Nucleic acids

Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.

Hourly volumes* :

            CM: 15 H  

            TD: 5 H

The lecture aims at providing the students the fundamentals of oligonucleotide synthesis and to enable them to understand the stakes and recent applications in the diagnostic and therapeutic fields.

Organic Chemistry level Master 1

2-hour final written exam

Authorized documents: no

Non-graphic calculator allowed: yes

Internet allowed: no

Classes: 3 p.m.

DNA is a complex molecule that carries the information necessary for all forms of life. However, in the most basic sense, DNA is a chemical molecule whose properties and arrangements control its ability to code genetic information, as well as its sensitivity to degradation. The notions will be approached from the perspective of the fundamental chemistry of nucleic acids.

1. This course will explore the chemical nature of hereditary material from the perspective of chemical biology.
2. We will explore the structure, function and reactivity of nucleic acids, as well as the mechanisms by which DNA can be damaged and repaired.
3. We will examine how the chemical synthesis of oligonucleotides is integrated into biotechnology and advanced therapies, and how this impacts society.

TD: 5H

The concepts presented in a lecture style format will be reinforced through classroom discussion of articles from scholarly journals.