Innovative synthesis and extraction processes

This teaching unit is mutualized for the MI students of the Master Chemistry: ICAP P1, ICAP P2, MAT P1, MAT P2, BM (semester S2). The following topics will be covered:

• The 12 Principles of Green Chemistry and the Units of Measurement in Green Chemistry ;
• Synthesis strategies in sustainable chemistry;
• Alternative or eco-compatible solvents for synthesis and extraction;
• Non-conventional activation techniques and applications.

CM : 13

TD : 7 H

Be able to: 1) select the most appropriate activation technique and solvent for the preparation of an organic molecule/material; 2) design low environmental impact synthesis processes based on the 12 Principles of Green Chemistry and on step-reducing synthesis strategies; 3) perform green chemistrymetrics.

Organic chemistry level L3

Basic concepts of reactivity

Knowledge control:

Final written exam of 2 hours

• Authorized documents: no
• Non-graphic calculator allowed: yes
• Internet allowed : no

Course:

1. The 12 principles of Green Chemistry and the units of measurement (2h) ;
2. Synthesis strategies in sustainable chemistry (3h) :

• Domino, cascade, multi-component reaction,
• Catalysis (definitions, C-C, C-N, C-O coupling reaction and associated catalytic mechanism) ;

1. Alternative or eco-compatible solvents for synthesis andextraction (3 h);

• Ionic liquids (except biosourced) and fluorinated phases (synthesis and properties), and examples of extraction in non-conventional media;
• _sc-CO2 and SPE (Solid Phase Extraction): applications in synthesis and (micro)extraction of odorant molecules and cosmetics
• Selected examples of laboratory and industrial scale applications.

1. Non-conventional activation techniquesand applications in synthesis and/or extraction (5 hrs):

(For each technique, the principles of activation, the instruments and the applications will be illustrated by examples adapted to the course):

• Microwave and continuous flow;
• Mechanochemistry and solventless methods;
• Ultrasound ;
• Examples of application of each technique at laboratory and industrial scale;
• Biotransformations

TD (7H): Individual work, exercises to prepare before and during the session.

Case studies (exercises on the synthesis of alternative solvents, choice of solvent/activation method, exercises on the application of units of measure in sustainable chemistry and interpretation of results, exercises on the synthesis of complex molecules by eco-compatible strategies/methods.