Level of study
BAC +4
ECTS
2 credits
Component
Faculty of Science
Description
After generalities on the notions of prochirality and stereochemistry, this teaching will present the tools allowing the mastery of diastereoselective and enantioselective syntheses. The different approaches will be presented in a detailed and rational way. Examples of industrial syntheses of chiral bioactive molecules will be discussed.
Hourly volumes* :
CM : 15 H
TD : 5 H
Objectives
Acquisition of fundamental knowledge for the preparation of molecules containing stereocenters.
Necessary pre-requisites
Advanced organic chemistry; reaction mechanisms.
Knowledge control
Final written exam of 2 hours:
- Authorized documents: no
- Non-graphic calculator allowed: yes
- Internet allowed : no
Syllabus
Course:
- Stereochemistry; Prochirality; Chirality;
- Diastereocontrolled synthesis of achiral molecules (Z and E alkenes; cis/trans rings);
- Diastereoselective synthesis of chiral molecules
- addition on carbonyls ;
- addition on alkenes ;
- substitution reactions ;
- pericyclic reactions.
- Enantioselective synthesis using chiral reagents
- Enantioselective synthesis using chiral catalysts
- Examples of enantioselective and diastereoselective syntheses.
TD: Application exercises.
Additional information
Administrative contact(s):
Secretariat Master Chemistry
master-chimie @ umontpellier.fr @
https://master-chimie.edu.umontpellier.fr