Nucleic acids

Discusses the structure and function of nucleic acids. Reviews methods used to synthesize DNA- and RNA-based oligonucleotides, as well as chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and siRNA oligonucleotides, and DNA arrays.

Hourly Volumes*:

            CM: 3:00 p.m.  

            TD: 5 hours

The lecture aims to provide students with the fundamentals of oligonucleotide synthesis and to help them understand the implications and recent applications in the fields of diagnostics and therapeutics.

Organic Chemistry (Master's Level 1)

2-hour final written exam

Authorized documents: No

Non-graphical calculators allowed: yes

Internet access allowed: No

Class: 15 hours

DNA is a complex molecule that carries the information necessary for all forms of life. However, in the most basic sense, DNA is a chemical molecule whose properties and structure determine its ability to encode genetic information, as well as its susceptibility to degradation. These concepts will be explored from the perspective of the fundamental chemistry of nucleic acids.

1. This course will explore the chemical nature of genetic material from the perspective of chemical biology.
2. We will explore the structure, function, and reactivity of nucleic acids, as well as the mechanisms by which DNA can be damaged and repaired.
3. We will examine how the chemical synthesis of oligonucleotides is integrated into biotechnology and advanced therapies, and how this affects society.

TD: 5H

The concepts presented in a lecture-style format will be reinforced through classroom discussions of articles from scholarly journals.