Lipid compounds

The following topics will be covered:

- Triglycerides

- Phospholipids and sphingolipids

- Glycolipids

- Fat-soluble vitamins

- Steroid hormones

- Bile salts

- Structure and synthesis of prostaglandins and leukotrienes

Hourly volumes*:

CM: 15

TD: 5

The objective of this course is to illustrate the chemical and stereochemical structure of natural lipids, briefly describe their biological and pharmacological functions, and show some examples of stereoselective synthesis of lipids, particularly prostaglandins and leukotrienes.

Organic Chemistry Level L3

2-hour written final exam

• Authorized documents: no
• Non-graphing calculator permitted: yes
• Internet access: no

Course (15 hours): Materials available on the digital workspace (Moodle): Course documents, tutorial documents, past exam papers, and reference publications.

1. Biological structure and functions of: (3 H)

- Vegetable and animal triglycerides

- Phospholipids

- Sphingolipids

- Glycolipids:

cerebrosides

gangliosides

1. Fat-soluble vitamins: (3 H)

vitamins_K1 and_K2

retinol and dehydroretinol

tocopherols

vitamins_D3 and_D2

1. Structure and structure-activity relationship of steroid hormones: (4,5 H)

corticosteroids (cortisone, hydrocortisone, aldosterone)

sex steroids (testosterone, estrogens, progesterone)

1. Structure and conformation of bile salts: (1.5 hours)

cholic acids

desoxycholic

chenodeoxycholic acid

glycocholic

taurocholic.

1. Structure and total synthesis of prostaglandins and leukotrienes (³H)

TD (5 hours): Individual work, exercises to be prepared before and during the session.

Determination of the structure of different classes of lipids using chemical and spectroscopic analysis methods. Exercises on the total synthesis of prostaglandins and leukotrienes.

Administrative contact(s):

Master's Program in Chemistry Secretariat

https://master-chimie.edu.umontpellier.fr/