Study level
BAC +4
ECTS
2 credits
Component
Faculty of Science
Description
This teaching unit is shared with MI students in the Chemistry Master's courses: ICAP P1, ICAP P2, MAT P1, MAT P2, BM (semester S2). The following topics will be covered:
- The 12 Principles of Green Chemistry and units of measurement in Green Chemistry ;
- Synthesis strategies for sustainable chemistry ;
- Alternative or eco-compatible solvents for synthesis and extraction;
- Non-conventional activation techniques and applications.
CM: 13
TD: 7 H
Objectives
Be able to: 1) select the most appropriate activation technique and solvent for the preparation of an organic molecule/material; 2) design synthesis processes with low environmental impact based on the 12 Principles of Green Chemistry and on synthesis strategies allowing a reduction of steps; 3) perform green chemistrymetrics.
Necessary prerequisites
Organic chemistry, L3 level
Reactivity basics
Knowledge control
Assessment of knowledge :
2-hour written final exam
- Authorized documents: no
- Non-graphic calculator allowed: yes
- Internet allowed: no
Syllabus
Course:
- The 12 principles of Green Chemistry and units of measurement (2h) ;
- Synthesis strategies in sustainable chemistry (3h) :
- Domino, cascade and multicomponent reactions,
- Catalysis (definitions, C-C, C-N, C-O coupling reactions and associated catalytic mechanisms) ;
- Alternative or eco-compatible solvents for synthesis andextraction (3 h);
- Ionic liquids (except biobased) and fluorinated phases (synthesis and properties), and examples of extraction in non-conventional media;
- sc-CO2 and SPE (Solid Phase Extraction): applications in the synthesis and (micro)extraction of fragrance molecules and cosmetics;
- Selected examples of laboratory and industrial-scale applications.
- Non-conventional activation techniquesand applications in synthesis and/or extraction (5 h) :
(For each technique, the principles of activation, instruments and applications will be illustrated by appropriate examples, depending on the course):
- Microwaves and continuous flow ;
- Mechanochemistry and solvent-free methods ;
- Ultrasound ;
- Examples of laboratory and industrial-scale applications of each technique;
- Biotransformations
TD (7H): Individual work, exercises to prepare before and during the session.
Case studies (exercises on the synthesis of alternative solvents, choice of solvent/activation method, exercises on the application of units of measurement in sustainable chemistry and interpretation of results, exercises on the synthesis of complex molecules using eco-compatible strategies/methods.