MASTER CHEMISTRY

- Reminder of thermodynamics of single component systems.

- Basic notions of thermodynamics of multicomponent systems. Chemical potential, Gibbs-Duhem relation, variance.

- Knowledge of thermal analysis techniques that allow the construction of binary/ternary diagrams: TGA, DTA and DSC

- Construction and interpretation of binary phase diagrams from thermodynamic quantities. Diagrams of Gibbs free enthalpy, pressure and temperature as a function of the composition of the binary mixture. Liquid-liquid, liquid-vapor, solid-liquid mixtures.

- Phase transformation: first and second order transitions, critical points. Examples.

- The supercritical state: definition, thermodynamic properties, most extensive industrial applications.

- Construction and interpretation of ternary phase diagrams: variance, definitions of ternary eutectic, first and second order peritectic, isothermal section, study of cooling of alloys.

Hourly volumes* :

CM :13

TD :7

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This course of solution chemistry aims at introducing the different concepts necessary to the study of complex liquid mixtures used in separative chemistry. The proposed approach is mainly thermodynamic. We explain in particular the role of concentration effects, beyond the ideal laws valid only for dilute solutions.

CM : 12 H

TD : 8 H

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This lecture, entirely provided in English, gives a basic introduction into crystallography and electron diffraction for beginners. X-ray diffraction is an important characterization technique in modern chemistry the majority of crystalline structures in inorganic and organic solids have been solved by this method. It is therefore of importance for all students to have an understanding of its basic concepts and instrumentation. The course provides explanations and principles of X-ray diffraction together with the geometry and symmetry of X-ray patterns. Beside interaction principles of X-rays and matter, it treats how to obtain quantitative intensities for single crystal and powder diffraction patterns. It naturally includes the understanding of lattice planes and the reciprocal lattice concept together with the Ewald sphere construction. Further on it gives a basic understanding of the Fourier transform relation between the crystalline structure and the diffracted intensities as well as the reciprocal lattice concept.

Electron diffraction is a complementary technique to X-rays that provides information in terms of symmetry and geometry on the materials studied. In this course, we will therefore approach the description of the method for obtaining electron diffraction pattern and their interpretation. We will be able to obtain the lattice parameters, the reflection conditions as well as the groups of possible spaces.

This lecture serves also as the introductory part to the lecture Electron Microscopy and Crystallography II

CM :14

TD :6

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Knowledge of the latest mass spectrometry techniques for the qualitative analysis of organic molecules and biomolecules.

1) Description of Fundamentals (Ion Science and Technology):

- Ionization techniques

- Analysis techniques

- Tandem mass spectrometry (MS/MS)

- LC/MS and LC/MS/MS couplings

2) Application in the context of biomolecule analysis and organic chemistry reaction monitoring.

Hourly volumes* :

CM : 15 H

TD : 5 H

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Polymers are all around us: we eat them, we wear them, we build extremely complex buildings from them. From mature technologies to the most innovative materials, polymers are a crucial building block to build the world of tomorrow. In this course, we will address several aspects such as the controlled synthesis of polymers and cross-linked materials, surface modification by polymers, some characterization tools adapted to polymers and finally a last part developing the latest advances involving polymers.

Hourly volumes* :

            CM : 13h

            TD : 7h

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The HAC720C module deals, in 5 main parts, with "advanced inorganic materials". The^1st part is dedicated to the generalities of inorganic materials and approaches the structure-properties relations; a particular attention is brought to the chemical bond, the real crystal, and the polycrystalline solid; the various classes of inorganic materials are described. The ^2nd part deals with ceramic materials (definitions and properties) and their synthesis (raw materials including clays, shaping, drying and debinding, sintering); a distinction is made between traditional ceramics and technical ceramics (synthesis routes for oxide and non-oxide ceramics). The^3rd part concerns glasses (classification and synthesis routes) and glass-ceramics (devitrification and soft chemistry); their properties and applications are also discussed. The^4th part is dedicated to metals: properties of metals and metallic alloys; metallic nanoparticles; and, catalytic materials. The ^5th part is dedicated to inorganic materials developed for energy; ceramics (oxides and non-oxides; nanostructured) and metal hydrides are described (properties and syntheses) through several examples and in the context of their applications (accumulators, hydrogen storage and carbon dioxide capture)

Hourly volumes* :

CM : 13h

TD : 7h

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This course allows the acquisition of basic knowledge and transversal skills in the field of colloids and interfaces, common to the different courses of the Master Chemistry (Chemistry of Materials, Separative Chemistry, Materials and Processes, ICAP Cosmetics Engineering, Chemistry of Biomolecules). It is also offered to international students entering the SFRI program at the University of Montpellier where the teaching is given in English. An introductory presentation on the basic notions and concepts will allow to discover and better understand the main physicochemical properties of colloidal dispersions, associative colloids, and macromolecular solutions, as well as the parameters and phenomena governing the stability in colloidal dispersions and mixed solution-colloid systems. Then, an interdisciplinary practical teaching based on the principle of the flipped classroom will be proposed to help students build and deepen their knowledge through an individual and collective analysis of the various applications of colloidal and interfacial phenomena and systems.

Hourly volumes* :

CM : 7

TD : 13

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NMR:

NMR (Nuclear Magnetic Resonance) in liquid phase is an essential spectroscopic method of analysis for the chemist, allowing in particular to determine the structure of small organic molecules or macromolecules in solution, the study of dynamic phenomena... The objective of this course is to understand the phenomena involved in this technique and to relate them to the various structural information accessible by this method. The aim is to be able to exploit the spectral data resulting from this analysis to elucidate the structure and stereochemistry of organic molecules or polymer structures, or to carry out reaction monitoring.

X-ray diffraction:

X-ray diffraction is a powerful and non-destructive technique for characterizing the crystal structure of materials, but it is also able to provide crystallographic and structural information such as lattice parameters and atomic positions. This includes all crystallized materials such as ceramics, materials for energy and information storage and transformation as well as organic molecules and metal complexes (interatomic distances and angles, stereochemistry (chirality, stereoisomerism...), intra and intermolecular bonds...). The objective of this course is an introduction to crystallography and diffraction, with the aim of understanding the operation and characteristics of an X-ray diffractometer, as well as the interpretation of diffraction patterns (structural analysis, lattice parameters).

Hourly volumes* :

            CM : 10

            TD : 10

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This course will cover the fundamental concepts and practical tools related to chemometrics through : - statistical analysis of data ;

• laws of probability ;
• confidence interval estimation ;
• parametric and non-parametric tests.

An introduction to experimental design will be offered at the end of the module.

Hourly volumes* :

CM : 7h

TD : 13h

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The first part of the course presents the fundamental knowledge of organometallic chemistry of transition metals. It starts with the description of the Metal-C bond allowing the understanding of its stability and chemical reactivity. In a second step, the power of this synthesis tool for the formation of C-H, C-C bonds, ... Examples of their applications in different fields will allow the acquisition of these reactions and their fields of applications: fine chemistry, catalytic transformations of industrial importance, synthesis of natural products, preparation of materials.

The second part of this course is dedicated to the chemistry of hetero-elements focused on the elements Silicon, Tin and Boron. This part aims at presenting the different methods of preparation of boron, tin and silicon reagents as well as the main transformations performed with these compounds, with applications in organic synthesis and materials synthesis.

CM : 13 H 

TD : 7 H

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The program of this course focuses on the description of the principles and applications of the main methods for the structural characterization of solids, thin films, surfaces and interfaces, as well as several examples of applications in materials chemistry. It includes the following techniques.

• Introduction to solid state NMR (NMR signal, Interactions in solid state NMR, Magic angle rotation, NMR sequences, Cross polarization, Instrumentation, etc.)
• Electron microscopy: principle and application of scanning and transmission electron microscopies and correlated techniques (EDS microanalysis).
• Spectroscopic methods: Raman spectroscopy, photoelectron spectroscopy, X-ray spectroscopies (XAS, XRF, etc.), Mössbauer spectrometry.

Hourly volumes* :

            CM : 10 h

            TD : 10 h

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This teaching unit is dedicated to the deepening of the bases of organic chemistry and coordination chemistry seen in L3 and to the acquisition of notions related to molecular engineering and molecular chemistry. The UE includes lectures and tutorials. The students will work before some lectures and tutorials with course documents provided so that the lectures and tutorials can allow them to be fully involved in the training, to understand the concepts presented and the skills to be acquired. The progression program and activities will be proposed. For those students who have not seen the basics of coordination chemistry and organic chemistry, the documents will be made available.

Coordination chemistry: The teaching will cover the different aspects of transition metal and lanthanide complexes, molecular materials (polynuclear complexes and coordination polymers with extended structures (MOFs, etc.)) and their properties and applications. Structural aspects, bonding description, properties, as well as stability and reactivity aspects will be discussed. Emphasis will be put on the complexation effect and on the stability of metal, lanthanide and actinide complexes with certain ligands for applications in the biomedical field (imaging and therapy), decontamination (nuclear field), etc. The electronic (relaxivity, magnetism) and optical (absorption, luminescence) properties of these complexes will be discussed and put in the context of applications in various fields, such as imaging, electronics, sensors, etc.

Organic Chemistry: The teaching is based on the knowledge acquired in the Bachelor's degree and will approach through a reasoned study the main reaction mechanisms of organic chemistry and will allow to give a common base to all the students of the Master Chemistry. The main processes (substitution, addition, elimination, transposition...) and their essential characteristics and applications to mechanistic sequences will be examined. This course should provide the student with general tools for the analysis of mechanisms (ionic, radical, concerted) in order to understand these mechanisms in their variety.

Hourly volumes* :

CM : 13 H

TD : 7 H

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The professionalization project provides a link between the traditional practical work and the internship in a laboratory or company. It is carried out in the form of a tutored project consisting of putting the student in a professional situation through collaborative (group) work based on the realization of a project in response to a problem set by a company, community, association or academic. It is part of the core curriculum of the Chemistry Master's program and is carried out under the responsibility of a member of the teaching team (university or industry). Carried out throughout the semester, this project aims to relate and anchor the knowledge/know-how acquired in the framework of the Bachelor's degree and the beginning of the Master's degree through this professional situation. These situations will be directly linked to the Master's program chosen by the students. In addition to the disciplinary skills of chemistry, other relational, organizational and communication skills, intrinsically linked to project management, will also be acquired and will arm the students for their future professional life.

Answer a research problem: example of synthesis of new phosphorescent materials.

Hourly volumes* :

CM : 5h

TD : 5h

Practical work : 40h

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The internship in semester 8 of the Master 1 Chemistry of Biomolecules aims to familiarize students with research careers in life chemistry. Thus, the students will have the possibility of carrying out this training course of initiation to research within academic or private laboratories. Subject to prior acceptance by the teaching staff (internship subject related to the Master's courses and adequate environment/means), the student may look for a host team in an academic environment in the institutes of the Chemistry Pole of the University of Montpellier (IBMM, ICGM, ...), in academic laboratories outside the University of Montpellier (in France or abroad) or in the private sector (chemical, pharmaceutical, agri-food industries, biotech laboratories, ...).

Field : 2 to 4 months of internship

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The goal of this course is to enable students with a chemistry background to understand the fundamentals of process engineering.

The course consists on two main parts that are illustrated by the same process.

In the first part of the course, a drying process will be used to introduce the most common heat and mass transfer phenomena found in process engineering, from which the dimensionless numbers can be derived. In the second part, the thermodynamic properties of the air/water vapor mixtures will be used to derive basic dimensioning rules for the same drying process.

This course will be entirely taught in English.

Hourly volumes* :

CM : 10

TD : 10

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The following topics will be covered:

- Biobased solvents

- Fuels from biomass

- Antioxidants derived from lignin

- Metal catalysts from plants

- Surfactants obtained from renewable resources

- Examples of industrial applications of enzymatic synthesis

Hourly volumes* :

CM : 15

TD : 5

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A general approach to liquid-liquid extraction will be developed through thermodynamic and kinetic notions in order to understand the mechanisms responsible for extraction as well as the processes taking place at the liquid-liquid interface. Fundamental aspects of other types of extraction (liquid-solid, supercritical fluid, distillation) will also be discussed.

Hourly volumes* :

            CM : 12h

            TD : 8h

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The medicinal chemistry course aims to introduce students to the key steps in the development process of molecules with biological activities. In particular, a description of the interactions involved, the notion of pharmocophores, bio-isosteria..., as well as structure-activity relationship studies will be addressed in order to consider strategies and adequate structural modifications.

Hourly volumes* :

CM : 3 pm

TD : 5 h

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This teaching unit is mutualized for the MI students of the Master Chemistry: ICAP P1, ICAP P2, MAT P1, MAT P2, BM (semester S2). The following topics will be covered:

• The 12 Principles of Green Chemistry and the Units of Measurement in Green Chemistry ;
• Synthesis strategies in sustainable chemistry;
• Alternative or eco-compatible solvents for synthesis and extraction;
• Non-conventional activation techniques and applications.

CM : 13

TD : 7 H

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The mechanical and thermal properties of materials are at the heart of many applications in the field of materials for energy. After an introduction to these different fields of application, this course aims to define the different concepts necessary to master both the mechanical and thermal properties of materials, limiting itself to bulk materials.

Hourly volumes* :

            CM : 11H

            TD : 9H

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General presentation of the most commonly used computational and modeling methods in the field of solid state chemistry according to the spatial and temporal scales that can be studied with them:

(1) Quantum calculations (Hartree Fock, Post-Hartree Fock methods, DFT),

(2) Force field based modeling (atomistic and coarse grain),

(3) Hybrid QMM and AACG modeling.

Presentation of the different calculation techniques: static and optimization calculations, molecular dynamics and Monte Carlo.

The UE will have courses of type CM and TP. Two practical modeling works will be proposed: modeling techniques in classical mechanics and quantum calculations.

            CM : 11H

            TD : 9H

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This teaching unit is dedicated to the presentation of inorganic materials and nanomaterials for use in the biomedical field (imaging, therapy, implants). This UE is the deepening of the knowledge acquired in the UE HAC930C (Development of materials for health). The aim is to develop health issues and inorganic materials and nanomaterials in diagnosis, therapy and well-being. Strategies for the development of future inorganic materials and nanomaterials based on therapeutics and multifunctionality, and smart materials will also be addressed.

The UE includes lectures and tutorials. A group project on the (theoretical) study of an inorganic material or nanomaterials for health will be proposed to the students.    

CM : 11

 TD : 9

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This UE will address in small groups or in a personalized way the pedagogical tools and good practices related to communication and professional insertion, through :

• knowledge, skills, competencies, attitudes and motivations assessments;
• awareness of job search techniques;
• CV and cover letter writing;
• rules of oral and written communication;
• mock job interviews.

Situations directly related to the sectors of activity targeted by the students' courses will be proposed.

TP : 20h

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The electronic and optical properties of solids are at the heart of many applications in the field of energy (photovoltaic panels, passive coolants...), light production (white diodes, lasers...), electronics (components, microprocessors...). After an introduction to these different fields of application, this course aims to define the different concepts necessary to master both the electronic and optical properties of materials, which are essential for understanding the most modern technologies.

Hourly volumes* :

            CM : 11H

            TD : 9H

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Hybrid" materials are a new family of materials, associating organic ligands with inorganic entities, and are increasingly studied at both fundamental and application levels.

In this EU, two main categories of hybrid materials will be discussed:

• Coordination Networks and Metal-Organic Frameworks
• Organosilicon/carbon materials

CM : 10 h

TD : 10 h

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The theoretical knowledge necessary for the understanding, formulation and implementation of dispersed systems will be detailed in this module. The physico-chemical principles governing the preparation and stability of solid-liquid and liquid-liquid dispersions will be detailed in accordance with the specifications and the expected properties of use. The different concepts addressed are dispersibility of powders, modification of the solid/liquid interface for the control of zeta potential and colloidal interactions (extended DLVO), rheology of dispersed systems in relation with the state of dispersion. Liquid-liquid dispersion: emulsification, Winsor's R ratio, HLD formulation and formulation maps.

Introduction to synthesis techniques in dispersed media: emulsion synthesis of nanoparticles, latex, microcapsules...

CM : 11

TD : 9

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The substitution of materials of petroleum origin is an increasingly important issue from both a technological and economic point of view. This module provides skills in the field of agropolymers, biosourced polymers, degradable materials and biocomposites. New and more environmentally friendly synthesis routes will be presented in order to prepare synthetic degradable polymers

Degradation, biodegradation and recyclability of polymers will also be addressed

Hourly volumes* :

            CM : 11CM

            TD : 9 TD

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The elaboration of materials involves many coupled phenomena, some of which are related to the nature of materials and their intrinsic properties, others to the processes implemented during the operations of transformation of matter and/or energy. Morphogenesis is thus the result of interdependent, coupled mechanisms, whose relative kinetics will lead to one structure or another. The control of these coupled mechanisms requires a good knowledge of the dynamics of transformation of the materials themselves as well as a precise description of the transfer and transport phenomena implemented in the process. The integration in the reactive environment will be addressed at the end of the course.

Hourly volumes* :

            CM : 11

            TD : 9

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One of the major issues related to the use of different materials in our daily life is their durability and therefore their degradation. In this course, we will address the issues related to the durability of materials (resources, reserves, criticality of materials, ...) as well as the methodologies for studying durability (types of aging surface / volume, temporal extrapolation, multi-scale, combination of effects, experimental representation and industrial validation). This will then allow to model the aging kinetics from different models.

The different types of degradation affecting polymers will then be analyzed.

Finally, the aging of different types of materials will be illustrated by different concrete case studies (concrete, ceramic, metals and elastomers).

Hourly volume* : 11h CM :

                                    9h TD

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The materials used for housing and roads have various characteristics and properties (durability, mechanical resistance, thermal and acoustic insulation) allowing them to adapt to the characteristics, the conditions of implementation or the cost, fixed by a specific specification. This course provides the basic notions on different types of materials used for housing (concrete, plaster, paints, adhesives...) and road construction (bitumen) in terms of preparation, formulation and implementation. For each of the materials presented, innovative approaches to reduce their ecological footprint while maintaining their performance will also be described.

Hourly volumes* :

            CM : 11

            TD : 9

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The principles governing the exploitation of thermal energy are addressed in this course. After a presentation of the technological issues and perspectives associated with thermoelectric conversion and thermochemical storage, the focus is on the design and development of functional materials for the direct conversion of thermal energy into electricity and for the storage of thermal energy by sorption.

Hourly volumes* :

            CM : 11 H

            TD : 9 H

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This teaching unit is dedicated to the presentation of materials and nanomaterials for use in the biomedical field (imaging, therapy, implants, etc.). The aim is to give a representative image of the health issues where materials and nanomaterials play an indispensable role in diagnosis, therapy and well-being. Strategies for developing the materials and nanomaterials of the future will also be discussed.

The prerequisites for the development of materials for health and their behavior/interaction with a living organism will be explained. Examples of inorganic (inorganic nanoparticles, various materials for implants...), organic (polymers, liposomes, etc.) and biologically derived materials used as contrast agents for various types of imaging, as therapeutic agents, or as implants will be presented.

The UE includes lessons given in lectures and tutorials. 

Hourly volumes* :

            CM : 11

            TD : 9

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This teaching unit covers the different aspects of the current and future nuclear fuel cycle. It will successively cover the notions of the upstream part of the cycle (mineral resources, extraction and purification of uranium, isotopic enrichment), the passage of fuels through nuclear reactors and then the downstream part of the cycle (reprocessing of spent fuels, recycling of recoverable materials and remanufacturing of fuels, management of ultimate nuclear waste). This will be followed by several aspects of future nuclear fuel cycles, in particular the use of non-conventional resources, advanced separation concepts and the development of fourth generation reactors.

Hourly volumes* :

            CM : 15h

            TD : 5h

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Metallurgy groups together all the industries and techniques that ensure the transformation of metals.

Hourly volumes* :

            CM : 11

            TD : 9

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This course will cover the main conventional membrane technologies in liquid and gas media. Concerning the liquid medium, baromembrane technologies such as microfiltration, ultrafiltration, nanofiltration and reverse osmosis will be mainly described, but also those based on electrochemical potential gradients (electrodeionization) or temperature (membrane distillation). In addition, gas permeation and pervaporation for the separation of gases and/or vapors will also be presented. For all the technologies, the question of the choice of the adapted membrane materials will be addressed and representative examples of appropriate fields of use (in connection with the current environmental and energy problems) will be given.

Hourly volumes* :

            CM : 11h

            TD : 9h

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This course will focus on the energy context and methods of energy conversion and storage, the historical development of electrochemical energy conversion and storage technologies and modern applications, and electrochemical mechanisms. Finally, links will be made between modern energy conversion and storage technologies and current societal issues.

Hourly volumes* :

            CM : 11

            TD : 9

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This course consists of an in-depth study of a problem or a chosen subject related to the chemistry of materials for the three targeted orientations of the course: sustainable development, health and membrane engineering. This can take the form of a study in research, development or analysis at the laboratory level or in a company. Students will work in small groups - projects. They will choose their subject, define the goal, the objectives and the means under the guidance of a tutor. The final goal is to develop a product/methodology using the knowledge of synthesis and analysis already acquired to prepare for the internships that will take place in S8.  

Hourly volumes* :

            CM : 6h

            TD : 6h

            TP : 16 hours

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Membrane materials are usually divided into two families: polymeric membranes and inorganic (or ceramic) membranes. Each of these families will constitute a part of this course. The first part will be devoted to the design of polymeric membranes. In this part, we will mainly deal with the techniques of preparation by phase inversion (NIPS, VIPS, TIPS) with an opening on research and innovation (SNIPS, aquaporin...). In addition, the additives (especially pore-forming and hydrophilizing agents), which play an important role in the phase inversion approaches, will be described and the different chemical modification routes of the post-synthesis membranes will be presented. The second part will be devoted to the design of inorganic membranes. In this part, we will present on the one hand the wet processes, i.e. the main methods of deposition of liquid films (dip-coating, spin-coating, sputtering, tape-casting, silk-screening) and of deposition from solutions (electrolytic or chemical processes) or suspensions (electrophoresis, Langmuir-Blodgett), and on the other hand the dry processes (PVD techniques (evap. and spray), CVD techniques (thermal, PECVD and ALD), MBE, surface treatment). Finally, as an illustration of the two families of membranes, we will deal with case studies on membrane applications, in particular in the field of packaging.

Hourly volumes* :

            CM : 11h

            TD : 9h

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Today, it is essential to design products that are environmentally friendly throughout their life cycle. It is commonly accepted that as the manufacturing process of a product progresses, the technical choices become narrower and the possibilities to reduce environmental impacts become less and less. It is therefore from the start, i.e. at the product design stage, that the environment must be integrated.

The method is based on the life cycle analysis of a product. It takes into account factors such as :

• The choice of materials and raw materials
• The technologies implemented during the manufacture, use, maintenance of the product and during its treatment as waste.
• The life span of the product and the possibility of recovering materials at the end of its life (recycling, etc.).
• User behavior analysis.

Hourly volumes* :

            CM : 11h

            TD :9h

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This is a lecture course, mainly intended for students in materials and sustainable development. It presents the role played by heterogeneous catalysis in the development of a clean chemistry and in the depollution of gas/liquid effluents. The basic notions of heterogeneous catalysis, as well as the main families of catalytic materials will be discussed.  

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• Transport mechanisms in solids,
• Complex impedance spectroscopy
• Electrochemical systems with solid electrolyte,
• Application in solid electrochemistry: energy and environment (Batteries, Accumulators, Sensors, Electrochromes...)

Hourly volumes* :

            CM : 11H

            TD : 9H

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This end-of-studies internship in Master 2 is designed to put the student in a pre-professional situation, in an academic research laboratory or an industrial research and development laboratory, in France or abroad.  

The student will look for a host team in an academic environment in the institutes of the Chemistry Pole of the University of Montpellier (ICGM, IEM, IBMM...), in academic laboratories outside the University of Montpellier (in France or abroad) or in the private sector working in the field of materials. The research project on which the student will work will have been validated beforehand by the teaching team in order to ensure that the internship subject is in line with the Master's courses, the skills and expertise acquired during the previous semesters and the teaching units followed in particular in semester 9 according to the chosen orientation. Furthermore, the teaching staff will make sure that the internship will take place in an environment and with adequate means.

This 5 to 6 month internship may begin in mid-January after the exam session and may not exceed 6 months in semester 10.

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The substitution of materials of petroleum origin is an increasingly important issue from both a technological and economic point of view. This module provides skills in the field of agropolymers, biosourced polymers, degradable materials and biocomposites. New and more environmentally friendly synthesis routes will be presented in order to prepare synthetic degradable polymers

Degradation, biodegradation and recyclability of polymers will also be addressed

Hourly volumes* :

            CM : 11CM

            TD : 9 TD

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Knowledge of the main families of polymers used in the biomedical field.

1) Specificity of polymers for biomedical applications and main families of polymers used

2) Description of the application families

3) Discussion on the notion of synthesis and the structure/property/software relationship

Hourly volumes* :

CM : 15 H

TD : 5 H

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This teaching unit is dedicated to the presentation of materials and nanomaterials for use in the biomedical field (imaging, therapy, implants, etc.). The aim is to give a representative image of the health issues where materials and nanomaterials play an indispensable role in diagnosis, therapy and well-being. Strategies for developing the materials and nanomaterials of the future will also be discussed.

The prerequisites for the development of materials for health and their behavior/interaction with a living organism will be explained. Examples of inorganic (inorganic nanoparticles, various materials for implants...), organic (polymers, liposomes, etc.) and biologically derived materials used as contrast agents for various types of imaging, as therapeutic agents, or as implants will be presented.

The UE includes lessons given in lectures and tutorials. 

Hourly volumes* :

            CM : 11

            TD : 9

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In this course, the different molecular or supramolecular tools for the delivery of active ingredients according to the type of cells or intracellular organelles targeted are discussed. Ligand-receptor interactions will be discussed as well as the methods of preparation and activation of conjugates. Examples of drugs will be presented.

Hourly volumes* :

CM : 15 H

TD : 5 H

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This teaching unit is dedicated to the presentation of inorganic materials and nanomaterials for use in the biomedical field (imaging, therapy, implants). This UE is the deepening of the knowledge acquired in the UE HAC930C (Development of materials for health). The aim is to develop health issues and inorganic materials and nanomaterials in diagnosis, therapy and well-being. Strategies for the development of future inorganic materials and nanomaterials based on therapeutics and multifunctionality, and smart materials will also be addressed.

The UE includes lectures and tutorials. A group project on the (theoretical) study of an inorganic material or nanomaterials for health will be proposed to the students

Hourly volumes* :

            CM : 11

            TD : 9

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This teaching unit is dedicated to the acquisition of notions related to medical devices and biomaterials. The course includes traditional lectures and tutorials as well as interactive Learning Lab sessions on innovation in medical devices. 

CM: 3 HCM

TD: 5HTD

12H CM-TD Learning Lab

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This course consists of an in-depth study of a problem or a chosen subject related to the chemistry of materials for the three targeted orientations of the course: sustainable development, health and membrane engineering. This can take the form of a study in research, development or analysis at the laboratory level or in a company. Students will work in small groups - projects. They will choose their subject, define the goal, the objectives and the means under the guidance of a tutor. The final goal is to develop a product/methodology using the knowledge of synthesis and analysis already acquired to prepare for the internships that will take place in S8.  

Hourly volumes* :

            CM : 6h

            TD : 6h

            TP : 16 hours

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Membrane materials are usually divided into two families: polymeric membranes and inorganic (or ceramic) membranes. Each of these families will constitute a part of this course. The first part will be devoted to the design of polymeric membranes. In this part, we will mainly deal with the techniques of preparation by phase inversion (NIPS, VIPS, TIPS) with an opening on research and innovation (SNIPS, aquaporin...). In addition, the additives (especially pore-forming and hydrophilizing agents), which play an important role in the phase inversion approaches, will be described and the different chemical modification routes of the post-synthesis membranes will be presented. The second part will be devoted to the design of inorganic membranes. In this part, we will present on the one hand the wet processes, i.e. the main methods of deposition of liquid films (dip-coating, spin-coating, sputtering, tape-casting, silk-screening) and of deposition from solutions (electrolytic or chemical processes) or suspensions (electrophoresis, Langmuir-Blodgett), and on the other hand the dry processes (PVD techniques (evap. and spray), CVD techniques (thermal, PECVD and ALD), MBE, surface treatment). Finally, as an illustration of the two families of membranes, we will deal with case studies on membrane applications, in particular in the field of packaging.

Hourly volumes* :

            CM : 11h

            TD : 9h

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This course will cover the main conventional membrane technologies in liquid and gas media. Concerning the liquid medium, baromembrane technologies such as microfiltration, ultrafiltration, nanofiltration and reverse osmosis will be mainly described, but also those based on electrochemical potential gradients (electrodeionization) or temperature (membrane distillation). In addition, gas permeation and pervaporation for the separation of gases and/or vapors will also be presented. For all the technologies, the question of the choice of the adapted membrane materials will be addressed and representative examples of appropriate fields of use (in connection with the current environmental and energy problems) will be given.

Hourly volumes* :

            CM : 11h

            TD : 9h

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This end-of-studies internship in Master 2 is designed to put the student in a pre-professional situation, in an academic research laboratory or an industrial research and development laboratory, in France or abroad.  

The student will look for a host team in an academic environment in the institutes of the Chemistry Pole of the University of Montpellier (ICGM, IEM, IBMM...), in academic laboratories outside the University of Montpellier (in France or abroad) or in the private sector working in the field of materials. The research project on which the student will work will have been validated beforehand by the teaching team in order to ensure that the internship subject is in line with the Master's courses, the skills and expertise acquired during the previous semesters and the teaching units followed in particular in semester 9 according to the chosen orientation. Furthermore, the teaching staff will make sure that the internship will take place in an environment and with adequate means.

This 5 to 6 month internship may begin in mid-January after the exam session and may not exceed 6 months in semester 10.

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This teaching unit is dedicated to the acquisition of notions related to pigments, dyes and adsorbents, from the point of view of their structures and their applications. Emphasis will be put on applications in the field of flavors & fragrances (food coloring, perfumery) and cosmetics (hair coloring, powders, toothpastes...). Some sessions are specific to each of the two courses (P1, Cosmetics Engineering; P2, Flavors & Fragrances) of the Master's degree in Chemistry specializing in Cosmetics, Flavors and Fragrances Engineering (ICAP). The UE includes lessons given in lectures and tutorials.

Hourly volumes* :

CM : 10 h

TD : 10 h

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Some fundamental basics of microbiology will be covered so that students have an overview of the diversity of microorganisms. The mode of nutrition and multiplication of bacteria according to the physico-chemical parameters of the environment will be studied.

The composition and role of the skin and digestive microbiota will be discussed.

The microbiological criteria used for the quality control of cosmetic and food products will be defined.

Physical and chemical antimicrobial agents to control microbial growth will be reviewed.

At the practical level, the student will be expected to know how to handle bacteria and to know the rules of microbiological safety. Usual techniques of microbiological controls and effectiveness of preservatives will be performed on cosmetic products.

Hourly volumes* :

CM : 12h

TP : 8h

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This module covers all the knowledge on raw materials necessary to work in the cosmetic industry.

These are:

• to describe the different chemical classes of raw materials, to understand the structure/activity relationships as well as the sensory rendering.
• The study of documents related to the marketing of cosmetic raw materials

Hourly volumes* :

            CM : 18

            TD : 6

            TP : 16

The course is based on case studies of ingredients in aqueous or fatty phases, and both polymers and polymerization processes will be developed.

The practical part of the module will allow the implementation of major categories of raw materials:

Implementation of gelling agents: implementation, study of their properties, sensory evaluation

Implementation of surfactants: Formulation of a foaming product with research of the ingredients, design of the formula and sensory evaluation

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This EU addresses:

- the foundations of colorimetry, which allow to define an unambiguous measure of color from psychophysical experiments.

- the principle and practical use of color measuring devices (colorimeters and spectro-colorimeters).

- the principles of color reproduction, particularly in the context of perfumes and cosmetics.

Theoretical ideas are complemented by an important part of observation and manipulations during the practical sessions.

Hourly volumes* :

CM : 12h

TP : 8h

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Study of the entire development of a cosmetic product

• Definition of a cosmetic product
• Launch of the development, interactions of the development department with the marketing, industry and regulatory departments: needs, expectations, operation and procedures
• Study of all possible tests: sensory analysis, physicochemical stability, safety and sanitary security, efficiency.
• Study of the industrial transposition
• Study of the interactions with the packaging and the associated tests
• Description of the product information file or legal cosmetic file

Study of emulsions, definitions, characteristics and formulation

Study of the instability phenomena of emulsions and stabilization solutions

Practical part:

Formulation of water-in-oil, oil-in-water and gel-cream emulsions

Study of ingredients, chemical nature, physical behavior and formulation

Study of the formulation material

Implementation of sensory, physicochemical and stability tests.

Development of a formula in several steps with imposed constraints.

Critical analysis of the results obtained.

For the introduction to chemical engineering applied to the field of cosmetics, students will have to work on a case study that describes the laboratory scale production of a cosmetic product, and then find a way to produce it at a larger scale.

Hourly volumes* :

 CM :15

TP : 25

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This course allows the acquisition of basic knowledge and transversal skills in the field of colloids and interfaces, common to the different courses of the Master Chemistry (Chemistry of Materials, Separative Chemistry, Materials and Processes, ICAP Cosmetics Engineering, Chemistry of Biomolecules). It is also offered to international students entering the SFRI program at the University of Montpellier where the teaching is given in English. An introductory presentation on the basic notions and concepts will allow to discover and better understand the main physicochemical properties of colloidal dispersions, associative colloids, and macromolecular solutions, as well as the parameters and phenomena governing the stability in colloidal dispersions and mixed solution-colloid systems. Then, an interdisciplinary practical teaching based on the principle of the flipped classroom will be proposed to help students build and deepen their knowledge through an individual and collective analysis of the various applications of colloidal and interfacial phenomena and systems.

Hourly volumes* :

CM : 7

TD : 13

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Know and know how to apply the various regulations related to the cosmetics industry (Regulation 1223/2009, REACH, CLP, etc..)

To deepen the important articles of the European regulation in cosmetics - Regulation 1223/2009

Learn how to make a DIP

Focus on the safety report using an example

Hourly volumes* :

            CM : 10

            TD : 10

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This course will cover the fundamental concepts and practical tools related to chemometrics through : - statistical analysis of data ;

• laws of probability ;
• confidence interval estimation ;
• parametric and non-parametric tests.

An introduction to experimental design will be offered at the end of the module.

Hourly volumes* :

CM : 7h

TD : 13h

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This course is designed to teach liquid chromatography and gas chromatography.

Hourly volumes* :

            CM :15h

            TD : 5h

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The professionalization project provides a link between the traditional practical work and the internship in a laboratory or company. It is carried out in the form of a tutored project consisting of putting the student in a professional situation through collaborative (group) work based on the realization of a project in response to a problem set by a company, community, association or academic. It is part of the core curriculum of the Chemistry Master's program and is carried out under the responsibility of a member of the teaching team (university or industry). Carried out throughout the semester, this project aims to relate and anchor the knowledge/know-how acquired in the framework of the Bachelor's degree and the beginning of the Master's degree through this professional situation. These situations will be directly linked to the Master's program chosen by the students. In addition to the disciplinary skills of chemistry, other relational, organizational and communication skills, intrinsically linked to project management, will also be acquired and will arm the students for their future professional life.

Answer a research problem: example of synthesis of new phosphorescent materials.

Hourly volumes* :

CM : 5h

TD : 5h

Practical work : 40h

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This module focuses on R&D in the cosmetic industries and will emphasize scientific expertise and innovation through lectures and conferences. In addition, there will be case studies on the design and development of cosmetic and wellness products.

The practical part will focus on the development of make-up products:

Review of the composition of make-up products

The natural or synthetic coloring raw materials. To know the different galenics used in make-up and to know how to select the raw materials.

Know how to select pigments according to the desired target. Know how to disperse them and know the surface treatment.

Marketing study on defined make-up galenics

Theoretical courses on raw materials and galenics used in make-up, manufacturing process, as well as market trends and possible tests (claims, physico-chemical tests, efficiency tests, ...)

In practice:

Practical courses on pigment premixes, foundations and lipsticks, combined with sensory evaluations

Application to the formulation of various make-up products (foundation, lipstick, mascara, etc.) and quality control of finished products.

Hourly volumes* :

            CM : 20

            TD : 5

            TP : 15

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This teaching unit is mutualized for the MI students of the Master Chemistry: ICAP P1, ICAP P2, MAT P1, MAT P2, BM (semester S2). The following topics will be covered:

• The 12 Principles of Green Chemistry and the Units of Measurement in Green Chemistry ;
• Synthesis strategies in sustainable chemistry;
• Alternative or eco-compatible solvents for synthesis and extraction;
• Non-conventional activation techniques and applications.

CM : 13

TD : 7 H

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This 4 to 6 month internship will be carried out in an R&D laboratory in the cosmetics and well-being industries.

The missions entrusted by the company to the student trainee will be in line with the objectives of the Master.

This internship can start in February/March and will be carried out in France or abroad.

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This UE will address in small groups or in a personalized way the pedagogical tools and good practices related to communication and professional insertion, through :

• knowledge, skills, competencies, attitudes and motivations assessments;
• awareness of job search techniques;
• CV and cover letter writing;
• rules of oral and written communication;
• mock job interviews.

Situations directly related to the sectors of activity targeted by the students' courses will be proposed.

TP : 20h

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This module focuses on:

• Tools and sources of information (patents, databases, journals, trade fairs and scientific days, etc.) and communication: knowing how to identify relevant sources of information, knowing how to analyze and use them, knowing how to communicate internally and externally.
• What is business intelligence, how to understand and use it
• Marketing fundamentals: presentation of what marketing does, presentation of tools that can help students in their future work, detailed explanation of the development process of a cosmetic product in marketing, and the different jobs available to students.

A project will be developed by the students.

Hourly volumes* :

CM :15h

TD : 5h

TP : 10h

Exit : 10 am

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An experimental design is the ordered sequence of trials of an experiment whose purpose is to test the validity of a hypothesis by reproducing a phenomenon and varying one or more parameters. Each test produces a data and all the data produced during an experiment must be analyzed by rigorous methods to validate or not the hypothesis. This experimental approach makes it possible to acquire new knowledge by confirming a model with a good economy of means (the smallest possible number of tests, for example).

Starting from a simple problem, the module develops methodological and statistical tools that allow to support more and more complex hypotheses in the most optimal way possible. The implementation of these methodologies is done via the statistical language R.

Hourly volumes* :

            CM : 15h

            Practical work : 5h

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To provide students with the theoretical understanding of inferential statistics necessary for the statistical analysis of data from sensory tests. General problem: extract interpretable regularities from sensory measurements to make the right decisions.

The lessons will cover the needs of each pathway, through examples and applications adapted to each.

Hourly volumes* :

            CM : 10 H

            PRACTICAL TRAINING : 10H

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Polymers are used in a large number of cosmetic formulations with various functions, the main ones being rheology control, formulation stabilization and as a conditioning agent. It is therefore important to know their behavior in these complex environments, especially by studying polymer-surfactant interactions since these two constituents are often present together in these environments, as well as interactions with solid surfaces (suspensions, applications on hair or skin) or liquids (emulsions).

The course describes: (1) the different types of polymers used: water soluble, synthetic, natural and semi-natural, amphiphilic and structure-property relationships, (2) principle of thickening formulas or gelling using polymers, (3) interactions with surfactants, presentation of the different types of surfactants and their physico-chemical properties in particular polymeric surfactants, (4) interactions with surfaces (skin, hair) as well as any type of solid surface, (5) principle of stabilization of emulsions and suspensions using polymers.

A second part of this module is devoted to silicones and their use in cosmetics:

The chemistry of silicones, silicones for cosmetics: categories, their uses and sensory effects with examples of application.

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Basic knowledge of skin structure and physiology: skin structure; sensory receptors; mechanical and thermal sensitivity.

Skin penetration; skin hydration and moisturizing products; seborrhea, acne; Dermocosmetic typologies: skin penetration; skin aging, infant skin; cellulite

Hourly volumes* :

            CM : 16

            TD : 4

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This module is devoted to the study of the main classes of cosmetic additives and to the study of natural, biotechnological and synthetic active ingredients.

The first part of this course will focus on the marine flora through the general composition and specificities of different algae. What is the place and effectiveness of marine flora in cosmetics?

The course will conclude with case studies and perspectives.

A second part will talk about the plant world in order to allow formulators and those responsible for regulatory issues to understand the implementation of plant molecules for their beneficial effects in relation to the main cosmetic indications. Essential oils: what are the production techniques, their chemical compositions, their cosmetic properties, their formulation, their safety of use?

The third part of the module will focus on the different classes of additives used in cosmetics.

The focus will be on the chemical and organoleptic study of the main raw materials (synthetic or natural) used in the perfuming of cosmetics and the regulatory constraints related to their use (cosmetic guidelines on the dosage of allergens).

The families of odorant molecules used in cosmetics (molecules without organic function or containing alcohol, aldehyde, ketone, ester functions) will be studied:
- molecules with an aromatic ring
- phenol type molecules
- cyclic and acyclic aliphatic molecules.
- acyclic and cyclic terpene molecules
- odor field.

-Notions of stability and volatility of molecules.

The course will conclude with an apprenticeship in the formulation of perfume compositions for cosmetic products.

Hourly volumes* :

            CM : 20

            TD : 10

            TP : 10

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What is eco-design? 

Product Life Cycle Assessment (LCA)
Who certifies?
Eco-design & raw materials
Biodiversity and Nagoya protocol.
Reminder on the principles of Green Chemistry
Eco toxicology and biodegradability
Manufacture of a cosmetic product in eco-design
The trends related to eco-design

Packaging in eco-design, what is their impact?

Notion of ecotoxicology: impact on the environment/biodegradability

Information on ecodesign measurement: what tools are available/impact measurement Recylability of packaging: measurement and analysis (raw materials/formulations/ecotoxicology).

Students will be offered a role-playing situation.

Hourly volumes* :

            CM : 20

            TD : 10

            TP : 10

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The objective of the course is to understand and apply the principles of color formulation as practiced in the color industry. For this purpose, the basics of spectrocolorimetry, light-matter interactions and the simplest formulation models (Beer-Lambert and Kubelka-Munk) are studied and used in practical work.

Hourly volumes:

            CM : 12

            TP : 8

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Reminder of European legislation and its hierarchy: regulations, directives, decisions, resolutions, national laws, institutions and authorities in charge of the regulatory system.

Description of the main regulations around the world and a global view of progress

Institutions and authorities in charge of the regulatory system

Regulatory framework applied to cosmetic packaging

The compliance process for cosmetic packaging and its main difficulties

New requirements for cosmetic packaging under European and French laws on the circular economy

The course will address the Good Manufacturing Practices (GMP) designed to ensure the reproducibility and quality of cosmetic products.

It will allow to know the measures to adopt regarding the processes of production, control, storage and shipment and to ensure the compliance of cosmetic products with the regulations in force (EC 1223/2009, ISO 22716 standard, etc.)

Hourly volumes* :

            CM : 15

            TD : 15

            Land : 10

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This module focuses on all aspects of photoprotection:

It will begin with a reminder of the sun's rays and the skin, with an emphasis on natural melanin and non-melanin photoprotection. The skin's reaction to the sun will allow us to discuss the benefits of the sun but will focus on the harmful side effects for the skin. What are the possibilities offered by the cosmetic industry to protect oneself? How to analyze the effectiveness of sunscreen products? What is the impact of filters on the environment?

• Study of the development of suncare formulas: raw materials, chemical and physical filters, formulation techniques, regulations, the relationship between the sun and the skin.

• Use of software to calculate theoretical SPF

• Acquire knowledge in the formulation of suncare products
• Manufacturing processes
• Fine analysis of INCI formulas

• Formulation of microemulsion by phase inversion

Hourly volumes* :

            CM : 15

            TP : 25

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This teaching unit has several components:

• The lessons will show that chemistry opens up to various professions in the field of cosmetics, and not only to formulation.

• To know how to bring a reflection on the scientific method in order to avoid errors of judgment and to know how to bring a scientific reflection in front of any information. The teaching will be based on concrete examples related to cosmetics (difference between risk and danger, reflection on various applications/consumer information, etc.)

• The course is based on concrete marketing projects, from market research to the formalization of a marketing concept in cosmetics.

Hourly volumes* :

            CM : 12

            TD : 8

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In-depth study of the different cosmetic galenic forms: composition, description of the main components, formulation, principle, galenic forms

Study of ingredient families including emollients, esters, emulsifiers, sunscreens, preservatives and innovation in skin care and make-up products

Study of the INCI list of formulations, INCI nomenclatures

Study of the different types of cosmetic companies

Study of manufacturing processes (agitation equipment, complementary manufacturing processes, impact of physical and chemical parameters on manufacturing)

The application will be in different areas.

For example: formulation of moisturizing emulsions with electrolytes (stability disrupting elements), formulation of cleansing milk and cleansing lotion and the implementation of tests to measure the effectiveness of the cleansing, formulation of make-up products.

Hourly volumes* :

            CM : 15

            TP : 25

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This module consists of putting students in a professional context, in relation with a cosmetics development and production company or raw material supplier. The module will be organized in the form of industrial projects:

The students are divided into groups, as would be composed of a scientific team. They will have to apply their theoretical knowledge, in close collaboration with the industrialist. The industrialist will be able to guide them or help them to contact new suppliers, to realize a cosmetic file, to make a market study, etc., according to the assigned project.

Activity reports will be produced via the sharing networks commonly used in the field. The groups will be asked to work independently, following a set of specifications defined by the industrialist, in line with the diploma program.

This could be, for example, the development of an innovative product, in compliance with French and European regulations, or countertyping.

Hourly volumes* :

            CM : 10

            TP : 30

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This module will allow students to understand the importance of innovation in a sector as dynamic as cosmetics.

This environment is indeed governed by regulatory constraints, innovations in packaging, innovations in formulation but also in ingredients.

This is also governed by the expectations of increasingly demanding consumers.

It is therefore essential for these future graduates to understand the ins and outs of innovation in cosmetics and to know how to implement it while respecting certain criteria.

A project will be proposed to the students: Presentation of the project in group and setting up of the instructions for its realization.

Hourly volumes* :

            CM : 20

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This 5 to 6 month internship or work-study program will be carried out in an R&D laboratory in the cosmetics and well-being industries.

The missions entrusted by the company to the student intern will be related to the objectives of the Master.

This internship or work-study assignment will be carried out in France or abroad.

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This teaching unit is dedicated to the acquisition of notions related to pigments, dyes and adsorbents, from the point of view of their structures and their applications. Emphasis will be put on applications in the field of flavors & fragrances (food coloring, perfumery) and cosmetics (hair coloring, powders, toothpastes...). Some sessions are specific to each of the two courses (P1, Cosmetics Engineering; P2, Flavors & Fragrances) of the Master's degree in Chemistry specializing in Cosmetics, Flavors and Fragrances Engineering (ICAP). The UE includes lessons given in lectures and tutorials.

Hourly volumes* :

CM : 10 h

TD : 10 h

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Some fundamental basics of microbiology will be covered so that students have an overview of the diversity of microorganisms. The mode of nutrition and multiplication of bacteria according to the physico-chemical parameters of the environment will be studied.

The composition and role of the skin and digestive microbiota will be discussed.

The microbiological criteria used for the quality control of cosmetic and food products will be defined.

Physical and chemical antimicrobial agents to control microbial growth will be reviewed.

At the practical level, the student will be expected to know how to handle bacteria and to know the rules of microbiological safety. Usual techniques of microbiological controls and effectiveness of preservatives will be performed on cosmetic products.

Hourly volumes* :

CM : 12h

TP : 8h

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This module covers all the knowledge on raw materials necessary to work in the cosmetic industry.

These are:

• to describe the different chemical classes of raw materials, to understand the structure/activity relationships as well as the sensory rendering.
• The study of documents related to the marketing of cosmetic raw materials

Hourly volumes* :

            CM : 18

            TD : 6

            TP : 16

The course is based on case studies of ingredients in aqueous or fatty phases, and both polymers and polymerization processes will be developed.

The practical part of the module will allow the implementation of major categories of raw materials:

Implementation of gelling agents: implementation, study of their properties, sensory evaluation

Implementation of surfactants: Formulation of a foaming product with research of the ingredients, design of the formula and sensory evaluation

See full page

This EU addresses:

- the foundations of colorimetry, which allow to define an unambiguous measure of color from psychophysical experiments.

- the principle and practical use of color measuring devices (colorimeters and spectro-colorimeters).

- the principles of color reproduction, particularly in the context of perfumes and cosmetics.

Theoretical ideas are complemented by an important part of observation and manipulations during the practical sessions.

Hourly volumes* :

CM : 12h

TP : 8h

See full page

Study of the entire development of a cosmetic product

• Definition of a cosmetic product
• Launch of the development, interactions of the development department with the marketing, industry and regulatory departments: needs, expectations, operation and procedures
• Study of all possible tests: sensory analysis, physicochemical stability, safety and sanitary security, efficiency.
• Study of the industrial transposition
• Study of the interactions with the packaging and the associated tests
• Description of the product information file or legal cosmetic file

Study of emulsions, definitions, characteristics and formulation

Study of the instability phenomena of emulsions and stabilization solutions

Practical part:

Formulation of water-in-oil, oil-in-water and gel-cream emulsions

Study of ingredients, chemical nature, physical behavior and formulation

Study of the formulation material

Implementation of sensory, physicochemical and stability tests.

Development of a formula in several steps with imposed constraints.

Critical analysis of the results obtained.

For the introduction to chemical engineering applied to the field of cosmetics, students will have to work on a case study that describes the laboratory scale production of a cosmetic product, and then find a way to produce it at a larger scale.

Hourly volumes* :

 CM :15

TP : 25

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This course allows the acquisition of basic knowledge and transversal skills in the field of colloids and interfaces, common to the different courses of the Master Chemistry (Chemistry of Materials, Separative Chemistry, Materials and Processes, ICAP Cosmetics Engineering, Chemistry of Biomolecules). It is also offered to international students entering the SFRI program at the University of Montpellier where the teaching is given in English. An introductory presentation on the basic notions and concepts will allow to discover and better understand the main physicochemical properties of colloidal dispersions, associative colloids, and macromolecular solutions, as well as the parameters and phenomena governing the stability in colloidal dispersions and mixed solution-colloid systems. Then, an interdisciplinary practical teaching based on the principle of the flipped classroom will be proposed to help students build and deepen their knowledge through an individual and collective analysis of the various applications of colloidal and interfacial phenomena and systems.

Hourly volumes* :

CM : 7

TD : 13

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Know and know how to apply the various regulations related to the cosmetics industry (Regulation 1223/2009, REACH, CLP, etc..)

To deepen the important articles of the European regulation in cosmetics - Regulation 1223/2009

Learn how to make a DIP

Focus on the safety report using an example

Hourly volumes* :

            CM : 10

            TD : 10

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This course will cover the fundamental concepts and practical tools related to chemometrics through : - statistical analysis of data ;

• laws of probability ;
• confidence interval estimation ;
• parametric and non-parametric tests.

An introduction to experimental design will be offered at the end of the module.

Hourly volumes* :

CM : 7h

TD : 13h

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This course is designed to teach liquid chromatography and gas chromatography.

Hourly volumes* :

            CM :15h

            TD : 5h

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The M1 ICAP apprentice student is put in a professional situation to carry out a project in response to an industrial problem. This project will be carried out under the responsibility of a member of the teaching team (academic or industrial). Carried out throughout the semester, this project aims to put into practice the knowledge/know-how acquired during the Bachelor's and early Master's degree. In addition to the disciplinary skills of chemistry, other relational, organizational and communication skills, intrinsically linked to project management, will also be acquired and will prepare the students for their future professional life.

Example of an industrial problem: evaluation of the oxidative stability of perfumed ingredients in the presence of antioxidants

Example of an industrial problem: analysis of allergens in perfumes: technique of solid phase microextraction (SPME) of the headspace (HS) followed by analysis by gas chromatography coupled to mass spectrometry (GC-MS)

Examples of industrial problems: detection and identification of compounds responsible for a taste defect or "off-flavour" by gas chromatography coupled with olfactometry

Examples of industrial problems: Know and know how to use the essential physico-chemical analysis techniques implemented during the control of a finished product

Hourly volumes* :

            CM : 5h

            TD : 5h

            Practical work : 40h

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This module focuses on R&D in the cosmetic industries and will emphasize scientific expertise and innovation through lectures and conferences. In addition, there will be case studies on the design and development of cosmetic and wellness products.

The practical part will focus on the development of make-up products:

Review of the composition of make-up products

The natural or synthetic coloring raw materials. To know the different galenics used in make-up and to know how to select the raw materials.

Know how to select pigments according to the desired target. Know how to disperse them and know the surface treatment.

Marketing study on defined make-up galenics

Theoretical courses on raw materials and galenics used in make-up, manufacturing process, as well as market trends and possible tests (claims, physico-chemical tests, efficiency tests, ...)

In practice:

Practical courses on pigment premixes, foundations and lipsticks, combined with sensory evaluations

Application to the formulation of various make-up products (foundation, lipstick, mascara, etc.) and quality control of finished products.

Hourly volumes* :

            CM : 20

            TD : 5

            TP : 15

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This teaching unit is mutualized for the MI students of the Master Chemistry: ICAP P1, ICAP P2, MAT P1, MAT P2, BM (semester S2). The following topics will be covered:

• The 12 Principles of Green Chemistry and the Units of Measurement in Green Chemistry ;
• Synthesis strategies in sustainable chemistry;
• Alternative or eco-compatible solvents for synthesis and extraction;
• Non-conventional activation techniques and applications.

CM : 13

TD : 7 H

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This UE corresponds to the work-study mission carried out in an R&D laboratory in the cosmetics and well-being industries.

The missions entrusted by the company to the student will be in line with the objectives of the Master's degree.

The duration of the student's work-study assignment follows the work-study schedule offered to partner companies.

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This UE will address in small groups or in a personalized way the pedagogical tools and good practices related to communication and professional insertion, through :

• knowledge, skills, competencies, attitudes and motivations assessments;
• awareness of job search techniques;
• CV and cover letter writing;
• rules of oral and written communication;
• mock job interviews.

Situations directly related to the sectors of activity targeted by the students' courses will be proposed.

TP : 20h

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This module focuses on:

• Tools and sources of information (patents, databases, journals, trade fairs and scientific days, etc.) and communication: knowing how to identify relevant sources of information, knowing how to analyze and use them, knowing how to communicate internally and externally.
• What is business intelligence, how to understand and use it
• Marketing fundamentals: presentation of what marketing does, presentation of tools that can help students in their future work, detailed explanation of the development process of a cosmetic product in marketing, and the different jobs available to students.

A project will be developed by the students.

Hourly volumes* :

CM :15h

TD : 5h

TP : 10h

Exit : 10 am

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An experimental design is the ordered sequence of trials of an experiment whose purpose is to test the validity of a hypothesis by reproducing a phenomenon and varying one or more parameters. Each test produces a data and all the data produced during an experiment must be analyzed by rigorous methods to validate or not the hypothesis. This experimental approach makes it possible to acquire new knowledge by confirming a model with a good economy of means (the smallest possible number of tests, for example).

Starting from a simple problem, the module develops methodological and statistical tools that allow to support more and more complex hypotheses in the most optimal way possible. The implementation of these methodologies is done via the statistical language R.

Hourly volumes* :

            CM : 15h

            Practical work : 5h

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To provide students with the theoretical understanding of inferential statistics necessary for the statistical analysis of data from sensory tests. General problem: extract interpretable regularities from sensory measurements to make the right decisions.

The lessons will cover the needs of each pathway, through examples and applications adapted to each.

Hourly volumes* :

            CM : 10 H

            PRACTICAL TRAINING : 10H

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Polymers are used in a large number of cosmetic formulations with various functions, the main ones being rheology control, formulation stabilization and as a conditioning agent. It is therefore important to know their behavior in these complex environments, especially by studying polymer-surfactant interactions since these two constituents are often present together in these environments, as well as interactions with solid surfaces (suspensions, applications on hair or skin) or liquids (emulsions).

The course describes: (1) the different types of polymers used: water soluble, synthetic, natural and semi-natural, amphiphilic and structure-property relationships, (2) principle of thickening formulas or gelling using polymers, (3) interactions with surfactants, presentation of the different types of surfactants and their physico-chemical properties in particular polymeric surfactants, (4) interactions with surfaces (skin, hair) as well as any type of solid surface, (5) principle of stabilization of emulsions and suspensions using polymers.

A second part of this module is devoted to silicones and their use in cosmetics:

The chemistry of silicones, silicones for cosmetics: categories, their uses and sensory effects with examples of application.

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Basic knowledge of skin structure and physiology: skin structure; sensory receptors; mechanical and thermal sensitivity.

Skin penetration; skin hydration and moisturizing products; seborrhea, acne; Dermocosmetic typologies: skin penetration; skin aging, infant skin; cellulite

Hourly volumes* :

            CM : 16

            TD : 4

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This module is devoted to the study of the main classes of cosmetic additives and to the study of natural, biotechnological and synthetic active ingredients.

The first part of this course will focus on the marine flora through the general composition and specificities of different algae. What is the place and effectiveness of marine flora in cosmetics?

The course will conclude with case studies and perspectives.

A second part will talk about the plant world in order to allow formulators and those responsible for regulatory issues to understand the implementation of plant molecules for their beneficial effects in relation to the main cosmetic indications. Essential oils: what are the production techniques, their chemical compositions, their cosmetic properties, their formulation, their safety of use?

The third part of the module will focus on the different classes of additives used in cosmetics.

The focus will be on the chemical and organoleptic study of the main raw materials (synthetic or natural) used in the perfuming of cosmetics and the regulatory constraints related to their use (cosmetic guidelines on the dosage of allergens).

The families of odorant molecules used in cosmetics (molecules without organic function or containing alcohol, aldehyde, ketone, ester functions) will be studied:
- molecules with an aromatic ring
- phenol type molecules
- cyclic and acyclic aliphatic molecules.
- acyclic and cyclic terpene molecules
- odor field.

-Notions of stability and volatility of molecules.

The course will conclude with an apprenticeship in the formulation of perfume compositions for cosmetic products.

Hourly volumes* :

            CM : 20

            TD : 10

            TP : 10

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What is eco-design? 

Product Life Cycle Assessment (LCA)
Who certifies?
Eco-design & raw materials
Biodiversity and Nagoya protocol.
Reminder on the principles of Green Chemistry
Eco toxicology and biodegradability
Manufacture of a cosmetic product in eco-design
The trends related to eco-design

Packaging in eco-design, what is their impact?

Notion of ecotoxicology: impact on the environment/biodegradability

Information on ecodesign measurement: what tools are available/impact measurement Recylability of packaging: measurement and analysis (raw materials/formulations/ecotoxicology).

Students will be offered a role-playing situation.

Hourly volumes* :

            CM : 20

            TD : 10

            TP : 10

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The objective of the course is to understand and apply the principles of color formulation as practiced in the color industry. For this purpose, the basics of spectrocolorimetry, light-matter interactions and the simplest formulation models (Beer-Lambert and Kubelka-Munk) are studied and used in practical work.

Hourly volumes:

            CM : 12

            TP : 8

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Reminder of European legislation and its hierarchy: regulations, directives, decisions, resolutions, national laws, institutions and authorities in charge of the regulatory system.

Description of the main regulations around the world and a global view of progress

Institutions and authorities in charge of the regulatory system

Regulatory framework applied to cosmetic packaging

The compliance process for cosmetic packaging and its main difficulties

New requirements for cosmetic packaging under European and French laws on the circular economy

The course will address the Good Manufacturing Practices (GMP) designed to ensure the reproducibility and quality of cosmetic products.

It will allow to know the measures to adopt regarding the processes of production, control, storage and shipment and to ensure the compliance of cosmetic products with the regulations in force (EC 1223/2009, ISO 22716 standard, etc.)

Hourly volumes* :

            CM : 15

            TD : 15

            Land : 10

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This module focuses on all aspects of photoprotection:

It will begin with a reminder of the sun's rays and the skin, with an emphasis on natural melanin and non-melanin photoprotection. The skin's reaction to the sun will allow us to discuss the benefits of the sun but will focus on the harmful side effects for the skin. What are the possibilities offered by the cosmetic industry to protect oneself? How to analyze the effectiveness of sunscreen products? What is the impact of filters on the environment?

• Study of the development of suncare formulas: raw materials, chemical and physical filters, formulation techniques, regulations, the relationship between the sun and the skin.

• Use of software to calculate theoretical SPF

• Acquire knowledge in the formulation of suncare products
• Manufacturing processes
• Fine analysis of INCI formulas

• Formulation of microemulsion by phase inversion

Hourly volumes* :

            CM : 15

            TP : 25

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This teaching unit has several components:

• The lessons will show that chemistry opens up to various professions in the field of cosmetics, and not only to formulation.

• To know how to bring a reflection on the scientific method in order to avoid errors of judgment and to know how to bring a scientific reflection in front of any information. The teaching will be based on concrete examples related to cosmetics (difference between risk and danger, reflection on various applications/consumer information, etc.)

• The course is based on concrete marketing projects, from market research to the formalization of a marketing concept in cosmetics.

Hourly volumes* :

            CM : 12

            TD : 8

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In-depth study of the different cosmetic galenic forms: composition, description of the main components, formulation, principle, galenic forms

Study of ingredient families including emollients, esters, emulsifiers, sunscreens, preservatives and innovation in skin care and make-up products

Study of the INCI list of formulations, INCI nomenclatures

Study of the different types of cosmetic companies

Study of manufacturing processes (agitation equipment, complementary manufacturing processes, impact of physical and chemical parameters on manufacturing)

The application will be in different areas.

For example: formulation of moisturizing emulsions with electrolytes (stability disrupting elements), formulation of cleansing milk and cleansing lotion and the implementation of tests to measure the effectiveness of the cleansing, formulation of make-up products.

Hourly volumes* :

            CM : 15

            TP : 25

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This module will allow students to understand the importance of innovation in a sector as dynamic as cosmetics.

This environment is indeed governed by regulatory constraints, innovations in packaging, innovations in formulation but also in ingredients.

This is also governed by the expectations of increasingly demanding consumers.

It is therefore essential for these future graduates to understand the ins and outs of innovation in cosmetics and to know how to implement it while respecting certain criteria.

A project will be proposed to the students: Presentation of the project in group and setting up of the instructions for its realization.

Hourly volumes* :

            CM : 20

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This 5 to 6 month internship or work-study program will be carried out in an R&D laboratory in the cosmetics and well-being industries.

The missions entrusted by the company to the student intern will be related to the objectives of the Master.

This internship or work-study assignment will be carried out in France or abroad.

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The objectives of the course are to explain the macroscopic behavior of systems by their microscopic description and to present the universal characteristics in the study of thermodynamic systems.

1. Reminder of thermodynamics
2. A more general approach to statistical thermodynamics

III. Generalities on systems of identical particles without interaction

1. Applications of Boltzmann statistics
2. An example of the use of another statistic: blackbody radiation.

Hourly volumes* :

CM : 30

TD : 10

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NMR:

NMR (Nuclear Magnetic Resonance) in liquid phase is an essential spectroscopic method of analysis for the chemist, allowing in particular to determine the structure of small organic molecules or macromolecules in solution, the study of dynamic phenomena... The objective of this course is to understand the phenomena involved in this technique and to relate them to the various structural information accessible by this method. The aim is to be able to exploit the spectral data resulting from this analysis to elucidate the structure and stereochemistry of organic molecules or polymer structures, or to carry out reaction monitoring.

X-ray diffraction:

X-ray diffraction is a powerful and non-destructive technique for characterizing the crystal structure of materials, but it is also able to provide crystallographic and structural information such as lattice parameters and atomic positions. This includes all crystallized materials such as ceramics, materials for energy and information storage and transformation as well as organic molecules and metal complexes (interatomic distances and angles, stereochemistry (chirality, stereoisomerism...), intra and intermolecular bonds...). The objective of this course is an introduction to crystallography and diffraction, with the aim of understanding the operation and characteristics of an X-ray diffractometer, as well as the interpretation of diffraction patterns (structural analysis, lattice parameters).

Hourly volumes* :

            CM : 10

            TD : 10

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The HAC720C module deals, in 5 main parts, with "advanced inorganic materials". The^1st part is dedicated to the generalities of inorganic materials and approaches the structure-properties relations; a particular attention is brought to the chemical bond, the real crystal, and the polycrystalline solid; the various classes of inorganic materials are described. The ^2nd part deals with ceramic materials (definitions and properties) and their synthesis (raw materials including clays, shaping, drying and debinding, sintering); a distinction is made between traditional ceramics and technical ceramics (synthesis routes for oxide and non-oxide ceramics). The^3rd part concerns glasses (classification and synthesis routes) and glass-ceramics (devitrification and soft chemistry); their properties and applications are also discussed. The^4th part is dedicated to metals: properties of metals and metallic alloys; metallic nanoparticles; and, catalytic materials. The ^5th part is dedicated to inorganic materials developed for energy; ceramics (oxides and non-oxides; nanostructured) and metal hydrides are described (properties and syntheses) through several examples and in the context of their applications (accumulators, hydrogen storage and carbon dioxide capture)

Hourly volumes* :

CM : 13h

TD : 7h

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- Reminder of thermodynamics of single component systems.

- Basic notions of thermodynamics of multicomponent systems. Chemical potential, Gibbs-Duhem relation, variance.

- Knowledge of thermal analysis techniques that allow the construction of binary/ternary diagrams: TGA, DTA and DSC

- Construction and interpretation of binary phase diagrams from thermodynamic quantities. Diagrams of Gibbs free enthalpy, pressure and temperature as a function of the composition of the binary mixture. Liquid-liquid, liquid-vapor, solid-liquid mixtures.

- Phase transformation: first and second order transitions, critical points. Examples.

- The supercritical state: definition, thermodynamic properties, most extensive industrial applications.

- Construction and interpretation of ternary phase diagrams: variance, definitions of ternary eutectic, first and second order peritectic, isothermal section, study of cooling of alloys.

Hourly volumes* :

CM :13

TD :7

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This course will cover the fundamental concepts and practical tools related to chemometrics through : - statistical analysis of data ;

• laws of probability ;
• confidence interval estimation ;
• parametric and non-parametric tests.

An introduction to experimental design will be offered at the end of the module.

Hourly volumes* :

CM : 7h

TD : 13h

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The first part of the course presents the fundamental knowledge of organometallic chemistry of transition metals. It starts with the description of the Metal-C bond allowing the understanding of its stability and chemical reactivity. In a second step, the power of this synthesis tool for the formation of C-H, C-C bonds, ... Examples of their applications in different fields will allow the acquisition of these reactions and their fields of applications: fine chemistry, catalytic transformations of industrial importance, synthesis of natural products, preparation of materials.

The second part of this course is dedicated to the chemistry of hetero-elements focused on the elements Silicon, Tin and Boron. This part aims at presenting the different methods of preparation of boron, tin and silicon reagents as well as the main transformations performed with these compounds, with applications in organic synthesis and materials synthesis.

CM : 13 H 

TD : 7 H

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The program of this course focuses on the description of the principles and applications of the main methods for the structural characterization of solids, thin films, surfaces and interfaces, as well as several examples of applications in materials chemistry. It includes the following techniques.

• Introduction to solid state NMR (NMR signal, Interactions in solid state NMR, Magic angle rotation, NMR sequences, Cross polarization, Instrumentation, etc.)
• Electron microscopy: principle and application of scanning and transmission electron microscopies and correlated techniques (EDS microanalysis).
• Spectroscopic methods: Raman spectroscopy, photoelectron spectroscopy, X-ray spectroscopies (XAS, XRF, etc.), Mössbauer spectrometry.

Hourly volumes* :

            CM : 10 h

            TD : 10 h

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This lecture, entirely provided in English, gives a basic introduction into crystallography and electron diffraction for beginners. X-ray diffraction is an important characterization technique in modern chemistry the majority of crystalline structures in inorganic and organic solids have been solved by this method. It is therefore of importance for all students to have an understanding of its basic concepts and instrumentation. The course provides explanations and principles of X-ray diffraction together with the geometry and symmetry of X-ray patterns. Beside interaction principles of X-rays and matter, it treats how to obtain quantitative intensities for single crystal and powder diffraction patterns. It naturally includes the understanding of lattice planes and the reciprocal lattice concept together with the Ewald sphere construction. Further on it gives a basic understanding of the Fourier transform relation between the crystalline structure and the diffracted intensities as well as the reciprocal lattice concept.

Electron diffraction is a complementary technique to X-rays that provides information in terms of symmetry and geometry on the materials studied. In this course, we will therefore approach the description of the method for obtaining electron diffraction pattern and their interpretation. We will be able to obtain the lattice parameters, the reflection conditions as well as the groups of possible spaces.

This lecture serves also as the introductory part to the lecture Electron Microscopy and Crystallography II

CM :14

TD :6

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This teaching unit is dedicated to the deepening of the bases of organic chemistry and coordination chemistry seen in L3 and to the acquisition of notions related to molecular engineering and molecular chemistry. The UE includes lectures and tutorials. The students will work before some lectures and tutorials with course documents provided so that the lectures and tutorials can allow them to be fully involved in the training, to understand the concepts presented and the skills to be acquired. The progression program and activities will be proposed. For those students who have not seen the basics of coordination chemistry and organic chemistry, the documents will be made available.

Coordination chemistry: The teaching will cover the different aspects of transition metal and lanthanide complexes, molecular materials (polynuclear complexes and coordination polymers with extended structures (MOFs, etc.)) and their properties and applications. Structural aspects, bonding description, properties, as well as stability and reactivity aspects will be discussed. Emphasis will be put on the complexation effect and on the stability of metal, lanthanide and actinide complexes with certain ligands for applications in the biomedical field (imaging and therapy), decontamination (nuclear field), etc. The electronic (relaxivity, magnetism) and optical (absorption, luminescence) properties of these complexes will be discussed and put in the context of applications in various fields, such as imaging, electronics, sensors, etc.

Organic Chemistry: The teaching is based on the knowledge acquired in the Bachelor's degree and will approach through a reasoned study the main reaction mechanisms of organic chemistry and will allow to give a common base to all the students of the Master Chemistry. The main processes (substitution, addition, elimination, transposition...) and their essential characteristics and applications to mechanistic sequences will be examined. This course should provide the student with general tools for the analysis of mechanisms (ionic, radical, concerted) in order to understand these mechanisms in their variety.

Hourly volumes* :

CM : 13 H

TD : 7 H

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The professionalization project provides a link between the traditional practical work and the internship in a laboratory or company. It is carried out in the form of a tutored project consisting of putting the student in a professional situation through collaborative (group) work based on the realization of a project in response to a problem set by a company, community, association or academic. It is part of the core curriculum of the Chemistry Master's program and is carried out under the responsibility of a member of the teaching team (university or industry). Carried out throughout the semester, this project aims to relate and anchor the knowledge/know-how acquired in the framework of the Bachelor's degree and the beginning of the Master's degree through this professional situation. These situations will be directly linked to the Master's program chosen by the students. In addition to the disciplinary skills of chemistry, other relational, organizational and communication skills, intrinsically linked to project management, will also be acquired and will arm the students for their future professional life.

Answer a research problem: example of synthesis of new phosphorescent materials.

Hourly volumes* :

CM : 5h

TD : 5h

Practical work : 40h

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This teaching module aims at providing and understanding the theoretical bases associated with some modeling methods found in different domains, from "small molecules" to life and materials. This module aims to answer, in part, three questions: 1) Why model? 2) What to model? 3) How to model?

Hourly volumes* :

CM : 14

TP : 6

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An internship of 2 to 4 months must be carried out in a research or research and development laboratory specialized in theoretical chemistry. Thus, students will have the opportunity to do this internship in academic or private research laboratories. Subject to the prior approval of the teaching staff (internship subject related to the master's courses and adequate environment/means), the student will be able to look for a host team in an academic environment in the institutes of the Chemistry Pole of the University of Montpellier, in academic laboratories outside the University of Montpellier (in France or abroad) or in the private sector (chemical, pharmaceutical industries, ...)

This 2 to 4 month internship may begin in mid-May after the examination session and may not exceed 4 months.

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This course provides the theoretical basis for the analysis of the microscopic origin of unusual physico-chemical properties.

The properties that are crucial because of the intensity of the research they generate and their technological applications are addressed: electronic transfer, magnetism, photomagnetism, bistability, conduction, etc. Several types of compounds will be studied: molecular switches, mono- and multi-radical aromatic molecules and assembly strategy of ordered organic structures with high spin, spin transition compounds, magnet molecules, ferro-, antiferro- or ferrimagnetically coupled poly-metallic complexes.

1. Derivation of simple models for strongly correlated systems (Heisenberg).
2. Hydrocarbon compounds: aromaticity and magnetic properties of cyclic and polycyclic polyradical systems.
3. Monometallic complexes: compounds with spin transition (crystal field and ligand field theories, bistability concept). Magnetically anisotropic compounds (spin-orbit coupling), towards molecular magnets (hysteresis)...
4. Bimetallic complexes: electronic transfer (molecular switches) in mixed valence compounds and spin exchange in magnetic compounds (ferro- and antiferromagnetic couplings), photomagnetism.

Hourly volumes* :

CM : 24

TP : 8

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This course aims to deepen and complete the knowledge acquired from a theoretical point of view in
spectroscopy by the students during their undergraduate studies.

Hourly volumes* :

CM : 15

TD : 9

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This UE will address in small groups or in a personalized way the pedagogical tools and good practices related to communication and professional insertion, through :

• knowledge, skills, competencies, attitudes and motivations assessments;
• awareness of job search techniques;
• CV and cover letter writing;
• rules of oral and written communication;
• mock job interviews.

Situations directly related to the sectors of activity targeted by the students' courses will be proposed.

TP : 20h

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The electronic and optical properties of solids are at the heart of many applications in the field of energy (photovoltaic panels, passive coolants...), light production (white diodes, lasers...), electronics (components, microprocessors...). After an introduction to these different fields of application, this course aims to define the different concepts necessary to master both the electronic and optical properties of materials, which are essential for understanding the most modern technologies.

Hourly volumes* :

            CM : 11H

            TD : 9H

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A general approach to the coordination chemistry of the f-elements will be developed through the notions of atomistics, oxidation state and coordination polyhedron in order to highlight the specific characteristics of the f-elements. Direct comparisons will be made with the coordination chemistry of the transition elements and applications to nuclear chemistry will be discussed.

Hourly volumes* :

            CM : 12h

            TD : 8h

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Examples of homogeneous catalysis reactions will be presented, with emphasis on the underlying concepts and the limitations of theoretical approaches (mainly DFT). Olein metathesis and polymerization examples will illustrate supported catalysis, with emphasis on the influence of the support.

Various examples will illustrate the specificity of nanocatalysts, distinguishing the respective role of electronic and geometrical factors.

Hourly volumes* :

CM : 20

TD : 10

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The objective is to acquire strong skills in theoretical chemistry through the discovery or the deepening of various themes.

This module is organized in two phases: (i) online courses/seminars, delivered throughout the first semester; (ii) one week of intensive training at the beginning of January, on one of the sites of the South-West pole of the French Theoretical Chemistry Network (Bordeaux, Montpellier, Pau, Toulouse).

Topics include:

- quantum chemistry and relativity

- Monte-Carlo methods

- exploration of potential energy surfaces

- calculation of the electronic structure of periodic systems

- quantum dynamics

- calculation of spectroscopic properties

Hourly volumes* :

CM : 40

TD : 20

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This module is a preparation for the pursuit of doctoral studies in the field of theoretical chemistry and especially in the field of quantum chemistry. Recent methodological developments and the development of more and more powerful software have democratized the use of quantum chemistry software.

The module contains teachings in the fields of electronic structure and molecular dynamics. The formalism of the different methods and their field of application will be detailed to allow an enlightened use of theoretical chemistry software and in particular quantum chemistry.

(1) electronic structure

- Hartree-Fock

- electronic correlation, configuration interaction, coupled cluster

- Density Functional Theory (DFT)

(2) nuclear dynamics

- classical and ab initio dynamics (Car Parrinello, Born-Oppenheimer, "propagators", thermodynamic sets, free energy calculation)

- quantum dynamics of photo-induced processes (wave packet, adiabatic and non-adiabatic dynamics, link with the absorption spectrum, diabatic representation, mixed classical-quantum dynamics)

Hourly volumes* :

CM : 10

TD : 20

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To present the methods that allow the exploration of the physico-chemical properties of materials by numerical calculation. To give the mathematical foundations of the numerical tools presented in the framework of the "Modeling" course in M1 and to complete the applications approached in the framework of this course.

Hourly volumes* :

CM : 28

TD : 12

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During this course, students will learn about the main numerical methods used in scientific software and more specifically in theoretical chemistry programs.

Hourly volumes* :

CM : 21

TD : 9

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To present the methods that allow the exploration of the physico-chemical properties of materials by numerical calculation. To give the mathematical foundations of the associated numerical tools.

I- Introduction

II- Quantum approach: molecular methods: quantum mechanics, Schrödinger equation, DFT methods.

III- Quantum approach: periodic systems

IV- Molecular dynamics: classical approach

Hourly volumes* :

CM : 30

TD : 10

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An internship of 5 to 6 months must be carried out in a research or research and development laboratory specialized in theoretical chemistry. Thus, students will have the opportunity to do this end-of-study internship in academic or private research laboratories. Subject to the prior approval of the teaching staff (internship subject related to the master's courses and adequate environment/means), the student will be able to look for a host team in an academic environment in the institutes of the Chemistry Pole of the University of Montpellier, in academic laboratories outside the University of Montpellier (in France or abroad) or in the private sector (chemical, pharmaceutical industries, ...)

This 5 to 6 month internship may begin in mid-January after the exam session and may not exceed 6 months for a period in semester 10 during the validity of the university registration.

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Fluorinated biomolecules. Current developments of fluorinated molecules. Methods of fluorination: nucleophilic or electrophilic mono-fluorination, introduction of difluoromethyl or trifluoromethyl groups. Contribution of fluorine atoms in the activity of these compounds. Examples of syntheses of fluorinated compounds used as antitumor agents, antiviral agents, antidepressants, anxiolytics, anti-inflammatories...

Phosphorus biomolecules. Structure, nomenclature, reactivity, structural analysis and applications.

Some synthetic routes of compounds of each of the treated families will be discussed, highlighting, if necessary, non-conventional activation methods. Biomedical applications will be targeted, as well as other applications in agrochemistry, optoelectronics, nanomaterials, ...

Hourly volumes* :

CM : 15 h (7,5h Fluorinated biomolecules and 7,5h Phosphorated biomolecules)

TD : 5 h

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This course allows the acquisition of basic knowledge and transversal skills in the field of colloids and interfaces, common to the different courses of the Master Chemistry (Chemistry of Materials, Separative Chemistry, Materials and Processes, ICAP Cosmetics Engineering, Chemistry of Biomolecules). It is also offered to international students entering the SFRI program at the University of Montpellier where the teaching is given in English. An introductory presentation on the basic notions and concepts will allow to discover and better understand the main physicochemical properties of colloidal dispersions, associative colloids, and macromolecular solutions, as well as the parameters and phenomena governing the stability in colloidal dispersions and mixed solution-colloid systems. Then, an interdisciplinary practical teaching based on the principle of the flipped classroom will be proposed to help students build and deepen their knowledge through an individual and collective analysis of the various applications of colloidal and interfacial phenomena and systems.

Hourly volumes* :

CM : 7

TD : 13

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This course is designed to teach liquid chromatography and gas chromatography.

Hourly volumes* :

            CM :15h

            TD : 5h

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Knowledge of gas chromatography and electron impact ionization mass spectrometry and quadrupole mass analyzer techniques for the analysis of volatile organic molecules.

1) GC-MS analyses of volatile organic compounds:

• Electron impact ionization (EI) techniques
• Chemical ionization (CI) techniques
• Quadrupole analysis techniques (Q)
• GC/MS Couplings

2) Applications in organic chemistry analysis, characterization of volatile samples.

Hourly volumes* :

CM : 15 H

TD : 5 H

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Knowledge of the main families of polymers used in the biomedical field.

1) Specificity of polymers for biomedical applications and main families of polymers used

2) Description of the application families

3) Discussion on the notion of synthesis and the structure/property/software relationship

Hourly volumes* :

CM : 15 H

TD : 5 H

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This course deals concisely and systematically with all aspects of heterocycle chemistry, from nomenclature to applications such as the principles of action of drugs, toxins or drugs, pigments, food coloring etc...

Hourly volumes* :

CM : 15 H

TD : 5 H

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Natural products occupy a major place in the field of biomolecular chemistry. They represent an important source of bioactive compounds for medicinal chemistry. This course provides a comprehensive overview of the secondary metabolism and origin of natural products from plants. The emphasis in this unit will be on the organic chemistry behind the various biotransformations that occur during the biosynthesis of each major class of molecules. A mechanistic approach will be used to understand the chemical basis of each transformation.

Hourly volumes* :

CM : 13 

TD : 7

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NMR:

NMR (Nuclear Magnetic Resonance) in liquid phase is an essential spectroscopic method of analysis for the chemist, allowing in particular to determine the structure of small organic molecules or macromolecules in solution, the study of dynamic phenomena... The objective of this course is to understand the phenomena involved in this technique and to relate them to the various structural information accessible by this method. The aim is to be able to exploit the spectral data resulting from this analysis to elucidate the structure and stereochemistry of organic molecules or polymer structures, or to carry out reaction monitoring.

X-ray diffraction:

X-ray diffraction is a powerful and non-destructive technique for characterizing the crystal structure of materials, but it is also able to provide crystallographic and structural information such as lattice parameters and atomic positions. This includes all crystallized materials such as ceramics, materials for energy and information storage and transformation as well as organic molecules and metal complexes (interatomic distances and angles, stereochemistry (chirality, stereoisomerism...), intra and intermolecular bonds...). The objective of this course is an introduction to crystallography and diffraction, with the aim of understanding the operation and characteristics of an X-ray diffractometer, as well as the interpretation of diffraction patterns (structural analysis, lattice parameters).

Hourly volumes* :

            CM : 10

            TD : 10

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Knowledge of the latest mass spectrometry techniques for the qualitative analysis of organic molecules and biomolecules.

1) Description of Fundamentals (Ion Science and Technology):

- Ionization techniques

- Analysis techniques

- Tandem mass spectrometry (MS/MS)

- LC/MS and LC/MS/MS couplings

2) Application in the context of biomolecule analysis and organic chemistry reaction monitoring.

Hourly volumes* :

CM : 15 H

TD : 5 H

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This course will cover the fundamental concepts and practical tools related to chemometrics through : - statistical analysis of data ;

• laws of probability ;
• confidence interval estimation ;
• parametric and non-parametric tests.

An introduction to experimental design will be offered at the end of the module.

Hourly volumes* :

CM : 7h

TD : 13h

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The first part of the course presents the fundamental knowledge of organometallic chemistry of transition metals. It starts with the description of the Metal-C bond allowing the understanding of its stability and chemical reactivity. In a second step, the power of this synthesis tool for the formation of C-H, C-C bonds, ... Examples of their applications in different fields will allow the acquisition of these reactions and their fields of applications: fine chemistry, catalytic transformations of industrial importance, synthesis of natural products, preparation of materials.

The second part of this course is dedicated to the chemistry of hetero-elements focused on the elements Silicon, Tin and Boron. This part aims at presenting the different methods of preparation of boron, tin and silicon reagents as well as the main transformations performed with these compounds, with applications in organic synthesis and materials synthesis.

CM : 13 H 

TD : 7 H

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This teaching unit is dedicated to the deepening of the bases of organic chemistry and coordination chemistry seen in L3 and to the acquisition of notions related to molecular engineering and molecular chemistry. The UE includes lectures and tutorials. The students will work before some lectures and tutorials with course documents provided so that the lectures and tutorials can allow them to be fully involved in the training, to understand the concepts presented and the skills to be acquired. The progression program and activities will be proposed. For those students who have not seen the basics of coordination chemistry and organic chemistry, the documents will be made available.

Coordination chemistry: The teaching will cover the different aspects of transition metal and lanthanide complexes, molecular materials (polynuclear complexes and coordination polymers with extended structures (MOFs, etc.)) and their properties and applications. Structural aspects, bonding description, properties, as well as stability and reactivity aspects will be discussed. Emphasis will be put on the complexation effect and on the stability of metal, lanthanide and actinide complexes with certain ligands for applications in the biomedical field (imaging and therapy), decontamination (nuclear field), etc. The electronic (relaxivity, magnetism) and optical (absorption, luminescence) properties of these complexes will be discussed and put in the context of applications in various fields, such as imaging, electronics, sensors, etc.

Organic Chemistry: The teaching is based on the knowledge acquired in the Bachelor's degree and will approach through a reasoned study the main reaction mechanisms of organic chemistry and will allow to give a common base to all the students of the Master Chemistry. The main processes (substitution, addition, elimination, transposition...) and their essential characteristics and applications to mechanistic sequences will be examined. This course should provide the student with general tools for the analysis of mechanisms (ionic, radical, concerted) in order to understand these mechanisms in their variety.

Hourly volumes* :

CM : 13 H

TD : 7 H

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The professionalization project provides a link between the traditional practical work and the internship in a laboratory or company. It is carried out in the form of a tutored project consisting of putting the student in a professional situation through collaborative (group) work based on the realization of a project in response to a problem set by a company, community, association or academic. It is part of the core curriculum of the Chemistry Master's program and is carried out under the responsibility of a member of the teaching team (university or industry). Carried out throughout the semester, this project aims to relate and anchor the knowledge/know-how acquired in the framework of the Bachelor's degree and the beginning of the Master's degree through this professional situation. These situations will be directly linked to the Master's program chosen by the students. In addition to the disciplinary skills of chemistry, other relational, organizational and communication skills, intrinsically linked to project management, will also be acquired and will arm the students for their future professional life.

Answer a research problem: example of synthesis of new phosphorescent materials.

Hourly volumes* :

CM : 5h

TD : 5h

Practical work : 40h

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The internship in semester 8 of the Master 1 Chemistry of Biomolecules aims to familiarize students with research careers in life chemistry. Thus, the students will have the possibility of carrying out this training course of initiation to research within academic or private laboratories. Subject to prior acceptance by the teaching staff (internship subject related to the Master's courses and adequate environment/means), the student may look for a host team in an academic environment in the institutes of the Chemistry Pole of the University of Montpellier (IBMM, ICGM, ...), in academic laboratories outside the University of Montpellier (in France or abroad) or in the private sector (chemical, pharmaceutical, agri-food industries, biotech laboratories, ...).

Field : 2 to 4 months of internship

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Nucleosides are the basic constituents of nucleic acids (DNA and RNA). As such, they play an essential role in many biological processes. In this course, the structure and biological role of natural nucleosides will be presented. The main synthesis and characterization routes of these compounds and their analogues (glycosylation reactions, structural modifications of the furanose ring, substitution and introduction of heteroatoms, configuration inversion, etc.) will also be discussed. The use of nucleoside analogues for the treatment of viral pathologies and cancers will also be discussed.

Hourly volumes* :

CM : 3 pm

TD : 5 h

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This teaching unit is mutualized for the MI students of the Master Chemistry: ICAP P1, ICAP P2, MAT P1, MAT P2, BM (semester S2). The following topics will be covered:

• The 12 Principles of Green Chemistry and the Units of Measurement in Green Chemistry ;
• Synthesis strategies in sustainable chemistry;
• Alternative or eco-compatible solvents for synthesis and extraction;
• Non-conventional activation techniques and applications.

CM : 13

TD : 7 H

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The medicinal chemistry course aims to introduce students to the key steps in the development process of molecules with biological activities. In particular, a description of the interactions involved, the notion of pharmocophores, bio-isosteria..., as well as structure-activity relationship studies will be addressed in order to consider strategies and adequate structural modifications.

Hourly volumes* :

CM : 3 pm

TD : 5 h

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After generalities on the notions of prochirality and stereochemistry, this teaching will present the tools allowing the mastery of diastereoselective and enantioselective syntheses. The different approaches will be presented in a detailed and rational way. Examples of industrial syntheses of chiral bioactive molecules will be discussed.

Hourly volumes* :

CM : 15 H

TD : 5 H

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This course discusses synthetic methods applied to obtain enantiopure amino acids as well as the use of chiral amino acids for the synthesis of other enantiopure compounds.

These amino acids are the basic elements of peptides. The different physico-chemical properties induced by the nature of these amino acids will allow to define strategies for the synthesis of peptides of interest and their characterization.

Hourly volumes* :

CM : 15 H

TD : 5 H

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The following topics will be covered:

- Biobased solvents

- Fuels from biomass

- Antioxidants derived from lignin

- Metal catalysts from plants

- Surfactants obtained from renewable resources

- Examples of industrial applications of enzymatic synthesis

Hourly volumes* :

CM : 15

TD : 5

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This UE will address in small groups or in a personalized way the pedagogical tools and good practices related to communication and professional insertion, through :

• knowledge, skills, competencies, attitudes and motivations assessments;
• awareness of job search techniques;
• CV and cover letter writing;
• rules of oral and written communication;
• mock job interviews.

Situations directly related to the sectors of activity targeted by the students' courses will be proposed.

TP : 20h

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