Liquid NMR spectroscopy and X-ray diffraction

RMN :

Liquid-phase NMR (Nuclear Magnetic Resonance) is an essential spectroscopic analysis method for chemists, enabling them to determine the structure of small organic molecules or macromolecules in solution, to study dynamic phenomena... The aim of this course is to understand the phenomena involved in this technique and to relate them to the different structural information accessible by this method. The aim is to be able to exploit the spectral data obtained from this analysis to elucidate the structure and stereochemistry of organic molecules or polymer structures, or to monitor reactions.

X-ray diffraction :

X-ray diffraction is a powerful, non-destructive technique not only for characterizing the crystalline structure of materials, but also for providing crystallographic and structural information such as lattice parameters and atomic positions. This includes all crystallized materials such as ceramics, materials for the storage and transformation of energy and information, as well as organic molecules and metal complexes (interatomic distances and angles, stereochemistry (chirality, stereoisomerism...), intra- and intermolecular bonds...). The aim of this course is to provide an introduction to crystallography and diffraction, with the aim of understanding the operation and characteristics of an X-ray diffractometer, as well as interpreting diffraction patterns (structural analysis, lattice parameters).

Hourly volumes* :

            CM: 10

            TD : 10

RMN :

Refine your knowledge of the phenomena involved in an NMR experiment.

Analyze spectral data from 1D 1H and 13C spectra, and relate them to the structure/stereochemistry of organic molecules, macromolecules or polymers.

X-ray diffraction :

Introduction to crystallography (lattice, crystal planes, symmetry) and crystal structure resolution (structure factor, intensities); operation of a diffractometer; interpretation of a diffraction pattern.

X-ray diffraction :

Physical chemistry L3

RMN :

Master the basic concepts of organic chemistry and spectroscopy.

Analytical chemistry, L3 level.

Assessment of knowledge will take the form of a final examination.

RMN :

Reminder of the fundamental principles of NMR (nuclear spin, Zeeman effect, magnetization, scalar coupling...)

1H NMR: coupling and stereochemistry. Exchangeable nuclei. Effect of chemical equilibria on spectra. Decoupling phenomenon.

13C NMR: broadband decoupling. T1 relaxation. Nuclear Overhauser Effect (NOE). Allocation techniques: APT, DEPT.

X-ray diffraction :

X-ray/matter interaction, diffraction, indexing, X-ray diffractometer, Bravais grating, crystal systems, structure factor, phase analysis, interpretation of X-ray diffractograms,

Administrative contact(s) :

Secretariat Master Chemistry

https://master-chimie.edu.umontpellier.fr/

Jean Protas: Diffraction of radiation, Dunod

1. and C. McKie: Essentials of Crystallography, Blackwell Scientific Publications
2. Borchardt-Ott: Crystallography: an introduction, Springer
3. Als-Nielsen, D. McMorrow: Elements of Modern X-ray Physics, Wiley