Receptology

Receptors are of major interest in medicinal chemistry and account for more than 40% of current therapeutic targets. This teaching unit takes an interdisciplinary approach to teaching the basic concepts and fundamental principles of receptor science required by students pursuing their studies in biomolecular chemistry at the chemistry-biology interface.

Hourly volumes*:

CM: 3 p.m. 

Tutorial: 5 hours

The objective of this module is to work with students to unravel the theoretical concepts at the interface between chemistry and biology concerning the study of the structure/activity of receptor proteins, the study of their ligands, conformational dynamics, and pharmacological approaches related to targeting these membrane and nuclear receptors.

At the end of this course, students will be able to analyze and access specialized scientific content (publications, conferences, etc.) in the field of medicinal chemistry relating to membrane and nuclear receptors.

Concepts of Cell Biology

Concepts of Structural Biochemistry

Continuous Integral Control

Course:

Concept of cellular communication

Basic concepts in receptor pharmacology

Nuclear receptors and their ligands:

• The different families of ligands and nuclear receptors
• Structure – Different areas of connections
• Mechanism of action: ligand-receptor interactions, receptor-DNA interaction, dimerization
• Examples of applications: retinoid receptors, retinoid-related receptors as therapeutic targets
• Rational agonist/antagonist design – Structure-activity relationships

Membrane receptors and their ligands:

• Specialized study of the structure/activity relationships of different classes of membrane receptors (educational support on RCPGs)
  • channel receptors
  • G protein-coupled receptors
  • enzymatic activity receptors
• Concept of conformational selectivity of RCPGs & new model systems
• Elements of physiology/pathology in human health
• Integration of signaling channels

TD: Case study. Work on scientific publications.

Teaching staff

Jean-Yves Winum

Jean-yves.winum@umontpellier.fr

Sophie Mary

Sophie.mary @ umontpellier.fr

Administrative contact(s):

Master's Program in Chemistry Secretariat

https://master-chimie.edu.umontpellier.fr/