ECTS
120 credits
Duration
2 years
Training structure
Faculty of Science
Language(s) of instruction
French
Presentation
The course offers a multidisciplinary training in organic chemistry oriented towards Life Sciences. The teaching is focused on the synthesis, characterization and study of the biological properties of essential biomolecules (nucleosides, oligonucleotides, saccharides, peptides, proteins, biopolymers, etc.) ...
93 %
Success rate
Objectives
The Biomolecular Chemistry program (3 orientations) aims to train managers capable of managing the various research/development and/or organizational aspects of a project in the field of biomolecular chemistry. This program covers a wide range of skills, including the most advanced organic synthesis methodologies for obtaining biomolecules, the most recent spectroscopic characterization and analysis methods, as well as skills in the design and development of biomolecules.
Know-how and skills
The acquisition of these skills will enable the holder of this Master's degree to interact with colleagues from other disciplines (biologists, physical chemists, biochemists) and to propose solutions beyond his or her core competence as a chemist. Graduates of this Master's degree can pursue their studies in a doctorate with a view to a position as a teacher-researcher or researcher (academic research or pharmaceutical industry). The holder of this Master is able to :
Cross-Cutting Skills:
- Work in a multidisciplinary team covering a broad spectrum of basic sciences
- Formulate a research project after analysis of the bibliography
- Designing new molecules for therapeutic purposes or biochemical tools
- Master the main analysis methods
- Implementing experimental approaches
- Use the computer tool
- Proficiency in scientific English (oral and written)
Specific disciplinary skills:
- Analyze the different steps of an experimental protocol
- Master the main techniques of synthesis, purification and qualitative and quantitative analysis of organic compounds
- Implement the most recent techniques of spectroscopy and analysis
- Designing new molecules
- Analyze and interpret experimental results of biological tests
General Science Skills:
- Use analytical equipment and techniques for organic compounds and biomolecules
- Analyze experimental data
- Identify and comply with regulations
- Understand a scientific text written in English
- Adopt a multidisciplinary approach
- Implement an experimental approach
- Understanding a complex situation
- Ability to integrate into a research organization: participation in projects, communication with specialists and non-specialists
General Skills:
- Ability to mobilize resources from several disciplinary fields
- Knowledge and understanding of a scientific field
- Ability to work in an international context
- Working independently: setting priorities, managing time
- Carry out a study: pose a problem; construct and develop an argument; interpret the results; draw up a synthesis
- Conduct a search for information: specify the purpose of the search, identify the modes of access, analyze the relevance, explain and transmit
- Working in a team: integration, positioning, collaboration
- Communicating: writing clearly, preparing adapted communication materials, speaking in front of a group, and commenting on materials
- Integrate into a professional environment
Organization
Knowledge control
Each teaching unit (UE) is subject to graded evaluations. Depending on the unit, they take the form of continuous assessment (practical work and internship), written final exams, reports and/or oral presentations. These UEs can be compensated for each other; an average of 10/20 or more for all the courses in the semester is required to validate the semester. The semesters cannot be compensated for each other.
Open in alternation
This course is open on a sandwich basis.
Internships, tutored projects
Internship | Mandatory |
---|
Semester 8: 2 to 4 month internship in an academic/public laboratory.
Semester 10: 5 to 6 month internship. Research and development in an academic/private laboratory.
Semester 7: Professional project - project follow-up (CM 5h, TD 5h, TP 40 hours)
Program
This Master's degree in Chemistry is in accordance with the European system. It is accessible to a holder of a Bachelor's degree in Chemistry. It is a university course validated by 120 ECTS. It is composed of 4 semesters of 30 ECTS each. The first year of Master 1 (60 ECST for S7 and S8) is common to all the orientations offered in M2. The second year (S9) includes a common core curriculum (major courses of 18 ECTS) and a choice of orientations (minor courses of 12 ECTS) corresponding to the Research Orientation (O1), and two professional courses, Synthesis Orientation (O2) and Omic Analysis Orientation (O3).
Select a program
M1 - Biomolecular Chemistry (BM)
Fluorinated and phosphorated biomolecules: synthesis and application
2 creditsCHOICE 1
4 creditsChoice of 2 out of 3
Solutions, colloids, interfaces
2 creditsSeparative techniques
2 creditsAnalysis of volatile molecules
2 credits
Polymers for health
2 creditsHeterocyclic chemistry
2 creditsChemistry of natural products
2 creditsLiquid NMR spectroscopy and X-ray diffraction
2 creditsAnalysis of biomolecules by mass spectrometry
2 creditsChemometrics, statistical data analysis, experimental design
2 creditsOrganometallic chemistry and heteroelement chemistry
2 creditsCoordination and organic chemistry
2 creditsProfessional projects - project follow-up
8 credits
M1 internship of 2-4 months with defense/report in English
10 creditsNucleosides and derivatives
2 creditsInnovative synthesis and extraction processes
2 creditsMedicinal chemistry
2 creditsAsymmetric synthesis
2 creditsAmino acids and derivatives
2 creditsBiosourced chemistry
2 creditsCommunication and professional insertion
2 creditsCHOICE 2
4 creditsChoice of 2 out of 3
Introduction to modeling
2 creditsHybrid and structured materials
2 creditsNanomaterials
2 credits
Strategy and tools in organic synthesis
2 credits
M2 - Biomolecular chemistry (BM)
Fluorinated and phosphorated biomolecules: synthesis and application
Level of study
BAC +4
ECTS
2 credits
Component
Faculty of Science
Fluorinated biomolecules. Current developments of fluorinated molecules. Methods of fluorination: nucleophilic or electrophilic mono-fluorination, introduction of difluoromethyl or trifluoromethyl groups. Contribution of fluorine atoms in the activity of these compounds. Examples of syntheses of fluorinated compounds used as antitumor agents, antiviral agents, antidepressants, anxiolytics, anti-inflammatories...
Phosphorus biomolecules. Structure, nomenclature, reactivity, structural analysis and applications.
Some synthetic routes of compounds of each of the treated families will be discussed, highlighting, if necessary, non-conventional activation methods. Biomedical applications will be targeted, as well as other applications in agrochemistry, optoelectronics, nanomaterials, ...
Hourly volumes* :
CM : 15 h (7,5h Fluorinated biomolecules and 7,5h Phosphorated biomolecules)
TD : 5 h
Solutions, colloids, interfaces
Level of study
BAC +4
ECTS
2 credits
Component
Faculty of Science
This course allows the acquisition of basic knowledge and transversal skills in the field of colloids and interfaces, common to the different courses of the Master Chemistry (Chemistry of Materials, Separative Chemistry, Materials and Processes, ICAP Cosmetics Engineering, Chemistry of Biomolecules). It is also offered to international students entering the SFRI program at the University of Montpellier where the teaching is given in English. An introductory presentation on the basic notions and concepts will allow to discover and better understand the main physicochemical properties of colloidal dispersions, associative colloids, and macromolecular solutions, as well as the parameters and phenomena governing the stability in colloidal dispersions and mixed solution-colloid systems. Then, an interdisciplinary practical teaching based on the principle of the flipped classroom will be proposed to help students build and deepen their knowledge through an individual and collective analysis of the various applications of colloidal and interfacial phenomena and systems.
Hourly volumes* :
CM : 7
TD : 13
Separative techniques
Level of study
BAC +4
ECTS
2 credits
Component
Faculty of Science
This course is designed to teach liquid chromatography and gas chromatography.
Hourly volumes* :
CM :15h
TD : 5h
Analysis of volatile molecules
Level of study
BAC +4
ECTS
2 credits
Component
Faculty of Science
Knowledge of gas chromatography and electron impact ionization mass spectrometry and quadrupole mass analyzer techniques for the analysis of volatile organic molecules.
1) GC-MS analyses of volatile organic compounds:
- Electron impact ionization (EI) techniques
- Chemical ionization (CI) techniques
- Quadrupole analysis techniques (Q)
- GC/MS Couplings
2) Applications in organic chemistry analysis, characterization of volatile samples.
Hourly volumes* :
CM : 15 H
TD : 5 H
Polymers for health
Level of study
BAC +5
ECTS
2 credits
Component
Faculty of Science
Knowledge of the main families of polymers used in the biomedical field.
1) Specificity of polymers for biomedical applications and main families of polymers used
2) Description of the application families
3) Discussion on the notion of synthesis and the structure/property/software relationship
Hourly volumes* :
CM : 15 H
TD : 5 H
Heterocyclic chemistry
Level of study
BAC +4
ECTS
2 credits
Component
Faculty of Science
This course deals concisely and systematically with all aspects of heterocycle chemistry, from nomenclature to applications such as the principles of action of drugs, toxins or drugs, pigments, food coloring etc...
Hourly volumes* :
CM : 15 H
TD : 5 H
Chemistry of natural products
Level of study
BAC +4
ECTS
2 credits
Component
Faculty of Science
Natural products occupy a major place in the field of biomolecular chemistry. They represent an important source of bioactive compounds for medicinal chemistry. This course provides a comprehensive overview of the secondary metabolism and origin of natural products from plants. The emphasis in this unit will be on the organic chemistry behind the various biotransformations that occur during the biosynthesis of each major class of molecules. A mechanistic approach will be used to understand the chemical basis of each transformation.
Hourly volumes* :
CM : 13
TD : 7
Liquid NMR spectroscopy and X-ray diffraction
Level of study
BAC +4
ECTS
2 credits
Component
Faculty of Science
NMR:
NMR (Nuclear Magnetic Resonance) in liquid phase is an essential spectroscopic method of analysis for the chemist, allowing in particular to determine the structure of small organic molecules or macromolecules in solution, the study of dynamic phenomena... The objective of this course is to understand the phenomena involved in this technique and to relate them to the various structural information accessible by this method. The aim is to be able to exploit the spectral data resulting from this analysis to elucidate the structure and stereochemistry of organic molecules or polymer structures, or to carry out reaction monitoring.
X-ray diffraction:
X-ray diffraction is a powerful and non-destructive technique for characterizing the crystal structure of materials, but it is also able to provide crystallographic and structural information such as lattice parameters and atomic positions. This includes all crystallized materials such as ceramics, materials for energy and information storage and transformation as well as organic molecules and metal complexes (interatomic distances and angles, stereochemistry (chirality, stereoisomerism...), intra and intermolecular bonds...). The objective of this course is an introduction to crystallography and diffraction, with the aim of understanding the operation and characteristics of an X-ray diffractometer, as well as the interpretation of diffraction patterns (structural analysis, lattice parameters).
Hourly volumes* :
CM : 10
TD : 10
Analysis of biomolecules by mass spectrometry
Level of study
BAC +4
ECTS
2 credits
Component
Faculty of Science
Knowledge of the latest mass spectrometry techniques for the qualitative analysis of organic molecules and biomolecules.
1) Description of Fundamentals (Ion Science and Technology):
- Ionization techniques
- Analysis techniques
- Tandem mass spectrometry (MS/MS)
- LC/MS and LC/MS/MS couplings
2) Application in the context of biomolecule analysis and organic chemistry reaction monitoring.
Hourly volumes* :
CM : 15 H
TD : 5 H
Chemometrics, statistical data analysis, experimental design
Level of study
BAC +4
ECTS
2 credits
Component
Faculty of Science
This course will cover the fundamental concepts and practical tools related to chemometrics through : - statistical analysis of data ;
- laws of probability ;
- confidence interval estimation ;
- parametric and non-parametric tests.
An introduction to experimental design will be offered at the end of the module.
Hourly volumes* :
CM : 7h
TD : 13h
Organometallic chemistry and heteroelement chemistry
Level of study
BAC +4
ECTS
2 credits
Component
Faculty of Science
The first part of the course presents the fundamental knowledge of organometallic chemistry of transition metals. It starts with the description of the Metal-C bond allowing the understanding of its stability and chemical reactivity. In a second step, the power of this synthesis tool for the formation of C-H, C-C bonds, ... Examples of their applications in different fields will allow the acquisition of these reactions and their fields of applications: fine chemistry, catalytic transformations of industrial importance, synthesis of natural products, preparation of materials.
The second part of this course is dedicated to the chemistry of hetero-elements focused on the elements Silicon, Tin and Boron. This part aims at presenting the different methods of preparation of boron, tin and silicon reagents as well as the main transformations performed with these compounds, with applications in organic synthesis and materials synthesis.
CM : 13 H
TD : 7 H
Coordination and organic chemistry
Level of study
BAC +4
ECTS
2 credits
Component
Faculty of Science
This teaching unit is dedicated to the deepening of the bases of organic chemistry and coordination chemistry seen in L3 and to the acquisition of notions related to molecular engineering and molecular chemistry. The UE includes lectures and tutorials. The students will work before some lectures and tutorials with course documents provided so that the lectures and tutorials can allow them to be fully involved in the training, to understand the concepts presented and the skills to be acquired. The progression program and activities will be proposed. For those students who have not seen the basics of coordination chemistry and organic chemistry, the documents will be made available.
Coordination chemistry: The teaching will cover the different aspects of transition metal and lanthanide complexes, molecular materials (polynuclear complexes and coordination polymers with extended structures (MOFs, etc.)) and their properties and applications. Structural aspects, bonding description, properties, as well as stability and reactivity aspects will be discussed. Emphasis will be put on the complexation effect and on the stability of metal, lanthanide and actinide complexes with certain ligands for applications in the biomedical field (imaging and therapy), decontamination (nuclear field), etc. The electronic (relaxivity, magnetism) and optical (absorption, luminescence) properties of these complexes will be discussed and put in the context of applications in various fields, such as imaging, electronics, sensors, etc.
Organic Chemistry: The teaching is based on the knowledge acquired in the Bachelor's degree and will approach through a reasoned study the main reaction mechanisms of organic chemistry and will allow to give a common base to all the students of the Master Chemistry. The main processes (substitution, addition, elimination, transposition...) and their essential characteristics and applications to mechanistic sequences will be examined. This course should provide the student with general tools for the analysis of mechanisms (ionic, radical, concerted) in order to understand these mechanisms in their variety.
Hourly volumes* :
CM : 13 H
TD : 7 H
Professional projects - project follow-up
Level of study
BAC +4
ECTS
8 credits
Component
Faculty of Science
The professionalization project provides a link between the traditional practical work and the internship in a laboratory or company. It is carried out in the form of a tutored project consisting of putting the student in a professional situation through collaborative (group) work based on the realization of a project in response to a problem set by a company, community, association or academic. It is part of the core curriculum of the Chemistry Master's program and is carried out under the responsibility of a member of the teaching team (university or industry). Carried out throughout the semester, this project aims to relate and anchor the knowledge/know-how acquired in the framework of the Bachelor's degree and the beginning of the Master's degree through this professional situation. These situations will be directly linked to the Master's program chosen by the students. In addition to the disciplinary skills of chemistry, other relational, organizational and communication skills, intrinsically linked to project management, will also be acquired and will arm the students for their future professional life.
Answer a research problem: example of synthesis of new phosphorescent materials.
Hourly volumes* :
CM : 5h
TD : 5h
Practical work : 40h
M1 internship of 2-4 months with defense/report in English
Level of study
BAC +4
ECTS
10 credits
Component
Faculty of Science
The internship in semester 8 of the Master 1 Chemistry of Biomolecules aims to familiarize students with research careers in life chemistry. Thus, the students will have the possibility of carrying out this training course of initiation to research within academic or private laboratories. Subject to prior acceptance by the teaching staff (internship subject related to the Master's courses and adequate environment/means), the student may look for a host team in an academic environment in the institutes of the Chemistry Pole of the University of Montpellier (IBMM, ICGM, ...), in academic laboratories outside the University of Montpellier (in France or abroad) or in the private sector (chemical, pharmaceutical, agri-food industries, biotech laboratories, ...).
Field : 2 to 4 months of internship
Nucleosides and derivatives
Level of study
BAC +4
ECTS
2 credits
Component
Faculty of Science
Nucleosides are the basic constituents of nucleic acids (DNA and RNA). As such, they play an essential role in many biological processes. In this course, the structure and biological role of natural nucleosides will be presented. The main synthesis and characterization routes of these compounds and their analogues (glycosylation reactions, structural modifications of the furanose ring, substitution and introduction of heteroatoms, configuration inversion, etc.) will also be discussed. The use of nucleoside analogues for the treatment of viral pathologies and cancers will also be discussed.
Hourly volumes* :
CM : 3 pm
TD : 5 h
Innovative synthesis and extraction processes
Level of study
BAC +4
ECTS
2 credits
Component
Faculty of Science
This teaching unit is mutualized for the MI students of the Master Chemistry: ICAP P1, ICAP P2, MAT P1, MAT P2, BM (semester S2). The following topics will be covered:
- The 12 Principles of Green Chemistry and the Units of Measurement in Green Chemistry ;
- Synthesis strategies in sustainable chemistry;
- Alternative or eco-compatible solvents for synthesis and extraction;
- Non-conventional activation techniques and applications.
CM : 13
TD : 7 H
Medicinal chemistry
Level of study
BAC +4
ECTS
2 credits
Component
Faculty of Science
The medicinal chemistry course aims to introduce students to the key steps in the development process of molecules with biological activities. In particular, a description of the interactions involved, the notion of pharmocophores, bio-isosteria..., as well as structure-activity relationship studies will be addressed in order to consider strategies and adequate structural modifications.
Hourly volumes* :
CM : 3 pm
TD : 5 h
Asymmetric synthesis
Level of study
BAC +4
ECTS
2 credits
Component
Faculty of Science
After generalities on the notions of prochirality and stereochemistry, this teaching will present the tools allowing the mastery of diastereoselective and enantioselective syntheses. The different approaches will be presented in a detailed and rational way. Examples of industrial syntheses of chiral bioactive molecules will be discussed.
Hourly volumes* :
CM : 15 H
TD : 5 H
Amino acids and derivatives
Level of study
BAC +4
ECTS
2 credits
Component
Faculty of Science
This course discusses synthetic methods applied to obtain enantiopure amino acids as well as the use of chiral amino acids for the synthesis of other enantiopure compounds.
These amino acids are the basic elements of peptides. The different physico-chemical properties induced by the nature of these amino acids will allow to define strategies for the synthesis of peptides of interest and their characterization.
Hourly volumes* :
CM : 15 H
TD : 5 H
Biosourced chemistry
Level of study
BAC +4
ECTS
2 credits
Component
Faculty of Science
The following topics will be covered:
- Biobased solvents
- Fuels from biomass
- Antioxidants derived from lignin
- Metal catalysts from plants
- Surfactants obtained from renewable resources
- Examples of industrial applications of enzymatic synthesis
Hourly volumes* :
CM : 15
TD : 5
Communication and professional insertion
Level of study
BAC +4
ECTS
2 credits
Component
Faculty of Science
This UE will address in small groups or in a personalized way the pedagogical tools and good practices related to communication and professional insertion, through :
- knowledge, skills, competencies, attitudes and motivations assessments;
- awareness of job search techniques;
- CV and cover letter writing;
- rules of oral and written communication;
- mock job interviews.
Situations directly related to the sectors of activity targeted by the students' courses will be proposed.
TP : 20h
Introduction to modeling
Level of study
BAC +4
ECTS
2 credits
Component
Faculty of Science
General presentation of the most commonly used computational and modeling methods in the field of solid state chemistry according to the spatial and temporal scales that can be studied with them:
(1) Quantum calculations (Hartree Fock, Post-Hartree Fock methods, DFT),
(2) Force field based modeling (atomistic and coarse grain),
(3) Hybrid QMM and AACG modeling.
Presentation of the different calculation techniques: static and optimization calculations, molecular dynamics and Monte Carlo.
The UE will have courses of type CM and TP. Two practical modeling works will be proposed: modeling techniques in classical mechanics and quantum calculations.
CM : 11H
TD : 9H
Hybrid and structured materials
Level of study
BAC +4
ECTS
2 credits
Component
Faculty of Science
Hybrid" materials are a new family of materials, associating organic ligands with inorganic entities, and are increasingly studied at both fundamental and application levels.
In this EU, two main categories of hybrid materials will be discussed:
- Coordination Networks and Metal-Organic Frameworks
- Organosilicon/carbon materials
CM : 10 h
TD : 10 h
Nanomaterials
Level of study
BAC +4
ECTS
2 credits
Component
Faculty of Science
This teaching unit is dedicated to the presentation of inorganic materials and nanomaterials for use in the biomedical field (imaging, therapy, implants). This UE is the deepening of the knowledge acquired in the UE HAC930C (Development of materials for health). The aim is to develop health issues and inorganic materials and nanomaterials in diagnosis, therapy and well-being. Strategies for the development of future inorganic materials and nanomaterials based on therapeutics and multifunctionality, and smart materials will also be addressed.
The UE includes lectures and tutorials. A group project on the (theoretical) study of an inorganic material or nanomaterials for health will be proposed to the students.
CM : 11
TD : 9
Strategy and tools in organic synthesis
Level of study
BAC +4
ECTS
2 credits
Component
Faculty of Science
The teaching of the module of strategies and tools in organic synthesis is centered on the deepening of the strategies of elaborations of molecules resulting or not from the natural environment using the tools of organic chemistry.
Hourly volumes* :
CM : 15 H
TD : 5 H
Chemoinformatics
Level of study
BAC +5
ECTS
2 credits
Component
Faculty of Science
The themes of the EU are the following:
A theoretical part dedicated to chemoinformatics
A theoretical part dedicated more specifically to modeling tools for drug design
Hourly volumes* :
CM : 15 H
TD : 5 H
A part dedicated to the practical aspect with work on computers
Project management - Corporate law
ECTS
4 credits
Component
Faculty of Science
Peptides and proteins
Level of study
BAC +5
ECTS
2 credits
Component
Faculty of Science
Peptides and proteins are composed of a sequence of amino acid residues that give them specific properties. Their functionality depends on their sequence and thus on the chemical functions they carry, and is also greatly modulated by their structure. In addition to conventional peptide synthesis, advanced functional modification options, structures, and properties that can significantly modify or improve the properties of the resulting peptide will be developed. Significant biotechnological developments in both the chemical and biological fields will be discussed leading to a wide range of applications in which peptides and proteins are successfully used.
Hourly volumes*:
CM :15
TD :5
Receptology
Level of study
BAC +5
ECTS
2 credits
Component
Faculty of Science
Receptors are of major interest in medicinal chemistry and constitute more than 40% of current therapeutic targets. This course is an interdisciplinary approach to provide the basic concepts and fundamentals of receptology necessary for students pursuing their training in biomolecular chemistry at the chemistry-biology interface.
Hourly volumes* :
CM : 15 H
TD : 5 H
Nucleic acids
Level of study
BAC +5
ECTS
2 credits
Component
Faculty of Science
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
Hourly volumes* :
CM : 15 H
TD : 5 H
NMR
Level of study
BAC +5
ECTS
2 credits
Component
Faculty of Science
Deepening of knowledge in 1H, 13C, 19F, 29Si, 31PNMR, as well as two-dimensional methods. Notions of EPR will also be covered (principle and applications).
Hourly volumes* :
CM : 15 H
TD : 5 H
Targeted delivery
Level of study
BAC +5
ECTS
2 credits
Component
Faculty of Science
Hourly volume
20h
In this course, the different molecular or supramolecular tools for the delivery of active ingredients according to the type of cells or intracellular organelles targeted are discussed. Ligand-receptor interactions will be discussed as well as the methods of preparation and activation of conjugates. Examples of drugs will be presented.
Hourly volumes* :
CM : 15 H
TD : 5 H
Structure-based drug design
ECTS
2 credits
Component
Faculty of Pharmacy
Mass spectrometry
Level of study
BAC +5
ECTS
2 credits
Component
Faculty of Science
Knowledge of the latest mass spectrometry techniques for the detection, identification and structural characterization of organic molecules and biomolecules.
Applications in chemistry (pharmaceutical industry) and biology (Omics approaches).
1) Structural elucidation (Ion characterization technologies):
- LC/MS/MS and exact mass measurements
- Isotopic labelling, H/D exchange
- Ionic mobility
2) Surface analysis and imaging (molecular mapping)
3) Application in chemistry and biology: characterization of small organic molecules and biomolecules.
Hourly volumes* :
CM : 15 H
TD : 5 H
Chemobiology (67% ENSCM)
Level of study
BAC +5
ECTS
2 credits
Component
Faculty of Science
The course will focus on organic chemistry and post-functionalization of biomolecules applied to peptides, proteins and nucleic acids (DNA and RNA) with applications in gene therapy, biosensing and design of probes for biological studies.
Hourly volumes* :
CM : 15 H
TD : 5 H
Lipidic compounds
Level of study
BAC +5
ECTS
2 credits
Component
Faculty of Science
The following topics will be covered:
- Triglycerides
- Phospholipids and sphingolipids
- Glycolipids
- Fat-soluble vitamins
- Steroid hormones
- Bile salts
- Structure and synthesis of prostaglandins and leukotrienes
Hourly volumes* :
CM : 15
TD : 5
Glycochemistry
Level of study
BAC +5
ECTS
2 credits
Component
Faculty of Science
The following topics will be covered:
- General mechanism of glycosylation
- Synthesis of glycosyl donors
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Hourly volumes* :
CM : 15
TD : 5
Drugs/bioprecursors
Level of study
BAC +5
ECTS
2 credits
Component
Faculty of Science
Knowledge of the limitations associated with the administration of an active ingredient (solubility, bioavailability, etc.).
General description of the enzymatic systems involved in the biotransformation of nutrients and exogenous compounds.
Description of the main modes of membrane passage and transport systems of fundamental biomolecules (sugars, amino acids, nucleosides...).
Examples of prodrug(s) and bioprecursor(s) design.
Hourly volumes* :
CM : 15 H
TD : 5 H
(Nano)inorganic materials for health
Level of study
BAC +5
ECTS
2 credits
Component
Faculty of Science
This teaching unit is dedicated to the presentation of inorganic materials and nanomaterials for use in the biomedical field (imaging, therapy, implants). This UE is the deepening of the knowledge acquired in the UE HAC930C (Development of materials for health). The aim is to develop health issues and inorganic materials and nanomaterials in diagnosis, therapy and well-being. Strategies for the development of future inorganic materials and nanomaterials based on therapeutics and multifunctionality, and smart materials will also be addressed.
The UE includes lectures and tutorials. A group project on the (theoretical) study of an inorganic material or nanomaterials for health will be proposed to the students
Hourly volumes* :
CM : 11
TD : 9
Nanotechnologies and multifunctional systems for therapy
Component
Faculty of Pharmacy
Internship
Level of study
BAC +5
ECTS
25 credits
Component
Faculty of Science
An internship of 5 to 6 months duration must be carried out in a research or research and development laboratory specialized in organic chemistry, biomolecular chemistry, life chemistry, analytical instrumentation or analytical analysis/development. Thus, students will have the opportunity to carry out this end-of-study internship in academic or private research laboratories. Subject to the prior acceptance of the teaching staff (internship subject in connection with the master's courses and adequate environment/means), the student will be able to look for a host team in the academic environment in the institutes of the Chemistry Pole of the University of Montpellier (IBMM, ICGM, IEM...), in academic laboratories outside the University of Montpellier (in France or abroad) or in the private sector (chemical, pharmaceutical, agri-food, cosmetic industries, biotechnology laboratories, etc.) as well as in research structures such as proteomic/metabolomic/flowomic platforms.
The research project that will be entrusted to the students will have to be linked to the skills and expertise acquired during the previous semesters and the teaching units followed, in particular in semester 9 according to the chosen orientation.
This internship of 5 to 6 months can start from mid-January after the exam session and cannot exceed 6 months for a period in semester 10 included during the validity of the university registration. The pedagogical team of the master Chemistry of Biomolecules will advise the students to find an internship corresponding to their aspirations and capacities.
Bibliography/Scientific Information Project
Level of study
BAC +5
ECTS
3 credits
Component
Faculty of Science
Scientific information: The aim of this course is to familiarize students with the search and management of scientific information. In this context, recent tools for bibliographic research will be explained and used during courses/DD (Electronic documentation: Scifinder / Isis / Belstein). Training in the functionalities of the Zotero tool and in the use of the electronic laboratory notebook will also be provided. The writing and use of scientific publications will be addressed.
Bibliographic project: The tools of scientific information research will be applied to a concrete case. The pedagogical team will propose a bibliographic subject to the student in relation with the chosen orientation. This bibliographic subject may, if necessary, be defined in agreement with the host organization where the internship will be carried out.
For this personal project, the student will have access to all the bibliographic sources of the university or the company that hosts him/her. The bibliographic work may be combined with the English teaching unit in order to prepare an oral presentation at an international conference.
Biotechnologies and applications
Level of study
BAC +5
ECTS
2 credits
Component
Faculty of Science
The aim of this course is to highlight biological processes at the cellular level or even in living subjects. Different molecular imaging approaches will be discussed (fluorescent probes, radiolabeling).
Hourly volumes* :
CM : 9 H
Field : 11 H
Green chemistry
Level of study
BAC +5
ECTS
2 credits
Component
Faculty of Science
The principles of Green Chemistry provide a basis for the evaluation and design of new chemical products and processes that minimize negative impacts on human health and the environment. In this teaching unit, offered to M2 students of the Master of Biomolecular Chemistry (BM), Orientation 2 (O2), the basic principles and concepts of Green Chemistry will be discussed, and their applications in the field of non-conventional activation methods and the use of alternative media in organic synthesis.
Hourly volumes* :
CM : 9 H
Field: 11 a.m.
Extraction and separation of biomolecules
Level of study
BAC +5
ECTS
2 credits
Component
Faculty of Science
This course will teach techniques for the extraction of biomolecules (protein precipitation, SPE), as well as techniques for the separation of biomolecules (chromatography, electrophoresis).
Hourly volumes* :
CM : 9 h
Field: 11 a.m.
Project management - Corporate law
ECTS
4 credits
Component
Faculty of Science
Peptides and proteins
Level of study
BAC +5
ECTS
2 credits
Component
Faculty of Science
Peptides and proteins are composed of a sequence of amino acid residues that give them specific properties. Their functionality depends on their sequence and thus on the chemical functions they carry, and is also greatly modulated by their structure. In addition to conventional peptide synthesis, advanced functional modification options, structures, and properties that can significantly modify or improve the properties of the resulting peptide will be developed. Significant biotechnological developments in both the chemical and biological fields will be discussed leading to a wide range of applications in which peptides and proteins are successfully used.
Hourly volumes*:
CM :15
TD :5
Supported Synthesis
Level of study
BAC +5
ECTS
2 credits
Component
Faculty of Science
In chemistry, solid phase synthesis is a method in which molecules are covalently bonded to a solid support and synthesized step by step using selective protecting groups. The purpose of this applied course is to provide a comprehensive understanding of this field and to examine supported strategies for the practical preparation of polypeptides and oligonucleotides.
Hourly volumes* :
CM : 9 H
Field : 11 H
Nucleic acids
Level of study
BAC +5
ECTS
2 credits
Component
Faculty of Science
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
Hourly volumes* :
CM : 15 H
TD : 5 H
Targeted delivery
Level of study
BAC +5
ECTS
2 credits
Component
Faculty of Science
Hourly volume
20h
In this course, the different molecular or supramolecular tools for the delivery of active ingredients according to the type of cells or intracellular organelles targeted are discussed. Ligand-receptor interactions will be discussed as well as the methods of preparation and activation of conjugates. Examples of drugs will be presented.
Hourly volumes* :
CM : 15 H
TD : 5 H
Chemobiology (67% ENSCM)
Level of study
BAC +5
ECTS
2 credits
Component
Faculty of Science
The course will focus on organic chemistry and post-functionalization of biomolecules applied to peptides, proteins and nucleic acids (DNA and RNA) with applications in gene therapy, biosensing and design of probes for biological studies.
Hourly volumes* :
CM : 15 H
TD : 5 H
NMR
Level of study
BAC +5
ECTS
2 credits
Component
Faculty of Science
Deepening of knowledge in 1H, 13C, 19F, 29Si, 31PNMR, as well as two-dimensional methods. Notions of EPR will also be covered (principle and applications).
Hourly volumes* :
CM : 15 H
TD : 5 H
Multi-step synthesis
Level of study
BAC +5
ECTS
2 credits
Component
Faculty of Science
This course aims at describing the synthesis tools applied to complex and polyfunctional molecules. Retrosynthetic and stereocontrolled approaches will be discussed as well as the rational use of protective groups.
Hourly volumes* :
CM : 9 H
Field : 11 H
Functionalization/Bioconjugation
Level of study
BAC +5
ECTS
2 credits
Component
Faculty of Science
Bioconjugation reactions are of major interest in the biomedical sciences and allow chemists to modify biomolecules to confer new functions or properties. In this course, bioconjugation and biomolecule labeling strategies will be discussed in order to explore complex biological systems. The practical sessions will illustrate these concepts through examples of bioconjugation of osidic and nucleotidic platforms.
Hourly volumes* :
CM : 9 H
Field : 11 H
Mass spectrometry
Level of study
BAC +5
ECTS
2 credits
Component
Faculty of Science
Knowledge of the latest mass spectrometry techniques for the detection, identification and structural characterization of organic molecules and biomolecules.
Applications in chemistry (pharmaceutical industry) and biology (Omics approaches).
1) Structural elucidation (Ion characterization technologies):
- LC/MS/MS and exact mass measurements
- Isotopic labelling, H/D exchange
- Ionic mobility
2) Surface analysis and imaging (molecular mapping)
3) Application in chemistry and biology: characterization of small organic molecules and biomolecules.
Hourly volumes* :
CM : 15 H
TD : 5 H
Lipidic compounds
Level of study
BAC +5
ECTS
2 credits
Component
Faculty of Science
The following topics will be covered:
- Triglycerides
- Phospholipids and sphingolipids
- Glycolipids
- Fat-soluble vitamins
- Steroid hormones
- Bile salts
- Structure and synthesis of prostaglandins and leukotrienes
Hourly volumes* :
CM : 15
TD : 5
Glycochemistry
Level of study
BAC +5
ECTS
2 credits
Component
Faculty of Science
The following topics will be covered:
- General mechanism of glycosylation
- Synthesis of glycosyl donors
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Hourly volumes* :
CM : 15
TD : 5
Internship
Level of study
BAC +5
ECTS
25 credits
Component
Faculty of Science
An internship of 5 to 6 months duration must be carried out in a research or research and development laboratory specialized in organic chemistry, biomolecular chemistry, life chemistry, analytical instrumentation or analytical analysis/development. Thus, students will have the opportunity to carry out this end-of-study internship in academic or private research laboratories. Subject to the prior acceptance of the teaching staff (internship subject in connection with the master's courses and adequate environment/means), the student will be able to look for a host team in the academic environment in the institutes of the Chemistry Pole of the University of Montpellier (IBMM, ICGM, IEM...), in academic laboratories outside the University of Montpellier (in France or abroad) or in the private sector (chemical, pharmaceutical, agri-food, cosmetic industries, biotechnology laboratories, etc.) as well as in research structures such as proteomic/metabolomic/flowomic platforms.
The research project that will be entrusted to the students will have to be linked to the skills and expertise acquired during the previous semesters and the teaching units followed, in particular in semester 9 according to the chosen orientation.
This internship of 5 to 6 months can start from mid-January after the exam session and cannot exceed 6 months for a period in semester 10 included during the validity of the university registration. The pedagogical team of the master Chemistry of Biomolecules will advise the students to find an internship corresponding to their aspirations and capacities.
Bibliography/Scientific Information Project
Level of study
BAC +5
ECTS
3 credits
Component
Faculty of Science
Scientific information: The aim of this course is to familiarize students with the search and management of scientific information. In this context, recent tools for bibliographic research will be explained and used during courses/DD (Electronic documentation: Scifinder / Isis / Belstein). Training in the functionalities of the Zotero tool and in the use of the electronic laboratory notebook will also be provided. The writing and use of scientific publications will be addressed.
Bibliographic project: The tools of scientific information research will be applied to a concrete case. The pedagogical team will propose a bibliographic subject to the student in relation with the chosen orientation. This bibliographic subject may, if necessary, be defined in agreement with the host organization where the internship will be carried out.
For this personal project, the student will have access to all the bibliographic sources of the university or the company that hosts him/her. The bibliographic work may be combined with the English teaching unit in order to prepare an oral presentation at an international conference.
Bioanalysis
Level of study
BAC +5
ECTS
2 credits
Component
Faculty of Science
Description of the most recent mass spectrometry techniques for analyses in the pharmaceutical industry (drug development : Drug discovery and pre-clinical analysis).
Mass spectrometry instrumentation and acquisition modes in the pharmaceutical industry for the following applications:
- Analyses in the various stages of drug development,
- Qualitative analysis in metabolism,
- Quantitative analyses in pharmacokinetics.
Hourly volumes* :
CM : 15 H
Field : 5 H
Extraction and separation of biomolecules
Level of study
BAC +5
ECTS
2 credits
Component
Faculty of Science
This course will teach techniques for the extraction of biomolecules (protein precipitation, SPE), as well as techniques for the separation of biomolecules (chromatography, electrophoresis).
Hourly volumes* :
CM : 9 h
Field: 11 a.m.
Project management - Corporate law
ECTS
4 credits
Component
Faculty of Science
Peptides and proteins
Level of study
BAC +5
ECTS
2 credits
Component
Faculty of Science
Peptides and proteins are composed of a sequence of amino acid residues that give them specific properties. Their functionality depends on their sequence and thus on the chemical functions they carry, and is also greatly modulated by their structure. In addition to conventional peptide synthesis, advanced functional modification options, structures, and properties that can significantly modify or improve the properties of the resulting peptide will be developed. Significant biotechnological developments in both the chemical and biological fields will be discussed leading to a wide range of applications in which peptides and proteins are successfully used.
Hourly volumes*:
CM :15
TD :5
Structure-based drug design
ECTS
2 credits
Component
Faculty of Pharmacy
Chemoinformatics
Level of study
BAC +5
ECTS
2 credits
Component
Faculty of Science
The themes of the EU are the following:
A theoretical part dedicated to chemoinformatics
A theoretical part dedicated more specifically to modeling tools for drug design
Hourly volumes* :
CM : 15 H
TD : 5 H
A part dedicated to the practical aspect with work on computers
Nucleic acids
Level of study
BAC +5
ECTS
2 credits
Component
Faculty of Science
Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.
Hourly volumes* :
CM : 15 H
TD : 5 H
LC-MS, MS/MS
Level of study
BAC +4
ECTS
2 credits
Component
Faculty of Science
Knowledge of LC/MS and LC/MS/MS techniques for the characterization of organic molecules and biomolecules in complex media.
Description of the instruments and acquisition modes that will be used in the lab.
1) Analytical Chromatography techniques coupled to mass spectrometry with ambient ionization:
- LC/MS type instrumentation,
- LC/MS/MS type instrumentation.
2) Coupled spectral data acquisition devices.
Hourly volumes* :
CM : 9 H
Field : 11 H
NMR
Level of study
BAC +5
ECTS
2 credits
Component
Faculty of Science
Deepening of knowledge in 1H, 13C, 19F, 29Si, 31PNMR, as well as two-dimensional methods. Notions of EPR will also be covered (principle and applications).
Hourly volumes* :
CM : 15 H
TD : 5 H
Separation/Purification
Level of study
BAC +5
ECTS
2 credits
Component
Faculty of Science
The objective of this course is to give students a theoretical and practical training in the fundamental techniques of separation and purification of biomolecules
Hourly volumes* :
CM : 9h
Field : 11h
Screening
ECTS
2 credits
Component
Faculty of Science
Understanding of screening techniques for bioactive molecules, and more generally in vitro tests used to measure a biological event in the perspective of drug discovery or diagnosis.
1) Pharmacological and biophysical fundamentals describing a biological event, target of biological tests:
2) Biological tests for the development of medicines or diagnostics
3) Applications, case studies, critical analyses.
Hourly volumes* :
CM : 15 H
TD : 5 H
Mass spectrometry
Level of study
BAC +5
ECTS
2 credits
Component
Faculty of Science
Knowledge of the latest mass spectrometry techniques for the detection, identification and structural characterization of organic molecules and biomolecules.
Applications in chemistry (pharmaceutical industry) and biology (Omics approaches).
1) Structural elucidation (Ion characterization technologies):
- LC/MS/MS and exact mass measurements
- Isotopic labelling, H/D exchange
- Ionic mobility
2) Surface analysis and imaging (molecular mapping)
3) Application in chemistry and biology: characterization of small organic molecules and biomolecules.
Hourly volumes* :
CM : 15 H
TD : 5 H
Lipidic compounds
Level of study
BAC +5
ECTS
2 credits
Component
Faculty of Science
The following topics will be covered:
- Triglycerides
- Phospholipids and sphingolipids
- Glycolipids
- Fat-soluble vitamins
- Steroid hormones
- Bile salts
- Structure and synthesis of prostaglandins and leukotrienes
Hourly volumes* :
CM : 15
TD : 5
Glycochemistry
Level of study
BAC +5
ECTS
2 credits
Component
Faculty of Science
The following topics will be covered:
- General mechanism of glycosylation
- Synthesis of glycosyl donors
- Methods of activation of glycosyl donors
- Stereoselective synthesis of some natural oligosaccharides
Hourly volumes* :
CM : 15
TD : 5
Internship
Level of study
BAC +5
ECTS
25 credits
Component
Faculty of Science
An internship of 5 to 6 months duration must be carried out in a research or research and development laboratory specialized in organic chemistry, biomolecular chemistry, life chemistry, analytical instrumentation or analytical analysis/development. Thus, students will have the opportunity to carry out this end-of-study internship in academic or private research laboratories. Subject to the prior acceptance of the teaching staff (internship subject in connection with the master's courses and adequate environment/means), the student will be able to look for a host team in the academic environment in the institutes of the Chemistry Pole of the University of Montpellier (IBMM, ICGM, IEM...), in academic laboratories outside the University of Montpellier (in France or abroad) or in the private sector (chemical, pharmaceutical, agri-food, cosmetic industries, biotechnology laboratories, etc.) as well as in research structures such as proteomic/metabolomic/flowomic platforms.
The research project that will be entrusted to the students will have to be linked to the skills and expertise acquired during the previous semesters and the teaching units followed, in particular in semester 9 according to the chosen orientation.
This internship of 5 to 6 months can start from mid-January after the exam session and cannot exceed 6 months for a period in semester 10 included during the validity of the university registration. The pedagogical team of the master Chemistry of Biomolecules will advise the students to find an internship corresponding to their aspirations and capacities.
Bibliography/Scientific Information Project
Level of study
BAC +5
ECTS
3 credits
Component
Faculty of Science
Scientific information: The aim of this course is to familiarize students with the search and management of scientific information. In this context, recent tools for bibliographic research will be explained and used during courses/DD (Electronic documentation: Scifinder / Isis / Belstein). Training in the functionalities of the Zotero tool and in the use of the electronic laboratory notebook will also be provided. The writing and use of scientific publications will be addressed.
Bibliographic project: The tools of scientific information research will be applied to a concrete case. The pedagogical team will propose a bibliographic subject to the student in relation with the chosen orientation. This bibliographic subject may, if necessary, be defined in agreement with the host organization where the internship will be carried out.
For this personal project, the student will have access to all the bibliographic sources of the university or the company that hosts him/her. The bibliographic work may be combined with the English teaching unit in order to prepare an oral presentation at an international conference.
Admission
Conditions of access
Applications are made on the following platforms:
French & European students:
- For the M1, follow the procedure " My Master " from the website : https://www.monmaster.gouv.fr/
- For M2, students must submit their application via the e-candidat application: https: //candidature.umontpellier.fr/candidature
International students from outside the EU: follow the "Studies in France" procedure: https: //pastel.diplomatie.gouv.fr/etudesenfrance/dyn/public/authentification/login.html
How to register
L3 Chemistry
Master 1 Pharmacy
Capacity
40 in M1 and M2
Necessary pre-requisites
Access to M1 is by application for holders of a national diploma of Bachelor of Science in Chemistry or Biochemistry, or a University Bachelor of Technology (BUT) in Chemistry.
Recommended prerequisites
Level L3
Organic Chemistry
Techniques for characterizing organic compounds
And then
Further studies
Doctoral thesis
IAE
Continuing your studies abroad
Ph. D.
Master of Business Administration
Bridges and reorientation
Admission on file for the candidates justifying the level M1 in chemistry or equivalent formations (M1 Pharmacy).
Outgoing flow Master mentioning Analytical Chemistry/Master mentioning Polymer Chemistry.
Professional integration
Sectors of activity: professions at the interface of chemistry and biology, pharmaceutical industry, food industry, biotechnologies, laboratory/analytical platform (analysis and quality control), fine organic chemistry, custom synthesis, pharmaceutical and parapharmaceutical industry.
Types of jobs available: pursue doctoral studies, researcher/executive in basic research and research and development, public/private research laboratory, teacher-researcher, researcher.