Level of study
BAC +4
ECTS
2 credits
Component
Faculty of Science
Description
This course deals concisely and systematically with all aspects of heterocycle chemistry, from nomenclature to applications such as the principles of action of drugs, toxins or drugs, pigments, food coloring etc...
Hourly volumes* :
CM : 15 H
TD : 5 H
Objectives
Become familiar with the nomenclature of heterocyclic compounds and their syntheses.
Explore classical methods for obtaining common nitrogen, oxygen and sulfur heterocycles.
Be able to propose access routes allowing the synthesis of heterocyclic molecules.
Necessary pre-requisites
Organic Chemistry, L3 level
Knowledge control
Final written exam of 2 hours
Authorized documents: no
Non-graphic calculator allowed: yes
Internet allowed : no
Syllabus
Course: 15H
The chemistry and retro-synthesis of each major heterocycle family (pyridines, diazines, quinolines, pyrroles, indoles, furans, thiophenes, azoles, purines and pteridines) are systematically discussed. The fields of application of each family of heterocycles are illustrated through concrete examples (active ingredients, drugs, flavors, pigments, etc.)
- Nomenclature of heterocycles
- General methods for the synthesis of 3-, 4-, 5- and 6-atom rings
- Palladium-catalyzed reactions in heterocyclic chemistry
- Heterocycles with more than two heteroatoms
TD :5H
The tutorials allow to illustrate and apply the concepts developed in the course through exercises on the nomenclature, synthesis, retrosynthetic analysis and reactivity of aromatic heterocycles, focusing mainly on 5- and 6-membered rings.
Additional information
Teaching team:
Michael Smietana,
Michael.smietana (Michael.smietana @ umontpellier.fr)@ (Michael.smietana @ umontpellier.fr)umontpellier.fr (Michael.smietana @ umontpellier.fr)
Jean-Pierre Uttaro
Jean-pierre.uttaro@umontpellier.fr