• Study level

    BAC +4

  • ECTS

    2 credits

  • Component

    Faculty of Science

Description

After a general introduction to the concepts of prochirality and stereochemistry, this course will present the tools needed to master diastereoselective and enantioselective syntheses. The different approaches will be presented in a detailed and rational manner. Examples of industrial syntheses of chiral bioactive molecules will be discussed.

Hourly volumes* :

CM: 15 H

TD: 5 H

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Objectives

Acquire fundamental knowledge for the preparation of molecules containing stereocenters.

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Necessary prerequisites

Advanced organic chemistry; reaction mechanisms.

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Knowledge control

Final written exam, 2 hours:

  • Authorized documents: no
  • Non-graphic calculator allowed: yes
  • Internet allowed: no
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Syllabus

Course:

  • Stereochemistry; Prochirality; Chirality;
  • Diastereocontrolled synthesis of achiral molecules (Z and E alkenes; cis/trans rings);
  • Diastereoselective synthesis of chiral molecules 
    • carbonyl addition ;
    • addition on alkenes ;
    • substitution reactions ;
    • pericyclic reactions.
  • Enantioselective synthesis using chiral reagents
  • Enantioselective synthesis using chiral catalysts
  • Examples of enantioselective and diastereoselective synthesis.

 

TD: Application exercises.

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Further information

Administrative contact(s) :

 

Secretariat Master Chemistry

master-chimie @ umontpellier.fr @

https://master-chimie.edu.umontpellier.fr

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