Nucleosides and Derivatives

Nucleosides are the basic building blocks of nucleic acids (DNA and RNA). As such, they play an essential role in many biological processes. This course will cover the structure and biological role of natural nucleosides. The course will also cover the main pathways for the synthesis and characterization of these compounds and their analogs (glycosylation reactions, structural modifications of the furanose ring, substitution and introduction of heteroatoms, configuration inversion, etc.). The use of nucleoside analogs in the treatment of viral diseases and cancers will also be discussed.

Hourly volumes*:

CM: 3:00 p.m.

TD: 5 hours

Understand the structure and role of natural nucleosides. Learn about the methods used to synthesize and characterize these compounds and their analogs. Explore their uses in the treatment of viral diseases and cancers.

L3 Organic Chemistry

2-hour written final exam

• Authorized documents: No
• Internet access allowed: No

Course: Inductive (problem-based) and deductive pedagogy Materials available on the digital learning platform (Moodle): Course materials, tutorial materials, past exam questions, and reference publications

1. Structure and Biological Role of Natural Nucleosides (1.5 hours)
2. Conformational Analysis of Nucleosides and Analogs (1.5 hours)
3. Synthesis and Structural Modifications of Nucleosides (7.5 hours)
4. An Introduction to the Synthesis of Carbonucleosides (3 hours)
5. Examples of Applications and Mechanisms of Action of Nucleosides Used in Antiviral/Antitumor Chemotherapy (1.5 hours)

TD (5 hours): Independent work; exercises to be prepared before and during the session.

Teaching Staff :

Christophe Mathé

christophe.mathe @ umontpellier.fr

Administrative contact(s):

Master's in Chemistry Office

https://master-chimie.edu.umontpellier.fr/