Nucleosides and derivatives

Nucleosides are the basic constituents of nucleic acids (DNA and RNA). As such, they play an essential role in many biological processes. In this course, the structure and biological role of natural nucleosides will be presented. The main synthesis and characterization routes of these compounds and their analogues (glycosylation reactions, structural modifications of the furanose ring, substitution and introduction of heteroatoms, configuration inversion, etc.) will also be discussed. The use of nucleoside analogues for the treatment of viral pathologies and cancers will also be discussed.

Hourly volumes* :

CM : 3 pm

TD : 5 h

Know the structure and role of natural nucleosides. Understand the methods of synthesis and characterization of these and their analogues. Address their uses in the treatment of viral/cancerous diseases.

L3 Organic Chemistry

Written final exam 2h

• Authorized documents: no
• Internet allowed : no

Course : Inductive (problematic) and deductive pedagogy Support(s) available on ENT (Moodle): Course documents, TD documents, exam annals and reference publications

1. Structure and biological role of natural nucleosides (1.5 h)
2. Conformational analysis of nucleosides and analogues (1.5 h)
3. Synthesis and structural modifications of nucleosides (7.5 h)
4. Approach to carbonucleoside synthesis (3 h)
5. Examples of application and mode of action of nucleosides used in antiviral/anti-tumor chemotherapy (1.5 h)

TD (5 h): Individual work, exercises to prepare before and during the session.

Teaching team :

Christophe Mathé

christophe.mathe @ umontpellier.fr (christophe.mathe @ umontpellier.fr)

Administrative contact(s):

Secretariat Master Chemistry

https://master-chimie.edu.umontpellier.fr/