Lipid compounds

The following topics will be covered:

- Triglycerides

- Phospholipids and sphingolipids

- Glycolipids

- Fat-soluble vitamins

- Steroid hormones

- Bile salts

- Structure and synthesis of prostaglandins and leukotrienes

Hourly volumes* :

CM: 15

TD : 5

The aim of this course is to illustrate the chemical and stereochemical structure of natural lipids, briefly describe their biological and pharmacological functions, and show some examples of stereoselective lipid synthesis, in particular prostaglandins and leukotrienes.

Organic chemistry, L3 level

2-hour written final exam

• Authorized documents: no
• Non-graphic calculator allowed: yes
• Internet allowed: no

Courses (15 H): Materials available on ENT (Moodle): Course documents, TD documents, exam annals and reference publications.

1. Structure and biological functions of : (3 H)

- Plant and animal triglycerides

- Phospholipids

- Sphingolipids

- Glycolipids :

cerebrosides

gangliosides

1. Fat-soluble vitamins: (3 H)

vitamins _K1 and _K2

retinol and dehydroretinol

tocopherols

vitamins _D3 and_D2

1. Structure and structure-activity relationship of steroid hormones: (4,5 H)

corticosteroids (cortisone, hydrocortisone, aldosterone)

sex steroids (testosterone, estrogen, progesterone)

1. Structure and conformation of bile salts: (1,5 H)

cholic acids

deoxycholic

chenodesoxycholic

glycocholic

taurocholic.

1. Structure and total synthesis of prostaglandins and leukotrienes (3 H)

Tutorials (5 hours): Individual work, exercises to be prepared before and during the session.

Determination of the structure of different classes of lipids using chemical and spectroscopic analysis methods. Exercises on total synthesis of prostaglandins and leukotrienes.

Administrative contact(s) :

Secretariat Master Chemistry

https://master-chimie.edu.umontpellier.fr/