Study level
BAC +5
ECTS
2 credits
Component
Faculty of Science
Description
Peptides and proteins are made up of a sequence of amino acid residues, giving them specific properties. Their functionality depends on their sequence and thus on the chemical functions they carry, and is also greatly modulated by their structure. In addition to conventional peptide synthesis, advanced functional modification options, structures and properties that can significantly modify or enhance the properties of the resulting peptide will be developed. Significant biotechnological developments in both the chemical and biological fields will be discussed, leading to a wide range of applications in which peptides and proteins are successfully used.
Hourly volumes*:
CM :15
TD :5
Objectives
Knowledge and skills :
Structure and biological role of peptides and proteins
Solid-state synthesis of peptides and modified peptides
Chemical modification of peptides and proteins
Necessary prerequisites
Level M1 Organic Chemistry, Chemistry of Biomolecules, mastery of peptide synthesis strategies in solution
Knowledge control
Final exam 2h
Syllabus
Course (15h): Support(s) available on ENT (Moodle) : Course documents, TD documents, exam annals and reference publications.
TD (5h): Case studies: application of strategies for synthesizing peptides of interest, study of publications covering the various concepts.
- Basics (4.5h)
I.1 Peptide and Protein functions
I.2 Classification and Conformation of peptides and proteins
I.3 Post-translational Modifications
- Solid Phase Peptide Synthesis (3h)
II.1 Basics
II.2 Automated Synthesis
II.3 Treatment/Purification
- Protein Ingeniering (3h)
II.1 Synthesis/ Characterization
II.2 Non canonical Aminoacids Incorporation
II.3 Ligation
III. Structural Consideration (3h)
III.1 Modified peptides (cyclotides, stapple peptides)
III.2 Foldamers
IV Biological Application for Diagnosis and Therapy (6h)
IV.1 CPP (auto-assembling)
IV.2 ADC
IV.3 PDC/ PROTAC
IV.4 ABP
Further information
Administrative contact(s) :
Secretariat Master Chemistry
https://master-chimie.edu.umontpellier.fr/