Nucleosides and derivatives

Nucleosides are the basic building blocks of nucleic acids (DNA and RNA). As such, they play an essential role in many biological processes. This course will present the structure and biological role of natural nucleosides. The main methods of synthesis and characterization of these compounds and their analogues (glycosylation reactions, structural modifications of the furanose ring, substitution and introduction of heteroatoms, configuration inversion, etc.) will also be discussed. The use of nucleoside analogues for the treatment of viral diseases and cancers will also be addressed.

Hourly volumes:

CM: 3 p.m.

Tutorial: 5 hours

Understand the structure and role of natural nucleosides. Learn about methods for synthesizing and characterizing nucleosides and their analogues. Explore their uses in treating viral diseases and cancers.

L3 Organic Chemistry

2-hour written final exam

• Authorized documents: no
• Internet access: no

Course: Inductive (problem-based) and deductive teaching methods Materials available on the digital workspace (Moodle): Course documents, tutorial documents, past exam papers, and reference publications

1. Structure and biological role of natural nucleosides (1.5 hours)
2. Conformational analysis of nucleosides and analogues (1.5 hours)
3. Synthesis and Structural Modifications of Nucleosides (7.5 hours)
4. Approach to Carbonucléoside Synthesis (3 hours)
5. Examples of applications and modes of action of nucleosides used in antiviral/anti-tumor chemotherapy (1.5 hours)

Tutorial (5 hours): Individual work, exercises to be prepared before and during the session.

Teaching staff :

Christophe Mathé

christophe.mathe @ umontpellier.fr

Administrative contact(s):

Master's Program in Chemistry Secretariat

https://master-chimie.edu.umontpellier.fr/