Biomolecular Chemistry (BM)

Fluorinated biomolecules. Current developments in fluorinated molecules. Fluorination methods: nucleophilic and electrophilic monofluorination, introduction of difluoromethyl or trifluoromethyl groups. Contribution of fluorine atoms to the activity of these compounds. Examples of syntheses of fluorinated compounds used as antitumor agents, antivirals, antidepressants, anxiolytics, anti-inflammatories, etc.

Phosphorus-containing biomolecules. Structure, nomenclature, reactivity, structural analysis, and applications.

Several methods for synthesizing compounds from each of the families covered will be discussed, highlighting unconventional activation methods where applicable. Biomedical applications will be targeted, as well as other applications in agrochemistry, optoelectronics, nanomaterials, etc.

Hourly volumes:

CM: 15 hours (7.5 hours fluorinated biomolecules and 7.5 hours phosphorous biomolecules)

Tutorial: 5 hours

See the full page

See the full page

This course unit enables students to acquire basic knowledge and cross-disciplinary skills in the field of colloids and interfaces, which are common to the various tracks of the Master's degree in Chemistry (Materials Chemistry, Separative Chemistry, Materials and Processes, ICAP Cosmetics Engineering, Biomolecular Chemistry). It is also offered to international students enrolled in the SFRI program at the University of Montpellier, where courses are taught in English. An introductory presentation on basic notions and concepts will enable students to discover and better understand the main physicochemical properties of colloidal dispersions, associative colloids, and macromolecular solutions, as well as the parameters and phenomena governing stability in colloidal dispersions and mixed solution-colloid systems. This will be followed by interdisciplinary practical teaching based on the flipped classroom principle to help students build and deepen their knowledge through individual and collective analysis of the various applications of colloidal and interfacial phenomena and systems.

Hourly volumes:

CM: 7

TD: 13

See the full page

This course aims to teach liquid chromatography and gas chromatography.

Hourly volumes:

            CM: 3:00 p.m.

            Tutorial: 5 hours

See the full page

Knowledge of gas chromatography techniques and mass spectrometry with electron impact ionization and quadrupole mass analyzer for the analysis of volatile organic molecules.

1) GC-MS analyses of volatile organic compounds:

• Electron impact (EI) ionization techniques
• Chemical ionization (CI) techniques
• Quadrupole (Q) analysis techniques
• GC/MS Couplings

2) Applications in organic chemistry analysis and characterization of volatile samples.

Hourly volumes*:

CM: 3 p.m.

Tutorial: 5 hours

See the full page

Knowledge of the major families of polymers used in the biomedical field.

1) Specificity of polymers for biomedical applications and major families of polymers used

2) Description of application families

3) Discussion on the concept of synthesis and the relationship between structure, properties, and specifications

Hourly volumes*:

CM: 3 p.m.

Tutorial: 5 hours

See the full page

This course concisely and systematically covers all aspects of heterocyclic chemistry, from nomenclature to applications such as the principles of action of medicines, toxins, drugs, pigments, food colorings, etc.

Hourly volumes*:

CM: 3 p.m.

Tutorial: 5 hours

See the full page

Natural products occupy a major place in the field of biomolecular chemistry. They represent an important source of bioactive compounds for medicinal chemistry. This teaching unit provides a comprehensive overview of secondary metabolism and the origin of natural products derived from plants. This teaching unit will focus on the organic chemistry behind the various biotransformations that occur during the biosynthesis of each major class of molecule. A mechanistic approach will be used to understand the chemical basis of each transformation.

Hourly volumes*:

CM: 13 

TD: 7

See the full page

NMR:

Liquid-phase NMR (Nuclear Magnetic Resonance) is an essential spectroscopic analysis method for chemists, enabling them to determine the structure of small organic molecules or macromolecules in solution, study dynamic phenomena, and more. The aim of this course unit is to understand the phenomena involved in this technique and to relate them to the various structural information accessible by this method. The goal is to be able to use the spectral data from this analysis to elucidate the structure and stereochemistry of organic molecules or polymer structures, or to monitor reactions.

X-ray diffraction:

X-ray diffraction is a powerful, non-destructive technique for characterizing the crystalline structure of materials. It can also provide crystallographic and structural information such as lattice parameters and atomic positions. This includes all crystallized materials such as ceramics, materials for energy and information storage and conversion, as well as organic molecules and metal complexes (interatomic distances and angles, stereochemistry (chirality, stereoisomerism, etc.), intra- and intermolecular bonds, etc.). The objective of this course unit is to provide an introduction to crystallography and diffraction, with the aim of understanding the operation and characteristics of an X-ray diffractometer, as well as interpreting diffraction patterns (structural analysis, lattice parameters).

Hourly volumes:

            CM: 10

            TD: 10

See the full page

Knowledge of the latest mass spectrometry techniques for the qualitative analysis of organic molecules and biomolecules.

1) Description of fundamental principles (Ion science and technology):

- Ionization techniques

- Analysis techniques

- Tandem mass spectrometry (MS/MS)

- LC/MS and LC/MS/MS couplings

2) Application in the context of biomolecule analysis and monitoring of organic chemistry reactions.

Hourly volumes*:

CM: 3 p.m.

Tutorial: 5 hours

See the full page

This course will cover the fundamental concepts and practical tools related to chemometrics through: - statistical data analysis;

• the laws of probability;
• confidence interval estimation;
• parametric and nonparametric tests.

An introduction to design of experiments will be offered at the end of the module.

Hourly volumes:

CM: 7 a.m.

TD: 1:00 PM

See the full page

The first part of the course presents the fundamental knowledge of organometallic chemistry of transition metals. It begins with a description of the metal-carbon bond, enabling an understanding of its stability and chemical reactivity.  Next, we will demonstrate the power of this synthesis tool for forming C-H, C-C, and other bonds. Examples of their applications in different fields will help students learn about these reactions and their fields of application: fine chemistry, catalytic transformations of industrial importance, synthesis of natural products, and preparation of materials.

The second part of this course is devoted to the chemistry of heteroelements, focusing on silicon, tin, and boron. This part aims to present the different methods of preparing boron-, tin-, and silicon-based reagents, as well as the main transformations carried out with these compounds, with applications in organic synthesis and materials synthesis.

CM: 1:00 PM 

Tutorial: 7 hours

See the full page

This teaching unit is dedicated to deepening the foundations of organic chemistry and coordination chemistry covered in L3 and to acquiring concepts related to molecular engineering and molecular chemistry. The teaching unit consists of lectures and tutorials. Students will prepare for certain lectures and tutorials using course materials provided, enabling them to participate fully in the lectures and tutorials, understand the concepts presented, and acquire the necessary skills. The progression program and activities will be proposed. For students who have not studied the basics of coordination chemistry and organic chemistry, documents will be made available.

Coordination chemistry: The course will cover various aspects of transition metal and lanthanide complexes, molecular materials (polynuclear complexes and coordination polymers with extended structures (MOFs, etc.)) as well as their properties and applications. Structural aspects, bond descriptions, properties, and aspects related to stability and reactivity will be addressed. Emphasis will be placed on the complexation effect and the stability of metal, lanthanide, and actinide complexes with certain ligands for applications in the biomedical field (imaging and therapy), decontamination (nuclear field), etc. The electronic (relaxivity, magnetism) and optical (absorption, luminescence) properties of these complexes will be discussed and placed in the context of applications in various fields, such as imaging, electronics, sensors, etc.

Organic Chemistry: The course builds on the knowledge acquired in the Bachelor's degree and will use a reasoned study approach to address the main reaction mechanisms in organic chemistry, providing a common foundation for all students in the Master's in Chemistry program. The main processes (substitution, addition, elimination, transposition, etc.) and their essential characteristics and applications to mechanistic sequences will be examined. This course should provide students with general tools for analyzing mechanisms (ionic, radical, concerted) in order to understand these mechanisms in all their variety.

Hourly volumes:

CM: 1:00 PM

Tutorial: 7 hours

See the full page

The professional project bridges the gap between traditional practical work and internships in laboratories or companies. It takes the form of a supervised project consisting of placing students in a professional situation through collaborative (group) work based on carrying out a project in response to a problem set by a company, local authority, association, or academic. It is part of the core curriculum of the Master's in Chemistry and is carried out under the supervision of a member of the teaching team (academic or industrial). Conducted throughout the semester, this project aims to connect and consolidate the knowledge and skills acquired during the Bachelor's and early Master's programs through this professional situation. These scenarios will be directly related to the Master's program chosen by the students. In addition to chemistry-specific skills, other interpersonal, organizational, and communication skills intrinsically linked to project management will also be acquired, equipping students for their future professional lives.

Addressing a research issue: example of a summary of new phosphorescent materials.

Hourly volumes:

CM: 5 hours

Tutorial: 5 hours

Practical work: 40 hours

See the full page

The internship in semester 8 of the Master 1 in Biomolecular Chemistry aims to familiarize students with careers in life sciences research. Students will have the opportunity to complete this introductory research internship in academic or private laboratories. Subject to prior approval by the teaching team (internship topic related to the Master's program and appropriate environment/resources), students may seek a host team in an academic setting at one of the institutes of the Chemistry Cluster at the University of Montpellier (IBMM, ICGM, , etc.), in academic laboratories outside the University of Montpellier (in France or abroad), or in the private sector (chemical, pharmaceutical, and agri-food industries, biotechnology laboratories, etc.).

Fieldwork: 2 to 4 months of internship

See the full page

Nucleosides are the basic building blocks of nucleic acids (DNA and RNA). As such, they play an essential role in many biological processes. This course will present the structure and biological role of natural nucleosides. The main methods of synthesis and characterization of these compounds and their analogues (glycosylation reactions, structural modifications of the furanose ring, substitution and introduction of heteroatoms, configuration inversion, etc.) will also be discussed. The use of nucleoside analogues for the treatment of viral diseases and cancers will also be addressed.

Hourly volumes:

CM: 3 p.m.

Tutorial: 5 hours

See the full page

This teaching unit is shared by MI students in the Master's in Chemistry program: ICAP P1, ICAP P2, MAT P1, MAT P2, and BM (semester S2) courses. The following topics will be covered:

• The 12 Principles of Green Chemistry and units of measurement in Green Chemistry;
• Synthesis strategies in sustainable chemistry;
• Alternative or eco-friendly solvents for synthesis and extraction;
• Unconventional activation techniques and applications.

CM: 13

Tutorial: 7 hours

See the full page

The aim of teaching medicinal chemistry is to introduce students to the key stages in the process of developing molecules with biological activities. In particular, a description of the interactions involved, the concept of pharmacophores, bioisosterism, etc., as well as structure-activity relationship studies will be covered, enabling students to consider appropriate strategies and structural modifications.

Hourly volumes:

CM: 3 p.m.

Tutorial: 5 hours

See the full page

After covering the basics of prochirality and stereochemistry, this course will introduce the tools needed to master diastereoselective and enantioselective synthesis. The various approaches will be presented in a detailed and rational manner. Examples of industrial synthesis of chiral bioactive molecules will be discussed.

Hourly volumes*:

CM: 3 p.m.

Tutorial: 5 hours

See the full page

This course covers synthesis methods applied to obtaining enantiopure amino acids, as well as the use of chiral amino acids for the synthesis of other enantiopure compounds.

These amino acids are the basic building blocks of peptides. The different physicochemical properties induced by the nature of these amino acids will enable the definition of strategies for synthesizing peptides of interest and their characterization.

Hourly volumes*:

CM: 3 p.m.

Tutorial: 5 hours

See the full page

The following topics will be covered:

- Bio-based solvents

- Fuels derived from biomass

- Antioxidants derived from lignin

- Metal catalysts derived from plants

- Surfactants obtained from renewable resources

- Examples of industrial applications of enzymatic synthesis

Hourly volumes*:

CM: 15

TD: 5

See the full page

This EU will address, in small groups or on an individual basis, teaching tools and best practices related to communication and professional integration, through:

• assessment of knowledge, skills, competencies, interpersonal skills, and motivations;
• awareness of job search techniques;
• writing resumes and cover letters;
• rules for oral and written communication;
• job interview simulations.

Scenarios directly related to the sectors of activity targeted by the courses of the students concerned will be offered.

Practical work: 20 hours

See the full page

See the full page

General overview of the most commonly used calculation and modeling methods in the field of solid-state chemistry according to the spatial and temporal scales that can be studied with them:

(1) Quantum calculations (Hartree Fock, Post-Hartree Fock methods, DFT),

(2) Force field-based modeling (atomistic and coarse-grained),

(3) Hybrid QMMM and AACG modeling.

Presentation of different calculation techniques: static and optimization calculations, molecular dynamics, and Monte Carlo.

The EU will offer lectures and practical classes. Two practical modeling assignments will be offered: modeling techniques in classical mechanics and quantum calculations.

            CM: 11 a.m.

            TD: 9 a.m.

See the full page

Hybrid materials are a new family of materials combining organic ligands that connect inorganic entities, and are increasingly being studied at both a fundamental and applied level.

As part of this course unit, two main categories of hybrid materials will be covered:

• Coordination Networks and Metal-Organic Frameworks
• Organosilicon/carbon materials

CM: 10 a.m.

Tutorial: 10 a.m.

See the full page

This teaching unit is dedicated to the presentation of inorganic materials and nanomaterials intended for use in the biomedical field (imaging, therapy, implants). This teaching unit builds on the knowledge acquired in teaching unit HAC930C (Development of Materials for Health). It aims to develop health issues and inorganic materials and nanomaterials in diagnosis, therapy, and well-being. Strategies for developing the inorganic materials and nanomaterials of the future based on theranostics and multifunctionality, as well as smart materials, will also be addressed.

The EU includes lectures and tutorials. Students will be offered a group project on the (theoretical) study of inorganic materials or nanomaterials for health.    

CM: 11

 TD: 9

See the full page

The teaching of the module on strategies and tools in organic synthesis focuses on deepening students' understanding of strategies for developing molecules, whether derived from the natural environment or not, using the tools of organic chemistry.

Hourly volumes:

CM: 3 p.m.

Tutorial: 5 hours

See the full page

The EU themes are as follows:

A theoretical section dedicated to chemoinformatics

A theoretical section dedicated more specifically to modeling tools for drug design

Hourly volumes*:

CM: 3 p.m. 

Tutorial: 5 hours

A section dedicated to practical skills with computer work

See the full page

See the full page

Peptides and proteins are made up of chains of amino acid residues that give them specific properties. Their functionality depends on their sequence and therefore on the chemical functions they carry, and is also greatly modulated by their structure. In addition to conventional peptide synthesis, advanced options for functional modification, structures, and properties that can significantly alter or improve the properties of the resulting peptide will be developed. Significant biotechnological developments in both the chemical and biological fields will be addressed, leading to a wide range of applications in which peptides and proteins are used successfully.

Hourly volumes*:

CM: 15

TD: 5

See the full page

Receptors are of major interest in medicinal chemistry and account for more than 40% of current therapeutic targets. This teaching unit takes an interdisciplinary approach to teaching the basic concepts and fundamental principles of receptor science required by students pursuing their studies in biomolecular chemistry at the chemistry-biology interface.

Hourly volumes*:

CM: 3 p.m. 

Tutorial: 5 hours

See the full page

Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and siRNA oligonucleotides, and DNA arrays.

Hourly volumes*:

            CM: 3 p.m.  

            Tutorial: 5 hours

See the full page

 In-depth study of NMR ^1H, ^13C, ^19F, ^29Si, ^31P, as well as two-dimensional methods. RPE concepts will also be covered (principles and applications).

Hourly volumes*:

CM: 3 p.m.

Tutorial: 5 hours

See the full page

This course covers the various molecular and supramolecular tools used for vectorization and delivery of active ingredients according to the type of cells or intracellular organelles targeted. Ligand-receptor interactions will be discussed, as well as methods for preparing and activating conjugates. Examples of drugs will be presented.

Hourly volumes*:

CM: 3 p.m.

Tutorial: 5 hours

See the full page

See the full page

Knowledge of the latest mass spectrometry techniques for the detection, identification, and structural characterization of organic molecules and biomolecules.

Applications in chemistry (pharmaceutical industry) and biology (Omics approaches).

1) Structural elucidation (ion characterization technologies):

• LC/MS/MS and accurate mass measurements 
• Isotopic labeling, H/D exchange
• Ionic mobility

2) Surface analysis and imaging (molecular mapping)

3) Application in chemistry and biology: characterization of small organic molecules and biomolecules.

Hourly volumes*:

CM: 3 p.m.

Tutorial: 5 hours

See the full page

The course will focus on organic chemistry and post-functionalization of biomolecules applied to peptides, proteins, and nucleic acids (DNA and RNA) with applications in gene therapy, biosensing, and design of probes for biological studies.

Hourly volumes*:

CM: 3 p.m. 

Tutorial: 5 hours

See the full page

The following topics will be covered:

- Triglycerides

- Phospholipids and sphingolipids

- Glycolipids

- Fat-soluble vitamins

- Steroid hormones

- Bile salts

- Structure and synthesis of prostaglandins and leukotrienes

Hourly volumes*:

CM: 15

TD: 5

See the full page

The following topics will be covered:

- General mechanism of glycosylation

- Summary of glycosyl donors

- Methods for activating glycosyl donors

- Stereoselective synthesis of some natural oligosaccharides

Hourly volumes*:

CM: 15

TD: 5

See the full page

Knowledge of the limitations associated with the administration of an active ingredient (solubility, bioavailability, etc.).

General description of the enzyme systems involved in the biotransformation of nutrients and exogenous compounds.

Description of the main modes of membrane passage and transport systems for fundamental biomolecules (sugars, amino acids, nucleosides, etc.).

Examples of prodrug(s) and bioprecursor(s) design.

Hourly volumes*:

CM: 3 p.m.

Tutorial: 5 hours

See the full page

See the full page

This teaching unit is dedicated to the presentation of inorganic materials and nanomaterials intended for use in the biomedical field (imaging, therapy, implants). This teaching unit builds on the knowledge acquired in teaching unit HAC930C (Development of Materials for Health). It aims to develop health issues and inorganic materials and nanomaterials in diagnosis, therapy, and well-being. Strategies for developing the inorganic materials and nanomaterials of the future based on theranostics and multifunctionality, as well as smart materials, will also be addressed.

The EU includes lectures and tutorials. Students will be offered a group project on the (theoretical) study of inorganic materials or nanomaterials for health.

Hourly volumes:

            CM: 11

            TD: 9

See the full page

See the full page

A 5- to 6-month internship must be completed in a research or research and development laboratory specializing in organic chemistry, biomolecular chemistry, life sciences, analytical instrumentation, or analytical analysis/development. Students will therefore have the opportunity to complete this end-of-study internship in academic or private research laboratories. Subject to prior approval by the teaching team (internship topic related to the master's program and adequate environment/resources), students may seek a host team in an academic setting at the institutes of the Chemistry Cluster of the University of Montpellier (IBMM, ICGM, IEM, etc.), in academic laboratories outside the University of Montpellier (in France or abroad), or in the private sector (chemical, pharmaceutical, agri-food, and cosmetics industries, biotechnology laboratories, etc.), as well as in research structures such as proteomics/metabolomics/fluxomics platforms.

The research project assigned to students must be related to the skills and expertise acquired during previous semesters and courses taken, particularly in semester 9, depending on the chosen specialization.

This internship, lasting 5 to 6 months, may begin in mid-January after the exam session and may not exceed 6 months for a period in semester 10 included during the validity of university enrollment. The teaching team of the Master's in Biomolecular Chemistry will advise students on finding an internship that matches their aspirations and abilities.

See the full page

See the full page

Scientific information: This course aims to familiarize students with scientific information research and management. In this context, the latest bibliographic research tools will be explained and used during lectures/tutorials (Electronic documentation: Scifinder/Isis/Belstein). Training in the features of the Zotero tool and the use of the electronic laboratory notebook will also be provided. The writing and use of scientific publications will be discussed.

Bibliographic project: Scientific information research tools will be applied to a specific case. The teaching team will propose a bibliographic topic to the student related to their chosen field of study. Where appropriate, this bibliographic topic may be defined in agreement with the host organization where the internship will take place.

For this personal project, students will have access to all bibliographic sources at the university or company hosting them. The bibliographic work may be combined with the English teaching unit in order to prepare for an oral defense similar to an oral presentation at an international conference.

See the full page

This course aims to highlight biological processes at the cellular level or even in living subjects. Different approaches to molecular imaging will be discussed (fluorescent probes, radiolabeling).

Hourly volumes*:

            CM: 9 a.m.

           Field: 11 a.m.

See the full page

The principles of green chemistry provide a basis for evaluating and designing new chemical products and processes that minimize negative impacts on human health and the environment. In this teaching unit, offered to M2 students in the Master's program in Biomolecular Chemistry (BM), Orientation 2 (O2), the basic principles and concepts of green chemistry will be addressed, along with their applications in the field of unconventional activation methods and the use of alternative media in organic synthesis.

Hourly volumes*:

CM: 9 a.m.

Field: 11 a.m.

See the full page

This course will cover techniques for extracting biomolecules (protein precipitation, SPE) and techniques for separating biomolecules (chromatography, electrophoresis).

Hourly volumes:

            CM: 9 a.m.

            Field: 11 a.m.

See the full page

See the full page

Peptides and proteins are made up of chains of amino acid residues that give them specific properties. Their functionality depends on their sequence and therefore on the chemical functions they carry, and is also greatly modulated by their structure. In addition to conventional peptide synthesis, advanced options for functional modification, structures, and properties that can significantly alter or improve the properties of the resulting peptide will be developed. Significant biotechnological developments in both the chemical and biological fields will be addressed, leading to a wide range of applications in which peptides and proteins are used successfully.

Hourly volumes*:

CM: 15

TD: 5

See the full page

In chemistry, solid-phase synthesis is a method in which molecules are covalently bound to a solid support and synthesized step by step using selective protective groups. This applied course aims to provide a comprehensive understanding of this field and to examine the supported strategies that enable the practical preparation of polypeptides and oligonucleotides.

Hourly volumes*:

CM: 9 H 

Field: 11 a.m.

See the full page

Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and siRNA oligonucleotides, and DNA arrays.

Hourly volumes*:

            CM: 3 p.m.  

            Tutorial: 5 hours

See the full page

See the full page

This course covers the various molecular and supramolecular tools used for vectorization and delivery of active ingredients according to the type of cells or intracellular organelles targeted. Ligand-receptor interactions will be discussed, as well as methods for preparing and activating conjugates. Examples of drugs will be presented.

Hourly volumes*:

CM: 3 p.m.

Tutorial: 5 hours

See the full page

The course will focus on organic chemistry and post-functionalization of biomolecules applied to peptides, proteins, and nucleic acids (DNA and RNA) with applications in gene therapy, biosensing, and design of probes for biological studies.

Hourly volumes*:

CM: 3 p.m. 

Tutorial: 5 hours

See the full page

 In-depth study of NMR ^1H, ^13C, ^19F, ^29Si, ^31P, as well as two-dimensional methods. RPE concepts will also be covered (principles and applications).

Hourly volumes*:

CM: 3 p.m.

Tutorial: 5 hours

See the full page

This course aims to describe the synthesis tools applied to complex and polyfunctional molecules. Retrosynthetic and stereocontrolled approaches will be discussed, as well as the judicious use of protective groups.

Hourly volumes*:

CM: 9 a.m.

Field: 11 a.m.

See the full page

Bioconjugation reactions are of major interest in biomedical sciences and enable chemists to modify biomolecules in order to give them new functions or properties. This course will cover bioconjugation and biomolecule labeling strategies that enable the exploration of complex biological systems. Practical sessions will illustrate these concepts through examples of bioconjugation of osidic and nucleotide platforms.

Hourly volumes*:

CM: 9 H 

Field: 11 a.m.

See the full page

Knowledge of the latest mass spectrometry techniques for the detection, identification, and structural characterization of organic molecules and biomolecules.

Applications in chemistry (pharmaceutical industry) and biology (Omics approaches).

1) Structural elucidation (ion characterization technologies):

• LC/MS/MS and accurate mass measurements 
• Isotopic labeling, H/D exchange
• Ionic mobility

2) Surface analysis and imaging (molecular mapping)

3) Application in chemistry and biology: characterization of small organic molecules and biomolecules.

Hourly volumes*:

CM: 3 p.m.

Tutorial: 5 hours

See the full page

The following topics will be covered:

- Triglycerides

- Phospholipids and sphingolipids

- Glycolipids

- Fat-soluble vitamins

- Steroid hormones

- Bile salts

- Structure and synthesis of prostaglandins and leukotrienes

Hourly volumes*:

CM: 15

TD: 5

See the full page

The following topics will be covered:

- General mechanism of glycosylation

- Summary of glycosyl donors

- Methods for activating glycosyl donors

- Stereoselective synthesis of some natural oligosaccharides

Hourly volumes*:

CM: 15

TD: 5

See the full page

A 5- to 6-month internship must be completed in a research or research and development laboratory specializing in organic chemistry, biomolecular chemistry, life sciences, analytical instrumentation, or analytical analysis/development. Students will therefore have the opportunity to complete this end-of-study internship in academic or private research laboratories. Subject to prior approval by the teaching team (internship topic related to the master's program and adequate environment/resources), students may seek a host team in an academic setting at the institutes of the Chemistry Cluster of the University of Montpellier (IBMM, ICGM, IEM, etc.), in academic laboratories outside the University of Montpellier (in France or abroad), or in the private sector (chemical, pharmaceutical, agri-food, and cosmetics industries, biotechnology laboratories, etc.), as well as in research structures such as proteomics/metabolomics/fluxomics platforms.

The research project assigned to students must be related to the skills and expertise acquired during previous semesters and courses taken, particularly in semester 9, depending on the chosen specialization.

This internship, lasting 5 to 6 months, may begin in mid-January after the exam session and may not exceed 6 months for a period in semester 10 included during the validity of university enrollment. The teaching team of the Master's in Biomolecular Chemistry will advise students on finding an internship that matches their aspirations and abilities.

See the full page

See the full page

Scientific information: This course aims to familiarize students with scientific information research and management. In this context, the latest bibliographic research tools will be explained and used during lectures/tutorials (Electronic documentation: Scifinder/Isis/Belstein). Training in the features of the Zotero tool and the use of the electronic laboratory notebook will also be provided. The writing and use of scientific publications will be discussed.

Bibliographic project: Scientific information research tools will be applied to a specific case. The teaching team will propose a bibliographic topic to the student related to their chosen field of study. Where appropriate, this bibliographic topic may be defined in agreement with the host organization where the internship will take place.

For this personal project, students will have access to all bibliographic sources at the university or company hosting them. The bibliographic work may be combined with the English teaching unit in order to prepare for an oral defense similar to an oral presentation at an international conference.

See the full page

Description of the latest mass spectrometry techniques for analysis in the pharmaceutical industry (drug development: drug discovery and preclinical analysis).

Instrumentation and acquisition modes in mass spectrometry in the pharmaceutical industry for the following applications:

• Analyses at various stages of drug development,
• Qualitative analyses in metabolism,
• Quantitative pharmacokinetic analyses.

Hourly volumes*:

            CM: 3 p.m.

           Land: 5 H

See the full page

This course will cover techniques for extracting biomolecules (protein precipitation, SPE) and techniques for separating biomolecules (chromatography, electrophoresis).

Hourly volumes:

            CM: 9 a.m.

            Field: 11 a.m.

See the full page

See the full page

Peptides and proteins are made up of chains of amino acid residues that give them specific properties. Their functionality depends on their sequence and therefore on the chemical functions they carry, and is also greatly modulated by their structure. In addition to conventional peptide synthesis, advanced options for functional modification, structures, and properties that can significantly alter or improve the properties of the resulting peptide will be developed. Significant biotechnological developments in both the chemical and biological fields will be addressed, leading to a wide range of applications in which peptides and proteins are used successfully.

Hourly volumes*:

CM: 15

TD: 5

See the full page

See the full page

See the full page

The EU themes are as follows:

A theoretical section dedicated to chemoinformatics

A theoretical section dedicated more specifically to modeling tools for drug design

Hourly volumes*:

CM: 3 p.m. 

Tutorial: 5 hours

A section dedicated to practical skills with computer work

See the full page

Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and siRNA oligonucleotides, and DNA arrays.

Hourly volumes*:

            CM: 3 p.m.  

            Tutorial: 5 hours

See the full page

Knowledge of LC/MS and LC/MS/MS techniques for characterizing organic molecules and biomolecules in complex environments. 

Description of the instruments and acquisition methods that will be used in practical work.

1) Chromatography techniques in analytical mode coupled with mass spectrometry with ambient ionization:

• LC/MS instruments,
• LC/MS/MS instrumentation.

2) Coupled spectral data acquisition devices.

Hourly volumes*:

CM: 9 H

Field: 11 a.m.

See the full page

 In-depth study of NMR ^1H, ^13C, ^19F, ^29Si, ^31P, as well as two-dimensional methods. RPE concepts will also be covered (principles and applications).

Hourly volumes*:

CM: 3 p.m.

Tutorial: 5 hours

See the full page

The objective of this course unit is to provide students with theoretical and practical training in the fundamental techniques of biomolecule separation and purification.

Hours per week*:
CM: 9 hours
Field: 11 hours

See the full page

Understanding of screening techniques for bioactive molecules, and more generally in vitro tests used to measure a biological event in the context of drug discovery or diagnosis.

1) Pharmacological and biophysical fundamentals describing a biological event, target of biological tests:

2) Biological tests for the development of medicines or diagnostics

3) Applications, case studies, critical analyses.

Hourly volumes*:

CM: 3 p.m.

Tutorial: 5 hours

See the full page

Knowledge of the latest mass spectrometry techniques for the detection, identification, and structural characterization of organic molecules and biomolecules.

Applications in chemistry (pharmaceutical industry) and biology (Omics approaches).

1) Structural elucidation (ion characterization technologies):

• LC/MS/MS and accurate mass measurements 
• Isotopic labeling, H/D exchange
• Ionic mobility

2) Surface analysis and imaging (molecular mapping)

3) Application in chemistry and biology: characterization of small organic molecules and biomolecules.

Hourly volumes*:

CM: 3 p.m.

Tutorial: 5 hours

See the full page

The following topics will be covered:

- Triglycerides

- Phospholipids and sphingolipids

- Glycolipids

- Fat-soluble vitamins

- Steroid hormones

- Bile salts

- Structure and synthesis of prostaglandins and leukotrienes

Hourly volumes*:

CM: 15

TD: 5

See the full page

See the full page

The following topics will be covered:

- General mechanism of glycosylation

- Summary of glycosyl donors

- Methods for activating glycosyl donors

- Stereoselective synthesis of some natural oligosaccharides

Hourly volumes*:

CM: 15

TD: 5

See the full page

A 5- to 6-month internship must be completed in a research or research and development laboratory specializing in organic chemistry, biomolecular chemistry, life sciences, analytical instrumentation, or analytical analysis/development. Students will therefore have the opportunity to complete this end-of-study internship in academic or private research laboratories. Subject to prior approval by the teaching team (internship topic related to the master's program and adequate environment/resources), students may seek a host team in an academic setting at the institutes of the Chemistry Cluster of the University of Montpellier (IBMM, ICGM, IEM, etc.), in academic laboratories outside the University of Montpellier (in France or abroad), or in the private sector (chemical, pharmaceutical, agri-food, and cosmetics industries, biotechnology laboratories, etc.), as well as in research structures such as proteomics/metabolomics/fluxomics platforms.

The research project assigned to students must be related to the skills and expertise acquired during previous semesters and courses taken, particularly in semester 9, depending on the chosen specialization.

This internship, lasting 5 to 6 months, may begin in mid-January after the exam session and may not exceed 6 months for a period in semester 10 included during the validity of university enrollment. The teaching team of the Master's in Biomolecular Chemistry will advise students on finding an internship that matches their aspirations and abilities.

See the full page

See the full page

Scientific information: This course aims to familiarize students with scientific information research and management. In this context, the latest bibliographic research tools will be explained and used during lectures/tutorials (Electronic documentation: Scifinder/Isis/Belstein). Training in the features of the Zotero tool and the use of the electronic laboratory notebook will also be provided. The writing and use of scientific publications will be discussed.

Bibliographic project: Scientific information research tools will be applied to a specific case. The teaching team will propose a bibliographic topic to the student related to their chosen field of study. Where appropriate, this bibliographic topic may be defined in agreement with the host organization where the internship will take place.

For this personal project, students will have access to all bibliographic sources at the university or company hosting them. The bibliographic work may be combined with the English teaching unit in order to prepare for an oral defense similar to an oral presentation at an international conference.

See the full page