Recipe Collection

Receptors are of major interest in medicinal chemistry and account for more than 40% of current therapeutic targets. This course takes an interdisciplinary approach to teaching the basic concepts and fundamental principles of receptor science necessary for students pursuing studies in biomolecular chemistry at the interface of chemistry and biology.

Hourly Volumes*:

CM: 3:00 p.m. 

TD: 5 hours

The objective of this module is to work with students to unpack the theoretical concepts at the interface between chemistry and biology concerning the structure-activity relationships of receptor proteins, the study of their ligands, conformational dynamics, and pharmacological approaches to targeting these membrane-bound and nuclear receptors.

Upon completion of this course, students will be able to analyze and access specialized scientific content (publications, conferences, etc.) in the field of medicinal chemistry related to membrane and nuclear receptors.

Concepts in Cell Biology

Concepts in Structural Biochemistry

Continuous Integral Control

Course:

The Concept of Cell Communication

Basic Concepts in Receptor Pharmacology

Nuclear receptors and their ligands:

• The Different Families of Ligands and Nuclear Receptors
• Structure – Different Types of Connections
• Mechanism of action: ligand-receptor interactions, receptor-DNA interactions, dimerization
• Examples of applications: retinoid receptors, retinoid-related receptors as therapeutic targets
• Rational Design of Agonists and Antagonists – Structure-Activity Relationships

Membrane receptors and their ligands:

• A specialized study of the structure-function relationships of different classes of membrane receptors (Educational Resource on RCPGs)
  • channel receivers
  • G protein-coupled receptors
  • enzymatically active receptors
• Conformational Selectivity Concept in GPCRs & New Model Systems
• Elements of Physiology and Pathology in Human Health
• Integration of Signal Lanes

TD: Case Study. Work on Scientific Publications.

Teaching Staff

Jean-Yves Winum

Jean-yves.winum@umontpellier.fr

Sophie Mary

Sophie.mary @ umontpellier.fr

Administrative contact(s):

Master's in Chemistry Office

https://master-chimie.edu.umontpellier.fr/