Lipid Compounds

The following topics will be covered:

- Triglycerides

- Phospholipids and sphingolipids

- Glycolipids

- Fat-soluble vitamins

- Steroid hormones

- Bile salts

- Structure and Synthesis of Prostaglandins and Leukotrienes

Hourly Volumes*:

CM: 15

TD: 5

The objective of this course is to illustrate the chemical and stereochemical structure of natural lipids, briefly describe their biological and pharmacological functions, and present some examples of the stereoselective synthesis of lipids, particularly prostaglandins and leukotrienes.

Organic Chemistry (L3 Level)

2-hour written final exam

• Authorized documents: No
• Non-graphical calculators allowed: yes
• Internet access allowed: No

Course (15 hours): Materials available on the digital learning platform (Moodle): Course materials, tutorial materials, past exam papers, and reference publications.

1. Structure and biological functions of: (3 H)

- Plant and animal triglycerides

- Phospholipids

- Sphingolipids

- Glycolipids:

cerebrosides

gangliosides

1. Fat-soluble vitamins: (3 H)

Vitamins_K1 and_K2

retinol and dehydroretinol

tocopherols

vitamins_D3 and_D2

1. Structure and Structure-Activity Relationships of Steroid Hormones: (4,5 H)

corticosteroids (cortisone, hydrocortisone, aldosterone)

sex hormones (testosterone, estrogens, progesterone)

1. Structure and Conformation of Bile Salts: (1.5 H)

cholic acids

deoxycholic

chenodeoxycholic

glycocholic

taurocholic.

1. Structure and Total Synthesis of Prostaglandins and Leukotrienes (³H)

TD (5 hours): Individual work; exercises to be prepared before and during the session.

Determination of the structure of various classes of lipids using chemical and spectroscopic analytical methods. Exercises on the total synthesis of prostaglandins and leukotrienes.

Administrative contact(s):

Master's in Chemistry Office

https://master-chimie.edu.umontpellier.fr/