Study level
BAC +4
ECTS
2 credits
Component
Faculty of Science
Description
The aim of the medicinal chemistry course is to introduce students to the key stages in the process of developing molecules with biological activity. In particular, a description of the interactions involved, the notion of pharmocophores, bio-isosteria, etc., as well as structure-activity relationship studies will be covered, enabling students to envisage appropriate strategies and structural modifications.
Hourly volumes* :
WC: 3 p.m.
TD: 5 h
Objectives
The aim of this course is to understand the issues involved in medicinal chemistry research.
Necessary prerequisites
Organic chemistry L3
Biomolecule Chemistry, M1 level:
Knowledge of the various families (structures, properties)
Knowledge control
Final written exam, 2 hours:
- Authorized documents: no
- Internet allowed: no
Syllabus
Course : Inductive (problem-based) and deductive pedagogy. Support(s) available on ENT (Moodle): Course documents, TD documents, exam annals and reference publications.
- Molecular interactions of biomolecules with their targets (1.5 h)
- Pharmacophore and pharmacophore analogues (3 h)
- Notions of bio-isostery/homologation/inversion of functions (4.5 h)
- Structure-activity relationships (4.5 h)
- Physico-chemical properties (1.5 h)
TD (5h): Individual work, exercises to prepare before and during the session.
Further information
Teaching team :
Christophe Mathé
christophe.mathe@umontpellier.fr
Administrative contact(s) :
Secretariat Master Chemistry
https://master-chimie.edu.umontpellier.fr/