Biomolecular chemistry (BM)

Fluorinated biomolecules. Current developments of fluorinated molecules. Methods of fluorination: nucleophilic or electrophilic mono-fluorination, introduction of difluoromethyl or trifluoromethyl groups. Contribution of fluorine atoms in the activity of these compounds. Examples of syntheses of fluorinated compounds used as antitumor agents, antiviral agents, antidepressants, anxiolytics, anti-inflammatories...

Phosphorus biomolecules. Structure, nomenclature, reactivity, structural analysis and applications.

Some synthetic routes of compounds of each of the treated families will be discussed, highlighting, if necessary, non-conventional activation methods. Biomedical applications will be targeted, as well as other applications in agrochemistry, optoelectronics, nanomaterials, ...

Hourly volumes* :

CM : 15 h (7,5h Fluorinated biomolecules and 7,5h Phosphorated biomolecules)

TD : 5 h

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This course allows the acquisition of basic knowledge and transversal skills in the field of colloids and interfaces, common to the different courses of the Master Chemistry (Chemistry of Materials, Separative Chemistry, Materials and Processes, ICAP Cosmetics Engineering, Chemistry of Biomolecules). It is also offered to international students entering the SFRI program at the University of Montpellier where the teaching is given in English. An introductory presentation on the basic notions and concepts will allow to discover and better understand the main physicochemical properties of colloidal dispersions, associative colloids, and macromolecular solutions, as well as the parameters and phenomena governing the stability in colloidal dispersions and mixed solution-colloid systems. Then, an interdisciplinary practical teaching based on the principle of the flipped classroom will be proposed to help students build and deepen their knowledge through an individual and collective analysis of the various applications of colloidal and interfacial phenomena and systems.

Hourly volumes* :

CM : 7

TD : 13

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This course is designed to teach liquid chromatography and gas chromatography.

Hourly volumes* :

            CM :15h

            TD : 5h

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Knowledge of gas chromatography and electron impact ionization mass spectrometry and quadrupole mass analyzer techniques for the analysis of volatile organic molecules.

1) GC-MS analyses of volatile organic compounds:

• Electron impact ionization (EI) techniques
• Chemical ionization (CI) techniques
• Quadrupole analysis techniques (Q)
• GC/MS Couplings

2) Applications in organic chemistry analysis, characterization of volatile samples.

Hourly volumes* :

CM : 15 H

TD : 5 H

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Knowledge of the main families of polymers used in the biomedical field.

1) Specificity of polymers for biomedical applications and main families of polymers used

2) Description of the application families

3) Discussion on the notion of synthesis and the structure/property/software relationship

Hourly volumes* :

CM : 15 H

TD : 5 H

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This course deals concisely and systematically with all aspects of heterocycle chemistry, from nomenclature to applications such as the principles of action of drugs, toxins or drugs, pigments, food coloring etc...

Hourly volumes* :

CM : 15 H

TD : 5 H

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Natural products occupy a major place in the field of biomolecular chemistry. They represent an important source of bioactive compounds for medicinal chemistry. This course provides a comprehensive overview of the secondary metabolism and origin of natural products from plants. The emphasis in this unit will be on the organic chemistry behind the various biotransformations that occur during the biosynthesis of each major class of molecules. A mechanistic approach will be used to understand the chemical basis of each transformation.

Hourly volumes* :

CM : 13 

TD : 7

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NMR:

NMR (Nuclear Magnetic Resonance) in liquid phase is an essential spectroscopic method of analysis for the chemist, allowing in particular to determine the structure of small organic molecules or macromolecules in solution, the study of dynamic phenomena... The objective of this course is to understand the phenomena involved in this technique and to relate them to the various structural information accessible by this method. The aim is to be able to exploit the spectral data resulting from this analysis to elucidate the structure and stereochemistry of organic molecules or polymer structures, or to carry out reaction monitoring.

X-ray diffraction:

X-ray diffraction is a powerful and non-destructive technique for characterizing the crystal structure of materials, but it is also able to provide crystallographic and structural information such as lattice parameters and atomic positions. This includes all crystallized materials such as ceramics, materials for energy and information storage and transformation as well as organic molecules and metal complexes (interatomic distances and angles, stereochemistry (chirality, stereoisomerism...), intra and intermolecular bonds...). The objective of this course is an introduction to crystallography and diffraction, with the aim of understanding the operation and characteristics of an X-ray diffractometer, as well as the interpretation of diffraction patterns (structural analysis, lattice parameters).

Hourly volumes* :

            CM : 10

            TD : 10

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Knowledge of the latest mass spectrometry techniques for the qualitative analysis of organic molecules and biomolecules.

1) Description of Fundamentals (Ion Science and Technology):

- Ionization techniques

- Analysis techniques

- Tandem mass spectrometry (MS/MS)

- LC/MS and LC/MS/MS couplings

2) Application in the context of biomolecule analysis and organic chemistry reaction monitoring.

Hourly volumes* :

CM : 15 H

TD : 5 H

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This course will cover the fundamental concepts and practical tools related to chemometrics through : - statistical analysis of data ;

• laws of probability ;
• confidence interval estimation ;
• parametric and non-parametric tests.

An introduction to experimental design will be offered at the end of the module.

Hourly volumes* :

CM : 7h

TD : 13h

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The first part of the course presents the fundamental knowledge of organometallic chemistry of transition metals. It starts with the description of the Metal-C bond allowing the understanding of its stability and chemical reactivity. In a second step, the power of this synthesis tool for the formation of C-H, C-C bonds, ... Examples of their applications in different fields will allow the acquisition of these reactions and their fields of applications: fine chemistry, catalytic transformations of industrial importance, synthesis of natural products, preparation of materials.

The second part of this course is dedicated to the chemistry of hetero-elements focused on the elements Silicon, Tin and Boron. This part aims at presenting the different methods of preparation of boron, tin and silicon reagents as well as the main transformations performed with these compounds, with applications in organic synthesis and materials synthesis.

CM : 13 H 

TD : 7 H

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This teaching unit is dedicated to the deepening of the bases of organic chemistry and coordination chemistry seen in L3 and to the acquisition of notions related to molecular engineering and molecular chemistry. The UE includes lectures and tutorials. The students will work before some lectures and tutorials with course documents provided so that the lectures and tutorials can allow them to be fully involved in the training, to understand the concepts presented and the skills to be acquired. The progression program and activities will be proposed. For those students who have not seen the basics of coordination chemistry and organic chemistry, the documents will be made available.

Coordination chemistry: The teaching will cover the different aspects of transition metal and lanthanide complexes, molecular materials (polynuclear complexes and coordination polymers with extended structures (MOFs, etc.)) and their properties and applications. Structural aspects, bonding description, properties, as well as stability and reactivity aspects will be discussed. Emphasis will be put on the complexation effect and on the stability of metal, lanthanide and actinide complexes with certain ligands for applications in the biomedical field (imaging and therapy), decontamination (nuclear field), etc. The electronic (relaxivity, magnetism) and optical (absorption, luminescence) properties of these complexes will be discussed and put in the context of applications in various fields, such as imaging, electronics, sensors, etc.

Organic Chemistry: The teaching is based on the knowledge acquired in the Bachelor's degree and will approach through a reasoned study the main reaction mechanisms of organic chemistry and will allow to give a common base to all the students of the Master Chemistry. The main processes (substitution, addition, elimination, transposition...) and their essential characteristics and applications to mechanistic sequences will be examined. This course should provide the student with general tools for the analysis of mechanisms (ionic, radical, concerted) in order to understand these mechanisms in their variety.

Hourly volumes* :

CM : 13 H

TD : 7 H

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The professionalization project provides a link between the traditional practical work and the internship in a laboratory or company. It is carried out in the form of a tutored project consisting of putting the student in a professional situation through collaborative (group) work based on the realization of a project in response to a problem set by a company, community, association or academic. It is part of the core curriculum of the Chemistry Master's program and is carried out under the responsibility of a member of the teaching team (university or industry). Carried out throughout the semester, this project aims to relate and anchor the knowledge/know-how acquired in the framework of the Bachelor's degree and the beginning of the Master's degree through this professional situation. These situations will be directly linked to the Master's program chosen by the students. In addition to the disciplinary skills of chemistry, other relational, organizational and communication skills, intrinsically linked to project management, will also be acquired and will arm the students for their future professional life.

Answer a research problem: example of synthesis of new phosphorescent materials.

Hourly volumes* :

CM : 5h

TD : 5h

Practical work : 40h

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The internship in semester 8 of the Master 1 Chemistry of Biomolecules aims to familiarize students with research careers in life chemistry. Thus, the students will have the possibility of carrying out this training course of initiation to research within academic or private laboratories. Subject to prior acceptance by the teaching staff (internship subject related to the Master's courses and adequate environment/means), the student may look for a host team in an academic environment in the institutes of the Chemistry Pole of the University of Montpellier (IBMM, ICGM, ...), in academic laboratories outside the University of Montpellier (in France or abroad) or in the private sector (chemical, pharmaceutical, agri-food industries, biotech laboratories, ...).

Field : 2 to 4 months of internship

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Nucleosides are the basic constituents of nucleic acids (DNA and RNA). As such, they play an essential role in many biological processes. In this course, the structure and biological role of natural nucleosides will be presented. The main synthesis and characterization routes of these compounds and their analogues (glycosylation reactions, structural modifications of the furanose ring, substitution and introduction of heteroatoms, configuration inversion, etc.) will also be discussed. The use of nucleoside analogues for the treatment of viral pathologies and cancers will also be discussed.

Hourly volumes* :

CM : 3 pm

TD : 5 h

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This teaching unit is mutualized for the MI students of the Master Chemistry: ICAP P1, ICAP P2, MAT P1, MAT P2, BM (semester S2). The following topics will be covered:

• The 12 Principles of Green Chemistry and the Units of Measurement in Green Chemistry ;
• Synthesis strategies in sustainable chemistry;
• Alternative or eco-compatible solvents for synthesis and extraction;
• Non-conventional activation techniques and applications.

CM : 13

TD : 7 H

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The medicinal chemistry course aims to introduce students to the key steps in the development process of molecules with biological activities. In particular, a description of the interactions involved, the notion of pharmocophores, bio-isosteria..., as well as structure-activity relationship studies will be addressed in order to consider strategies and adequate structural modifications.

Hourly volumes* :

CM : 3 pm

TD : 5 h

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After generalities on the notions of prochirality and stereochemistry, this teaching will present the tools allowing the mastery of diastereoselective and enantioselective syntheses. The different approaches will be presented in a detailed and rational way. Examples of industrial syntheses of chiral bioactive molecules will be discussed.

Hourly volumes* :

CM : 15 H

TD : 5 H

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This course discusses synthetic methods applied to obtain enantiopure amino acids as well as the use of chiral amino acids for the synthesis of other enantiopure compounds.

These amino acids are the basic elements of peptides. The different physico-chemical properties induced by the nature of these amino acids will allow to define strategies for the synthesis of peptides of interest and their characterization.

Hourly volumes* :

CM : 15 H

TD : 5 H

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The following topics will be covered:

- Biobased solvents

- Fuels from biomass

- Antioxidants derived from lignin

- Metal catalysts from plants

- Surfactants obtained from renewable resources

- Examples of industrial applications of enzymatic synthesis

Hourly volumes* :

CM : 15

TD : 5

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This UE will address in small groups or in a personalized way the pedagogical tools and good practices related to communication and professional insertion, through :

• knowledge, skills, competencies, attitudes and motivations assessments;
• awareness of job search techniques;
• CV and cover letter writing;
• rules of oral and written communication;
• mock job interviews.

Situations directly related to the sectors of activity targeted by the students' courses will be proposed.

TP : 20h

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General presentation of the most commonly used computational and modeling methods in the field of solid state chemistry according to the spatial and temporal scales that can be studied with them:

(1) Quantum calculations (Hartree Fock, Post-Hartree Fock methods, DFT),

(2) Force field based modeling (atomistic and coarse grain),

(3) Hybrid QMM and AACG modeling.

Presentation of the different calculation techniques: static and optimization calculations, molecular dynamics and Monte Carlo.

The UE will have courses of type CM and TP. Two practical modeling works will be proposed: modeling techniques in classical mechanics and quantum calculations.

            CM : 11H

            TD : 9H

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Hybrid" materials are a new family of materials, associating organic ligands with inorganic entities, and are increasingly studied at both fundamental and application levels.

In this EU, two main categories of hybrid materials will be discussed:

• Coordination Networks and Metal-Organic Frameworks
• Organosilicon/carbon materials

CM : 10 h

TD : 10 h

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This teaching unit is dedicated to the presentation of inorganic materials and nanomaterials for use in the biomedical field (imaging, therapy, implants). This UE is the deepening of the knowledge acquired in the UE HAC930C (Development of materials for health). The aim is to develop health issues and inorganic materials and nanomaterials in diagnosis, therapy and well-being. Strategies for the development of future inorganic materials and nanomaterials based on therapeutics and multifunctionality, and smart materials will also be addressed.

The UE includes lectures and tutorials. A group project on the (theoretical) study of an inorganic material or nanomaterials for health will be proposed to the students.    

CM : 11

 TD : 9

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The teaching of the module of strategies and tools in organic synthesis is centered on the deepening of the strategies of elaborations of molecules resulting or not from the natural environment using the tools of organic chemistry.

Hourly volumes* :

CM : 15 H

TD : 5 H

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The themes of the EU are the following:

A theoretical part dedicated to chemoinformatics

A theoretical part dedicated more specifically to modeling tools for drug design

Hourly volumes* :

CM : 15 H 

TD : 5 H

A part dedicated to the practical aspect with work on computers

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Peptides and proteins are composed of a sequence of amino acid residues that give them specific properties. Their functionality depends on their sequence and thus on the chemical functions they carry, and is also greatly modulated by their structure. In addition to conventional peptide synthesis, advanced functional modification options, structures, and properties that can significantly modify or improve the properties of the resulting peptide will be developed. Significant biotechnological developments in both the chemical and biological fields will be discussed leading to a wide range of applications in which peptides and proteins are successfully used.

Hourly volumes*:

CM :15

TD :5

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Receptors are of major interest in medicinal chemistry and constitute more than 40% of current therapeutic targets. This course is an interdisciplinary approach to provide the basic concepts and fundamentals of receptology necessary for students pursuing their training in biomolecular chemistry at the chemistry-biology interface.

Hourly volumes* :

CM : 15 H 

TD : 5 H

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Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.

Hourly volumes* :

            CM : 15 H  

            TD : 5 H

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 Deepening of knowledge in ^1H, ^13C, ^19F, ^29Si, ^31PNMR, as well as two-dimensional methods. Notions of EPR will also be covered (principle and applications).

Hourly volumes* :

CM : 15 H

TD : 5 H

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In this course, the different molecular or supramolecular tools for the delivery of active ingredients according to the type of cells or intracellular organelles targeted are discussed. Ligand-receptor interactions will be discussed as well as the methods of preparation and activation of conjugates. Examples of drugs will be presented.

Hourly volumes* :

CM : 15 H

TD : 5 H

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Knowledge of the latest mass spectrometry techniques for the detection, identification and structural characterization of organic molecules and biomolecules.

Applications in chemistry (pharmaceutical industry) and biology (Omics approaches).

1) Structural elucidation (Ion characterization technologies):

• LC/MS/MS and exact mass measurements 
• Isotopic labelling, H/D exchange
• Ionic mobility

2) Surface analysis and imaging (molecular mapping)

3) Application in chemistry and biology: characterization of small organic molecules and biomolecules.

Hourly volumes* :

CM : 15 H

TD : 5 H

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The course will focus on organic chemistry and post-functionalization of biomolecules applied to peptides, proteins and nucleic acids (DNA and RNA) with applications in gene therapy, biosensing and design of probes for biological studies.

Hourly volumes* :

CM : 15 H 

TD : 5 H

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The following topics will be covered:

- Triglycerides

- Phospholipids and sphingolipids

- Glycolipids

- Fat-soluble vitamins

- Steroid hormones

- Bile salts

- Structure and synthesis of prostaglandins and leukotrienes

Hourly volumes* :

CM : 15

TD : 5

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The following topics will be covered:

- General mechanism of glycosylation

- Synthesis of glycosyl donors

- Methods of activation of glycosyl donors

- Stereoselective synthesis of some natural oligosaccharides

Hourly volumes* :

CM : 15

TD : 5

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Knowledge of the limitations associated with the administration of an active ingredient (solubility, bioavailability, etc.).

General description of the enzymatic systems involved in the biotransformation of nutrients and exogenous compounds.

Description of the main modes of membrane passage and transport systems of fundamental biomolecules (sugars, amino acids, nucleosides...).

Examples of prodrug(s) and bioprecursor(s) design.

Hourly volumes* :

CM : 15 H

TD : 5 H

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This teaching unit is dedicated to the presentation of inorganic materials and nanomaterials for use in the biomedical field (imaging, therapy, implants). This UE is the deepening of the knowledge acquired in the UE HAC930C (Development of materials for health). The aim is to develop health issues and inorganic materials and nanomaterials in diagnosis, therapy and well-being. Strategies for the development of future inorganic materials and nanomaterials based on therapeutics and multifunctionality, and smart materials will also be addressed.

The UE includes lectures and tutorials. A group project on the (theoretical) study of an inorganic material or nanomaterials for health will be proposed to the students

Hourly volumes* :

            CM : 11

            TD : 9

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An internship of 5 to 6 months duration must be carried out in a research or research and development laboratory specialized in organic chemistry, biomolecular chemistry, life chemistry, analytical instrumentation or analytical analysis/development. Thus, students will have the opportunity to carry out this end-of-study internship in academic or private research laboratories. Subject to the prior acceptance of the teaching staff (internship subject in connection with the master's courses and adequate environment/means), the student will be able to look for a host team in the academic environment in the institutes of the Chemistry Pole of the University of Montpellier (IBMM, ICGM, IEM...), in academic laboratories outside the University of Montpellier (in France or abroad) or in the private sector (chemical, pharmaceutical, agri-food, cosmetic industries, biotechnology laboratories, etc.) as well as in research structures such as proteomic/metabolomic/flowomic platforms.

The research project that will be entrusted to the students will have to be linked to the skills and expertise acquired during the previous semesters and the teaching units followed, in particular in semester 9 according to the chosen orientation.

This internship of 5 to 6 months can start from mid-January after the exam session and cannot exceed 6 months for a period in semester 10 included during the validity of the university registration. The pedagogical team of the master Chemistry of Biomolecules will advise the students to find an internship corresponding to their aspirations and capacities.

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Scientific information: The aim of this course is to familiarize students with the search and management of scientific information. In this context, recent tools for bibliographic research will be explained and used during courses/DD (Electronic documentation: Scifinder / Isis / Belstein). Training in the functionalities of the Zotero tool and in the use of the electronic laboratory notebook will also be provided. The writing and use of scientific publications will be addressed.

Bibliographic project: The tools of scientific information research will be applied to a concrete case. The pedagogical team will propose a bibliographic subject to the student in relation with the chosen orientation. This bibliographic subject may, if necessary, be defined in agreement with the host organization where the internship will be carried out.

For this personal project, the student will have access to all the bibliographic sources of the university or the company that hosts him/her. The bibliographic work may be combined with the English teaching unit in order to prepare an oral presentation at an international conference.

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The aim of this course is to highlight biological processes at the cellular level or even in living subjects. Different molecular imaging approaches will be discussed (fluorescent probes, radiolabeling).

Hourly volumes* :

            CM : 9 H

           Field : 11 H

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The principles of Green Chemistry provide a basis for the evaluation and design of new chemical products and processes that minimize negative impacts on human health and the environment. In this teaching unit, offered to M2 students of the Master of Biomolecular Chemistry (BM), Orientation 2 (O2), the basic principles and concepts of Green Chemistry will be discussed, and their applications in the field of non-conventional activation methods and the use of alternative media in organic synthesis.

Hourly volumes* :

CM : 9 H

Field: 11 a.m.

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This course will teach techniques for the extraction of biomolecules (protein precipitation, SPE), as well as techniques for the separation of biomolecules (chromatography, electrophoresis).

Hourly volumes* :

            CM : 9 h

            Field: 11 a.m.

See full page

See full page

Peptides and proteins are composed of a sequence of amino acid residues that give them specific properties. Their functionality depends on their sequence and thus on the chemical functions they carry, and is also greatly modulated by their structure. In addition to conventional peptide synthesis, advanced functional modification options, structures, and properties that can significantly modify or improve the properties of the resulting peptide will be developed. Significant biotechnological developments in both the chemical and biological fields will be discussed leading to a wide range of applications in which peptides and proteins are successfully used.

Hourly volumes*:

CM :15

TD :5

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In chemistry, solid phase synthesis is a method in which molecules are covalently bonded to a solid support and synthesized step by step using selective protecting groups. The purpose of this applied course is to provide a comprehensive understanding of this field and to examine supported strategies for the practical preparation of polypeptides and oligonucleotides.

Hourly volumes* :

CM : 9 H 

Field : 11 H

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Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.

Hourly volumes* :

            CM : 15 H  

            TD : 5 H

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In this course, the different molecular or supramolecular tools for the delivery of active ingredients according to the type of cells or intracellular organelles targeted are discussed. Ligand-receptor interactions will be discussed as well as the methods of preparation and activation of conjugates. Examples of drugs will be presented.

Hourly volumes* :

CM : 15 H

TD : 5 H

See full page

The course will focus on organic chemistry and post-functionalization of biomolecules applied to peptides, proteins and nucleic acids (DNA and RNA) with applications in gene therapy, biosensing and design of probes for biological studies.

Hourly volumes* :

CM : 15 H 

TD : 5 H

See full page

 Deepening of knowledge in ^1H, ^13C, ^19F, ^29Si, ^31PNMR, as well as two-dimensional methods. Notions of EPR will also be covered (principle and applications).

Hourly volumes* :

CM : 15 H

TD : 5 H

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This course aims at describing the synthesis tools applied to complex and polyfunctional molecules. Retrosynthetic and stereocontrolled approaches will be discussed as well as the rational use of protective groups.

Hourly volumes* :

CM : 9 H

Field : 11 H

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Bioconjugation reactions are of major interest in the biomedical sciences and allow chemists to modify biomolecules to confer new functions or properties. In this course, bioconjugation and biomolecule labeling strategies will be discussed in order to explore complex biological systems. The practical sessions will illustrate these concepts through examples of bioconjugation of osidic and nucleotidic platforms.

Hourly volumes* :

CM : 9 H 

Field : 11 H

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Knowledge of the latest mass spectrometry techniques for the detection, identification and structural characterization of organic molecules and biomolecules.

Applications in chemistry (pharmaceutical industry) and biology (Omics approaches).

1) Structural elucidation (Ion characterization technologies):

• LC/MS/MS and exact mass measurements 
• Isotopic labelling, H/D exchange
• Ionic mobility

2) Surface analysis and imaging (molecular mapping)

3) Application in chemistry and biology: characterization of small organic molecules and biomolecules.

Hourly volumes* :

CM : 15 H

TD : 5 H

See full page

The following topics will be covered:

- Triglycerides

- Phospholipids and sphingolipids

- Glycolipids

- Fat-soluble vitamins

- Steroid hormones

- Bile salts

- Structure and synthesis of prostaglandins and leukotrienes

Hourly volumes* :

CM : 15

TD : 5

See full page

The following topics will be covered:

- General mechanism of glycosylation

- Synthesis of glycosyl donors

- Methods of activation of glycosyl donors

- Stereoselective synthesis of some natural oligosaccharides

Hourly volumes* :

CM : 15

TD : 5

See full page

An internship of 5 to 6 months duration must be carried out in a research or research and development laboratory specialized in organic chemistry, biomolecular chemistry, life chemistry, analytical instrumentation or analytical analysis/development. Thus, students will have the opportunity to carry out this end-of-study internship in academic or private research laboratories. Subject to the prior acceptance of the teaching staff (internship subject in connection with the master's courses and adequate environment/means), the student will be able to look for a host team in the academic environment in the institutes of the Chemistry Pole of the University of Montpellier (IBMM, ICGM, IEM...), in academic laboratories outside the University of Montpellier (in France or abroad) or in the private sector (chemical, pharmaceutical, agri-food, cosmetic industries, biotechnology laboratories, etc.) as well as in research structures such as proteomic/metabolomic/flowomic platforms.

The research project that will be entrusted to the students will have to be linked to the skills and expertise acquired during the previous semesters and the teaching units followed, in particular in semester 9 according to the chosen orientation.

This internship of 5 to 6 months can start from mid-January after the exam session and cannot exceed 6 months for a period in semester 10 included during the validity of the university registration. The pedagogical team of the master Chemistry of Biomolecules will advise the students to find an internship corresponding to their aspirations and capacities.

See full page

See full page

Scientific information: The aim of this course is to familiarize students with the search and management of scientific information. In this context, recent tools for bibliographic research will be explained and used during courses/DD (Electronic documentation: Scifinder / Isis / Belstein). Training in the functionalities of the Zotero tool and in the use of the electronic laboratory notebook will also be provided. The writing and use of scientific publications will be addressed.

Bibliographic project: The tools of scientific information research will be applied to a concrete case. The pedagogical team will propose a bibliographic subject to the student in relation with the chosen orientation. This bibliographic subject may, if necessary, be defined in agreement with the host organization where the internship will be carried out.

For this personal project, the student will have access to all the bibliographic sources of the university or the company that hosts him/her. The bibliographic work may be combined with the English teaching unit in order to prepare an oral presentation at an international conference.

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Description of the most recent mass spectrometry techniques for analyses in the pharmaceutical industry (drug development : Drug discovery and pre-clinical analysis).

Mass spectrometry instrumentation and acquisition modes in the pharmaceutical industry for the following applications:

• Analyses in the various stages of drug development,
• Qualitative analysis in metabolism,
• Quantitative analyses in pharmacokinetics.

Hourly volumes* :

            CM : 15 H

           Field : 5 H

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This course will teach techniques for the extraction of biomolecules (protein precipitation, SPE), as well as techniques for the separation of biomolecules (chromatography, electrophoresis).

Hourly volumes* :

            CM : 9 h

            Field: 11 a.m.

See full page

See full page

Peptides and proteins are composed of a sequence of amino acid residues that give them specific properties. Their functionality depends on their sequence and thus on the chemical functions they carry, and is also greatly modulated by their structure. In addition to conventional peptide synthesis, advanced functional modification options, structures, and properties that can significantly modify or improve the properties of the resulting peptide will be developed. Significant biotechnological developments in both the chemical and biological fields will be discussed leading to a wide range of applications in which peptides and proteins are successfully used.

Hourly volumes*:

CM :15

TD :5

See full page

See full page

See full page

The themes of the EU are the following:

A theoretical part dedicated to chemoinformatics

A theoretical part dedicated more specifically to modeling tools for drug design

Hourly volumes* :

CM : 15 H 

TD : 5 H

A part dedicated to the practical aspect with work on computers

See full page

Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.

Hourly volumes* :

            CM : 15 H  

            TD : 5 H

See full page

Knowledge of LC/MS and LC/MS/MS techniques for the characterization of organic molecules and biomolecules in complex media. 

Description of the instruments and acquisition modes that will be used in the lab.

1) Analytical Chromatography techniques coupled to mass spectrometry with ambient ionization:

• LC/MS type instrumentation,
• LC/MS/MS type instrumentation.

2) Coupled spectral data acquisition devices.

Hourly volumes* :

CM : 9 H

Field : 11 H

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 Deepening of knowledge in ^1H, ^13C, ^19F, ^29Si, ^31PNMR, as well as two-dimensional methods. Notions of EPR will also be covered (principle and applications).

Hourly volumes* :

CM : 15 H

TD : 5 H

See full page

The objective of this course is to give students a theoretical and practical training in the fundamental techniques of separation and purification of biomolecules

Hourly volumes* :
CM : 9h
Field : 11h

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Understanding of screening techniques for bioactive molecules, and more generally in vitro tests used to measure a biological event in the perspective of drug discovery or diagnosis.

1) Pharmacological and biophysical fundamentals describing a biological event, target of biological tests:

2) Biological tests for the development of medicines or diagnostics

3) Applications, case studies, critical analyses.

Hourly volumes* :

CM : 15 H

TD : 5 H

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Knowledge of the latest mass spectrometry techniques for the detection, identification and structural characterization of organic molecules and biomolecules.

Applications in chemistry (pharmaceutical industry) and biology (Omics approaches).

1) Structural elucidation (Ion characterization technologies):

• LC/MS/MS and exact mass measurements 
• Isotopic labelling, H/D exchange
• Ionic mobility

2) Surface analysis and imaging (molecular mapping)

3) Application in chemistry and biology: characterization of small organic molecules and biomolecules.

Hourly volumes* :

CM : 15 H

TD : 5 H

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The following topics will be covered:

- Triglycerides

- Phospholipids and sphingolipids

- Glycolipids

- Fat-soluble vitamins

- Steroid hormones

- Bile salts

- Structure and synthesis of prostaglandins and leukotrienes

Hourly volumes* :

CM : 15

TD : 5

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The following topics will be covered:

- General mechanism of glycosylation

- Synthesis of glycosyl donors

- Methods of activation of glycosyl donors

- Stereoselective synthesis of some natural oligosaccharides

Hourly volumes* :

CM : 15

TD : 5

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An internship of 5 to 6 months duration must be carried out in a research or research and development laboratory specialized in organic chemistry, biomolecular chemistry, life chemistry, analytical instrumentation or analytical analysis/development. Thus, students will have the opportunity to carry out this end-of-study internship in academic or private research laboratories. Subject to the prior acceptance of the teaching staff (internship subject in connection with the master's courses and adequate environment/means), the student will be able to look for a host team in the academic environment in the institutes of the Chemistry Pole of the University of Montpellier (IBMM, ICGM, IEM...), in academic laboratories outside the University of Montpellier (in France or abroad) or in the private sector (chemical, pharmaceutical, agri-food, cosmetic industries, biotechnology laboratories, etc.) as well as in research structures such as proteomic/metabolomic/flowomic platforms.

The research project that will be entrusted to the students will have to be linked to the skills and expertise acquired during the previous semesters and the teaching units followed, in particular in semester 9 according to the chosen orientation.

This internship of 5 to 6 months can start from mid-January after the exam session and cannot exceed 6 months for a period in semester 10 included during the validity of the university registration. The pedagogical team of the master Chemistry of Biomolecules will advise the students to find an internship corresponding to their aspirations and capacities.

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Scientific information: The aim of this course is to familiarize students with the search and management of scientific information. In this context, recent tools for bibliographic research will be explained and used during courses/DD (Electronic documentation: Scifinder / Isis / Belstein). Training in the functionalities of the Zotero tool and in the use of the electronic laboratory notebook will also be provided. The writing and use of scientific publications will be addressed.

Bibliographic project: The tools of scientific information research will be applied to a concrete case. The pedagogical team will propose a bibliographic subject to the student in relation with the chosen orientation. This bibliographic subject may, if necessary, be defined in agreement with the host organization where the internship will be carried out.

For this personal project, the student will have access to all the bibliographic sources of the university or the company that hosts him/her. The bibliographic work may be combined with the English teaching unit in order to prepare an oral presentation at an international conference.

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