Level of study
BAC +4
ECTS
2 credits
Component
Faculty of Science
Description
The medicinal chemistry course aims to introduce students to the key steps in the development process of molecules with biological activities. In particular, a description of the interactions involved, the notion of pharmocophores, bio-isosteria..., as well as structure-activity relationship studies will be addressed in order to consider strategies and adequate structural modifications.
Hourly volumes* :
CM : 3 pm
TD : 5 h
Objectives
The objective of this course is to understand the problems of research in medicinal chemistry.
Necessary pre-requisites
Organic chemistry L3
Chemistry of Biomolecules, M1 level:
Knowledge of the various families (structures, properties)
Knowledge control
Final written exam of 2 hours:
- Authorized documents: no
- Internet allowed : no
Syllabus
Course : Inductive (problematic) and deductive pedagogy. Support(s) available on ENT (Moodle): Course documents, TD documents, exam annals and reference publications
- Molecular interactions of biomolecules with their targets (1.5 h)
- Pharmacophore and pharmacophore analogues (3 h)
- Concepts of bio-isostery/homologation/inversion of functions (4.5 h)
- Structure-activity relationships (4.5 h)
- Physical and chemical properties (1.5 h)
TD (5h): Individual work, exercises to prepare before and during the session.
Additional information
Teaching team :
Christophe Mathé
christophe.mathe@umontpellier.fr
Administrative contact(s):
Secretariat Master Chemistry
https://master-chimie.edu.umontpellier.fr/