Nucleosides and derivatives

Nucleosides are the basic building blocks of nucleic acids (DNA and RNA). As such, they play an essential role in many biological processes. In this course, the structure and biological role of natural nucleosides will be presented. It will also cover the main routes to synthesis and characterization of these compounds and their analogues (glycosylation reactions, structural modifications of the furanose ring, substitution and introduction of heteroatoms, configuration inversion, etc.). The use of nucleoside analogues in the treatment of viral pathologies and cancers will also be addressed.

Hourly volumes* :

WC: 3 p.m.

TD: 5 h

Understand the structure and role of natural nucleosides. Understand the methods used to synthesize and characterize them and their analogues. Discuss their use in the treatment of viral/cancerous diseases.

L3 Organic chemistry

Written final examination 2h

• Authorized documents: no
• Internet allowed: no

Course: Inductive (problem-based) and deductive pedagogy Support(s) available on ENT (Moodle) : Course documents, TD documents, exam annals and reference publications

1. Structure and biological role of natural nucleosides (1.5 h)
2. Conformational analysis of nucleosides and analogues (1.5 h)
3. Synthesis and structural modifications of nucleosides (7.5 h)
4. Approach to carbonucleoside synthesis (3 h)
5. Application examples and mode of action of nucleosides used in antiviral/anti-tumor chemotherapy (1.5 h)

TD (5 h): Individual work, exercises to prepare before and during the session.

Teaching team :

Christophe Mathé

christophe.mathe @ umontpellier.fr (christophe.mathe @ umontpellier.fr)

Administrative contact(s) :

Secretariat Master Chemistry

https://master-chimie.edu.umontpellier.fr/