Level of study
BAC +5
ECTS
2 credits
Component
Faculty of Science
Hourly volume
20h
Description
In this course, the different molecular or supramolecular tools for the delivery of active ingredients according to the type of cells or intracellular organelles targeted are discussed. Ligand-receptor interactions will be discussed as well as the methods of preparation and activation of conjugates. Examples of drugs will be presented.
Hourly volumes* :
CM : 15 H
TD : 5 H
Objectives
To know the molecular or supramolecular tools allowing the vectorization and targeted delivery of active ingredients.
Necessary pre-requisites
Chemistry of biomolecules level M1
Some notions of cell biology
Knowledge control
Final written exam of 2 hours:
- Authorized documents: no
- Non-graphic calculator allowed: yes
- Internet allowed : no
Syllabus
Course:
- non-viral gene therapy (lipoplexes, polyplexes) ;
- Targeted nanoparticles (PMO, MSN, silicon, etc. for 1photon or 2photon PDT, or cancer therapy; RPE effect);
- targeted therapeutic liposomes ;
- transport of active ingredients by cyclodextrins ;
- use of drug-antibody conjugates (DACs) for the treatment of certain cancers;
- targeting of the lysosome (LYTAC) for the degradation of pathogenic molecules.
TD: Study of publications
Additional information
Administrative contact(s):
Secretariat Master Chemistry
https://master-chimie.edu.umontpellier.fr/