Innovative synthesis and extraction processes

This teaching unit is shared with MI students in the Chemistry Master's courses: ICAP P1, ICAP P2, MAT P1, MAT P2, BM (semester S2). The following topics will be covered:

• The 12 Principles of Green Chemistry and units of measurement in Green Chemistry ;
• Synthesis strategies for sustainable chemistry ;
• Alternative or eco-compatible solvents for synthesis and extraction;
• Non-conventional activation techniques and applications.

CM: 13

TD: 7 H

Be able to: 1) select the most appropriate activation technique and solvent for the preparation of an organic molecule/material; 2) design synthesis processes with low environmental impact based on the 12 Principles of Green Chemistry and on synthesis strategies allowing a reduction of steps; 3) perform green chemistrymetrics.

Organic chemistry, L3 level

Reactivity basics

Assessment of knowledge :

2-hour written final exam

• Authorized documents: no
• Non-graphic calculator allowed: yes
• Internet allowed: no

Course:

1. The 12 principles of Green Chemistry and units of measurement (2h) ;
2. Synthesis strategies in sustainable chemistry (3h) :

• Domino, cascade and multicomponent reactions,
• Catalysis (definitions, C-C, C-N, C-O coupling reactions and associated catalytic mechanisms) ;

1. Alternative or eco-compatible solvents for synthesis andextraction (3 h);

• Ionic liquids (except biobased) and fluorinated phases (synthesis and properties), and examples of extraction in non-conventional media;
• _sc-CO2 and SPE (Solid Phase Extraction): applications in the synthesis and (micro)extraction of fragrance molecules and cosmetics;
• Selected examples of laboratory and industrial-scale applications.

1. Non-conventional activation techniquesand applications in synthesis and/or extraction (5 h) :

(For each technique, the principles of activation, instruments and applications will be illustrated by appropriate examples, depending on the course):

• Microwaves and continuous flow ;
• Mechanochemistry and solvent-free methods ;
• Ultrasound ;
• Examples of laboratory and industrial-scale applications of each technique;
• Biotransformations

TD (7H): Individual work, exercises to prepare before and during the session.

Case studies (exercises on the synthesis of alternative solvents, choice of solvent/activation method, exercises on the application of units of measurement in sustainable chemistry and interpretation of results, exercises on the synthesis of complex molecules using eco-compatible strategies/methods.