ECTS
120 credits
Duration
2 years
Training structure
Faculty of Science
Language(s) of instruction
French
Presentation
The course offers multidisciplinary training in organic chemistry with a focus on life sciences. Teaching focuses on the synthesis, characterization and study of the biological properties of essential biomolecules (nucleosides, oligonucleotides, saccharides, peptides, proteins, biopolymers, etc.) ...
93 %
Success rates
Objectives
The aim of the Biomolecule Chemistry pathway (3 orientations) is to train managers capable of managing the various research/development and/or organizational aspects of a project in the field of biomolecule chemistry. This pathway covers a wide range of skills, including the most advanced organic synthesis methodologies for obtaining biomolecules, the latest spectroscopic characterization and analysis methods, and skills in biomolecule design and development.
Know-how and skills
The acquisition of these skills will enable the holder of this Master's degree to dialogue with colleagues from other disciplines (biologists, physical chemists, biochemists) and to propose solutions that go beyond his or her core competence as a chemist. Graduates of this Master's program are eligible to pursue doctoral studies, with a view to becoming a teacher-researcher or researcher (academic research or pharmaceutical industry). The holder of this Master's degree is able to :
Cross-disciplinary skills :
- Work as part of a multidisciplinary team covering a broad spectrum of basic sciences
- Formulate a research project after analyzing the bibliography
- Design new therapeutic molecules or biochemical tools
- Master the main analysis methods
- Implement experimental approaches
- Use computer tools
- Fluency in scientific English (spoken and written)
Specific disciplinary skills :
- Analyze the various stages of an experimental protocol
- Master the main techniques for the synthesis, purification and qualitative and quantitative analysis of organic compounds
- Use the latest spectroscopic and analytical techniques
- Designing new molecules
- Analyze and interpret experimental results of biological tests
General scientific skills :
- Use equipment and techniques for analyzing organic compounds and biomolecules
- Analyze experimental data
- Identifying and complying with regulations
- Understand a scientific text written in English
- Adopting a multidisciplinary approach
- Implementing an experimental approach
- Understanding a complex situation
- Ability to integrate into a research organization: participation in projects, communications with specialists and non-specialists alike.
General skills :
- Ability to mobilize resources from several disciplinary fields
- Knowledge and understanding of a scientific field
- Ability to work in an international context
- Working independently: setting priorities, managing time
- Carrying out a study: posing a problem; constructing and developing an argument; interpreting results; drawing up a summary.
- Carry out an information search: specify the purpose of the search, identify access methods, analyze relevance, explain and communicate.
- Teamwork: integration, positioning, collaboration
- Communicating: writing clearly, preparing appropriate communication media, speaking in front of a group, and commenting on media.
- Integration into a professional environment
Organization
Knowledge control
Each teaching unit (UE) is subject to graded assessment. Depending on the UE, these take the form of continuous assessments (practical work and internships), written final exams, reports and/or oral presentations. These UEs can be offset against each other, and an average of at least 10/20 for all the courses in the semester is required to pass the semester. Semesters cannot be offset against each other.
Open on a sandwich basis
This course is offered on a sandwich basis.
Internships, tutored projects
Internship | Mandatory |
---|
Semester 8: 2 to 4-month research internship in an academic/public laboratory.
Semester 10: 5-6 month internship. Research and development in an academic/private laboratory.
Semester 7: Professional project - project follow-up (CM 5h, TD 5h, TP 40 hours)
Program
This Master's program in Chemistry complies with the European system. It is open to holders of a bachelor's degree in chemistry. It is a university course validated by 120 ECTS. It comprises 4 semesters of 30 ECTS each. The first year of Master 1 (60 ECST for S7 and S8) is common to all M2 orientations. The second year (S9) comprises a common core curriculum (18 ECTS for major courses) and a block of electives (12 ECTS for minor courses) corresponding to the Research Orientation (O1), and two career paths: Synthesis Orientation (O2) and Omic Analysis Orientation (O3).
Select a program
M1 - Biomolecular chemistry (BM)
Fluorinated and phosphorated biomolecules: synthesis and application
2 creditsCHOICE 1
4 creditsChoice of 2 out of 3
Solutions, colloids, interfaces
2 creditsSeparative techniques
2 creditsAnalysis of volatile molecules
2 credits
Polymers for health
2 creditsHeterocyclic chemistry
2 creditsChemistry of natural products
2 creditsLiquid NMR spectroscopy and X-ray diffraction
2 creditsAnalysis of biomolecules by mass spectrometry
2 creditsChemometrics, statistical data analysis, experimental design
2 creditsOrganometallic and hetero-element chemistry
2 creditsCoordination and organic chemistry
2 creditsProfessional projects - project follow-up
8 credits
2-4 month M1 internship with presentation/report in English
10 creditsNucleosides and derivatives
2 creditsInnovative synthesis and extraction processes
2 creditsMedicinal chemistry
2 creditsAsymmetric synthesis
2 creditsAmino acids and derivatives
2 creditsBiosourced chemistry
2 creditsCommunication and professional integration
2 creditsCHOICE 2
4 creditsChoice of 2 out of 3
Introduction to modeling
2 creditsHybrid and structured materials
2 creditsNanomaterials
2 credits
Strategy and tools for organic synthesis
2 credits
M2 - Biomolecular chemistry (BM)
Fluorinated and phosphorated biomolecules: synthesis and application
Study level
BAC +4
ECTS
2 credits
Component
Faculty of Science
Fluorinated biomolecules. Current developments in fluorinated molecules. Fluorination methods: nucleophilic or electrophilic mono-fluorination, introduction of difluoromethyl or trifluoromethyl groups. Contribution of fluorine atoms to the activity of these compounds. Examples of the synthesis of fluorinated compounds used as antitumoral agents, antiviral agents, antidepressants, anxiolytics, anti-inflammatories, etc.
Phosphorus biomolecules. Structure, nomenclature, reactivity, structural analysis and applications.
A number of synthesis routes for compounds in each of the families covered will be discussed, highlighting unconventional activation methods where appropriate. Biomedical applications will be targeted, as well as other applications in agrochemistry, optoelectronics, nanomaterials, etc.
Hourly volumes* :
CM: 15 h (7.5h Fluorinated biomolecules and 7.5h Phosphorus biomolecules)
TD: 5 h
Solutions, colloids, interfaces
Study level
BAC +4
ECTS
2 credits
Component
Faculty of Science
This course provides basic knowledge and cross-disciplinary skills in the field of colloids and interfaces, which are common to the various courses in the Chemistry Master's program (Chemistry of Materials, Separative Chemistry, Materials and Processes, ICAP Cosmetics Engineering, Chemistry of Biomolecules). It is also offered to international students enrolled in the SFRI program at the University of Montpellier, where the course is taught in English. An introductory presentation covering the basic concepts and notions will enable students to discover and better understand the main physico-chemical properties of colloidal dispersions, associative colloids and solutions of macromolecules, as well as the parameters and phenomena governing stability in colloidal dispersions and mixed solution-colloid systems. This will be followed by interdisciplinary hands-on teaching based on the flipped classroom principle, to help students build and deepen their knowledge through individual and group analysis of various applications of colloidal and interfacial phenomena and systems.
Hourly volumes* :
CM: 7
TD : 13
Separative techniques
Study level
BAC +4
ECTS
2 credits
Component
Faculty of Science
This course is designed to teach liquid and gas chromatography.
Hourly volumes* :
CM :15h
TD: 5h
Analysis of volatile molecules
Study level
BAC +4
ECTS
2 credits
Component
Faculty of Science
Knowledge of gas chromatography and mass spectrometry techniques with electron impact ionization and quadrupole mass analyzer for the analysis of volatile organic molecules.
1) GC-MS analysis of volatile organic compounds :
- Electron impact ionization (EI) techniques
- Chemical ionization (CI) techniques
- Quadrupole (Q) analysis techniques
- GC/MS coupling
2) Applications in organic chemistry analysis and characterization of volatile samples.
Hourly volumes* :
CM: 15 H
TD: 5 H
Polymers for health
Study level
BAC +5
ECTS
2 credits
Component
Faculty of Science
Knowledge of the main polymer families used in the biomedical field.
1) Specificity of polymers for biomedical applications and the main polymer families used
2) Description of application families
3) Discussion of the concept of synthesis and the relationship between structure/properties and specifications
Hourly volumes* :
CM: 15 H
TD: 5 H
Heterocyclic chemistry
Study level
BAC +4
ECTS
2 credits
Component
Faculty of Science
This course deals concisely and systematically with all aspects of heterocycle chemistry, from nomenclature to applications such as the principles of action of medicines, toxins or drugs, pigments, food colorants etc...
Hourly volumes* :
CM: 15 H
TD: 5 H
Chemistry of natural products
Study level
BAC +4
ECTS
2 credits
Component
Faculty of Science
Natural products play a major role in biomolecular chemistry. They represent an important source of bioactive compounds for medicinal chemistry. This teaching unit provides a comprehensive overview of secondary metabolism and the origin of natural products from plants. Emphasis will be placed on the organic chemistry behind the various biotransformations that occur during the biosynthesis of each major class of molecules. A mechanistic approach will be used to understand the chemical basis of each transformation.
Hourly volumes* :
CM: 13
TD : 7
Liquid NMR spectroscopy and X-ray diffraction
Study level
BAC +4
ECTS
2 credits
Component
Faculty of Science
RMN :
Liquid-phase NMR (Nuclear Magnetic Resonance) is an essential spectroscopic analysis method for chemists, enabling them to determine the structure of small organic molecules or macromolecules in solution, to study dynamic phenomena... The aim of this course is to understand the phenomena involved in this technique and to relate them to the different structural information accessible by this method. The aim is to be able to exploit the spectral data obtained from this analysis to elucidate the structure and stereochemistry of organic molecules or polymer structures, or to monitor reactions.
X-ray diffraction :
X-ray diffraction is a powerful, non-destructive technique not only for characterizing the crystalline structure of materials, but also for providing crystallographic and structural information such as lattice parameters and atomic positions. This includes all crystallized materials such as ceramics, materials for the storage and transformation of energy and information, as well as organic molecules and metal complexes (interatomic distances and angles, stereochemistry (chirality, stereoisomerism...), intra- and intermolecular bonds...). The aim of this course is to provide an introduction to crystallography and diffraction, with the aim of understanding the operation and characteristics of an X-ray diffractometer, as well as interpreting diffraction patterns (structural analysis, lattice parameters).
Hourly volumes* :
CM: 10
TD : 10
Analysis of biomolecules by mass spectrometry
Study level
BAC +4
ECTS
2 credits
Component
Faculty of Science
Knowledge of the latest mass spectrometry techniques for the qualitative analysis of organic molecules and biomolecules.
1) Description of fundamental principles (Ion Science and Technology) :
- Ionization techniques
- Analysis techniques
- Tandem mass spectrometry (MS/MS)
- LC/MS and LC/MS/MS couplings
2) Application in biomolecule analysis and organic chemistry reaction monitoring.
Hourly volumes* :
CM: 15 H
TD: 5 H
Chemometrics, statistical data analysis, experimental design
Study level
BAC +4
ECTS
2 credits
Component
Faculty of Science
This course covers the fundamental concepts and practical tools of chemometrics through : - statistical data analysis ;
- probability laws ;
- confidence interval estimation ;
- parametric and non-parametric tests.
An introduction to experimental design will be offered at the end of the module.
Hourly volumes* :
CM: 7h
TD: 13h
Organometallic and hetero-element chemistry
Study level
BAC +4
ECTS
2 credits
Component
Faculty of Science
The first part of the course introduces the fundamentals of transition metal organometallic chemistry. It begins with a description of the Metal-C bond, enabling us to understand its stability and chemical reactivity. Secondly, the power of this synthesis tool for the formation of C-H, C-C, etc. bonds will be demonstrated. Examples of their applications in various fields will enable the acquisition of these reactions and their fields of application: fine chemistry, catalytic transformations of industrial importance, synthesis of natural products, preparation of materials.
The second part of this course is dedicated to hetero-element chemistry, focusing on the elements Silicon, Tin and Boron. The aim of this part is to present the various methods for preparing boron-, tin- and silicon-based reagents, as well as the main transformations carried out with these compounds, with applications in organic synthesis and materials synthesis.
CM: 13 H
TD: 7 H
Coordination and organic chemistry
Study level
BAC +4
ECTS
2 credits
Component
Faculty of Science
This teaching unit is dedicated to deepening the foundations of organic chemistry and coordination chemistry covered in L3, and acquiring notions linked to molecular engineering and molecular chemistry. The course comprises lectures and tutorials. Students will work in advance of certain lectures and tutorials, with course documents provided, to ensure that the lectures and tutorials enable them to play a full part in the course, understand the concepts presented and the skills to be acquired. A progression program and activities will be proposed. For students who have not seen the basics of coordination chemistry and organic chemistry, documents will be made available.
Coordination chemistry: The course will cover various aspects of transition metal and lanthanide complexes, molecular materials (polynuclear complexes and coordination polymers with extended structures (MOFs, etc.)), their properties and applications. Structural aspects, bonding description, properties, as well as stability and reactivity aspects will be covered. Emphasis will be placed on the complexation effect and stability of metal, lanthanide and actinide complexes with certain ligands, with a view to applications in the biomedical field (imaging and therapy), decontamination (nuclear field), etc. The electronic (relaxivity, magnetism) and optical (absorption, luminescence) properties of these complexes will be discussed and put into the context of applications in various fields, such as imaging, electronics, sensors, etc.
Organic Chemistry: This course builds on the knowledge acquired in the Bachelor's degree, and will involve a reasoned study of the main reaction mechanisms in organic chemistry, providing a common foundation for all students in the Chemistry Master's program. The main processes (substitution, addition, elimination, transposition...) and their essential characteristics and applications to mechanistic sequences will be examined. The course is designed to provide students with general tools for analyzing mechanisms (ionic, radical, concerted) in order to grasp their variety.
Hourly volumes* :
CM: 13 H
TD: 7 H
Professional projects - project follow-up
Study level
BAC +4
ECTS
8 credits
Component
Faculty of Science
The professional project bridges the gap between traditional practical work and the internship in a laboratory or company. It is carried out in the form of a tutored project, which puts students in a professional situation through collaborative (group) work based on the realization of a project in response to a problem set by a company, community, association or academic. It is part of the Chemistry Master's core curriculum, and is carried out under the responsibility of a member of the teaching team (academic or industrial). Carried out throughout the semester, this project aims to link and anchor the knowledge and know-how acquired during the Bachelor's degree and the early Master's program, through a professional setting. These situations will be directly linked to the Master's course chosen by the students. In addition to their chemistry-disciplinary skills, students will also acquire the interpersonal, organizational and communication skills intrinsically linked to project management, which will equip them for their future professional life.
Responding to a research problem: example of the synthesis of new phosphorescent materials.
Hourly volumes* :
CM: 5h
TD: 5h
Practical work: 40h
2-4 month M1 internship with presentation/report in English
Study level
BAC +4
ECTS
10 credits
Component
Faculty of Science
The internship in semester 8 of the Master 1 Chemistry of Biomolecules is designed to familiarize students with research careers in life chemistry. Students will have the opportunity to carry out this introductory research internship in academic or private laboratories. Subject to prior approval by the teaching staff (internship subject in line with the Master's courses and suitable environment/means), students can look for a host team in an academic environment in the University of Montpellier's Chemistry Pole institutes (IBMM, ICGM, etc.), in academic laboratories outside the University of Montpellier (in France or abroad) or in the private sector (chemical, pharmaceutical and agri-food industries, biotechnology laboratories, etc.).
Fieldwork: 2 to 4 months' internship
Nucleosides and derivatives
Study level
BAC +4
ECTS
2 credits
Component
Faculty of Science
Nucleosides are the basic building blocks of nucleic acids (DNA and RNA). As such, they play an essential role in many biological processes. In this course, the structure and biological role of natural nucleosides will be presented. It will also cover the main routes to synthesis and characterization of these compounds and their analogues (glycosylation reactions, structural modifications of the furanose ring, substitution and introduction of heteroatoms, configuration inversion, etc.). The use of nucleoside analogues in the treatment of viral pathologies and cancers will also be addressed.
Hourly volumes* :
WC: 3 p.m.
TD: 5 h
Innovative synthesis and extraction processes
Study level
BAC +4
ECTS
2 credits
Component
Faculty of Science
This teaching unit is shared with MI students in the Chemistry Master's courses: ICAP P1, ICAP P2, MAT P1, MAT P2, BM (semester S2). The following topics will be covered:
- The 12 Principles of Green Chemistry and units of measurement in Green Chemistry ;
- Synthesis strategies for sustainable chemistry ;
- Alternative or eco-compatible solvents for synthesis and extraction;
- Non-conventional activation techniques and applications.
CM: 13
TD: 7 H
Medicinal chemistry
Study level
BAC +4
ECTS
2 credits
Component
Faculty of Science
The aim of the medicinal chemistry course is to introduce students to the key stages in the process of developing molecules with biological activity. In particular, a description of the interactions involved, the notion of pharmocophores, bio-isosteria, etc., as well as structure-activity relationship studies will be covered, enabling students to envisage appropriate strategies and structural modifications.
Hourly volumes* :
WC: 3 p.m.
TD: 5 h
Asymmetric synthesis
Study level
BAC +4
ECTS
2 credits
Component
Faculty of Science
After a general introduction to the concepts of prochirality and stereochemistry, this course will present the tools needed to master diastereoselective and enantioselective syntheses. The different approaches will be presented in a detailed and rational manner. Examples of industrial syntheses of chiral bioactive molecules will be discussed.
Hourly volumes* :
CM: 15 H
TD: 5 H
Amino acids and derivatives
Study level
BAC +4
ECTS
2 credits
Component
Faculty of Science
This course covers synthetic methods for obtaining enantiopure amino acids, as well as the use of chiral amino acids for the synthesis of other enantiopure compounds.
These amino acids are the building blocks of peptides. The different physico-chemical properties induced by the nature of these amino acids will enable us to define strategies for the synthesis and characterization of peptides of interest.
Hourly volumes* :
CM: 15 H
TD: 5 H
Biosourced chemistry
Study level
BAC +4
ECTS
2 credits
Component
Faculty of Science
The following topics will be covered:
- Biobased solvents
- Biomass fuels
- Antioxidants derived from lignin
- Metal catalysts from plants
- Surfactants obtained from renewable resources
- Examples of industrial applications of enzymatic synthesis
Hourly volumes* :
CM: 15
TD : 5
Communication and professional integration
Study level
BAC +4
ECTS
2 credits
Component
Faculty of Science
In small groups or on a one-to-one basis, this course will cover pedagogical tools and best practices relating to communication and professional integration, through :
- assessments of knowledge, skills, competencies, attitudes and motivations;
- awareness of job search techniques ;
- CV and cover letter writing ;
- rules of oral and written communication ;
- mock job interviews.
Students will be able to take part in role-playing exercises directly linked to the sectors targeted by their career paths.
Practical work: 20h
Introduction to modeling
Study level
BAC +4
ECTS
2 credits
Component
Faculty of Science
General presentation of the most commonly used calculation and modelling methods in the field of solid state chemistry according to the spatial and temporal scales that can be studied with them:
(1) Quantum calculations (Hartree Fock, Post-Hartree Fock methods, DFT),
(2) Force-field modeling (atomistic and coarse-grained),
(3) Hybrid QMM and AACG modeling.
Overview of different calculation techniques: static and optimization calculations, molecular dynamics and Monte Carlo.
The UE will include lectures and practical work. Two practical modeling exercises will be offered: modeling techniques in classical mechanics and quantum calculations.
CM: 11H
TD : 9H
Hybrid and structured materials
Study level
BAC +4
ECTS
2 credits
Component
Faculty of Science
Hybrid" materials are a new family of materials, combining organic ligands with inorganic entities, and are increasingly being studied at both fundamental and application levels.
In this course, two main categories of hybrid materials will be discussed:
- Coordination Networks and Metal-Organic Frameworks
- Organosilicon/carbon materials
CM: 10 h
TD: 10 h
Nanomaterials
Study level
BAC +4
ECTS
2 credits
Component
Faculty of Science
This teaching unit is dedicated to the presentation of inorganic materials and nanomaterials for use in the biomedical field (imaging, therapy, implants). It builds on the knowledge acquired in UE HAC930C (Development of materials for health). The aim is to develop health issues and inorganic materials and nanomaterials in diagnostics, therapy and wellness. Strategies for developing the inorganic materials and nanomaterials of the future based on therapeutics and multifunctionality, and intelligent materials will also be addressed.
The course comprises lectures and tutorials. Students will be offered a group project on the (theoretical) study of an inorganic material or nanomaterials for health.
CM: 11
TD : 9
Strategy and tools for organic synthesis
Study level
BAC +4
ECTS
2 credits
Component
Faculty of Science
The teaching of the Organic Synthesis Strategies and Tools module focuses on the development of strategies for the elaboration of molecules, whether or not derived from the natural environment, using the tools of organic chemistry.
Hourly volumes* :
CM: 15 H
TD: 5 H
Chemoinformatics
Study level
BAC +5
ECTS
2 credits
Component
Faculty of Science
The EU themes are as follows:
A theoretical section dedicated to chemoinformatics
A theoretical section devoted more specifically to modeling tools for drug design
Hourly volumes* :
CM: 15 H
TD: 5 H
A practical section with computer work
Project management - Corporate law
ECTS
4 credits
Component
Faculty of Science
Peptides and proteins
Study level
BAC +5
ECTS
2 credits
Component
Faculty of Science
Peptides and proteins are made up of a sequence of amino acid residues, giving them specific properties. Their functionality depends on their sequence and thus on the chemical functions they carry, and is also greatly modulated by their structure. In addition to conventional peptide synthesis, advanced functional modification options, structures and properties that can significantly modify or enhance the properties of the resulting peptide will be developed. Significant biotechnological developments in both the chemical and biological fields will be discussed, leading to a wide range of applications in which peptides and proteins are successfully used.
Hourly volumes*:
CM :15
TD :5
Receptology
Study level
BAC +5
ECTS
2 credits
Component
Faculty of Science
Receptors are of major interest in medicinal chemistry and represent over 40% of current therapeutic targets. This teaching unit provides an interdisciplinary approach to the basic concepts and notions of receptology required by students pursuing their training in biomolecular chemistry at the chemistry-biology interface.
Hourly volumes* :
CM: 15 H
TD: 5 H
Nucleic acids
Study level
BAC +5
ECTS
2 credits
Component
Faculty of Science
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
Hourly volumes* :
CM: 15 H
TD: 5 H
NMR
Study level
BAC +5
ECTS
2 credits
Component
Faculty of Science
In-depth knowledge of 1H, 13C, 19F, 29Siand 31PNMR, as well as two-dimensional methods. Notions of EPR will also be covered (principle and applications).
Hourly volumes* :
CM: 15 H
TD: 5 H
Targeted delivery
Study level
BAC +5
ECTS
2 credits
Component
Faculty of Science
Hourly volume
20h
This course covers the various molecular and supramolecular tools available for the vectorization and delivery of active ingredients, depending on the type of cells or intracellular organelles targeted. Ligand-receptor interactions are covered, as are methods for preparing and activating conjugates. Examples of drugs will be presented.
Hourly volumes* :
CM: 15 H
TD: 5 H
Structure-based drug design
ECTS
2 credits
Component
Faculty of Pharmacy
Mass spectrometry
Study level
BAC +5
ECTS
2 credits
Component
Faculty of Science
Knowledge of the latest mass spectrometry techniques for the detection, identification and structural characterization of organic molecules and biomolecules.
Applications in chemistry (pharmaceutical industry) and biology (omic approaches).
1) Structural elucidation (Ion characterization technologies) :
- LC/MS/MS and exact mass measurements
- Isotope marking, H/D exchange
- Ion mobility
2) Surface analysis and imaging (molecular mapping)
3) Applications in chemistry and biology: characterization of small organic molecules and biomolecules.
Hourly volumes* :
CM: 15 H
TD: 5 H
Chemobiology (67% ENSCM)
Study level
BAC +5
ECTS
2 credits
Component
Faculty of Science
The course will focus on organic chemistry and post-functionalization of biomolecules applied to peptides, proteins and nucleic acids (DNA and RNA) with applications in gene therapy, biosensing and design of probes for biological studies.
Hourly volumes* :
CM: 15 H
TD: 5 H
Lipid compounds
Study level
BAC +5
ECTS
2 credits
Component
Faculty of Science
The following topics will be covered:
- Triglycerides
- Phospholipids and sphingolipids
- Glycolipids
- Fat-soluble vitamins
- Steroid hormones
- Bile salts
- Structure and synthesis of prostaglandins and leukotrienes
Hourly volumes* :
CM: 15
TD : 5
Glycochemistry
Study level
BAC +5
ECTS
2 credits
Component
Faculty of Science
The following topics will be covered:
- General mechanism of glycosylation
- Glycosyl donor synthesis
- Glycosyl donor activation methods
- Stereoselective synthesis of some natural oligosaccharides
Hourly volumes* :
CM: 15
TD : 5
Prodrugs/bioprecursors
Study level
BAC +5
ECTS
2 credits
Component
Faculty of Science
Knowledge of the limitations associated with the administration of an active ingredient (solubility, bioavailability, etc.).
General description of the enzymatic systems involved in the biotransformation of nutrients and exogenous compounds.
Description of the main membrane passageways and transport systems for fundamental biomolecules (sugars, amino acids, nucleosides, etc.).
Examples of prodrug and bioprecursor design.
Hourly volumes* :
CM: 15 H
TD: 5 H
(Nano)inorganic materials for health
Study level
BAC +5
ECTS
2 credits
Component
Faculty of Science
This teaching unit is dedicated to the presentation of inorganic materials and nanomaterials for use in the biomedical field (imaging, therapy, implants). It builds on the knowledge acquired in UE HAC930C (Development of materials for health). The aim is to develop health issues and inorganic materials and nanomaterials in diagnostics, therapy and wellness. Strategies for developing the inorganic materials and nanomaterials of the future based on therapeutics and multifunctionality, and intelligent materials will also be addressed.
The course comprises lectures and tutorials. A group project on the (theoretical) study of an inorganic material or nanomaterials for health will be proposed to students.
Hourly volumes* :
CM: 11
TD : 9
Nanotechnologies and multifunctional systems for therapy
Component
Faculty of Pharmacy
Internship
Study level
BAC +5
ECTS
25 credits
Component
Faculty of Science
An internship lasting 5 to 6 months must be carried out in a research or R&D laboratory specializing in organic chemistry, biomolecule chemistry, life chemistry, analytical instrumentation or analytical analysis/development. Students will have the opportunity to carry out this end-of-study internship in academic or private research laboratories. Subject to prior approval by the teaching staff (internship subject in line with the Master's courses and suitable environment/means), students can look for a host team in an academic environment in the institutes of the Chemistry Pole of the University of Montpellier (IBMM, ICGM, IEM....), in academic laboratories outside the University of Montpellier (in France or abroad) or in the private sector (chemical, pharmaceutical, agri-food and cosmetics industries, biotechnology laboratories, etc.), as well as in research structures such as proteomics / metabolomics / fluxomics platforms.
The research project entrusted to students must be linked to the skills and expertise acquired in previous semesters and teaching units, particularly in semester 9, depending on the direction chosen.
This 5 to 6 month internship may start in mid-January after the exam session, and may not exceed 6 months for a period in semester 10 within the validity of the university registration. The teaching staff of the Chemistry of Biomolecules master's program will advise students on finding an internship that matches their aspirations and abilities.
Bibliographic project/Scientific information
Study level
BAC +5
ECTS
3 credits
Component
Faculty of Science
Scientific information: The aim of this course is to familiarize students with the search for and management of scientific information. Recent bibliographic research tools will be explained and used in lectures and practical work (electronic documentation: Scifinder / Isis / Belstein). Training in the functionalities of the Zotero tool and in the use of the electronic laboratory notebook will also be provided. The writing and use of scientific publications will also be covered.
Bibliographic project: Scientific information research tools will be applied to a concrete case. The pedagogical team will propose a bibliographical subject related to the student's chosen field of study. This bibliographical subject may, where appropriate, be defined in agreement with the host organization where the internship is to be carried out.
For this personal project, students will have access to all the bibliographic sources of the university or company hosting them. Bibliographic work may be combined with the English teaching unit to prepare an oral presentation at an international conference.
Biotechnologies and applications
Study level
BAC +5
ECTS
2 credits
Component
Faculty of Science
The aim of this course is to highlight biological processes at the cellular level or even in living subjects. Various molecular imaging approaches will be discussed (fluorescent probes, radiolabeling).
Hourly volumes* :
CM: 9 H
Field : 11 H
Green chemistry
Study level
BAC +5
ECTS
2 credits
Component
Faculty of Science
The principles of Green Chemistry provide a basis for the evaluation and design of new chemical products and processes that minimize negative impacts on human health and the environment. In this teaching unit, offered to M2 students in the Master of Biomolecular Chemistry (BM), Orientation 2 (O2), the basic principles and concepts of Green Chemistry will be covered, and their applications in the field of non-conventional activation methods and the use of alternative media in organic synthesis.
Hourly volumes* :
CM: 9 H
Field: 11 a.m.
Biomolecule extraction and separation
Study level
BAC +5
ECTS
2 credits
Component
Faculty of Science
This course covers techniques for extracting biomolecules (protein precipitation, SPE), as well as techniques for separating biomolecules (chromatography, electrophoresis).
Hourly volumes* :
CM: 9 h
Field: 11 a.m.
Project management - Corporate law
ECTS
4 credits
Component
Faculty of Science
Peptides and proteins
Study level
BAC +5
ECTS
2 credits
Component
Faculty of Science
Peptides and proteins are made up of a sequence of amino acid residues, giving them specific properties. Their functionality depends on their sequence and thus on the chemical functions they carry, and is also greatly modulated by their structure. In addition to conventional peptide synthesis, advanced functional modification options, structures and properties that can significantly modify or enhance the properties of the resulting peptide will be developed. Significant biotechnological developments in both the chemical and biological fields will be discussed, leading to a wide range of applications in which peptides and proteins are successfully used.
Hourly volumes*:
CM :15
TD :5
Supported syntheses
Study level
BAC +5
ECTS
2 credits
Component
Faculty of Science
In chemistry, solid-phase synthesis is a method in which molecules are covalently bonded to a solid support and synthesized step by step using selective protecting groups. The aim of this applied course is to provide a comprehensive understanding of this field and to examine supported strategies for the practical preparation of polypeptides and oligonucleotides.
Hourly volumes* :
CM: 9 H
Field : 11 H
Nucleic acids
Study level
BAC +5
ECTS
2 credits
Component
Faculty of Science
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
Hourly volumes* :
CM: 15 H
TD: 5 H
Targeted delivery
Study level
BAC +5
ECTS
2 credits
Component
Faculty of Science
Hourly volume
20h
This course covers the various molecular and supramolecular tools available for the vectorization and delivery of active ingredients, depending on the type of cells or intracellular organelles targeted. Ligand-receptor interactions are covered, as are methods for preparing and activating conjugates. Examples of drugs will be presented.
Hourly volumes* :
CM: 15 H
TD: 5 H
Chemobiology (67% ENSCM)
Study level
BAC +5
ECTS
2 credits
Component
Faculty of Science
The course will focus on organic chemistry and post-functionalization of biomolecules applied to peptides, proteins and nucleic acids (DNA and RNA) with applications in gene therapy, biosensing and design of probes for biological studies.
Hourly volumes* :
CM: 15 H
TD: 5 H
NMR
Study level
BAC +5
ECTS
2 credits
Component
Faculty of Science
In-depth knowledge of 1H, 13C, 19F, 29Siand 31PNMR, as well as two-dimensional methods. Notions of EPR will also be covered (principle and applications).
Hourly volumes* :
CM: 15 H
TD: 5 H
Multi-step synthesis
Study level
BAC +5
ECTS
2 credits
Component
Faculty of Science
The aim of this course is to describe synthesis tools applied to complex, polyfunctional molecules. Retrosynthetic and stereocontrolled approaches will be covered, as well as the rational use of protecting groups.
Hourly volumes* :
CM: 9 H
Field : 11 H
Functionalization/Bioconjugation
Study level
BAC +5
ECTS
2 credits
Component
Faculty of Science
Bioconjugation reactions are of major interest in the biomedical sciences, enabling chemists to modify biomolecules to confer new functions or properties. This course covers bioconjugation and biomolecule labeling strategies for exploring complex biological systems. Practical sessions will illustrate these concepts through examples of bioconjugation of osidic and nucleotide platforms.
Hourly volumes* :
CM: 9 H
Field : 11 H
Mass spectrometry
Study level
BAC +5
ECTS
2 credits
Component
Faculty of Science
Knowledge of the latest mass spectrometry techniques for the detection, identification and structural characterization of organic molecules and biomolecules.
Applications in chemistry (pharmaceutical industry) and biology (omic approaches).
1) Structural elucidation (Ion characterization technologies) :
- LC/MS/MS and exact mass measurements
- Isotope marking, H/D exchange
- Ion mobility
2) Surface analysis and imaging (molecular mapping)
3) Applications in chemistry and biology: characterization of small organic molecules and biomolecules.
Hourly volumes* :
CM: 15 H
TD: 5 H
Lipid compounds
Study level
BAC +5
ECTS
2 credits
Component
Faculty of Science
The following topics will be covered:
- Triglycerides
- Phospholipids and sphingolipids
- Glycolipids
- Fat-soluble vitamins
- Steroid hormones
- Bile salts
- Structure and synthesis of prostaglandins and leukotrienes
Hourly volumes* :
CM: 15
TD : 5
Glycochemistry
Study level
BAC +5
ECTS
2 credits
Component
Faculty of Science
The following topics will be covered:
- General mechanism of glycosylation
- Glycosyl donor synthesis
- Glycosyl donor activation methods
- Stereoselective synthesis of some natural oligosaccharides
Hourly volumes* :
CM: 15
TD : 5
Internship
Study level
BAC +5
ECTS
25 credits
Component
Faculty of Science
An internship lasting 5 to 6 months must be carried out in a research or R&D laboratory specializing in organic chemistry, biomolecule chemistry, life chemistry, analytical instrumentation or analytical analysis/development. Students will have the opportunity to carry out this end-of-study internship in academic or private research laboratories. Subject to prior approval by the teaching staff (internship subject in line with the Master's courses and suitable environment/means), students can look for a host team in an academic environment in the institutes of the Chemistry Pole of the University of Montpellier (IBMM, ICGM, IEM....), in academic laboratories outside the University of Montpellier (in France or abroad) or in the private sector (chemical, pharmaceutical, agri-food and cosmetics industries, biotechnology laboratories, etc.), as well as in research structures such as proteomics / metabolomics / fluxomics platforms.
The research project entrusted to students must be linked to the skills and expertise acquired in previous semesters and teaching units, particularly in semester 9, depending on the direction chosen.
This 5 to 6 month internship may start in mid-January after the exam session, and may not exceed 6 months for a period in semester 10 within the validity of the university registration. The teaching staff of the Chemistry of Biomolecules master's program will advise students on finding an internship that matches their aspirations and abilities.
Bibliographic project/Scientific information
Study level
BAC +5
ECTS
3 credits
Component
Faculty of Science
Scientific information: The aim of this course is to familiarize students with the search for and management of scientific information. Recent bibliographic research tools will be explained and used in lectures and practical work (electronic documentation: Scifinder / Isis / Belstein). Training in the functionalities of the Zotero tool and in the use of the electronic laboratory notebook will also be provided. The writing and use of scientific publications will also be covered.
Bibliographic project: Scientific information research tools will be applied to a concrete case. The pedagogical team will propose a bibliographical subject related to the student's chosen field of study. This bibliographical subject may, where appropriate, be defined in agreement with the host organization where the internship is to be carried out.
For this personal project, students will have access to all the bibliographic sources of the university or company hosting them. Bibliographic work may be combined with the English teaching unit to prepare an oral presentation at an international conference.
Bioanalysis
Study level
BAC +5
ECTS
2 credits
Component
Faculty of Science
Description of the latest mass spectrometry techniques for analyses in the pharmaceutical industry (drug development : Drug discovery and pre-clinical analysis).
Mass spectrometry instrumentation and acquisition in the pharmaceutical industry for the following applications:
- Analysis in the various stages of drug development,
- Qualitative metabolic analysis,
- Quantitative pharmacokinetic analyses.
Hourly volumes* :
CM: 15 H
Field : 5 H
Biomolecule extraction and separation
Study level
BAC +5
ECTS
2 credits
Component
Faculty of Science
This course covers techniques for extracting biomolecules (protein precipitation, SPE), as well as techniques for separating biomolecules (chromatography, electrophoresis).
Hourly volumes* :
CM: 9 h
Field: 11 a.m.
Project management - Corporate law
ECTS
4 credits
Component
Faculty of Science
Peptides and proteins
Study level
BAC +5
ECTS
2 credits
Component
Faculty of Science
Peptides and proteins are made up of a sequence of amino acid residues, giving them specific properties. Their functionality depends on their sequence and thus on the chemical functions they carry, and is also greatly modulated by their structure. In addition to conventional peptide synthesis, advanced functional modification options, structures and properties that can significantly modify or enhance the properties of the resulting peptide will be developed. Significant biotechnological developments in both the chemical and biological fields will be discussed, leading to a wide range of applications in which peptides and proteins are successfully used.
Hourly volumes*:
CM :15
TD :5
Structure-based drug design
ECTS
2 credits
Component
Faculty of Pharmacy
Chemoinformatics
Study level
BAC +5
ECTS
2 credits
Component
Faculty of Science
The EU themes are as follows:
A theoretical section dedicated to chemoinformatics
A theoretical section devoted more specifically to modeling tools for drug design
Hourly volumes* :
CM: 15 H
TD: 5 H
A practical section with computer work
Nucleic acids
Study level
BAC +5
ECTS
2 credits
Component
Faculty of Science
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
Hourly volumes* :
CM: 15 H
TD: 5 H
LC-MS, MS/MS
Study level
BAC +4
ECTS
2 credits
Component
Faculty of Science
Knowledge of LC/MS and LC/MS/MS techniques for characterizing organic molecules and biomolecules in complex media.
Description of the instruments and acquisition modes to be used in practical work.
1) Analytical chromatography-mass spectrometry techniques with ambient ionization:
- LC/MS instrumentation,
- LC/MS/MS instrumentation.
2) Coupled spectral data acquisition devices.
Hourly volumes* :
CM: 9 H
Field : 11 H
NMR
Study level
BAC +5
ECTS
2 credits
Component
Faculty of Science
In-depth knowledge of 1H, 13C, 19F, 29Siand 31PNMR, as well as two-dimensional methods. Notions of EPR will also be covered (principle and applications).
Hourly volumes* :
CM: 15 H
TD: 5 H
Separation/Purification
Study level
BAC +5
ECTS
2 credits
Component
Faculty of Science
The aim of this course is to provide students with theoretical and practical training in fundamental techniques for the separation and purification of biomolecules.
Timetable*:
CM: 9h
Field: 11h
Screening
ECTS
2 credits
Component
Faculty of Science
Understanding of screening techniques for bioactive molecules, and more generally in vitro tests used to measure a biological event in the perspective of drug discovery or diagnosis.
1) Pharmacological and biophysical fundamentals describing a biological event, target of biological tests:
2) Biological tests for the development of medicines or diagnostics
3) Applications, case studies, critical analyses.
Hourly volumes* :
CM: 15 H
TD: 5 H
Mass spectrometry
Study level
BAC +5
ECTS
2 credits
Component
Faculty of Science
Knowledge of the latest mass spectrometry techniques for the detection, identification and structural characterization of organic molecules and biomolecules.
Applications in chemistry (pharmaceutical industry) and biology (omic approaches).
1) Structural elucidation (Ion characterization technologies) :
- LC/MS/MS and exact mass measurements
- Isotope marking, H/D exchange
- Ion mobility
2) Surface analysis and imaging (molecular mapping)
3) Applications in chemistry and biology: characterization of small organic molecules and biomolecules.
Hourly volumes* :
CM: 15 H
TD: 5 H
Lipid compounds
Study level
BAC +5
ECTS
2 credits
Component
Faculty of Science
The following topics will be covered:
- Triglycerides
- Phospholipids and sphingolipids
- Glycolipids
- Fat-soluble vitamins
- Steroid hormones
- Bile salts
- Structure and synthesis of prostaglandins and leukotrienes
Hourly volumes* :
CM: 15
TD : 5
Glycochemistry
Study level
BAC +5
ECTS
2 credits
Component
Faculty of Science
The following topics will be covered:
- General mechanism of glycosylation
- Glycosyl donor synthesis
- Glycosyl donor activation methods
- Stereoselective synthesis of some natural oligosaccharides
Hourly volumes* :
CM: 15
TD : 5
Internship
Study level
BAC +5
ECTS
25 credits
Component
Faculty of Science
An internship lasting 5 to 6 months must be carried out in a research or R&D laboratory specializing in organic chemistry, biomolecule chemistry, life chemistry, analytical instrumentation or analytical analysis/development. Students will have the opportunity to carry out this end-of-study internship in academic or private research laboratories. Subject to prior approval by the teaching staff (internship subject in line with the Master's courses and suitable environment/means), students can look for a host team in an academic environment in the institutes of the Chemistry Pole of the University of Montpellier (IBMM, ICGM, IEM....), in academic laboratories outside the University of Montpellier (in France or abroad) or in the private sector (chemical, pharmaceutical, agri-food and cosmetics industries, biotechnology laboratories, etc.), as well as in research structures such as proteomics / metabolomics / fluxomics platforms.
The research project entrusted to students must be linked to the skills and expertise acquired in previous semesters and teaching units, particularly in semester 9, depending on the direction chosen.
This 5 to 6 month internship may start in mid-January after the exam session, and may not exceed 6 months for a period in semester 10 within the validity of the university registration. The teaching staff of the Chemistry of Biomolecules master's program will advise students on finding an internship that matches their aspirations and abilities.
Bibliographic project/Scientific information
Study level
BAC +5
ECTS
3 credits
Component
Faculty of Science
Scientific information: The aim of this course is to familiarize students with the search for and management of scientific information. Recent bibliographic research tools will be explained and used in lectures and practical work (electronic documentation: Scifinder / Isis / Belstein). Training in the functionalities of the Zotero tool and in the use of the electronic laboratory notebook will also be provided. The writing and use of scientific publications will also be covered.
Bibliographic project: Scientific information research tools will be applied to a concrete case. The pedagogical team will propose a bibliographical subject related to the student's chosen field of study. This bibliographical subject may, where appropriate, be defined in agreement with the host organization where the internship is to be carried out.
For this personal project, students will have access to all the bibliographic sources of the university or company hosting them. Bibliographic work may be combined with the English teaching unit to prepare an oral presentation at an international conference.
Admission
Access conditions
Applications can be submitted on the following platforms:
French & European students :
- For M1, follow the "My Master" procedure on the website: https: //www.monmaster.gouv.fr/
- For M2, students must submit their application via the e-candidat application: https: //candidature.umontpellier.fr/candidature
International students from outside the EU: follow the "Études en France" procedure: https: //pastel.diplomatie.gouv.fr/etudesenfrance/dyn/public/authentification/login.html
How to register
L3 Chemistry
Master 1 Pharmacy
Capacity
40 in M1 and M2
Necessary prerequisites
Admission to M1 is by application for holders of a national Bachelor's degree in Chemistry or Biochemistry, or a Bachelor of Technology (BUT) in Chemistry.
Recommended prerequisites
Level L3
Organic Chemistry
Characterization techniques for organic compounds
And then
Further studies
Doctoral thesis
IAE
Studying abroad
Ph. D.
Master of Business Administration
Bridges and reorientation
Candidates with an M1 in chemistry or equivalent training (M1 Pharmacy) are admitted on the basis of their academic record.
Outgoing flow Master's degree in Analytical Chemistry/Master's degree in Polymer Chemistry.
Professional integration
Business sectors: jobs at the interface of chemistry and biology, pharmaceutical industry, food industry, biotechnologies, laboratory/analytical platform (analysis and quality control), fine organic chemistry, custom synthesis, pharmaceutical and parapharmaceutical industry.
Types of jobs available: pursuing doctoral studies, researcher/executive in basic research and R&D, public/private research laboratory, teacher-researcher, researcher.