M1 - Biomolecular Chemistry (BM)

Fluorinated biomolecules. Current developments of fluorinated molecules. Methods of fluorination: nucleophilic or electrophilic mono-fluorination, introduction of difluoromethyl or trifluoromethyl groups. Contribution of fluorine atoms in the activity of these compounds. Examples of syntheses of fluorinated compounds used as antitumor agents, antiviral agents, antidepressants, anxiolytics, anti-inflammatories...

Phosphorus biomolecules. Structure, nomenclature, reactivity, structural analysis and applications.

Some synthetic routes of compounds of each of the treated families will be discussed, highlighting, if necessary, non-conventional activation methods. Biomedical applications will be targeted, as well as other applications in agrochemistry, optoelectronics, nanomaterials, ...

Hourly volumes* :

CM : 15 h (7,5h Fluorinated biomolecules and 7,5h Phosphorated biomolecules)

TD : 5 h

See full page

See full page

This course allows the acquisition of basic knowledge and transversal skills in the field of colloids and interfaces, common to the different courses of the Master Chemistry (Chemistry of Materials, Separative Chemistry, Materials and Processes, ICAP Cosmetics Engineering, Chemistry of Biomolecules). It is also offered to international students entering the SFRI program at the University of Montpellier where the teaching is given in English. An introductory presentation on the basic notions and concepts will allow to discover and better understand the main physicochemical properties of colloidal dispersions, associative colloids, and macromolecular solutions, as well as the parameters and phenomena governing the stability in colloidal dispersions and mixed solution-colloid systems. Then, an interdisciplinary practical teaching based on the principle of the flipped classroom will be proposed to help students build and deepen their knowledge through an individual and collective analysis of the various applications of colloidal and interfacial phenomena and systems.

Hourly volumes* :

CM : 7

TD : 13

See full page

This course is designed to teach liquid chromatography and gas chromatography.

Hourly volumes* :

            CM :15h

            TD : 5h

See full page

Knowledge of gas chromatography and electron impact ionization mass spectrometry and quadrupole mass analyzer techniques for the analysis of volatile organic molecules.

1) GC-MS analyses of volatile organic compounds:

• Electron impact ionization (EI) techniques
• Chemical ionization (CI) techniques
• Quadrupole analysis techniques (Q)
• GC/MS Couplings

2) Applications in organic chemistry analysis, characterization of volatile samples.

Hourly volumes* :

CM : 15 H

TD : 5 H

See full page

Knowledge of the main families of polymers used in the biomedical field.

1) Specificity of polymers for biomedical applications and main families of polymers used

2) Description of the application families

3) Discussion on the notion of synthesis and the structure/property/software relationship

Hourly volumes* :

CM : 15 H

TD : 5 H

See full page

This course deals concisely and systematically with all aspects of heterocycle chemistry, from nomenclature to applications such as the principles of action of drugs, toxins or drugs, pigments, food coloring etc...

Hourly volumes* :

CM : 15 H

TD : 5 H

See full page

Natural products occupy a major place in the field of biomolecular chemistry. They represent an important source of bioactive compounds for medicinal chemistry. This course provides a comprehensive overview of the secondary metabolism and origin of natural products from plants. The emphasis in this unit will be on the organic chemistry behind the various biotransformations that occur during the biosynthesis of each major class of molecules. A mechanistic approach will be used to understand the chemical basis of each transformation.

Hourly volumes* :

CM : 13 

TD : 7

See full page

NMR:

NMR (Nuclear Magnetic Resonance) in liquid phase is an essential spectroscopic method of analysis for the chemist, allowing in particular to determine the structure of small organic molecules or macromolecules in solution, the study of dynamic phenomena... The objective of this course is to understand the phenomena involved in this technique and to relate them to the various structural information accessible by this method. The aim is to be able to exploit the spectral data resulting from this analysis to elucidate the structure and stereochemistry of organic molecules or polymer structures, or to carry out reaction monitoring.

X-ray diffraction:

X-ray diffraction is a powerful and non-destructive technique for characterizing the crystal structure of materials, but it is also able to provide crystallographic and structural information such as lattice parameters and atomic positions. This includes all crystallized materials such as ceramics, materials for energy and information storage and transformation as well as organic molecules and metal complexes (interatomic distances and angles, stereochemistry (chirality, stereoisomerism...), intra and intermolecular bonds...). The objective of this course is an introduction to crystallography and diffraction, with the aim of understanding the operation and characteristics of an X-ray diffractometer, as well as the interpretation of diffraction patterns (structural analysis, lattice parameters).

Hourly volumes* :

            CM : 10

            TD : 10

See full page

Knowledge of the latest mass spectrometry techniques for the qualitative analysis of organic molecules and biomolecules.

1) Description of Fundamentals (Ion Science and Technology):

- Ionization techniques

- Analysis techniques

- Tandem mass spectrometry (MS/MS)

- LC/MS and LC/MS/MS couplings

2) Application in the context of biomolecule analysis and organic chemistry reaction monitoring.

Hourly volumes* :

CM : 15 H

TD : 5 H

See full page

This course will cover the fundamental concepts and practical tools related to chemometrics through : - statistical analysis of data ;

• laws of probability ;
• confidence interval estimation ;
• parametric and non-parametric tests.

An introduction to experimental design will be offered at the end of the module.

Hourly volumes* :

CM : 7h

TD : 13h

See full page

The first part of the course presents the fundamental knowledge of organometallic chemistry of transition metals. It starts with the description of the Metal-C bond allowing the understanding of its stability and chemical reactivity. In a second step, the power of this synthesis tool for the formation of C-H, C-C bonds, ... Examples of their applications in different fields will allow the acquisition of these reactions and their fields of applications: fine chemistry, catalytic transformations of industrial importance, synthesis of natural products, preparation of materials.

The second part of this course is dedicated to the chemistry of hetero-elements focused on the elements Silicon, Tin and Boron. This part aims at presenting the different methods of preparation of boron, tin and silicon reagents as well as the main transformations performed with these compounds, with applications in organic synthesis and materials synthesis.

CM : 13 H 

TD : 7 H

See full page

This teaching unit is dedicated to the deepening of the bases of organic chemistry and coordination chemistry seen in L3 and to the acquisition of notions related to molecular engineering and molecular chemistry. The UE includes lectures and tutorials. The students will work before some lectures and tutorials with course documents provided so that the lectures and tutorials can allow them to be fully involved in the training, to understand the concepts presented and the skills to be acquired. The progression program and activities will be proposed. For those students who have not seen the basics of coordination chemistry and organic chemistry, the documents will be made available.

Coordination chemistry: The teaching will cover the different aspects of transition metal and lanthanide complexes, molecular materials (polynuclear complexes and coordination polymers with extended structures (MOFs, etc.)) and their properties and applications. Structural aspects, bonding description, properties, as well as stability and reactivity aspects will be discussed. Emphasis will be put on the complexation effect and on the stability of metal, lanthanide and actinide complexes with certain ligands for applications in the biomedical field (imaging and therapy), decontamination (nuclear field), etc. The electronic (relaxivity, magnetism) and optical (absorption, luminescence) properties of these complexes will be discussed and put in the context of applications in various fields, such as imaging, electronics, sensors, etc.

Organic Chemistry: The teaching is based on the knowledge acquired in the Bachelor's degree and will approach through a reasoned study the main reaction mechanisms of organic chemistry and will allow to give a common base to all the students of the Master Chemistry. The main processes (substitution, addition, elimination, transposition...) and their essential characteristics and applications to mechanistic sequences will be examined. This course should provide the student with general tools for the analysis of mechanisms (ionic, radical, concerted) in order to understand these mechanisms in their variety.

Hourly volumes* :

CM : 13 H

TD : 7 H

See full page

The professionalization project provides a link between the traditional practical work and the internship in a laboratory or company. It is carried out in the form of a tutored project consisting of putting the student in a professional situation through collaborative (group) work based on the realization of a project in response to a problem set by a company, community, association or academic. It is part of the core curriculum of the Chemistry Master's program and is carried out under the responsibility of a member of the teaching team (university or industry). Carried out throughout the semester, this project aims to relate and anchor the knowledge/know-how acquired in the framework of the Bachelor's degree and the beginning of the Master's degree through this professional situation. These situations will be directly linked to the Master's program chosen by the students. In addition to the disciplinary skills of chemistry, other relational, organizational and communication skills, intrinsically linked to project management, will also be acquired and will arm the students for their future professional life.

Answer a research problem: example of synthesis of new phosphorescent materials.

Hourly volumes* :

CM : 5h

TD : 5h

Practical work : 40h

See full page

The internship in semester 8 of the Master 1 Chemistry of Biomolecules aims to familiarize students with research careers in life chemistry. Thus, the students will have the possibility of carrying out this training course of initiation to research within academic or private laboratories. Subject to prior acceptance by the teaching staff (internship subject related to the Master's courses and adequate environment/means), the student may look for a host team in an academic environment in the institutes of the Chemistry Pole of the University of Montpellier (IBMM, ICGM, ...), in academic laboratories outside the University of Montpellier (in France or abroad) or in the private sector (chemical, pharmaceutical, agri-food industries, biotech laboratories, ...).

Field : 2 to 4 months of internship

See full page

Nucleosides are the basic constituents of nucleic acids (DNA and RNA). As such, they play an essential role in many biological processes. In this course, the structure and biological role of natural nucleosides will be presented. The main synthesis and characterization routes of these compounds and their analogues (glycosylation reactions, structural modifications of the furanose ring, substitution and introduction of heteroatoms, configuration inversion, etc.) will also be discussed. The use of nucleoside analogues for the treatment of viral pathologies and cancers will also be discussed.

Hourly volumes* :

CM : 3 pm

TD : 5 h

See full page

This teaching unit is mutualized for the MI students of the Master Chemistry: ICAP P1, ICAP P2, MAT P1, MAT P2, BM (semester S2). The following topics will be covered:

• The 12 Principles of Green Chemistry and the Units of Measurement in Green Chemistry ;
• Synthesis strategies in sustainable chemistry;
• Alternative or eco-compatible solvents for synthesis and extraction;
• Non-conventional activation techniques and applications.

CM : 13

TD : 7 H

See full page

The medicinal chemistry course aims to introduce students to the key steps in the development process of molecules with biological activities. In particular, a description of the interactions involved, the notion of pharmocophores, bio-isosteria..., as well as structure-activity relationship studies will be addressed in order to consider strategies and adequate structural modifications.

Hourly volumes* :

CM : 3 pm

TD : 5 h

See full page

After generalities on the notions of prochirality and stereochemistry, this teaching will present the tools allowing the mastery of diastereoselective and enantioselective syntheses. The different approaches will be presented in a detailed and rational way. Examples of industrial syntheses of chiral bioactive molecules will be discussed.

Hourly volumes* :

CM : 15 H

TD : 5 H

See full page

This course discusses synthetic methods applied to obtain enantiopure amino acids as well as the use of chiral amino acids for the synthesis of other enantiopure compounds.

These amino acids are the basic elements of peptides. The different physico-chemical properties induced by the nature of these amino acids will allow to define strategies for the synthesis of peptides of interest and their characterization.

Hourly volumes* :

CM : 15 H

TD : 5 H

See full page

The following topics will be covered:

- Biobased solvents

- Fuels from biomass

- Antioxidants derived from lignin

- Metal catalysts from plants

- Surfactants obtained from renewable resources

- Examples of industrial applications of enzymatic synthesis

Hourly volumes* :

CM : 15

TD : 5

See full page

This UE will address in small groups or in a personalized way the pedagogical tools and good practices related to communication and professional insertion, through :

• knowledge, skills, competencies, attitudes and motivations assessments;
• awareness of job search techniques;
• CV and cover letter writing;
• rules of oral and written communication;
• mock job interviews.

Situations directly related to the sectors of activity targeted by the students' courses will be proposed.

TP : 20h

See full page

See full page

General presentation of the most commonly used computational and modeling methods in the field of solid state chemistry according to the spatial and temporal scales that can be studied with them:

(1) Quantum calculations (Hartree Fock, Post-Hartree Fock methods, DFT),

(2) Force field based modeling (atomistic and coarse grain),

(3) Hybrid QMM and AACG modeling.

Presentation of the different calculation techniques: static and optimization calculations, molecular dynamics and Monte Carlo.

The UE will have courses of type CM and TP. Two practical modeling works will be proposed: modeling techniques in classical mechanics and quantum calculations.

            CM : 11H

            TD : 9H

See full page

Hybrid" materials are a new family of materials, associating organic ligands with inorganic entities, and are increasingly studied at both fundamental and application levels.

In this EU, two main categories of hybrid materials will be discussed:

• Coordination Networks and Metal-Organic Frameworks
• Organosilicon/carbon materials

CM : 10 h

TD : 10 h

See full page

This teaching unit is dedicated to the presentation of inorganic materials and nanomaterials for use in the biomedical field (imaging, therapy, implants). This UE is the deepening of the knowledge acquired in the UE HAC930C (Development of materials for health). The aim is to develop health issues and inorganic materials and nanomaterials in diagnosis, therapy and well-being. Strategies for the development of future inorganic materials and nanomaterials based on therapeutics and multifunctionality, and smart materials will also be addressed.

The UE includes lectures and tutorials. A group project on the (theoretical) study of an inorganic material or nanomaterials for health will be proposed to the students.    

CM : 11

 TD : 9

See full page

The teaching of the module of strategies and tools in organic synthesis is centered on the deepening of the strategies of elaborations of molecules resulting or not from the natural environment using the tools of organic chemistry.

Hourly volumes* :

CM : 15 H

TD : 5 H

See full page