• Study level

    BAC +4

  • ECTS

    2 credits

  • Component

    Faculty of Science

Description

The aim of the medicinal chemistry course is to introduce students to the key stages in the process of developing molecules with biological activity. In particular, a description of the interactions involved, the notion of pharmocophores, bio-isosteria, etc., as well as structure-activity relationship studies will be covered, enabling students to envisage appropriate strategies and structural modifications.

Hourly volumes* :

WC: 3 p.m.

TD: 5 h

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Objectives

The aim of this course is to understand the issues involved in medicinal chemistry research.

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Necessary prerequisites

Organic chemistry L3

Biomolecule Chemistry, M1 level:

Knowledge of the various families (structures, properties)

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Knowledge control

Final written exam, 2 hours:

  • Authorized documents: no
  • Internet allowed: no
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Syllabus

Course : Inductive (problem-based) and deductive pedagogy. Support(s) available on ENT (Moodle): Course documents, TD documents, exam annals and reference publications.

 

  1. Molecular interactions of biomolecules with their targets (1.5 h)
  2. Pharmacophore and pharmacophore analogues (3 h)
  3. Notions of bio-isostery/homologation/inversion of functions (4.5 h)
  4. Structure-activity relationships (4.5 h)
  5. Physico-chemical properties (1.5 h)

 

TD (5h): Individual work, exercises to prepare before and during the session.

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Further information

Teaching team :

 

Christophe Mathé

christophe.mathe@umontpellier.fr

Administrative contact(s) :

Secretariat Master Chemistry

https://master-chimie.edu.umontpellier.fr/

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