Asymmetric synthesis

After covering the basics of prochirality and stereochemistry, this course will introduce the tools needed to master diastereoselective and enantioselective synthesis. The various approaches will be presented in a detailed and rational manner. Examples of industrial synthesis of chiral bioactive molecules will be discussed.

Hourly volumes*:

CM: 3 p.m.

Tutorial: 5 hours

Acquisition of fundamental knowledge for the preparation of molecules containing stereocenters.

Advanced organic chemistry; reaction mechanisms.

2-hour final written exam:

• Authorized documents: no
• Non-graphing calculator permitted: yes
• Internet access: no

Course:

• Stereochemistry; Prochirality; Chirality;
• Diastereocontrolled synthesis of achiral molecules (Z and E alkenes; cis/trans cycles);
• Diastereoselective synthesis of chiral molecules 
  • addition to carbonyls;
  • addition to alkenes;
  • substitution reactions;
  • pericyclic reactions.
• Enantioselective synthesis using chiral reagents
• Enantioselective synthesis using chiral catalysts
• Examples of enantioselective and diastereoselective syntheses.

TD: Application exercises.

Administrative contact(s):

Master's Program in Chemistry Secretariat

Master's degree in Chemistry @ umontpellier.fr

https://master-chimie.edu.umontpellier.fr