Peptides and proteins

Peptides and proteins are composed of a sequence of amino acid residues that give them specific properties. Their functionality depends on their sequence and thus on the chemical functions they carry, and is also greatly modulated by their structure. In addition to conventional peptide synthesis, advanced functional modification options, structures, and properties that can significantly modify or improve the properties of the resulting peptide will be developed. Significant biotechnological developments in both the chemical and biological fields will be discussed leading to a wide range of applications in which peptides and proteins are successfully used.

Hourly volumes*:

CM :15

TD :5

Knowledge and Skills :

Structure and biological role of peptides and proteins

Synthesis of peptides and modified peptides on solid support

Chemical modifications of peptides and proteins

Level M1 Organic Chemistry, Chemistry of Biomolecules, mastery of peptide synthesis strategies in solution

Final exam 2h

Course (15h): Support(s) available on ENT (Moodle) : Course documents, TD documents, exam annals and reference publications.

TD (5h): Case studies: application of strategies for the synthesis of peptides of interest, study of publications covering the different concepts.

1. Basics (4,5h)

I.1 Peptide and Protein functions

I.2 Classification and Conformation of peptides and proteins

I.3 Post-translational Modifications

1. Solid Phase Peptide Synthesis (3h)

II.1 Basics

II.2 Automated Synthesis

II.3 Treatment/Purification

1. Protein Ingeniering (3h)

II.1 Synthesis/ Characterization

II.2 Non canonical Aminoacids Incorporation

II.3 Ligation

III. Structural Consideration (3h)

III.1 Modified Peptides (cyclotides, stapple peptides)

III.2 Foldamers

IV Biological Application for Diagnosis and Therapy (6h)

IV.1 CPP (self-assembling)

IV.2 EDA

IV.3 PDC/ PROTAC

IV.4 ABP

Administrative contact(s):

Secretariat Master Chemistry

https://master-chimie.edu.umontpellier.fr/