Level of Education
4-year college degree
ECTS
2 credits
Training Structure
College of Sciences
Description
The course on medicinal chemistry aims to introduce students to the key steps in the process of developing molecules with biological activity. In particular, the course will cover the interactions involved, the concept of the pharmacophore, bioisostery, and other related topics, as well as structure-activity relationship studies, enabling students to consider appropriate strategies and structural modifications.
Hourly volumes*:
CM: 3:00 p.m.
TD: 5 hours
Objectives
The objective of this course is to provide an understanding of the challenges involved in medicinal chemistry research.
Class Hours
- Medicinal Chemistry - LectureLecture3:00 p.m.
- Medicinal Chemistry - TutorialsTutorials5 hours
Mandatory Prerequisites
Organic Chemistry, Junior Year
Biomolecular Chemistry, M1 Level:
Knowledge of the various families (structures, properties)
Knowledge Assessment
2-hour final written exam:
- Authorized documents: No
- Internet access allowed: No
Course Outline
Course: Inductive (problem-based) and deductive pedagogy. Materials available on the digital learning platform (Moodle): Course materials, tutorial materials, past exam questions, and reference publications
- Molecular interactions between biomolecules and their targets (1.5 hours)
- Pharmacophore and Pharmacophore Analogs (3 hours)
- Concepts of bioisosterism, homologation, and function inversion (4.5 hours)
- Structure-Activity Relationships (4.5 hours)
- Physicochemical Properties (1.5 hours)
TD (5 hours): Independent work; exercises to be prepared before and during the session.
Additional Information
Teaching Staff :
Christophe Mathé
christophe.mathe@umontpellier.fr
Administrative contact(s):
Master's in Chemistry Office
https://master-chimie.edu.umontpellier.fr/