Asymmetric Synthesis

Following an overview of the concepts of prochirality and stereochemistry, this course will introduce the tools needed to master diastereoselective and enantioselective syntheses. The various approaches will be presented in a detailed and systematic manner. Examples of industrial syntheses of chiral bioactive molecules will be discussed.

Hourly Volumes*:

CM: 3:00 p.m.

TD: 5 H

Acquiring the fundamental knowledge needed to synthesize molecules containing stereocenters.

Advanced organic chemistry; reaction mechanisms.

2-hour final written exam:

• Authorized documents: No
• Non-graphical calculators allowed: yes
• Internet access allowed: No

Course:

• Stereochemistry; Prochirality; Chirality;
• Diastereocontrolled synthesis of achiral molecules (Z- and E-alkenes; cis/trans rings);
• Diastereoselective Synthesis of Chiral Molecules 
  • addition to carbonyl groups;
  • addition to alkenes;
  • substitution reactions;
  • pericyclic reactions.
• Enantioselective synthesis using chiral reagents
• Enantioselective Synthesis Using Chiral Catalysts
• Examples of enantioselective and diastereoselective syntheses.

TD: Practice Exercises.

Administrative contact(s):

Master's in Chemistry Office

Master's in Chemistry @ umontpellier.fr

https://master-chimie.edu.umontpellier.fr