Peptides and Proteins

Peptides and proteins consist of chains of amino acid residues that confer specific properties upon them. Their functionality depends on their sequence—and thus on the chemical functions they possess—and is also greatly influenced by their structure. In addition to conventional peptide synthesis, advanced options for functional modification, structural changes, and property adjustments—which can significantly alter or enhance the properties of the resulting peptide—will be explored. Significant biotechnological developments in both the chemical and biological fields will be discussed, leading to a wide range of applications in which peptides and proteins are successfully utilized.

Hourly Volumes*:

CM: 15

TD: 5

Knowledge and Skills :

Structure and Biological Role of Peptides and Proteins

Synthesis of Peptides and Modified Peptides on a Solid Support

Chemical Modifications of Peptides and Proteins

M1 Level: Organic Chemistry, Biomolecular Chemistry, proficiency in peptide synthesis strategies in solution

Final Exam (2 hours)

Course (15 hours): Materials available on the digital learning platform (Moodle): Course materials, tutorial materials, past exam questions, and reference publications.

TD (5 hours): Case studies: application of strategies for synthesizing peptides of interest; review of publications covering the various concepts.

1. Basics (4.5 hours)

I.1 Peptide and Protein Functions

I.2 Classification and Conformation of Peptides and Proteins

I.3 Post-Translational Modifications

1. Solid-Phase Peptide Synthesis (3 hours)

II.1 Basics

II.2 Automated Synthesis

II.3 Treatment/Purification

1. Protein Engineering (3 hours)

II.1 Synthesis/Characterization

II.2 Incorporation of Non-Canonical Amino Acids

II.3 Ligation

III. Structural Considerations (3 hours)

III.1 Modified Peptides (cyclotides, staple peptides)

III.2 Foldamers

IV. Biological Applications for Diagnosis and Therapy (6 hours)

IV.1 CPP (self-assembling)

IV.2 ADC

IV.3 PDC/PROTAC

IV.4 ABP

Administrative contact(s):

Master's in Chemistry Office

https://master-chimie.edu.umontpellier.fr/