Peptides and proteins

Peptides and proteins are made up of chains of amino acid residues that give them specific properties. Their functionality depends on their sequence and therefore on the chemical functions they carry, and is also greatly modulated by their structure. In addition to conventional peptide synthesis, advanced options for functional modification, structures, and properties that can significantly alter or improve the properties of the resulting peptide will be developed. Significant biotechnological developments in both the chemical and biological fields will be addressed, leading to a wide range of applications in which peptides and proteins are used successfully.

Hourly volumes*:

CM: 15

TD: 5

Knowledge and Skills :

Structure and biological role of peptides and proteins

Synthesis of peptides and modified peptides on solid supports

Chemical modifications of peptides and proteins

Master's degree in Organic Chemistry, Biomolecular Chemistry, expertise in peptide synthesis strategies in solution

Final exam 2 hours

Course (15 hours): Materials available on the digital workspace (Moodle): Course documents, tutorial documents, past exam papers, and reference publications.

Tutorial (5 hours): Case studies: application of strategies for synthesizing peptides of interest, review of publications covering the various concepts.

1. Basics (4.5 hours)

I.1 Peptide and Protein Functions

I.2 Classification and Conformation of Peptides and Proteins

I.3 Post-translational Modifications

1. Solid Phase Peptide Synthesis (3 hours)

II.1 Basics

II.2 Automated Synthesis

II.3 Treatment/Purification

1. Protein Engineering (3 hours)

II.1 Synthesis/Characterization

II.2 Non-canonical Amino Acid Incorporation

II.3 Ligation

III. Structural Considerations (3 hours)

III.1 Modified Peptides (cyclotides, staple peptides)

III.2 Foldamers

IV Biological Application for Diagnosis and Therapy (6 hours)

IV.1 CPP (self-assembling)

IV.2 ADC

IV.3 PDC/PROTAC

IV.4 ABP

Administrative contact(s):

Master's Program in Chemistry Secretariat

https://master-chimie.edu.umontpellier.fr/