-Parfums) du master Chimie spécialité Ingénierie des cosmétiques, arômes, parfums (ICAP). L’UE comporte des enseignements dispensés en cours magistraux et travaux dirigés.
A part dedicated to the practical aspect with work on computers
This lecture is the continuation of the crystallography lecture of the1st semester and will give an advanced insight into structural characterization and structure refinements. It involves classical X-ray laboratory data collection and analysis, completed by synchrotron and neutron diffraction data analysis (powder and single crystal). The goal is to get familiar with the general principles of structure analysis, tanking advantage of the complementarity of X-ray and neutron diffraction. The lecture provides a detailed knowledge on how to understand and analyze phase transitions and how to deal with respective changes in the metric and associated data and structural transformations.
This lecture contains the following topics:
A theoretical part dedicated more specifically to modelling tools for drug design
CM: 9 h
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Field: 11 a.m.
- Supported syntheses
- In chemistry, solid phase synthesis is a method in which molecules are covalently bonded to a solid support and synthesised step by step using selective protecting groups. This applied course aims to provide a comprehensive understanding of this field and to examine supported strategies for the practical preparation of polypeptides and oligonucleotides.
- CM: 9 H
Biotechnology and applications
A part dedicated to the practical aspect with work on computers
The aim of this course is to highlight biological processes at the cellular level or even in living subjects. Different molecular imaging approaches will be discussed (fluorescent probes, radiolabelling).
CM: 9 H
A theoretical part dedicated more specifically to modelling tools for drug design
Techniques séparatives
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Cet enseignement a pour vocation d’enseigner la chromatographie en phase liquide et la chromatographie en phase gazeuse.
A part dedicated to the practical aspect with work on computers
CM :15h
The4th semester of the Master Course is entirely dedicated to the 5 months (minimum) master thesis project in Materials Science. Students get enrolled in a research topic, and to contribute to a scientific problem in a research team. It allows to apply acquired and to learn new scientific skills in order to identify the problem and to proceed for a (possible) solution. The topic is analysed and described in the written Master thesis memory and presented orally in from of a jury. It should allow the candidate to show his ability to conduct a scientific problem and to present it in an analytical way.
A theoretical part dedicated more specifically to modelling tools for drug design
Physique de la couleur
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Cette UE aborde :
- les fondements de la colorimétrie, qui permettent de définir une mesure non ambiguë de la couleur à partir d’expériences de psychophysique.
- le principe et l’usage pratique des appareils de mesure de la couleur (colorimètres et spectro-colorimètres).
- les principes de la reproduction de la couleur, en particulier dans le contexte des parfums et des cosmétiques.
Les idées théoriques sont complétées par une partie importante d’observation et de manipulations au courts des TP.
A part dedicated to the practical aspect with work on computers
CM : 12h
TP : 8h
A theoretical part dedicated more specifically to modelling tools for drug design
Ingénierie de la formulation cosmétique
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
2) Surface analysis and imaging (molecular mapping)
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Etude de l’ensemble du développement d’un produit cosmétique
- Définition d’un produit cosmétique
- Lancement du développement, les interactions du service développement avec les services marketing, industrie, réglementaire : besoins, attentes, fonctionnement et procédures
- Etude de l’ensemble des tests possibles : d’analyse sensorielle, de stabilités physicochimique, d’innocuité et de sécurité sanitaire, d’efficacité.
- Etude de la transposition industrielle
- Etude des interactions avec le packaging et les tests associés
- La description du dossier information produit ou dossier cosmétique légal
Etude des émulsions, définitions, caractéristiques et formulation
Etude des phénomènes d’instabilités des émulsions et des solutions de stabilisation
Partie pratique :
Formulation des émulsions eau dans huile, huile dans eau et gel crème
Etude des ingrédients, nature chimique, comportement physique et formulation
Etude du matériel de formulation
Mise en place des tests sensoriels, physicochimiques et de stabilité.
Développement d’une formule en plusieurs étapes avec des contraintes imposées.
Analyse critique des résultats obtenus.
En ce qui concerne l’initiation au génie chimique appliqué au domaine de la cosmétique, les étudiants devront travailler sur un cas d’étude qui décrit la production à l’échelle laboratoire d’un produit cosmétique, et puis trouver le moyen de le produire à une échelle supérieure.
A part dedicated to the practical aspect with work on computers
CM :15
TP : 25
A theoretical part dedicated more specifically to modelling tools for drug design
1) Pharmacological and biophysical fundamentals describing a biological event, target of biological tests:
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
2) Biological tests for the development of medicines or diagnostics
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
3) Applications, case studies, critical analyses.
Separation/Purification
A part dedicated to the practical aspect with work on computers
The objective of this course is to provide students with theoretical and practical training in the fundamental techniques of separation and purification of biomolecules
Hourly volumes*:
CM: 9 hours
Field: 11 hours
Thermodynamics and defects of solids
A theoretical part dedicated more specifically to modelling tools for drug design
Matières premières cosmétiques
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
2) Surface analysis and imaging (molecular mapping)
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Ce module couvre toutes les connaissances sur les matières premières nécessaires pour exercer dans l’industrie cosmétique.
Il s’agit :
- de décrire les différentes classes chimiques des matières premières, de comprendre les relations structures/activités ainsi que le rendu sensoriel.
- L’étude des documents relatifs à la commercialisation des matières premières cosmétiques
A part dedicated to the practical aspect with work on computers
CM : 18
TD : 6
TP : 16
Le cours s’appuie sur des études de cas d’ingrédients des phases aqueuses ou phases grasses, et les polymères comme les procédés de polymérisation seront développés.
La partie pratique du module permettra de mettre en œuvre des grandes catégories de matières premières:
Mise en œuvre des gélifiants : mise en œuvre, étude de leurs propriétés, évaluation sensorielle
Mise en œuvre des tensio-actifs : Formulation d’un produit moussant avec recherche des ingrédients, conception formule à la formulation et évaluation sensorielle
A theoretical part dedicated more specifically to modelling tools for drug design
R&D cosmétique
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
2) Surface analysis and imaging (molecular mapping)
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Ce module s’intéresse à la R&D dans les industries de la cosmétique et mettra l’accent sur l’expertise scientifique et l’innovation, à travers des cours et des conférences. De même, des mises en situations sur la conception et le développement de produits cosmétiques et de bien-être seront proposées.
La partie pratique s’intéressera particulièrement au développement des produits de maquillage :
Revue de la composition des produits de maquillage
Les matières premières colorantes naturelles ou synthétiques. Connaitre les différentes galéniques utilisées en maquillage et savoir sélectionner les matières premières.
Savoir sélectionner les pigments en fonction de la cible souhaitée. Savoir les disperser et connaitre le traitement de surface.
Étude marketing sur des galéniques de maquillage définies
Cours théoriques sur les matières premières et les galéniques utilisées en maquillage, process de fabrication, ainsi que les tendances du marché et les tests possibles (claims, tests physico-chimiques, tests d'efficacité, ...)
En pratique :
Cours pratiques sur les prémix de pigments, les fonds de teint et les rouges à lèvres, associés à des évaluations sensorielles
Application à la formulation de divers produits de maquillage (Fond de teint, Rouge à lèvre, mascara, etc ;) et contrôle qualité des produits finis.
A part dedicated to the practical aspect with work on computers
CM : 20
TD : 5
TP : 15
A theoretical part dedicated more specifically to modelling tools for drug design
Stage industriel 4 à 6 mois
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
18 crédits
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Ce stage d’une durée de 4 à 6 mois sera réalisé dans un laboratoire de R&D des industries de la cosmétique et du bien-être.
Les missions confiées par l’entreprise à l’étudiant stagiaire seront en lien avec les objectifs du Master.
Ce stage pourra commencer à partir de février/mars et sera réalisé en France ou à l’étranger.
A theoretical part dedicated more specifically to modelling tools for drug design
Symmetry and space groups
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Introduction into structure refinement (single crystal and powder methods)
- Neutron and synchrotron facilities
- Magnetic structures with neutron diffraction
- Structure determination from single crystals (experiment and theory)
- Structure determination from powder diffraction data (experiment and theory)
The applications of Fourier series for structure solution and refinements: from the Patterson Method to difference Fourier analysis
Crystal twinning,
A theoretical part dedicated more specifically to modelling tools for drug design
Phase transitions
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Anomalous scattering and absolute structure determination
- TD:15
- Metallurgy and electronics properties
- This teaching unit is devoted to give an introduction to the electronic properties in the solid state of bulk and/or nano-materials, magnetic properties in transition metal oxides, etc.... This unit is given by different, alternating external teachers to UM and the topics may vary with respect to the respective area of expertise of the teaching stuff.
- Students should get familiarized not only with the electronic properties and ordering of materials, but also with respect to ionic and mixed electronic ionic conductors, materials for spintronics. Another aspect concerns here their specific characterizations using neutron/synchrotron diffraction as well as complementary macroscopic characterization methods for magnetism, permeability, etc
- CM: 30 h
TD: 15 h
Materials for catalysis M2
A theoretical part dedicated more specifically to modelling tools for drug design
Intelligence économique et création
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
2) Surface analysis and imaging (molecular mapping)
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Ce module s’articule autour :
- Des outils et sources d’information (brevet, bases de données, revues, salons et journées scientifiques, etc..) et de communication: savoir identifier les sources d’information pertinentes, savoir les analyser et les utiliser, savoir communiquer en interne et en externe.
- A quoi correspond l’intelligence économique, comment l’appréhender et l’utiliser
- Des fondamentaux du marketing : présentation de ce que fait le marketing, présentation d’outils qui pourront aider les étudiants dans leurs travaux futurs, explication détaillée du processus de développement d’un produit cosmétique en marketing, et les différents métiers qui s’offrent aux étudiants.
Un projet sera développé par les étudiants.
A part dedicated to the practical aspect with work on computers
CM :15h
Hourly volumes*:
CM: 9 hours
Field: 11 hours
TP : 10h
Sortie : 10h
A theoretical part dedicated more specifically to modelling tools for drug design
Affaires règlementaires, évaluations et management qualité
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
2) Surface analysis and imaging (molecular mapping)
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Rappel de la législation européenne et sa hiérarchie : règlements, directives, décisions, résolutions, lois nationales, Institutions et autorités en charge du système réglementaire.
Descriptif des règlementations principales à travers le monde et vue globale des avancées
Institutions et autorités en charge du système réglementaire
Cadre réglementaire appliqué aux emballages cosmétiques
Démarche de mise en conformité des emballages cosmétiques et ses principales difficultés
Exigences nouvelles applicables aux emballages cosmétiques dans le cadre des lois européennes et françaises sur l’économie circulaire
Le cours abordera les Bonnes Pratiques de Fabrication (BPF) destinées à assurer la reproductibilité et la qualité de fabrication des produits cosmétiques.
Il permettra de connaitre les mesures à adopter vis-à-vis des processus de production, contrôle, stockage et expédition et pour assurer la conformité des produits cosmétiques en référence à la réglementation en vigueur (CE 1223/2009, norme ISO 22716, etc.)
A part dedicated to the practical aspect with work on computers
CM : 15
TD : 15
Terrain : 10
A theoretical part dedicated more specifically to modelling tools for drug design
Eco-conception cosmétique
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
2) Surface analysis and imaging (molecular mapping)
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Qu’est-ce que l’éco-conception?
L’ Analyse de Cycle de Vie de produits (ACV)
Qui certifie?
L’éco-conception & matières premières
Biodiversité et protocole de Nagoya.
Rappels sur les principes de la Chimie verte
Eco toxicologie et biodégradabilité
Fabrication d’un produit cosmétique en eco-conception
Les tendances liées à l’éco-conception
Les emballages en eco-conception, quel est leur impact ?
Notion d’ecotoxicologie : impact sur l’environnement/biodégradabilité
Information sur la mesure d’ecoconception : quels sont les outils à disposition/ mesure d’impact Recylabilité des packagings : mesure et analyses (matières premières/formules/écotoxicologie).
Une mise en situation sera proposée aux étudiants.
A part dedicated to the practical aspect with work on computers
CM : 20
Presentation of the Kröger-Vink Notation of defects
TP : 10
A theoretical part dedicated more specifically to modelling tools for drug design
Evaluations et statistique appliquée à l’analyse sensorielle
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Donner aux étudiants la compréhension théorique de la statistique inférentielle nécessaire à l'analyse statistique des données issues d'épreuves sensométriques. Problématique générale : extraire des mesures sensorielles des régularités interprétables pour prendre les bonnes décisions.
Les enseignements couvriront les besoins de chaque parcours, à travers des exemples et des applications adaptés.
For this personal project, the student will have access to all the bibliographic sources of the university or the company hosting him/her. The bibliographical work may be combined with the English teaching unit in order to prepare an oral presentation at an international conference.
CM : 10 H
TP : 10H
A theoretical part dedicated more specifically to modelling tools for drug design
Technologie cosmétique
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Les polymères interviennent dans de très nombreuses formulations cosmétiques avec des fonctions diverses dont les principales sont le contrôle de la rhéologie, la stabilisation de la formulation et comme agent de conditionnement. Il est donc important de connaître leur comportement dans ces milieux complexes, notamment en étudiant les interactions polymère-tensioactif puisque ces deux constituants sont souvent présents ensemble dans ces milieux, ainsi que les interactions avec les surfaces solides (suspensions, applications sur les cheveux ou sur la peau) ou liquides (émulsions).
Le cours décrit : (1) les différents types de polymères utilisés : hydrosolubles, synthétiques, naturels et semi-naturels, amphiphiles et les relations structures-propriétés, (2) principe d’épaississement des formules ou de gélification en utilisant les polymères, (3) les interactions avec les tensioactifs, présentation des différents types de tensioactifs et de leurs propriétés physico-chimiques en particulier les tensioactifs polymérique, (4) les interactions avec les surfaces (peau, cheveu) ainsi que tout type de surface solide, (5) principe de stabilisation des émulsions et des suspensions en utilisant les polymères.
Une deuxième partie de ce module est consacrée aux silicones et à leur utilisation en cosmétique :
La chimie des silicones, les silicones pour la cosmétique: les catégories, leurs utilisations et leurs effets sensoriels avec exemples d’application.
A theoretical part dedicated more specifically to modelling tools for drug design
Dermocosmétique
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Connaissances de base concernant la structure et la physiologie cutanée : structure de la peau ; les récepteurs sensoriels ; la sensibilité mécanique et thermique.
Pénétration cutanée ; hydratation cutanée et produits hydratants ; séborrhée, Acné ; typologies Dermocosmétique : pénétration cutanée ; vieillissement cutané, la peau du nourrisson ; la cellulite
A part dedicated to the practical aspect with work on computers
CM : 16
TD : 4
A theoretical part dedicated more specifically to modelling tools for drug design
Formulation couleur
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
L’objectif de l’UE est de comprendre et appliquer les principes de la formulation de la couleur telle que pratiquée dans l’industrie de la couleur. Pour cela les bases de la spectrocolorimétrie, les interactions lumière-matière et les modèles les plus simples de formulation (Beer-Lambert et Kubelka -Munk) sont étudiés et utilisés en travaux pratiques.
Volumes horaires :
CM : 12
TP : 8
A theoretical part dedicated more specifically to modelling tools for drug design
Anglais avancé
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Actifs et additifs naturels
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
2) Surface analysis and imaging (molecular mapping)
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Ce module est consacré d’une part à l'étude des principales classes d’additifs cosmétiques et d’autre part à l’étude des actifs naturels, biotechnologiques et de synthèse.
La première partie de cet enseignement permettra de se concentrer sur la flore marine à travers notamment la composition générale et les spécificités des différentes algues. Qu'elle est la place et l'efficacité de la flore marine en cosmétique ?
Le cours se conclura sur des études de cas et des perspectives.
Une deuxième partie parlera du monde végétal afin de permettre aux formulateurs et aux responsables des questions réglementaires de comprendre la mise en œuvre des molécules végétales pour leurs effets bénéfiques vis-à-vis des principales indications cosmétiques. Les huiles essentielles : quelles sont les techniques de production, leurs compositions chimiques, leurs propriétés cosmétiques, leur formulation, leur sécurité d’emploi ?
La troisième partie du module portera sur les différentes classes d’additifs utilisés en cosmétique.
L’accent sera mis sur l'étude chimique et organoleptique des principales matières premières (synthétiques ou naturelles) utilisées dans le parfumage des cosmétiques et les contraintes réglementaires liées à leur utilisation (directives cosmétiques relatives au dosage des allergènes).
Les familles de molécules odorantes utilisées dans les cosmétiques (molécules sans fonction organique ou contenant des fonctions alcool, aldéhyde, cétone, ester) seront étudiées:
- molécules avec un cycle aromatique
- molécules de type phénol
- molécules aliphatiques cycliques et acycliques.
- molécules terpéniques acycliques et cycliques
- champ des odeurs.
-Notions de stabilité et de volatilité des molécules.
L’enseignement se conclura par un apprentissage à la formulation de compositions parfumantes pour produits cosmétiques.
A part dedicated to the practical aspect with work on computers
CM : 20
Presentation of the Kröger-Vink Notation of defects
TP : 10
A theoretical part dedicated more specifically to modelling tools for drug design
Photoprotection
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
2) Surface analysis and imaging (molecular mapping)
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Ce module s’articule autour de tous les aspects relatifs à la photoprotection :
Il commencera par un rappel sur les rayonnements solaires et sur la peau en mettant l'accent sur la photoprotection naturelle mélanique et non mélanique. La réaction de la peau au soleil permettra d'aborder les bienfaits du soleil mais se concentrera surtout les effets secondaires néfastes pour la peau. Quelles sont les possibilités offertes par l'industrie cosmétique pour se protéger? Comment analyser l'efficacité des produits solaires? Quel est l’impact des filtres sur l’environnement ?
- Etude du développement des formules solaires : les matières premières, les filtres chimiques et physiques, les techniques de formulation, la règlementation, le rapport du soleil avec la peau.
- Utilisation des logiciels permettant le calcul des SPF théoriques
- Acquérir les connaissances en formulation de produits solaires
- Procédés de fabrication
- L’analyse fine des formules INCI
- Formulation de microémulsion par inversion de phase
A part dedicated to the practical aspect with work on computers
CM : 15
TP : 25
A theoretical part dedicated more specifically to modelling tools for drug design
Plan d’expérience
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Un plan d'expériences est la suite ordonnée d'essais d'une expérimentation dont le but est de tester la validité d'une hypothèse en reproduisant un phénomène et en faisant varier un ou plusieurs paramètres. Chaque essai produit une donnée et l’ensemble des données produites lors d’une expérience doit être analysé par des méthodes rigoureuses pour valider ou non l'hypothèse. Cette démarche expérimentale permet d'acquérir de nouvelles connaissances en confortant un modèle avec une bonne économie de moyens (nombre d'essais le plus faible possible, par exemple).
Partant d’un problème simple, le module développe les outils méthodologiques et statistiques permettant de conforter des hypothèses de plus en plus complexes de la façon la plus optimale possible. La mise en œuvre de ces méthodologies se fait via le langage statistique R.
A part dedicated to the practical aspect with work on computers
Master thesis
TP : 5h
A theoretical part dedicated more specifically to modelling tools for drug design
Stratégies de l'entreprise
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Cette unité d’enseignement comprend plusieurs axes :
- Les enseignements montreront que la chimie ouvre à divers métiers dans le domaine de la cosmétique, et pas uniquement à la formulation.
- Savoir apporter une réflexion sur la méthode scientifique afin d’éviter les erreurs de jugement et savoir apporter une réflexion scientifique devant toute information. L’enseignement s’appuiera sur des exemples concrets liés à la cosmétique (différence entre risque et danger, réflexion sur diverses applications/informations consommateur, etc.)
- Une mise en situation permet de travailler sur des projets concrets de marketing, de l’étude de marché jusqu’à la formalisation d’un concept marketing en cosmétique.
A part dedicated to the practical aspect with work on computers
CM : 12
TD : 8
A theoretical part dedicated more specifically to modelling tools for drug design
Prospective
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
In this part, we will be interested in electron microscopy through flipped classes. We will discuss the following topics: Electron sources, lens and aberrations, sample preparation, electron diffraction, Structural and chemical analysis, Imaging techniques.
CM: 34
Ce module permettra aux étudiants de comprendre l’importance de l’innovation dans un secteur aussi dynamique que celui de la cosmétique.
Cet environnement est en effet régi par des contraintes réglementaires, des innovations en packaging, des innovations en formulation mais aussi en ingrédients.
Le tout est également gouverné par les attentes des consommateurs de plus en plus exigeants.
Il est donc primordial pour ces futurs diplômés de comprendre les tenants et aboutissants de l’innovation en cosmétique et de savoir la mettre en œuvre en respectant cependant quelques critères.
Un projet sera propose aux étudiants: Présentation du projet en groupe et mise en place des consignes pour sa réalisation.
A part dedicated to the practical aspect with work on computers
CM : 20
A theoretical part dedicated more specifically to modelling tools for drug design
Ingénierie cosmétique et innovation
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
2) Surface analysis and imaging (molecular mapping)
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Etude approfondie des différentes galéniques cosmétiques : composition, description des composants principaux, formulation, principe, formes galéniques
Etude des familles d’ingrédients dont les émollients, esters, émulsionnants, filtres solaires, conservateurs et innovation en produits de soin et de maquillage
Etude des liste INCI des formulations, des nomenclatures INCI
Etude des différents types d’entreprises cosmétiques
Etude des procédés de fabrication (Le matériel d’agitation, les process complémentaires de fabrication, l’impact des paramètres physico chimiques sur la fabrication)
L’application se fera dans différents domaines.
Par exemple : formulation d’émulsions hydratantes avec électrolytes (éléments perturbateurs de stabilité), formulation de lait démaquillant et de lotion démaquillante et la mise en place de test pour mesurer l’efficacité démaquillante, formulation de produits de maquillage.
A part dedicated to the practical aspect with work on computers
CM : 15
TP : 25
A theoretical part dedicated more specifically to modelling tools for drug design
Mise en situation industrielle non apprentis
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
2) Surface analysis and imaging (molecular mapping)
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Le présent module consiste en la mise en situation des étudiants dans un contexte professionnel, en relation avec une entreprise de mise au point et production de cosmétiques ou fournisseur de matières premières. Le module sera organisé sous forme de projets industriels :
Les étudiants sont répartis en groupes, telle que serait composée une équipe scientifique. Ils devront donc mettre en application leurs connaissances théoriques, en étroite collaboration avec l’industriel. L’industriel pourra ainsi les guider ou les aider à contacter de nouveaux fournisseurs, à réaliser un dossier cosmétique, à faire une étude de marché, etc., selon le projet attribué.
Des rapports d’activité seront réalisés via les réseaux de partage utilisés communément dans le milieu. Les groupes seront amenés à travailler en autonomie, en suivant un cahier des charges défini par l’industriel, en adéquation avec le programme du diplôme.
Cela pourra être par exemple la mise au point d’un produit innovant, dans le respect des règlementations Française et Européenne notamment ou le contretypage.
A part dedicated to the practical aspect with work on computers
Experimental investigations of measuring the ionic conductivity versus the temperature are described. The method of Impedance Spectroscopy Measurements is discussed.
TP : 30
A theoretical part dedicated more specifically to modelling tools for drug design
Stage industriel 5-6 mois
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
20 crédits
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Ce stage d’une durée de 5 à 6 mois, ou la mission d’alternance, sera réalisé dans un laboratoire de R&D des industries de la cosmétique et du bien-être.
Les missions confiées par l’entreprise à l’étudiant stagiaire/alternant seront en lien avec les objectifs du Master.
Ce stage, ou cette mission d’alternance, sera réalisé en France ou à l’étranger.
A theoretical part dedicated more specifically to modelling tools for drug design
Applications in chemistry (pharmaceutical industry) and biology (Omics approaches).
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
1) Structural elucidation (Ion characterisation technologies) :
A part dedicated to the practical aspect with work on computers
LC/MS/MS and exact mass measurements
Isotope labelling, H/D exchange
A theoretical part dedicated more specifically to modelling tools for drug design
Microbiologie
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Quelques bases fondamentales de la microbiologie seront traitées de façon à ce que les étudiants aient un aperçu de la diversité des microorganismes. Le mode de nutrition et de multiplication des bactéries en fonction des paramètres physico-chimiques de l’environnement seront étudiés.
On abordera la composition et le rôle des microbiotes cutané et digestif.
Les critères microbiologiques utilisés pour le contrôle qualité des produits cosmétiques et agroalimentaires seront définis.
Les agents antimicrobiens physiques et chimiques permettant de contrôler le développement microbien seront examinés.
Au niveau pratique, on s’attachera à ce que l’étudiant sache manipuler des bactéries et connaisse les règles de sécurité microbiologique. Des techniques usuelles de contrôles microbiologiques et d’efficacité des conservateurs seront effectuées sur des produits cosmétiques.
A part dedicated to the practical aspect with work on computers
CM : 12h
TP : 8h
A theoretical part dedicated more specifically to modelling tools for drug design
Affaires reglementaires
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Connaitre et savoir appliquer les divers règlements en lien avec l’industrie de la cosmétique (Règlement 1223/2009, REACH, CLP, etc..)
Approfondir les articles importants de la réglementation européenne en cosmétique - Règlement 1223/2009
Apprendre à réaliser un DIP
Se focaliser sur le rapport de sécurité à partir d'un exemple
A part dedicated to the practical aspect with work on computers
Experimental investigations of measuring the ionic conductivity versus the temperature are described. The method of Impedance Spectroscopy Measurements is discussed.
Presentation of the Kröger-Vink Notation of defects
A theoretical part dedicated more specifically to modelling tools for drug design
Pigments, colorants et adsorbant: Structures et caractérisat
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Cette unité d’enseignement est dédiée à l’acquisition de notions liées aux pigments, colorants, et adsorbants, du point de vue de leurs structures et de leurs applications. L’accent sera mis sur les applications dans le domaine des arômes & parfums (colorants alimentaires, parfumerie) et celui des cosmétiques (coloration capillaire, poudres, dentifrices…). Certaines séances sont spécifiques à chacun des deux parcours (P1, Ingénierie des cosmétiques ; P2, Arômes-Parfums) du master Chimie spécialité Ingénierie des cosmétiques, arômes, parfums (ICAP). L’UE comporte des enseignements dispensés en cours magistraux et travaux dirigés.
A part dedicated to the practical aspect with work on computers
This lecture is the continuation of the crystallography lecture of the1st semester and will give an advanced insight into structural characterization and structure refinements. It involves classical X-ray laboratory data collection and analysis, completed by synchrotron and neutron diffraction data analysis (powder and single crystal). The goal is to get familiar with the general principles of structure analysis, tanking advantage of the complementarity of X-ray and neutron diffraction. The lecture provides a detailed knowledge on how to understand and analyze phase transitions and how to deal with respective changes in the metric and associated data and structural transformations.
This lecture contains the following topics:
A theoretical part dedicated more specifically to modelling tools for drug design
CM: 9 h
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Field: 11 a.m.
- Supported syntheses
- In chemistry, solid phase synthesis is a method in which molecules are covalently bonded to a solid support and synthesised step by step using selective protecting groups. This applied course aims to provide a comprehensive understanding of this field and to examine supported strategies for the practical preparation of polypeptides and oligonucleotides.
- CM: 9 H
Biotechnology and applications
A part dedicated to the practical aspect with work on computers
The aim of this course is to highlight biological processes at the cellular level or even in living subjects. Different molecular imaging approaches will be discussed (fluorescent probes, radiolabelling).
CM: 9 H
A theoretical part dedicated more specifically to modelling tools for drug design
Techniques séparatives
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Cet enseignement a pour vocation d’enseigner la chromatographie en phase liquide et la chromatographie en phase gazeuse.
A part dedicated to the practical aspect with work on computers
CM :15h
The4th semester of the Master Course is entirely dedicated to the 5 months (minimum) master thesis project in Materials Science. Students get enrolled in a research topic, and to contribute to a scientific problem in a research team. It allows to apply acquired and to learn new scientific skills in order to identify the problem and to proceed for a (possible) solution. The topic is analysed and described in the written Master thesis memory and presented orally in from of a jury. It should allow the candidate to show his ability to conduct a scientific problem and to present it in an analytical way.
A theoretical part dedicated more specifically to modelling tools for drug design
Physique de la couleur
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Cette UE aborde :
- les fondements de la colorimétrie, qui permettent de définir une mesure non ambiguë de la couleur à partir d’expériences de psychophysique.
- le principe et l’usage pratique des appareils de mesure de la couleur (colorimètres et spectro-colorimètres).
- les principes de la reproduction de la couleur, en particulier dans le contexte des parfums et des cosmétiques.
Les idées théoriques sont complétées par une partie importante d’observation et de manipulations au courts des TP.
A part dedicated to the practical aspect with work on computers
CM : 12h
TP : 8h
A theoretical part dedicated more specifically to modelling tools for drug design
Ingénierie de la formulation cosmétique
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
2) Surface analysis and imaging (molecular mapping)
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Etude de l’ensemble du développement d’un produit cosmétique
- Définition d’un produit cosmétique
- Lancement du développement, les interactions du service développement avec les services marketing, industrie, réglementaire : besoins, attentes, fonctionnement et procédures
- Etude de l’ensemble des tests possibles : d’analyse sensorielle, de stabilités physicochimique, d’innocuité et de sécurité sanitaire, d’efficacité.
- Etude de la transposition industrielle
- Etude des interactions avec le packaging et les tests associés
- La description du dossier information produit ou dossier cosmétique légal
Etude des émulsions, définitions, caractéristiques et formulation
Etude des phénomènes d’instabilités des émulsions et des solutions de stabilisation
Partie pratique :
Formulation des émulsions eau dans huile, huile dans eau et gel crème
Etude des ingrédients, nature chimique, comportement physique et formulation
Etude du matériel de formulation
Mise en place des tests sensoriels, physicochimiques et de stabilité.
Développement d’une formule en plusieurs étapes avec des contraintes imposées.
Analyse critique des résultats obtenus.
En ce qui concerne l’initiation au génie chimique appliqué au domaine de la cosmétique, les étudiants devront travailler sur un cas d’étude qui décrit la production à l’échelle laboratoire d’un produit cosmétique, et puis trouver le moyen de le produire à une échelle supérieure.
A part dedicated to the practical aspect with work on computers
CM :15
TP : 25
A theoretical part dedicated more specifically to modelling tools for drug design
Matières premières cosmétiques
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
2) Surface analysis and imaging (molecular mapping)
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Ce module couvre toutes les connaissances sur les matières premières nécessaires pour exercer dans l’industrie cosmétique.
Il s’agit :
- de décrire les différentes classes chimiques des matières premières, de comprendre les relations structures/activités ainsi que le rendu sensoriel.
- L’étude des documents relatifs à la commercialisation des matières premières cosmétiques
A part dedicated to the practical aspect with work on computers
CM : 18
TD : 6
TP : 16
Le cours s’appuie sur des études de cas d’ingrédients des phases aqueuses ou phases grasses, et les polymères comme les procédés de polymérisation seront développés.
La partie pratique du module permettra de mettre en œuvre des grandes catégories de matières premières:
Mise en œuvre des gélifiants : mise en œuvre, étude de leurs propriétés, évaluation sensorielle
Mise en œuvre des tensio-actifs : Formulation d’un produit moussant avec recherche des ingrédients, conception formule à la formulation et évaluation sensorielle
A theoretical part dedicated more specifically to modelling tools for drug design
Projets professionnels – suivi de projets apprentis
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
2) Biological tests for the development of medicines or diagnostics
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Mise en situation professionnelle de l’étudiant apprenti en M1 ICAP qui mènera à bien un projet en réponse à une problématique industrielle. CE Projet qui s’effectuera sous la responsabilité d’un membre de l’équipe pédagogique tuteur (universitaire ou industriel). Mené tout au long du semestre, ce projet vise à mettre en situation les connaissances/savoir-faire acquis dans le cadre de la formation universitaire de Licence et de début de Master. En plus des compétences disciplinaires de la chimie, d’autres compétences relationnelles, organisationnelles et en communication, intrinsèquement liées à la conduite de projets, seront également acquises et prépareront les étudiants à leur future vie professionnelle.
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Exemple de problématique industrielle : évaluation de la stabilité oxydative d’ingrédients parfumés en présence d’antioxydants
Exemple de problématique industrielle : analyse d’allergènes dans les parfums : technique de la microextraction en phase solide (SPME) de l’espace de tête ou headspace (HS) suivi de l’analyse par chromatographie en phase gazeuse couplée à la spectrométrie de masse (GC-MS)
Exemples de problématique industrielle : détection et identification de composés responsables d'un défaut de goût ou "off-flavour" par chromatographie en phase gazeuse couplée à l'olfactométrie
Exemples de problématique industriel : Connaitre et savoir utiliser les techniques d'analyses physico-chimiques essentielles mise en œuvre lors du contrôle d'un produit fini
A part dedicated to the practical aspect with work on computers
CM : 5h
The4th semester of the Master Course is entirely dedicated to the 5 months (minimum) master thesis project in Materials Science. Students get enrolled in a research topic, and to contribute to a scientific problem in a research team. It allows to apply acquired and to learn new scientific skills in order to identify the problem and to proceed for a (possible) solution. The topic is analysed and described in the written Master thesis memory and presented orally in from of a jury. It should allow the candidate to show his ability to conduct a scientific problem and to present it in an analytical way.
TP : 40h
A theoretical part dedicated more specifically to modelling tools for drug design
R&D cosmétique
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
2) Surface analysis and imaging (molecular mapping)
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Ce module s’intéresse à la R&D dans les industries de la cosmétique et mettra l’accent sur l’expertise scientifique et l’innovation, à travers des cours et des conférences. De même, des mises en situations sur la conception et le développement de produits cosmétiques et de bien-être seront proposées.
La partie pratique s’intéressera particulièrement au développement des produits de maquillage :
Revue de la composition des produits de maquillage
Les matières premières colorantes naturelles ou synthétiques. Connaitre les différentes galéniques utilisées en maquillage et savoir sélectionner les matières premières.
Savoir sélectionner les pigments en fonction de la cible souhaitée. Savoir les disperser et connaitre le traitement de surface.
Étude marketing sur des galéniques de maquillage définies
Cours théoriques sur les matières premières et les galéniques utilisées en maquillage, process de fabrication, ainsi que les tendances du marché et les tests possibles (claims, tests physico-chimiques, tests d'efficacité, ...)
En pratique :
Cours pratiques sur les prémix de pigments, les fonds de teint et les rouges à lèvres, associés à des évaluations sensorielles
Application à la formulation de divers produits de maquillage (Fond de teint, Rouge à lèvre, mascara, etc ;) et contrôle qualité des produits finis.
A part dedicated to the practical aspect with work on computers
CM : 20
TD : 5
TP : 15
A theoretical part dedicated more specifically to modelling tools for drug design
Symmetry and space groups
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Introduction into structure refinement (single crystal and powder methods)
- Neutron and synchrotron facilities
- Magnetic structures with neutron diffraction
- Structure determination from single crystals (experiment and theory)
- Structure determination from powder diffraction data (experiment and theory)
The applications of Fourier series for structure solution and refinements: from the Patterson Method to difference Fourier analysis
Crystal twinning,
A theoretical part dedicated more specifically to modelling tools for drug design
Phase transitions
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Anomalous scattering and absolute structure determination
- TD:15
- Metallurgy and electronics properties
- This teaching unit is devoted to give an introduction to the electronic properties in the solid state of bulk and/or nano-materials, magnetic properties in transition metal oxides, etc.... This unit is given by different, alternating external teachers to UM and the topics may vary with respect to the respective area of expertise of the teaching stuff.
- Students should get familiarized not only with the electronic properties and ordering of materials, but also with respect to ionic and mixed electronic ionic conductors, materials for spintronics. Another aspect concerns here their specific characterizations using neutron/synchrotron diffraction as well as complementary macroscopic characterization methods for magnetism, permeability, etc
- CM: 30 h
TD: 15 h
Materials for catalysis M2
A theoretical part dedicated more specifically to modelling tools for drug design
Intelligence économique et création
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
2) Surface analysis and imaging (molecular mapping)
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Ce module s’articule autour :
- Des outils et sources d’information (brevet, bases de données, revues, salons et journées scientifiques, etc..) et de communication: savoir identifier les sources d’information pertinentes, savoir les analyser et les utiliser, savoir communiquer en interne et en externe.
- A quoi correspond l’intelligence économique, comment l’appréhender et l’utiliser
- Des fondamentaux du marketing : présentation de ce que fait le marketing, présentation d’outils qui pourront aider les étudiants dans leurs travaux futurs, explication détaillée du processus de développement d’un produit cosmétique en marketing, et les différents métiers qui s’offrent aux étudiants.
Un projet sera développé par les étudiants.
A part dedicated to the practical aspect with work on computers
CM :15h
Hourly volumes*:
CM: 9 hours
Field: 11 hours
TP : 10h
Sortie : 10h
A theoretical part dedicated more specifically to modelling tools for drug design
Stage industriel alternance
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
18 crédits
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Cette UE correspond à la mission d’alternance réalisée dans un laboratoire de R&D des industries de la cosmétique et du bien-être.
Les missions confiées par l’entreprise à l’alternant seront en lien avec les objectifs du Master.
La durée de la mission en entreprise de l‘alternant suit le calendrier d’alternance proposé aux entreprises partenaires.
A theoretical part dedicated more specifically to modelling tools for drug design
Affaires règlementaires, évaluations et management qualité
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
2) Surface analysis and imaging (molecular mapping)
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Rappel de la législation européenne et sa hiérarchie : règlements, directives, décisions, résolutions, lois nationales, Institutions et autorités en charge du système réglementaire.
Descriptif des règlementations principales à travers le monde et vue globale des avancées
Institutions et autorités en charge du système réglementaire
Cadre réglementaire appliqué aux emballages cosmétiques
Démarche de mise en conformité des emballages cosmétiques et ses principales difficultés
Exigences nouvelles applicables aux emballages cosmétiques dans le cadre des lois européennes et françaises sur l’économie circulaire
Le cours abordera les Bonnes Pratiques de Fabrication (BPF) destinées à assurer la reproductibilité et la qualité de fabrication des produits cosmétiques.
Il permettra de connaitre les mesures à adopter vis-à-vis des processus de production, contrôle, stockage et expédition et pour assurer la conformité des produits cosmétiques en référence à la réglementation en vigueur (CE 1223/2009, norme ISO 22716, etc.)
A part dedicated to the practical aspect with work on computers
CM : 15
TD : 15
Terrain : 10
A theoretical part dedicated more specifically to modelling tools for drug design
Eco-conception cosmétique
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
2) Surface analysis and imaging (molecular mapping)
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Qu’est-ce que l’éco-conception?
L’ Analyse de Cycle de Vie de produits (ACV)
Qui certifie?
L’éco-conception & matières premières
Biodiversité et protocole de Nagoya.
Rappels sur les principes de la Chimie verte
Eco toxicologie et biodégradabilité
Fabrication d’un produit cosmétique en eco-conception
Les tendances liées à l’éco-conception
Les emballages en eco-conception, quel est leur impact ?
Notion d’ecotoxicologie : impact sur l’environnement/biodégradabilité
Information sur la mesure d’ecoconception : quels sont les outils à disposition/ mesure d’impact Recylabilité des packagings : mesure et analyses (matières premières/formules/écotoxicologie).
Une mise en situation sera proposée aux étudiants.
A part dedicated to the practical aspect with work on computers
CM : 20
Presentation of the Kröger-Vink Notation of defects
TP : 10
A theoretical part dedicated more specifically to modelling tools for drug design
Evaluations et statistique appliquée à l’analyse sensorielle
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Donner aux étudiants la compréhension théorique de la statistique inférentielle nécessaire à l'analyse statistique des données issues d'épreuves sensométriques. Problématique générale : extraire des mesures sensorielles des régularités interprétables pour prendre les bonnes décisions.
Les enseignements couvriront les besoins de chaque parcours, à travers des exemples et des applications adaptés.
For this personal project, the student will have access to all the bibliographic sources of the university or the company hosting him/her. The bibliographical work may be combined with the English teaching unit in order to prepare an oral presentation at an international conference.
CM : 10 H
TP : 10H
A theoretical part dedicated more specifically to modelling tools for drug design
Technologie cosmétique
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Les polymères interviennent dans de très nombreuses formulations cosmétiques avec des fonctions diverses dont les principales sont le contrôle de la rhéologie, la stabilisation de la formulation et comme agent de conditionnement. Il est donc important de connaître leur comportement dans ces milieux complexes, notamment en étudiant les interactions polymère-tensioactif puisque ces deux constituants sont souvent présents ensemble dans ces milieux, ainsi que les interactions avec les surfaces solides (suspensions, applications sur les cheveux ou sur la peau) ou liquides (émulsions).
Le cours décrit : (1) les différents types de polymères utilisés : hydrosolubles, synthétiques, naturels et semi-naturels, amphiphiles et les relations structures-propriétés, (2) principe d’épaississement des formules ou de gélification en utilisant les polymères, (3) les interactions avec les tensioactifs, présentation des différents types de tensioactifs et de leurs propriétés physico-chimiques en particulier les tensioactifs polymérique, (4) les interactions avec les surfaces (peau, cheveu) ainsi que tout type de surface solide, (5) principe de stabilisation des émulsions et des suspensions en utilisant les polymères.
Une deuxième partie de ce module est consacrée aux silicones et à leur utilisation en cosmétique :
La chimie des silicones, les silicones pour la cosmétique: les catégories, leurs utilisations et leurs effets sensoriels avec exemples d’application.
A theoretical part dedicated more specifically to modelling tools for drug design
Dermocosmétique
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Connaissances de base concernant la structure et la physiologie cutanée : structure de la peau ; les récepteurs sensoriels ; la sensibilité mécanique et thermique.
Pénétration cutanée ; hydratation cutanée et produits hydratants ; séborrhée, Acné ; typologies Dermocosmétique : pénétration cutanée ; vieillissement cutané, la peau du nourrisson ; la cellulite
A part dedicated to the practical aspect with work on computers
CM : 16
TD : 4
A theoretical part dedicated more specifically to modelling tools for drug design
Formulation couleur
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
L’objectif de l’UE est de comprendre et appliquer les principes de la formulation de la couleur telle que pratiquée dans l’industrie de la couleur. Pour cela les bases de la spectrocolorimétrie, les interactions lumière-matière et les modèles les plus simples de formulation (Beer-Lambert et Kubelka -Munk) sont étudiés et utilisés en travaux pratiques.
Volumes horaires :
CM : 12
TP : 8
A theoretical part dedicated more specifically to modelling tools for drug design
Anglais avancé
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Actifs et additifs naturels
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
2) Surface analysis and imaging (molecular mapping)
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Ce module est consacré d’une part à l'étude des principales classes d’additifs cosmétiques et d’autre part à l’étude des actifs naturels, biotechnologiques et de synthèse.
La première partie de cet enseignement permettra de se concentrer sur la flore marine à travers notamment la composition générale et les spécificités des différentes algues. Qu'elle est la place et l'efficacité de la flore marine en cosmétique ?
Le cours se conclura sur des études de cas et des perspectives.
Une deuxième partie parlera du monde végétal afin de permettre aux formulateurs et aux responsables des questions réglementaires de comprendre la mise en œuvre des molécules végétales pour leurs effets bénéfiques vis-à-vis des principales indications cosmétiques. Les huiles essentielles : quelles sont les techniques de production, leurs compositions chimiques, leurs propriétés cosmétiques, leur formulation, leur sécurité d’emploi ?
La troisième partie du module portera sur les différentes classes d’additifs utilisés en cosmétique.
L’accent sera mis sur l'étude chimique et organoleptique des principales matières premières (synthétiques ou naturelles) utilisées dans le parfumage des cosmétiques et les contraintes réglementaires liées à leur utilisation (directives cosmétiques relatives au dosage des allergènes).
Les familles de molécules odorantes utilisées dans les cosmétiques (molécules sans fonction organique ou contenant des fonctions alcool, aldéhyde, cétone, ester) seront étudiées:
- molécules avec un cycle aromatique
- molécules de type phénol
- molécules aliphatiques cycliques et acycliques.
- molécules terpéniques acycliques et cycliques
- champ des odeurs.
-Notions de stabilité et de volatilité des molécules.
L’enseignement se conclura par un apprentissage à la formulation de compositions parfumantes pour produits cosmétiques.
A part dedicated to the practical aspect with work on computers
CM : 20
Presentation of the Kröger-Vink Notation of defects
TP : 10
A theoretical part dedicated more specifically to modelling tools for drug design
Photoprotection
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
2) Surface analysis and imaging (molecular mapping)
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Ce module s’articule autour de tous les aspects relatifs à la photoprotection :
Il commencera par un rappel sur les rayonnements solaires et sur la peau en mettant l'accent sur la photoprotection naturelle mélanique et non mélanique. La réaction de la peau au soleil permettra d'aborder les bienfaits du soleil mais se concentrera surtout les effets secondaires néfastes pour la peau. Quelles sont les possibilités offertes par l'industrie cosmétique pour se protéger? Comment analyser l'efficacité des produits solaires? Quel est l’impact des filtres sur l’environnement ?
- Etude du développement des formules solaires : les matières premières, les filtres chimiques et physiques, les techniques de formulation, la règlementation, le rapport du soleil avec la peau.
- Utilisation des logiciels permettant le calcul des SPF théoriques
- Acquérir les connaissances en formulation de produits solaires
- Procédés de fabrication
- L’analyse fine des formules INCI
- Formulation de microémulsion par inversion de phase
A part dedicated to the practical aspect with work on computers
CM : 15
TP : 25
A theoretical part dedicated more specifically to modelling tools for drug design
Plan d’expérience
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Un plan d'expériences est la suite ordonnée d'essais d'une expérimentation dont le but est de tester la validité d'une hypothèse en reproduisant un phénomène et en faisant varier un ou plusieurs paramètres. Chaque essai produit une donnée et l’ensemble des données produites lors d’une expérience doit être analysé par des méthodes rigoureuses pour valider ou non l'hypothèse. Cette démarche expérimentale permet d'acquérir de nouvelles connaissances en confortant un modèle avec une bonne économie de moyens (nombre d'essais le plus faible possible, par exemple).
Partant d’un problème simple, le module développe les outils méthodologiques et statistiques permettant de conforter des hypothèses de plus en plus complexes de la façon la plus optimale possible. La mise en œuvre de ces méthodologies se fait via le langage statistique R.
A part dedicated to the practical aspect with work on computers
Master thesis
TP : 5h
A theoretical part dedicated more specifically to modelling tools for drug design
Stratégies de l'entreprise
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Cette unité d’enseignement comprend plusieurs axes :
- Les enseignements montreront que la chimie ouvre à divers métiers dans le domaine de la cosmétique, et pas uniquement à la formulation.
- Savoir apporter une réflexion sur la méthode scientifique afin d’éviter les erreurs de jugement et savoir apporter une réflexion scientifique devant toute information. L’enseignement s’appuiera sur des exemples concrets liés à la cosmétique (différence entre risque et danger, réflexion sur diverses applications/informations consommateur, etc.)
- Une mise en situation permet de travailler sur des projets concrets de marketing, de l’étude de marché jusqu’à la formalisation d’un concept marketing en cosmétique.
A part dedicated to the practical aspect with work on computers
CM : 12
TD : 8
A theoretical part dedicated more specifically to modelling tools for drug design
Prospective
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
In this part, we will be interested in electron microscopy through flipped classes. We will discuss the following topics: Electron sources, lens and aberrations, sample preparation, electron diffraction, Structural and chemical analysis, Imaging techniques.
CM: 34
Ce module permettra aux étudiants de comprendre l’importance de l’innovation dans un secteur aussi dynamique que celui de la cosmétique.
Cet environnement est en effet régi par des contraintes réglementaires, des innovations en packaging, des innovations en formulation mais aussi en ingrédients.
Le tout est également gouverné par les attentes des consommateurs de plus en plus exigeants.
Il est donc primordial pour ces futurs diplômés de comprendre les tenants et aboutissants de l’innovation en cosmétique et de savoir la mettre en œuvre en respectant cependant quelques critères.
Un projet sera propose aux étudiants: Présentation du projet en groupe et mise en place des consignes pour sa réalisation.
A part dedicated to the practical aspect with work on computers
CM : 20
A theoretical part dedicated more specifically to modelling tools for drug design
Ingénierie cosmétique et innovation
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
2) Surface analysis and imaging (molecular mapping)
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Etude approfondie des différentes galéniques cosmétiques : composition, description des composants principaux, formulation, principe, formes galéniques
Etude des familles d’ingrédients dont les émollients, esters, émulsionnants, filtres solaires, conservateurs et innovation en produits de soin et de maquillage
Etude des liste INCI des formulations, des nomenclatures INCI
Etude des différents types d’entreprises cosmétiques
Etude des procédés de fabrication (Le matériel d’agitation, les process complémentaires de fabrication, l’impact des paramètres physico chimiques sur la fabrication)
L’application se fera dans différents domaines.
Par exemple : formulation d’émulsions hydratantes avec électrolytes (éléments perturbateurs de stabilité), formulation de lait démaquillant et de lotion démaquillante et la mise en place de test pour mesurer l’efficacité démaquillante, formulation de produits de maquillage.
A part dedicated to the practical aspect with work on computers
CM : 15
TP : 25
A theoretical part dedicated more specifically to modelling tools for drug design
Projets industriels apprentis
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
2) Surface analysis and imaging (molecular mapping)
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Le présent module consiste en la mise en situation des étudiants dans un contexte professionnel, en relation avec une entreprise de mise au point et production de cosmétiques ou fournisseur de matières premières. Le module sera organisé sous forme de projets industriels.
Les étudiants sont répartis en groupes, telle que serait composée une équipe scientifique. Ils devront donc mettre en application leurs connaissances théoriques, en étroite collaboration avec l’industriel.
Les projets seront notamment appliqués aux produits de maquillage.
A theoretical part dedicated more specifically to modelling tools for drug design
Stage industriel 5-6 mois
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
20 crédits
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Ce stage d’une durée de 5 à 6 mois, ou la mission d’alternance, sera réalisé dans un laboratoire de R&D des industries de la cosmétique et du bien-être.
Les missions confiées par l’entreprise à l’étudiant stagiaire/alternant seront en lien avec les objectifs du Master.
Ce stage, ou cette mission d’alternance, sera réalisé en France ou à l’étranger.
A theoretical part dedicated more specifically to modelling tools for drug design
- General mechanism of glycosylation
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
TD: 5 H
Chemoinformatics
The themes of the EU are the following:
A theoretical part dedicated to chemoinformatics
A theoretical part dedicated more specifically to modelling tools for drug design
Quantum Mechanics and Modelling I
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Wavefunction of an excited electron trapped in a cubic box: model for a quantum dot state
- Introduction to basic concepts in quantum physics and its relation to chemistry, modern materials science and engineering of nanodevices.
- To achieve the goals of this course, a mathematically-rigorous approach is combined with the physical interpretation of the concepts, and the application of the most important QM models to electronic and magnetic spectroscopies and chemistry is illustrated.
A part dedicated to the practical aspect with work on computers
CM (Lectures) : 24H
TD (Tutorials) : 12H
A theoretical part dedicated more specifically to modelling tools for drug design
CM: 9 H
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Field: 11 a.m.
Multi-step synthesis
The aim of this course is to describe the synthesis tools applied to complex and polyfunctional molecules. Retrosynthetic and stereocontrolled approaches will be discussed as well as the rational use of protective groups.
Field: 11 H
Extraction and separation of biomolecules
This course will teach techniques for the extraction of biomolecules (protein precipitation, SPE), as well as techniques for the separation of biomolecules (chromatography, electrophoresis).
A theoretical part dedicated more specifically to modelling tools for drug design
CM: 9 h
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Field: 11 a.m.
- Supported syntheses
- In chemistry, solid phase synthesis is a method in which molecules are covalently bonded to a solid support and synthesised step by step using selective protecting groups. This applied course aims to provide a comprehensive understanding of this field and to examine supported strategies for the practical preparation of polypeptides and oligonucleotides.
- CM: 9 H
Biotechnology and applications
A part dedicated to the practical aspect with work on computers
The aim of this course is to highlight biological processes at the cellular level or even in living subjects. Different molecular imaging approaches will be discussed (fluorescent probes, radiolabelling).
CM: 9 H
A theoretical part dedicated more specifically to modelling tools for drug design
Knowledge of LC/MS and LC/MS/MS techniques for the characterisation of organic molecules and biomolecules in complex media.
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Description of the instruments and acquisition modes that will be used in the lab.
- 1) Analytical Chromatography coupled with Ambient Ionisation Mass Spectrometry techniques:
- LC/MS type instrumentation,
- LC/MS/MS type instrumentation.
A part dedicated to the practical aspect with work on computers
2) Coupled spectral data acquisition devices.
CM: 9 H
A theoretical part dedicated more specifically to modelling tools for drug design
Ion mobility
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Field: 11 H
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Functionalisation/Bioconjugation
A part dedicated to the practical aspect with work on computers
Bioconjugation reactions are of major interest in the biomedical sciences and allow chemists to modify biomolecules to confer new functions or properties. In this course, bioconjugation and biomolecule labelling strategies will be discussed to explore complex biological systems. The practical sessions will illustrate these concepts through examples of bioconjugation of osidic and nucleotidic platforms.
LC-MS, MS/MS
A theoretical part dedicated more specifically to modelling tools for drug design
Bioanalysis
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Description of the most recent mass spectrometry techniques for analyses in the pharmaceutical industry (drug development : Drug discovery and pre-clinical analysis).
Mass spectrometry instrumentation and acquisition methods in the pharmaceutical industry for the following applications:
Analyses in the various stages of drug development,
Qualitative analyses in metabolism,
Quantitative analyses in pharmacokinetics.
CM: 15 H
Land: 5 H
A part dedicated to the practical aspect with work on computers
Screening
Understanding of screening techniques for bioactive molecules, and more generally in vitro tests used to measure a biological event in the perspective of drug discovery or diagnosis.
A theoretical part dedicated more specifically to modelling tools for drug design
1) Pharmacological and biophysical fundamentals describing a biological event, target of biological tests:
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
2) Biological tests for the development of medicines or diagnostics
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
3) Applications, case studies, critical analyses.
Separation/Purification
A part dedicated to the practical aspect with work on computers
The objective of this course is to provide students with theoretical and practical training in the fundamental techniques of separation and purification of biomolecules
Hourly volumes*:
CM: 9 hours
Field: 11 hours
Thermodynamics and defects of solids
A theoretical part dedicated more specifically to modelling tools for drug design
Inorganic materials
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
CM :15
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
TD :5
Receptology
Receptors are of major interest in medicinal chemistry and constitute more than 40% of current therapeutic targets. This course is an interdisciplinary approach to provide the basic concepts and fundamentals of receptology necessary for students pursuing their training in biomolecular chemistry at the chemistry-biology interface.
Chemobiology (67% ENSCM)
The course will focus on organic chemistry and post-functionalization of biomolecules applied to peptides, proteins and nucleic acids (DNA and RNA) with applications in gene therapy, biosensing and design of probes for biological studies.
A theoretical part dedicated more specifically to modelling tools for drug design
This module is devoted to deliver basic knowledge on the thermodynamics of defects. The understanding and basic concepts of defects in stoichiometric and non-stoichiometric solids is an important aspect to better understand and design materials for ionic and electronic conductivity with a specific relevance for energy materials. The lecture introduces and discusses the nature of point defects which intrude upon the perfect geometry of ideal crystal structures:
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Introduction into point defects (missing or misplaced atoms, ions or electrons)
Discussion of thermodynamic concepts of order-disorder phenomena in solid solutions
Understanding of Brouwer diagrams for oxides in order to emphasise the role of surrounding atmosphere onto the defect equilibrium at high temperature.
Understanding of diffusion pathways and energies of ions and electrons, as a major consequence of point defects, giving rise to electrical transport is investigated for ionic conductors.
A part dedicated to the practical aspect with work on computers
Experimental investigations of measuring the ionic conductivity versus the temperature are described. The method of Impedance Spectroscopy Measurements is discussed.
Presentation of the Kröger-Vink Notation of defects
A theoretical part dedicated more specifically to modelling tools for drug design
Statistical Mechanics (UE Toulouse 3)
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
2) Surface analysis and imaging (molecular mapping)
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Les objectifs du cours sont d’expliquer le comportement macroscopique des systèmes par leur description microscopique et de présenter les caractéristiques universelles dans l’étude des systèmes thermodynamiques.
- Rappels de thermodynamique
- Une approche plus générale de la thermodynamique statistique
III. Généralités sur les systèmes de particules identiques sans interaction
- Applications de la statistique de Boltzmann
- Un exemple d’utilisation d’une autre statistique : le rayonnement du corps noir.
A part dedicated to the practical aspect with work on computers
CM : 30
Materials for catalysis M1
A theoretical part dedicated more specifically to modelling tools for drug design
Matériaux à propriétés électroniques remarquables
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
2) Surface analysis and imaging (molecular mapping)
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Cet enseignement fournit les bases théoriques d’analyse de l’origine microscopique de propriétés physico-chimiques insolites.
Sont abordées des propriétés cruciales par l’intensité des recherches qu’elles suscitent et leurs applications technologiques : transfert électronique, magnétisme, photomagnétisme, bistabilité, conduction, etc. Plusieurs types de composés seront étudiés : interrupteurs moléculaires, molécules aromatiques mono et multi-radicalaires et stratégie d’assemblage de structures organiques ordonnées à haut spin, composés à transition de spin, molécules aimants, complexes poly-métalliques couplés ferro-, antiferro- ou ferrimagnétiquement.
- Dérivation de modèles simples pour les systèmes fortement corrélés (Heisenberg).
- Composés hydrocarbonés : aromaticité et propriétés magnétiques de systèmes cycliques et polycycliques polyradicalaires.
- Complexes monométalliques : composés à transition de spin (théories du champ cristallin et du champ de ligand, concept de bistabilité). Composés anisotropes magnétiquement (couplage spin orbite), vers les aimants moléculaires (hystérèse)...
- Complexes bimétalliques : transfert électronique (interrupteur moléculaires) dans les composés à valence mixte et échange de spin dans les composés magnétiques (couplages ferro- et antiferromagnétique), photomagnétisme.
A part dedicated to the practical aspect with work on computers
CM : 24
TP : 8
A theoretical part dedicated more specifically to modelling tools for drug design
Mott-Hubbard insulators
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Crystallography II and Electron Microscopy
A part dedicated to the practical aspect with work on computers
The structural characterization of Materials is a mandatory prerequisite to develop functional materials and an absolute must for materials science researchers and engineers. For the interpretation of diffraction patterns, structures, microstructures etc., a detailed knowledge in crystallography, structure analysis but equally of the instruments used is necessary. The necessary knowledge is developed from the scratch, progressively yielding an understanding on how to characterize materials by standard and sophisticated diffraction methods. The lecture also includes lab work on powder and single crystal diffractometers, allowing to acquire the competencies to correctly use and interpret diffraction data. The lecture during the1st semester involves essentially X-ray diffraction as well as electron microscopy, while the crystallography part continues during the2nd semester with symmetry, structure solution and structure refinements as well as neutron scattering and magnetic structure analysis.
This lecture contains 2 parts:
A theoretical part dedicated more specifically to modelling tools for drug design
Stage 2-4 mois
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
- Interaction neutrons/synchrotron radiation with matter
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Un stage d’une durée de 2 à 4 mois doit être effectué dans un laboratoire de recherche ou de recherche et développement spécialisé en chimie théorique. Ainsi, les étudiants auront la possibilité d’effectuer ce stage au sein de laboratoires de recherche académiques ou privés. Sous réserve de l’acceptation préalable de l’équipe pédagogique (sujet de stage en lien avec les enseignements du master et environnement/moyens adéquats), l’étudiant pourra rechercher une équipe d’accueil en milieu académique dans les instituts du Pôle Chimie de l’Université de Montpellier, dans des laboratoires académiques hors de l’Université de Montpellier (en France ou à l’étranger) ou en secteur privé (industries chimiques, pharmaceutiques, …).
Ce stage d’une durée de 2 à 4 mois pourra débuter à partir de mi-mai après la session d’examen et ne pourra excéder 4 mois.
A theoretical part dedicated more specifically to modelling tools for drug design
Quantum Mechanics and Modelling II
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
In this course a complete description of the structural, electronic and vibrational properties of molecules is given together with the quantum treatment of these properties in computer simulations.
In parallel the structural and electronic properties of solids is addressed with an emphasis on the properties of metals and semiconductors.
A part dedicated to the practical aspect with work on computers
CM : 42H
TD : 21H
A theoretical part dedicated more specifically to modelling tools for drug design
Spectroscopie Théorique
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
(2): Electron microscopy:
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Ce cours vise à approfondir et compléter les connaissances acquises d’un point de vue théorique en
spectroscopie par les étudiants lors de leur licence.
A part dedicated to the practical aspect with work on computers
This course provides a comprehensive knowledge and tools that relate to surface properties and interfacial behaviour of crystalline and amorphous solids in different media. It contains two parts: (1) Fundamentals of Colloid and Surface Science, divided and porous solids
as well as communication skills.
A theoretical part dedicated more specifically to modelling tools for drug design
Chimie de coordination des éléments f
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Une approche générale de la chimie de coordination des éléments f sera développée au travers des notions d’atomistique, de degré d’oxydation et de polyèdre de coordination dans le but de mettre en lumière les caractéristiques spécifiques des éléments f. Des comparaisons directes seront faites avec la chimie de coordination des éléments de transition et des applications en lien avec la chimie du nucléaire seront abordées.
A part dedicated to the practical aspect with work on computers
Physics of Low-dimensional systems
Quantum containment
A theoretical part dedicated more specifically to modelling tools for drug design
Phase transitions
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Anomalous scattering and absolute structure determination
- TD:15
- Metallurgy and electronics properties
- This teaching unit is devoted to give an introduction to the electronic properties in the solid state of bulk and/or nano-materials, magnetic properties in transition metal oxides, etc.... This unit is given by different, alternating external teachers to UM and the topics may vary with respect to the respective area of expertise of the teaching stuff.
- Students should get familiarized not only with the electronic properties and ordering of materials, but also with respect to ionic and mixed electronic ionic conductors, materials for spintronics. Another aspect concerns here their specific characterizations using neutron/synchrotron diffraction as well as complementary macroscopic characterization methods for magnetism, permeability, etc
- CM: 30 h
TD: 15 h
Materials for catalysis M2
A theoretical part dedicated more specifically to modelling tools for drug design
Modélisation Moléculaire (UE Toulouse 3)
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Ce module d’enseignement a pour but de fournir et d’appréhender les bases théoriques associées à certaines méthodes de modélisation que l’on trouve dans différents domaines, des « petites molécules » au vivant et aux matériaux. Ce module se propose de répondre, pour partie, à trois questions : 1) Pourquoi modéliser ? 2) Quoi modéliser ? 3) Comment modéliser ?
A part dedicated to the practical aspect with work on computers
CM : 14
TP : 6
A theoretical part dedicated more specifically to modelling tools for drug design
Méthodologie de la Chimie Quantique
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
(2): Electron microscopy:
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Ce module est une préparation à la poursuite d’études doctorales dans le domaine de la chimie théorique et spécialement dans le domaine de la chimie quantique. Les développements méthodologiques récents et le développement de logiciels de plus en plus performants ont démocratisé l’usage des logiciels de chimie quantique.
Le module contient des enseignements dans les domaines de la structure électronique et de la dynamique moléculaire . Le formalisme des différentes méthodes et leur domaine d’application seront détaillés pour permettre une utilisation éclairée des logiciels de chimie théorique et notamment quantique.
(1) structure électronique
– Hartree-Fock
– corrélation électronique, interaction de configurations, coupled cluster
– Théorie de la Fonctionnelle de la Densité (DFT)
(2) dynamique nucléaire
– dynamique classique et ab initio (Car Parrinello, Born-Oppenheimer, « propagateurs », ensembles thermodynamiques, calcul d’énergie libre)
– dynamique quantique des processus photos-induits (paquet d’ondes, dynamique adiabatique et non-adiabatique, lien avec le spectre d’absorption, représentation diabatique, dynamique mixte classique-quantique)
A part dedicated to the practical aspect with work on computers
TD: 8h
TD : 20
A theoretical part dedicated more specifically to modelling tools for drug design
Modélisation des matériaux à propriétés spécifiques
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
2) Surface analysis and imaging (molecular mapping)
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Présenter les méthodes qui permettent d’explorer les propriétés physico-chimiques des matériaux par le calcul numérique. Donner les fondements mathématiques des outils numériques présentés dans le cadre de l’UE «Modélisation » au M1 et compléter les applications abordées dans le cadre de cette UE.
A part dedicated to the practical aspect with work on computers
CM : 28
TD : 12
A theoretical part dedicated more specifically to modelling tools for drug design
Simulations atomistiques
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
2) Surface analysis and imaging (molecular mapping)
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Présenter les méthodes qui permettent d’explorer les propriétés physico-chimiques des matériaux par le calcul numérique. Donner les fondements mathématiques des outils numériques associés.
I- Introduction
II- Approche quantique : méthodes moléculaires : Mécanique quantique, équation de Schrödinger, méthodes DFT.
III- Approche quantique : les systèmes périodiques
IV- Dynamique moléculaire : approche classique
A part dedicated to the practical aspect with work on computers
CM : 30
Materials for catalysis M1
A theoretical part dedicated more specifically to modelling tools for drug design
Méthodes numériques pour la chimie théorique
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
2) Surface analysis and imaging (molecular mapping)
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Au cours de cet enseignement, les étudiants verront les principales méthodes numériques utilisées dans les logiciels scientifiques et plus particulièrement dans les programmes de chimie théorique.
A part dedicated to the practical aspect with work on computers
CM : 21
as well as communication skills.
A theoretical part dedicated more specifically to modelling tools for drug design
Modélisation et Réactivité
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
6 crédits
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
L’objectif est d’acquérir des compétences fortes en chimie théorique par la découverte ou l’approfondissement de diverses thématiques.
Ce module est organisé en deux phases : (i) des cours-séminaires en ligne, délivrés tout au long du premier semestre ; (ii) une semaine de formation intensive au début du mois de janvier, sur l’un des sites du pôle Sud- Ouest du Réseau Français de Chimie Théorique (Bordeaux, Montpellier, Pau, Toulouse).
Les thèmes abordés sont :
– chimie quantique et relativité
– méthodes Monte-Carlo
– exploration des surfaces d’énergie potentielle
– calcul de la structure électronique de systèmes périodiques
– dynamique quantique
– calcul de propriétés spectroscopiques
A part dedicated to the practical aspect with work on computers
CM : 40
TD : 20
A theoretical part dedicated more specifically to modelling tools for drug design
Réactivité organométallique théorique
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
(2): Electron microscopy:
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Des exemples de réactions de la catalyse homogène seront présentés en insistant sur les concepts sous-jacents et les limitations des approches théoriques (DFT principalement). La métathèse des oléines et des exemples de polymérisation illustreront la catalyse supportée, en insistant sur l’influence du support.
Divers exemples illustreront la spécificité des nanocatalyseurs, en distinguant le rôle respectif des facteurs électroniques et géométriques.
A part dedicated to the practical aspect with work on computers
CM : 20
Materials for catalysis M1
A theoretical part dedicated more specifically to modelling tools for drug design
Anglais avancé
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
TP: 12 hours
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
Practical work: 40h
2) Surface analysis and imaging (molecular mapping)
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Stage 5-6 mois
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
30 crédits
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Un stage d’une durée de 5 à 6 mois doit être effectué dans un laboratoire de recherche ou de recherche et développement spécialisé en chimie théorique. Ainsi, les étudiants auront la possibilité d’effectuer ce stage de fin d’étude au sein de laboratoires de recherche académiques ou privés. Sous réserve de l’acceptation préalable de l’équipe pédagogique (sujet de stage en lien avec les enseignements du master et environnement/moyens adéquats), l’étudiant pourra rechercher une équipe d’accueil en milieu académique dans les instituts du Pôle Chimie de l’Université de Montpellier, dans des laboratoires académiques hors de l’Université de Montpellier (en France ou à l’étranger) ou en secteur privé (industries chimiques, pharmaceutiques, …).
Ce stage d’une durée de 5 à 6 mois pourra débuter à partir de mi-janvier après la session d’examen et ne pourra excéder 6 mois pour une période au semestre 10 comprise durant la validité de l’inscription universitaire.
A theoretical part dedicated more specifically to modelling tools for drug design
Chimie hétérocyclique
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Ce cours aborde de façon concise et systématique tous les aspects de la chimie des hétérocycles, de la nomenclature aux applications comme les principes d'action des médicaments, des toxines ou des drogues, les pigments, les colorants alimentaires etc…
For this personal project, the student will have access to all the bibliographic sources of the university or the company hosting him/her. The bibliographical work may be combined with the English teaching unit in order to prepare an oral presentation at an international conference.
Green chemistry
The principles of Green Chemistry provide a basis for the evaluation and design of new chemical products and processes that minimise negative impacts on human health and the environment. In this teaching unit, offered to M2 students of the Master of Biomolecular Chemistry (BM), Orientation 2 (O2), the basic principles and concepts of Green Chemistry will be discussed, and their applications in the field of non-conventional activation methods and the use of alternative media in organic synthesis.
A theoretical part dedicated more specifically to modelling tools for drug design
- General mechanism of glycosylation
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
TD: 5 H
Chemoinformatics
The themes of the EU are the following:
A theoretical part dedicated to chemoinformatics
A theoretical part dedicated more specifically to modelling tools for drug design
Biomolécules fluorées et phosphorées: synthèse et appli
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Biomolécules fluorées. Développements actuels des molécules fluorées. Méthodes de fluoration : mono-fluoration nucléophile, électrophile, introduction de groupement difluorométhyle ou trifluorométhyle. Apport du ou des atomes de fluor dans l’activité de ces composés. Exemples de synthèses de composés fluorés utilisés comme agents antitumoraux, antiviraux; antidépresseurs, anxiolytiques, anti-inflammatoires…
Biomolécules phosphorées. Structure, nomenclature, réactivité, analyse structurale et applications.
Seront abordés quelques voies de synthèse de composés de chacune des familles traitées en mettant en avant, le cas échéant, des méthodes d'activation non conventionnelles. Les applications biomédicales seront ciblées, ainsi que d'autres applications en agrochimie, optoélectronique, nanomatériaux, ...
A part dedicated to the practical aspect with work on computers
CM : 15 h (7,5h Biomolécules fluorées et 7,5h Biomolécules phosphorées)
Microstructure
A theoretical part dedicated more specifically to modelling tools for drug design
Chimie des produits naturels
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Les produits naturels occupent une place majeure dans le domaine de la chimie des biomolécules. Ils représentent une source importante de composés bioactifs pour la chimie médicinale. Cette unité d’enseignement permet de dispenser un panorama complet du métabolisme secondaire et de l'origine des produits naturels provenant des plantes. L'accent sera mis dans cette UE sur la chimie organique à l'origine des différentes biotransformations qui se produisent au cours de la biosynthèse de chaque classe importante de molécule. Une approche mécanistique sera utilisée pour comprendre les bases chimiques de chaque transformation.
For this personal project, the student will have access to all the bibliographic sources of the university or the company hosting him/her. The bibliographical work may be combined with the English teaching unit in order to prepare an oral presentation at an international conference.
CM : 13
TD : 7
A theoretical part dedicated more specifically to modelling tools for drug design
CM: 9 H
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Field: 11 a.m.
Multi-step synthesis
The aim of this course is to describe the synthesis tools applied to complex and polyfunctional molecules. Retrosynthetic and stereocontrolled approaches will be discussed as well as the rational use of protective groups.
Field: 11 H
Extraction and separation of biomolecules
This course will teach techniques for the extraction of biomolecules (protein precipitation, SPE), as well as techniques for the separation of biomolecules (chromatography, electrophoresis).
A theoretical part dedicated more specifically to modelling tools for drug design
CM: 9 h
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Field: 11 a.m.
- Supported syntheses
- In chemistry, solid phase synthesis is a method in which molecules are covalently bonded to a solid support and synthesised step by step using selective protecting groups. This applied course aims to provide a comprehensive understanding of this field and to examine supported strategies for the practical preparation of polypeptides and oligonucleotides.
- CM: 9 H
Biotechnology and applications
A part dedicated to the practical aspect with work on computers
The aim of this course is to highlight biological processes at the cellular level or even in living subjects. Different molecular imaging approaches will be discussed (fluorescent probes, radiolabelling).
CM: 9 H
A theoretical part dedicated more specifically to modelling tools for drug design
Ion mobility
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
Practical work: 40h
2) Surface analysis and imaging (molecular mapping)
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Applications in chemistry (pharmaceutical industry) and biology (Omics approaches).
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
1) Structural elucidation (Ion characterisation technologies) :
A part dedicated to the practical aspect with work on computers
LC/MS/MS and exact mass measurements
Isotope labelling, H/D exchange
A theoretical part dedicated more specifically to modelling tools for drug design
Techniques séparatives
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Cet enseignement a pour vocation d’enseigner la chromatographie en phase liquide et la chromatographie en phase gazeuse.
A part dedicated to the practical aspect with work on computers
CM :15h
The4th semester of the Master Course is entirely dedicated to the 5 months (minimum) master thesis project in Materials Science. Students get enrolled in a research topic, and to contribute to a scientific problem in a research team. It allows to apply acquired and to learn new scientific skills in order to identify the problem and to proceed for a (possible) solution. The topic is analysed and described in the written Master thesis memory and presented orally in from of a jury. It should allow the candidate to show his ability to conduct a scientific problem and to present it in an analytical way.
A theoretical part dedicated more specifically to modelling tools for drug design
Analyse des molécules volatiles
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Connaissance des techniques de chromatographie en phase gazeuse et de spectrométrie de masse avec ionisation par impact électronique et analyseur de masse quadripôlaire pour l’analyse de molécules organiques volatiles.
1) Analyses GC-MS de composés organiques volatils :
- Techniques d’ionisation par impact électronique (EI)
- Techniques d’ionisation chimique (CI)
- Techniques d’analyse quadripolaire (Q)
- Couplages GC/MS
2) Applications dans le cadre d’analyses en chimie organique, de caractérisation d’échantillons volatils.
For this personal project, the student will have access to all the bibliographic sources of the university or the company hosting him/her. The bibliographical work may be combined with the English teaching unit in order to prepare an oral presentation at an international conference.
Green chemistry
The principles of Green Chemistry provide a basis for the evaluation and design of new chemical products and processes that minimise negative impacts on human health and the environment. In this teaching unit, offered to M2 students of the Master of Biomolecular Chemistry (BM), Orientation 2 (O2), the basic principles and concepts of Green Chemistry will be discussed, and their applications in the field of non-conventional activation methods and the use of alternative media in organic synthesis.
A theoretical part dedicated more specifically to modelling tools for drug design
5 credits
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
25 credits
An internship of 5 to 6 months duration must be carried out in a research or R&D laboratory specialised in organic chemistry, biomolecular chemistry, life chemistry, analytical instrumentation or analytical analysis/development. Thus, students will have the opportunity to carry out this end-of-study internship in academic or private research laboratories. Subject to prior acceptance by the teaching staff (internship subject in line with the Master's courses and adequate environment/means), the student will be able to look for a host team in an academic environment in the institutes of the Chemistry Pole of the University of Montpellier (IBMM, ICGM, IEM), in academic laboratories outside the University of Montpellier (in France or abroad) or in the private sector (chemical, pharmaceutical, agri-food, cosmetic industries, biotechnology laboratories, etc.) as well as in research structures such as proteomic/metabolomic/flowomic platforms.
The research project entrusted to the students must be related to the skills and expertise acquired during the previous semesters and the teaching units followed, in particular in semester 9 according to the chosen orientation.
This internship of 5 to 6 months duration can start from mid-January after the examination session and cannot exceed 6 months for a period in semester 10 included during the validity of the university registration. The teaching staff of the Master in Biomolecular Chemistry will advise students to find an internship corresponding to their aspirations and abilities.
Bibliographic project/Scientific information
Scientific information: The aim of this course is to familiarise students with the search for and management of scientific information. In this context, recent bibliographic research tools will be explained and used during the course (electronic documentation: Scifinder / Isis / Belstein). Training in the functionalities of the Zotero tool and in the use of the electronic laboratory notebook will also be provided. The writing and use of scientific publications will be covered.
Bibliographic project: The tools for researching scientific information will be applied to a concrete case. The student will be proposed a bibliographic subject by the teaching team in relation to the orientation he/she has chosen. This bibliographic subject may, if necessary, be defined in agreement with the host organisation where the internship will be carried out.
For this personal project, the student will have access to all the bibliographic sources of the university or the company hosting him/her. The bibliographical work may be combined with the English teaching unit in order to prepare an oral presentation at an international conference.
Green chemistry
The principles of Green Chemistry provide a basis for the evaluation and design of new chemical products and processes that minimise negative impacts on human health and the environment. In this teaching unit, offered to M2 students of the Master of Biomolecular Chemistry (BM), Orientation 2 (O2), the basic principles and concepts of Green Chemistry will be discussed, and their applications in the field of non-conventional activation methods and the use of alternative media in organic synthesis.
A theoretical part dedicated more specifically to modelling tools for drug design
1) Pharmacological and biophysical fundamentals describing a biological event, target of biological tests:
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
2) Biological tests for the development of medicines or diagnostics
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
3) Applications, case studies, critical analyses.
Separation/Purification
A part dedicated to the practical aspect with work on computers
The objective of this course is to provide students with theoretical and practical training in the fundamental techniques of separation and purification of biomolecules
Hourly volumes*:
CM: 9 hours
Field: 11 hours
Thermodynamics and defects of solids
A theoretical part dedicated more specifically to modelling tools for drug design
Polymères pour la santé
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Connaissance des grandes familles de polymères utilisés dans le domaine biomédical.
1) Spécificité des polymères pour applications biomédicales et grandes familles de polymères utilisés
2) Description des familles d’applications
3) Discussion sur la notion de synthèse et relation structure/propriétés/cahier des charges
For this personal project, the student will have access to all the bibliographic sources of the university or the company hosting him/her. The bibliographical work may be combined with the English teaching unit in order to prepare an oral presentation at an international conference.
CM : 15 H
TD : 5 H
A theoretical part dedicated more specifically to modelling tools for drug design
This module is devoted to deliver basic knowledge on the thermodynamics of defects. The understanding and basic concepts of defects in stoichiometric and non-stoichiometric solids is an important aspect to better understand and design materials for ionic and electronic conductivity with a specific relevance for energy materials. The lecture introduces and discusses the nature of point defects which intrude upon the perfect geometry of ideal crystal structures:
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Introduction into point defects (missing or misplaced atoms, ions or electrons)
Discussion of thermodynamic concepts of order-disorder phenomena in solid solutions
Understanding of Brouwer diagrams for oxides in order to emphasise the role of surrounding atmosphere onto the defect equilibrium at high temperature.
Understanding of diffusion pathways and energies of ions and electrons, as a major consequence of point defects, giving rise to electrical transport is investigated for ionic conductors.
A part dedicated to the practical aspect with work on computers
Experimental investigations of measuring the ionic conductivity versus the temperature are described. The method of Impedance Spectroscopy Measurements is discussed.
Presentation of the Kröger-Vink Notation of defects
A theoretical part dedicated more specifically to modelling tools for drug design
Synthèse asymétrique
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Après des généralités sur les notions de prochiralité et de stéréochimie, cet enseignement présentera les outils permettant la maîtrise de synthèses diastéréosélectives et énantiosélectives. Les différentes approches seront présentées de manière détaillée et rationnelle. Des exemples de synthèses industrielles de molécules bioactives chirales seront discutés.
For this personal project, the student will have access to all the bibliographic sources of the university or the company hosting him/her. The bibliographical work may be combined with the English teaching unit in order to prepare an oral presentation at an international conference.
CM : 15 H
TD : 5 H
A theoretical part dedicated more specifically to modelling tools for drug design
Nucléosides et dérivés
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Les nucléosides sont les constituants de base des acides nucléiques (ADN et ARN). A ce titre, ils jouent un rôle essentiel dans de nombreux processus biologiques. Dans ce cours, sera présentée la structure et le rôle biologique des nucléosides naturels. Seront abordée également les principales voies de synthèse et de caractérisation de ces composés et de leurs analogues (réactions de glycosylation, modifications structurales du cycle furanose, substitution et introduction d’hétéroatomes, inversion de configuration, etc..). L’utilisation d’analogues de nucléosides pour les traitements de pathologie d’origine virale, de cancers sera également abordée.
A part dedicated to the practical aspect with work on computers
Epitaxial films
TD : 5 h
A theoretical part dedicated more specifically to modelling tools for drug design
Stratégie et outils en synthèse organique
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
L’enseignement du module de stratégies et outils en synthèse organique est axé sur l’approfondissement des stratégies d’élaborations de molécules issues ou non du milieu naturel à l’aide des outils de la chimie organique.
A part dedicated to the practical aspect with work on computers
Green chemistry
The principles of Green Chemistry provide a basis for the evaluation and design of new chemical products and processes that minimise negative impacts on human health and the environment. In this teaching unit, offered to M2 students of the Master of Biomolecular Chemistry (BM), Orientation 2 (O2), the basic principles and concepts of Green Chemistry will be discussed, and their applications in the field of non-conventional activation methods and the use of alternative media in organic synthesis.
A theoretical part dedicated more specifically to modelling tools for drug design
Thermodynamic and kinetic bases to understand the optimal conditions for catalytic reactions and the requirement of activity and accessibility of catalysts.
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Methods for the preparation of porous and dispersed catalysts by nucleation-growth, aggregation and templating mechanisms.
Correlations between structural properties and activity of heterogeneous catalysts.
Examples of applications of heterogeneous catalysts to processes of refining and industrial chemistry.
Further on basic concepts of photocatalysis and electrocatalysis are explored
CM: 17:00
TD: 8 h
Surface properties M1
For this personal project, the student will have access to all the bibliographic sources of the university or the company hosting him/her. The bibliographical work may be combined with the English teaching unit in order to prepare an oral presentation at an international conference.
This course provides a comprehensive knowledge and tools that relate to surface properties and interfacial behaviour of crystalline and amorphous solids in different media. It contains two parts: (1) Fundamentals of Colloid and Surface Science, divided and porous solids
(2) Surface characterisation techniques and surface analysis
A theoretical part dedicated more specifically to modelling tools for drug design
Symmetry and space groups
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Introduction into structure refinement (single crystal and powder methods)
- Neutron and synchrotron facilities
- Magnetic structures with neutron diffraction
- Structure determination from single crystals (experiment and theory)
- Structure determination from powder diffraction data (experiment and theory)
The applications of Fourier series for structure solution and refinements: from the Patterson Method to difference Fourier analysis
Crystal twinning,
A theoretical part dedicated more specifically to modelling tools for drug design
Inorganic materials
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
Practical work: 40h
2) Surface analysis and imaging (molecular mapping)
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Dislocations and grain boundaries
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Coatings and applications
Diffusion barriers
Photo optical devices
Vacuum technology
High pressure synthesis
Synthesis of compounds with unusual valence and coordination states
CM: 17
TD: 8
A theoretical part dedicated more specifically to modelling tools for drug design
Project internship
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Preparation of the 3 months research internship, exploring the state of art of the project, preparing optimum experimental conditions, and to present it in front of a jury.
Internship research
- This module is devoted to an internship of 3 months minimum in a research laboratory or industry.
- Crystallography, crystal chemistry, Large scale facilities
This lecture is the continuation of the crystallography lecture of the1st semester and will give an advanced insight into structural characterization and structure refinements. It involves classical X-ray laboratory data collection and analysis, completed by synchrotron and neutron diffraction data analysis (powder and single crystal). The goal is to get familiar with the general principles of structure analysis, tanking advantage of the complementarity of X-ray and neutron diffraction. The lecture provides a detailed knowledge on how to understand and analyze phase transitions and how to deal with respective changes in the metric and associated data and structural transformations.
This lecture contains the following topics:
A theoretical part dedicated more specifically to modelling tools for drug design
Summer School: Large Scale Facilities
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
7 credits
72h
This module will help to develop 'transversal' skills such as the development and organization of a scientific project (organization between universities and different EU research centres)
The objective is to provide second year students master a good introduction in the use of "Large Scale Facilities" for the study and characterization of materials. In particular, we focus on the use of neutron scattering and 3rd generation synchrotron sources for the study of materials. Indeed, to date, the development and optimization of materials often require sophisticated methods, sometimes accessible only at Large Scale Facilities. This presents a major challenge for basic research and applied. The courses, which take place over two consecutive weeks, give basic instruction on the production of neutrons and synchrotron radiation as well as their specific applications and complementarity. The course content is as follows:
A theoretical part dedicated more specifically to modelling tools for drug design
Aminoacides et dérivés
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Ce cours aborde des méthodes de synthèse appliquées à l’obtention d’aminoacides énantiopurs ainsi que l’emploi d’aminoacides chiraux pour la synthèse d’autres composés énantiopurs.
Ces aminoacides sont les éléments de base des peptides. Les différentes propriétés physico-chimiques induites par la nature de ces aminoacides permettront de définir des stratégies de synthèse de peptides d’intérêt et leur caractérisation.
For this personal project, the student will have access to all the bibliographic sources of the university or the company hosting him/her. The bibliographical work may be combined with the English teaching unit in order to prepare an oral presentation at an international conference.
CM : 15 H
TD : 5 H
A theoretical part dedicated more specifically to modelling tools for drug design
Phase transitions
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Anomalous scattering and absolute structure determination
- TD:15
- Metallurgy and electronics properties
- This teaching unit is devoted to give an introduction to the electronic properties in the solid state of bulk and/or nano-materials, magnetic properties in transition metal oxides, etc.... This unit is given by different, alternating external teachers to UM and the topics may vary with respect to the respective area of expertise of the teaching stuff.
- Students should get familiarized not only with the electronic properties and ordering of materials, but also with respect to ionic and mixed electronic ionic conductors, materials for spintronics. Another aspect concerns here their specific characterizations using neutron/synchrotron diffraction as well as complementary macroscopic characterization methods for magnetism, permeability, etc
- CM: 30 h
TD: 15 h
Materials for catalysis M2
A theoretical part dedicated more specifically to modelling tools for drug design
Quantum Wells, 1D Quantum-wire, 0D Quantum dots
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Electron confinement and Density of States (DoS) formalism
A part dedicated to the practical aspect with work on computers
Epitaxial films
Microstructure
A theoretical part dedicated more specifically to modelling tools for drug design
- Neutron and synchrotron sources
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Practical work: 40h
- Interaction neutrons/synchrotron radiation with matter
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
- Diffraction methods and instrumentation for neutron and X-ray (synchrotron) scattering
- Spectroscopy: inelastic neutron scattering and X-ray absorption spectroscopy
A theoretical part dedicated more specifically to modelling tools for drug design
Composés lipidiques
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Methods for the preparation of porous and dispersed catalysts by nucleation-growth, aggregation and templating mechanisms.
- Triglycérides
- Phospholipides et sphingolipides
- Glycolipides
- Vitamines liposolubles
- Hormones stéroïdes
- Sels biliaires
- Structure et synthèse des prostaglandines et des leucotriènes
For this personal project, the student will have access to all the bibliographic sources of the university or the company hosting him/her. The bibliographical work may be combined with the English teaching unit in order to prepare an oral presentation at an international conference.
This course provides a comprehensive knowledge and tools that relate to surface properties and interfacial behaviour of crystalline and amorphous solids in different media. It contains two parts: (1) Fundamentals of Colloid and Surface Science, divided and porous solids
(2) Surface characterisation techniques and surface analysis
A theoretical part dedicated more specifically to modelling tools for drug design
Prodrogues/bioprécurseurs
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Connaissance des limitations associées à l’administration d’un principe actif (solubilité, biodisponibilité, …).
Descriptif général des systèmes enzymatiques impliqués dans la biotransformation des nutriments et composés exogènes.
Descriptif des principaux modes de passage membranaire et systèmes de transports des biomolécules fondamentales (sucres, amino-acides, nucléosides…).
Exemples de conception de prodrogue(s) et de bioprécurseur(s).
For this personal project, the student will have access to all the bibliographic sources of the university or the company hosting him/her. The bibliographical work may be combined with the English teaching unit in order to prepare an oral presentation at an international conference.
CM : 15 H
TD : 5 H
A theoretical part dedicated more specifically to modelling tools for drug design
RMN
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Approfondissement des connaissances en RMN 1H, 13C, 19F, 29Si, 31P, ainsi que des méthodes bidimentionnelles. Des notions de RPE seront également abordées (principe et applications).
For this personal project, the student will have access to all the bibliographic sources of the university or the company hosting him/her. The bibliographical work may be combined with the English teaching unit in order to prepare an oral presentation at an international conference.
CM : 15 H
TD : 5 H
A theoretical part dedicated more specifically to modelling tools for drug design
Glycochimie
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Methods for the preparation of porous and dispersed catalysts by nucleation-growth, aggregation and templating mechanisms.
- Mécanisme général de la glycosylation
- Synthèse des donneurs de glycosyle
- Méthodes d’activation des donneurs de glycosyle
- Synthèse stéréosélective de quelques oligosaccharides naturels
For this personal project, the student will have access to all the bibliographic sources of the university or the company hosting him/her. The bibliographical work may be combined with the English teaching unit in order to prepare an oral presentation at an international conference.
This course provides a comprehensive knowledge and tools that relate to surface properties and interfacial behaviour of crystalline and amorphous solids in different media. It contains two parts: (1) Fundamentals of Colloid and Surface Science, divided and porous solids
(2) Surface characterisation techniques and surface analysis
A theoretical part dedicated more specifically to modelling tools for drug design
Structure-based drug design
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
Faculté de pharmacie
Acides nucléiques
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
For this personal project, the student will have access to all the bibliographic sources of the university or the company hosting him/her. The bibliographical work may be combined with the English teaching unit in order to prepare an oral presentation at an international conference.
CM : 15 H
TD : 5 H
A theoretical part dedicated more specifically to modelling tools for drug design
Chemoinformatique
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical work: 40h
Nucleic acids
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
CM: 15 H
Les thématiques de l’UE sont les suivantes :
Une partie théorique dédiée à la chemoinformatique
Une partie théorique dédiée plus spécifiquement aux outils de modélisation pour le drug-design
For this personal project, the student will have access to all the bibliographic sources of the university or the company hosting him/her. The bibliographical work may be combined with the English teaching unit in order to prepare an oral presentation at an international conference.
CM : 15 H
TD : 5 H
Une partie dédiée à l’aspect pratique avec un travail sur ordinateurs
A theoretical part dedicated more specifically to modelling tools for drug design
Délivrance ciblée
- - Synthesis of glycosyl donors
- Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry
- Methods of activation of glycosyl donors
CM: 5h
Practical wor