Level of study
BAC +4
ECTS
2 credits
Component
Faculty of Science
Description
This teaching unit is mutualized for the MI students of the Master Chemistry: ICAP P1, ICAP P2, MAT P1, MAT P2, BM (semester S2). The following topics will be covered:
- The 12 Principles of Green Chemistry and the Units of Measurement in Green Chemistry ;
- Synthesis strategies in sustainable chemistry;
- Alternative or eco-compatible solvents for synthesis and extraction;
- Non-conventional activation techniques and applications.
CM : 13
TD : 7 H
Objectives
Be able to: 1) select the most appropriate activation technique and solvent for the preparation of an organic molecule/material; 2) design low environmental impact synthesis processes based on the 12 Principles of Green Chemistry and on step-reducing synthesis strategies; 3) perform green chemistrymetrics.
Necessary pre-requisites
Organic chemistry level L3
Basic concepts of reactivity
Knowledge control
Knowledge control:
Final written exam of 2 hours
- Authorized documents: no
- Non-graphic calculator allowed: yes
- Internet allowed : no
Syllabus
Course:
- The 12 principles of Green Chemistry and the units of measurement (2h) ;
- Synthesis strategies in sustainable chemistry (3h) :
- Domino, cascade, multi-component reaction,
- Catalysis (definitions, C-C, C-N, C-O coupling reaction and associated catalytic mechanism) ;
- Alternative or eco-compatible solvents for synthesis andextraction (3 h);
- Ionic liquids (except biosourced) and fluorinated phases (synthesis and properties), and examples of extraction in non-conventional media;
- sc-CO2 and SPE (Solid Phase Extraction): applications in synthesis and (micro)extraction of odorant molecules and cosmetics
- Selected examples of laboratory and industrial scale applications.
- Non-conventional activation techniquesand applications in synthesis and/or extraction (5 hrs):
(For each technique, the principles of activation, the instruments and the applications will be illustrated by examples adapted to the course):
- Microwave and continuous flow;
- Mechanochemistry and solventless methods;
- Ultrasound ;
- Examples of application of each technique at laboratory and industrial scale;
- Biotransformations
TD (7H): Individual work, exercises to prepare before and during the session.
Case studies (exercises on the synthesis of alternative solvents, choice of solvent/activation method, exercises on the application of units of measure in sustainable chemistry and interpretation of results, exercises on the synthesis of complex molecules by eco-compatible strategies/methods.