Target level of study
BAC +5
ECTS
120 credits
Duration
2 years
Training structure
Faculty of Pharmacy, Faculty of Science, Faculty of Medicine
Language(s) of instruction
French, English
Presentation
The Biology-Health master's degree is organized into 12 courses covering a wide choice of training and career opportunities (i) in biology and health research in public and private structures, or (ii) in technical and regulatory professions, in biotechnology for health, in pharmaceuticals, in neuroprosthetics and in clinical trials. This Master's degree, jointly offered by the Faculties of Medicine, Pharmacy and Science at the University of Montpellier, provides a truly coherent, cross-disciplinary training program.
4 courses in the Biology-Health master's program focus more specifically on professionalization, with the option of continuing on to a doctorate at the end of the master's program:
- Therapeutic engineering and bioproduction in health biotechnology (IBIS)
- Management and evaluation of therapeutic trials (GET)
- Project management and innovation in biotechnology (BIOTIN)
- Neuroprostheses
7 other courses are more focused on fundamental research, with the possibility of continuing studies at doctoral level, while retaining the possibility of professional integration at the end of the Master's degree:
- Cancer biology
- Medicinal and translational chemistry
- Epigenetics, Genetics and Cell Biology (EpiGenBio)
- Infection Biology
- Experimental and Regenerative Medicine (ERM)
- Neuroscience
- Quantitative Biology (qBio)
The DYMAMEID course - Dynamic of Emergence of Infectious Diseases - is reserved for students enrolled at partner universities, mainly in Asia.
The scientific environment of the Biology-Health master's program at the University of Montpellier is exceptional. In fact, this master's degree is very strongly rooted in research, with the involvement of teacher-researchers and researchers working in numerous institutes and laboratories in Montpellier and the wider region. The Health Biology master's program is perfectly aligned with the scientific priorities of the Health Biology research cluster of the MUSE I-SITE (Montpellier University of Excellence). This alignment between teaching and research offers students a wide choice of public and private laboratories for their internships (M1 and M2), as well as the opportunity to attend conferences, workshops and theme days, which provide an undeniable scientific opening and interaction with the professional world.
The various Master's courses share common core teaching units (UEs). The cross-disciplinary nature of these core courses in both M1 and M2 is in line with the desire for interaction between the courses in the Biology and Health field.
Teaching in English is gradually becoming the norm.
Students in the sciences and health. Entry to the first year of the Master's program (M1) is selective. Applications are made via the e-Candidat platform, generally in April and May. The exact dates on which the platform opens and closes vary from course to course.
Program
Select a program
DYNAMEID Dynamic and Emergence of Infectious Diseases
The COVID-19 crisis showed just how dangerous, stressful and disruptive a pandemic can be for our societies. It has been shown that simply reacting to disease is no way to stop the progression of a pandemic. We don't know when or where the next epidemic will break out. We don't know what kind it will be. One thing we can be sure of, however, is that there will be a next epidemic. In the meantime, we are constantly observing the emergence of new pathogens and resistance to treatments. How should we, as a community, prepare to deal with it when it comes? The answer is not a single one, and certainly should not come after the onset of disease. The solution lies in understanding the complex nature of an emerging infectious disease and managing the risk globally. We need to prevent the emergence of new diseases by organizing regulations and exchanges in society appropriately. We need a new generation capable of managing risk with a new, more global vision. DYNAMEID is designed to train this generation.
"The greatest victory is one that requires no battle" Sun Tzu
Sensory and Motor Neuroprostheses
Initially created around hearing prostheses (middle ear implants, cochlear implants, brainstem implants), this course aims to broaden its scope to include sensory neuroprostheses (visual implants) and motor neuroprostheses (stimulators). The course offers in-depth training in neurostimulation, implantable prostheses, prosthetic adaptation and functional sensory and motor exploration. This training meets a need recognized by all those involved - doctors, neuroprosthetists and nursing staff - who are looking for solid training in the field of neuroprosthetics. Such training requires knowledge that cannot be acquired in just 3 years. The development of implantable prostheses, and the specific nature of the populations they are designed to help, call for additional professional training at Master's level (Bac+5), leading to doctoral studies.
Translational Medicinal Chemistry
This course lies at the interface between chemistry and biology, and is aimed at students in the biological sciences, the health sector or ENSCM. Based on structural, molecular and cellular biology, this course provides theoretical and methodological training in drug design and rational innovation, as well as nanotechnologies for vectorization and targeting. Training in pharmacokinetics, toxicological investigation and therapeutic pharmacology then enables students to understand the fate of a molecule within the body.
IBIS Therapeutic Engineering and Bioproduction in Biotechnology-Health
The IBIS pathway (Ingéniérie thérapeutique et Bioproduction en Biotechnologie santé - Red Biotechnologies) in the Health Biology specialization is designed to train students to create and produce the therapies of tomorrow, using biotechnology tools. Scientific advances in the understanding of human diseases are leading to healthcare innovations, most of which are being driven by biotech companies. The dynamism in France and worldwide in the creation of highly specialized companies with specific know-how must coincide with an evolution in the training courses leading to these new professions and skills.
These therapies are complex in nature and use.
ation, and obtaining them will therefore require multidisciplinary and cross-disciplinary skills in biotechnology, which the IBIS pathway aims to meet. The IBIS course is based on the needs of the sector's industrialists, as identified in the report by Leem (the professional organization of pharmaceutical companies) "Plan compétences, Biotech/innovations, santé2020".
The aspects developed concern :
- Biotechnological tools for the discovery of innovative therapeutic molecules, whether biological (recombinant proteins and antibodies, cells) or chemical.
- The engineering of bioprocesses for the industrial production of these compounds will also be developed, as will their formulation and vectorization (nanobiotechnologies).
In addition, an opening towards agro-environmental (green and yellow), marine (blue) and industrial (white) biotechnologies will be offered through cross-disciplinary teaching units with other Masters programs. In addition, an agreement is planned with Polytech Montpellier to offer a double engineering/master's degree:
- 2 students per year from Polytech Montpellier, GBA Biological and Food Engineering, to enter the health biotechnology sector (pharmaceuticals, cosmetics, etc.).
- 2 students per year from the Biology-Health/IBIS Master's program to enter the agrifood and nutrition sector.
To sum up, the IBIS course is an innovative training program in the field of health biotechnologies, designed to meet the needs of the sector's industrialists, by offering applied, multi-disciplinary, practical and integrated teaching, aimed at students in science, pharmacy, engineering or continuing education.
Epigenetics, Genetics and Cell Biology (EpiGenBio)
At M1 level, a compulsory common core of knowledge enables the acquisition and consolidation of fundamental knowledge in genetics, genomics, cell and development biology. In the first year of the program, students are given the option of choosing 3 genetics courses to reinforce their knowledge. It should be noted that teaching in M1 is cross-disciplinary, as many of the courses are common to the various Biology-Health Master's courses. This enables students to choose a personalized pathway: molecular bases of hereditary diseases, signaling, structural biochemistry, biostatistics, physiopathology or R. programming.
At M2 level, courses are directly associated with research laboratories. A compulsory elective course is complemented by a thematic course.
This organization allows for cross-disciplinary training and an international outlook.
Within the thematic framework, an Epigenetics workshop is organized. This workshop provides an opportunity to bring together internationally renowned scientists and clinicians working on topical issues in genetics and epigenetics (evolutionary program). The aim of the workshop is twofold: to offer advanced training in the various fields of genetics research, and to provide an opportunity for students and professionals to exchange views on career development.
During the course, lectures are combined with guest seminars given by researchers who have been involved in major advances in the field.
These teaching sessions are then further developed in the form of article analysis, methodological discussions and round tables with specialist researchers. In this way, each student benefits from personalized supervision and direct exchanges with professionals. One day is also devoted to career development.
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Each year, students will take theoretical and practical courses (internships). The program includes:
- 3 required core courses (15 credits), shared with the other specializations of the BioHealth Master's program:
- 3 courses (15 credits) to be chosen among optional courses
- A 5-credit English course
- Internships and personal research projects.
The aim of the first year (M1) of this specialization is to consolidate and acquire new fundamental knowledge in Genetics, Genomics, Cell and Developmental Biology. Building on three required common core courses, students will choose additional courses for 15 credits to create their own personalized curriculum. Optional courses cover various topics such as the Molecular Basis of Diseases, Cell Signaling, Structural Biology, Statistics, Physiopathology, or R programming.
During the second year (M2), a series of advanced courses exploring major topics in Genetics, Epigenetics, Cell and Developmental Biology will be taught by scientific and medical researchers from various research institutes and hospitals in Montpellier, as well as by selected international guest speakers.
In this context, a workshop in Epigenetics is organized every year with leaders in the field. The goal is to introduce various aspects of epigenetic research with a highly interactive approach. We also dedicate time to discuss critical issues linked to ethics in science and to the choice of both academic and private sector career paths.
During both years, students will be trained to analyze research articles and to discuss methodology, working with an academic advisor.
The second semester of each year will be largely devoted to internships in research laboratories. Thus, students will have the opportunity to select among research internship projects at one of the many local Institutes in Montpellier or elsewhere in France, or abroad.
Quantitative Biology (qBio)
At the crossroads of Biology, Physics, Chemistry and Bioinformatics, qbio is the graduate program destined for students interested in studying Biology with a quantitative perspective founded on transdisciplinary approaches.
The qbio curriculum has been designed to be highly innovative in pedagogical terms. Discussions animated by the teachers, together with the observation and manipulation of real material and concrete difficulties will help the students to make the different subjects their own.
Qbio bases its foundations on practical project-based teaching units in the first year. The second year is focused on internships, communication and scientific writing. The background of different disciplines will be refreshed during the Bootcamp, an intensive teaching unit held at the beginning of the master.
For more information and a detailed description of the different courses, check out our website https://qbio.umontpellier.fr
Cancer Biology
The Cancer Biology program enables students to understand the molecular basis of cancer and explore the scientific rationale behind anti-tumor therapies in a cutting-edge scientific and medical environment. The program is supported by the Centre de Recherche Intégré en Cancérologie (SIRIC Montpellier Cancer), which brings together a cancer research center (ICM, l'Institut du Cancer de Montpellier), the Montpellier University Hospital and around a hundred teams based at various research institutes in Montpellier, all of which are likely to welcome Cancer Biology Master's students for internships and possibly doctoral theses.
The curriculum offered in the "Cancer Biology" course will allow students to acquire understanding of the molecular and cellular basis of cancer and the rationale underlying cancer therapies, in a leading scientific and medical environment. This course is supported by the Montpellier comprehensive cancer center (SIRIC Montpellier Cancer) which is composed of the Regional Cancer Centre (ICM), Montpellier University hospital, and over a hundred research teams located in different Montpellier research institutes. These teams propose internships for Masters students and, for those who continue after the Masters, PhD.
Infection Biology
This course is devoted to microbiology in the broadest sense, including the immune response to infection. It aims to provide Master's-level training in infectious processes and human pathogens (bacteria, viruses, unicellular parasites, etc.).
A particular feature of this Master's program is its focus on the molecular and cellular aspects of infection. It is rooted in the community of Montpellier research laboratories involved in these aspects of infectiology, including university laboratories (Faculties of Science, Medicine and Pharmacy), research institutes (CNRS, INSERM, IRD, CIRAD, etc.) and university hospitals in Montpellier and Nîmes.
The vast majority of laboratories likely to welcome students for this Master's program (and possibly for a subsequent doctorate) are associated with major French research institutes, and are particularly numerous (over 70 HDR supervisors). They represent considerable expertise in the field, as demonstrated by their involvement in national and European projects, and their well-established international visibility. Links with the COIMBRA group of European universities also give this Master's program an international outlook. The PACA-LR EuroBiomed inter-regional competitiveness cluster (one of whose major axes is "Diagnostics and therapeutics of infectious and tropical diseases") and the IHU "Méditerranée-Infection/Infectiopole Sud", with which many of the researchers involved in this course are associated, are levers of innovation and potentially of economic insertion.
The integrated teaching for both years of the Master's program, although not exhaustive in the field, aims to give students a level of competence that will enable them to grasp any specific research or development topic in the fields of Microbiology, under their molecular and cellular aspects. Teaching is in English. Courses are given in the form of lectures covering the most recent research work, and in the form of tutorials with critical analysis of articles. Practical training takes place mainly in research laboratories (2 internships in M1, 1 internship in M2), but also includes practical work in immunology.
Experimental and Regenerative Medicine
This 2-year course covers the major physiological functions and the most advanced methods for normalizing homeostasis disturbed by pathologies. This translational approach is made possible by numerous interactions between fundamentalists and clinicians.
Targeted approaches and, more specifically, modern therapeutic methods in humans are discussed.
It draws on the skills of specialists from research units in Montpellier and throughout France.
BIOTIN
The BIOTIN master's degree in biology and health is accredited by the universities of Montpellier and Nîmes, and by the Institut Mines-Télécom. It also has agreements with Polytech, the Kedge Business School in Marseille, the Etablissement Français du Sang and collaborates with Inserm-transfert. It is accredited by the Eurobiomed competitiveness cluster, which coordinates academic and industrial healthcare activities in the PACA and Occitanie regions, including research organizations and universities, as well as some 300 biotech and pharmaceutical companies.
Neuroscience
This course covers the major physiological and pathological functions of the nervous system. It focuses on fundamental aspects of neurobiology and neurophysiology, and covers the molecular, cellular and integrated aspects of neuronal communication and the integration of synaptic signals at the basis of an individual's behavior. These different aspects are dealt with in the context of normal and pathological functioning of the nervous system. Teaching will cover the latest conceptual and technological advances in neuroscience, as well as recent advances in the understanding and treatment of major neurological and psychiatric diseases. Particular attention will be paid to explaining and presenting the crucial interconnections between basic, translational and clinical research in the development of innovative therapies.
IDIL- Sciences for human health
The interdisciplinary, multi-scale research used in modern Bio-Health requires people working in the field to be trained in a wide range of disciplines. In this sense, the "Sciences for Human Health (SH2)" pathway provides a new training course within a higher education establishment for young scientists, ranging from Masters to Doctorate, while bringing together people with different backgrounds.
Based on this observation, the program (SH2) implements a dual curriculum in medicine and biology, to train future leaders, scientists and healthcare professionals in the field of Bio-Health. The training provides a solid grounding in key disciplines, and creates close links between training and research.
This course is aimed at students from science and technology backgrounds who work closely with the healthcare sector (doctors, pharmacists, odontologists).
Examples of teaching units:
- Cell biology
- Functional genomics
- Current research in immunology
Molecular basis of infectious diseases
Component
Faculty of Science
This UE consists mainly of theoretical courses dealing with the molecular aspects of infectious diseases (bacteriology, virology, parasitology).
Bacteriology: The nature of infectious agents. Methods for studying pathogenesis (in vivo, in vitro, in silico and post-genomic study technologies) Strategies of pathogenic bacteria to survive in organisms: Bacterial adhesion to eukaryotic cells, antigenic variation and phase variation, invasion of non-phagocytic eukaryotic cells, mechanisms of resistance to phagocytosis, mechanisms of bacterial survival in phagocytic cells, membrane permeability management, bacterial secretion systems (types I, II, III, IV, V and VI), iron acquisition mechanisms, bacterial exotoxins, bacterial biofilms, examples of environmental regulation (thermoregulation, quorum sensing, etc.).).
Parasitology: Organization and cellular physiology of major pathogens in unicellular eukaryotic parasites (invasion and modification of the host cell; metabolic particularities and therapeutic targets); Genetics and molecular biology (genome organization, antigenic variation); Physiopathology and escape from the immune response.
Virology: Molecular mechanisms of the viral cycle; Expression of viral genomes; Transformation by viruses; Viral replication strategy; Plasticity of viral genomes; Structural importance of viruses in host interaction;
Bibliographic survey
ECTS
2.5 credits
Component
Faculty of Pharmacy
Genomes and Evolution
ECTS
2.5 credits
Component
Faculty of Pharmacy
Infectious control policies
ECTS
2.5 credits
Component
Faculty of Pharmacy
Statistics applied to biology
ECTS
5 credits
Component
Faculty of Medicine
Cellular and Molecular Biology
ECTS
5 credits
Component
Faculty of Pharmacy
Environment, Geo, and Health
ECTS
2.5 credits
Component
Faculty of Pharmacy
Entomology and vector-borne diseases
ECTS
2.5 credits
Component
Faculty of Pharmacy
Bibliographic survey
ECTS
2.5 credits
Component
Faculty of Pharmacy
Integrated approach in Infectiology I
ECTS
5 credits
Component
Faculty of Pharmacy
Bioinformatic and OMICS
ECTS
2.5 credits
Component
Faculty of Pharmacy
CHOICE 1 Semester 1 M2 Dynameid
ECTS
2.5 credits
Component
Faculty of Pharmacy
Advanced Spatial Analysis
ECTS
2.5 credits
Component
Faculty of Pharmacy
Host pathogen interactions
ECTS
2.5 credits
Component
Faculty of Pharmacy
Computer modeling and databases
ECTS
5 credits
Component
Faculty of Pharmacy
International regulation and society
ECTS
2.5 credits
Component
Faculty of Pharmacy
CHOICE 2 Semester 1 M2 Dynameid
ECTS
2.5 credits
Component
Faculty of Pharmacy
Microbial genomics and metabolic diversity
ECTS
2.5 credits
Component
Faculty of Pharmacy
New generations of diagnostic technologies
ECTS
2.5 credits
Component
Faculty of Pharmacy
Integrated approach in Infectiology II
ECTS
5 credits
Component
Faculty of Pharmacy
Emerging diseases II
ECTS
2.5 credits
Component
Faculty of Pharmacy
Pathophysiology and hearing exploration
ECTS
5 credits
Component
Faculty of Pharmacy
Pathophysiology and exploration of hearing CC
Component
Faculty of Pharmacy
pathophysiology and CT hearing exploration
Component
Faculty of Pharmacy
Prolegomena of Electronics
ECTS
1 credits
Component
Faculty of Science
Prolegomena of Mathematics
ECTS
1 credits
Component
Faculty of Science
Signal Acquisition/Processing Level 1
Component
Faculty of Science
Statistics applied to biology
ECTS
5 credits
Component
Faculty of Medicine
Introduction to biological signal processing
ECTS
5 credits
Component
Faculty of Pharmacy
Introduction to biological signal processing CC
Component
Faculty of Pharmacy
Introduction to CT biological signal processing
Component
Faculty of Pharmacy
Statistics applied to biology
ECTS
5 credits
Component
Faculty of Medicine
Data analysis and visualization
ECTS
2 credits
Component
Faculty of Pharmacy
Speech exploration and disorders
ECTS
5 credits
Component
Faculty of Pharmacy
Speech exploration and disorders CC
Component
Faculty of Pharmacy
CT speech exploration and disorders
Component
Faculty of Pharmacy
Deafness and child neuropsychology
ECTS
5 credits
Component
Faculty of Pharmacy
Balance and motor skills disorders
ECTS
3 credits
Component
Faculty of Pharmacy
Biomedical data acquisition and signal processing
ECTS
5 credits
Component
Faculty of Science
Cochlear and retinal implants
ECTS
5 credits
Component
Faculty of Pharmacy
Toxicological investigation
ECTS
5 credits
Component
Faculty of Pharmacy
Cell Biology
ECTS
5 credits
Component
Faculty of Science
The program offers a refresher course and an in-depth study of the major concepts and methodologies of cell biology, organized around different themes:
1 Cytoskeleton:Introduction to the different types of cytoskeleton. Polymerization properties of actin and tubulin. Proteins associated with the cytoskeleton and regulating polymerization. Molecular motors. Principles of cell migration.
2.cell adhesion & signaling: cell-cell and cell-extracellular matrix adhesive structures, their molecular organization and dynamics. Functions and regulation during development and pathogenesis. Regulation by signaling pathways. Mechanotransduction.
3 Addressing and cell trafficking: Ubiquitination and proteasome. Addressing to subcellular compartments, endocytosis and secretion pathways. Molecular basis of vesicular transport, budding, fusion, molecular motors. Signaling in membrane trafficking, trafficking-related genetic diseases and pathogen detour.
4 Cell cycle: Historical introduction. Molecular regulation of the cell cycle. The mitotic spindle, microtubule dynamics and molecular motors, chromosome attachment mechanisms, checkpoints, regulation of mitosis exit and cytokinesis. Mitotic disorders associated with cancer cells.
5 Stem cells: cell differentiation, toti-, pluri- and multipotency, embryonic, adult and cancer stem cells.
6 Programmed cell death: Apoptosis, autophagy, necrosis. Stages and modalities of apoptosis, signaling pathways involved. Role in maintaining homeostasis. Pathophysiological consequences of deregulation of programmed cell death.
Different study models are presented, to introduce the importance of the contribution of biological diversity to the discovery of cellular and molecular mechanisms, and to the understanding of human pathologies.
The program offers a refresher of knowledge and an in-depth study of the major concepts and methodologies of cell biology, organized around different themes:
1. Cytoskeleton: Introduction to the different types of cytoskeleton. Polymerization properties of actin and tubulin. Proteins associated with the cytoskeleton and regulating polymerization. Molecular motors. Principles of cell migration.
2. Cellular Adhesion & Signaling: Cell-cell and extracellular cell-matrix adhesive structures, their molecular and dynamic organization. Functions and regulations during development and pathogenesis. Regulation by signaling channels. Mechanotransduction.
3. Addressing and cell traffic: Ubiquitination and proteasome. Addressing to subcellular compartments, endocytosis and secretion pathways. The molecular bases of vesicular transport, budding, fusion, molecular motors. Signaling in membrane trafficking, genetic diseases linked to trafficking and diversion by pathogens.
4. Cell cycle: Historical introduction. Molecular regulation of the cell cycle. The mitotic spindle, microtubule and molecular motor dynamics, chromosome attachment mechanisms, checkpoints, regulation of mitosis output and cytokinesis. Mitotic disorders associated with cancer cells.
5. Stem cells: cell differentiation, toti-, pluri-and multipotency, embryonic, adult and cancer stem cells.
6. Programmed cell death: Apoptosis, autophagy, necrosis. Stages and modalities of apoptosis, signaling pathways involved. Role in maintaining homeostasis. Physiopathological consequences of deregulation of programmed cell death.
Different study models are presented, in order to introduce the importance of the contribution of biological diversity in the discovery of cellular and molecular mechanisms, as well as in the understanding of human pathologies.
Cellular pathophysiology and cancer
ECTS
5 credits
Component
Faculty of Science
The aim of the "Cellular Physiopathology and Cancer" course is to provide students with the knowledge they need to follow the "Cancer Biology" pathway in M2. The course is organized in the form of a lecture, with an introductory section followed by a section on current laboratory research. Students are required to present a scientific article orally (usually in pairs).
The aim of the cellular pathophysiology and cancer teaching unit is to provide the scientific background necessary to follow the cancer biology M2 program.Each lecture is organized as a conference starting with a general introduction of the field and followed by a more specialized emphasis on research done in laboratories. Students have to prepare an oral presentation based on the analysis of a scientific article (generally in pair).
Developmental genetics
ECTS
5 credits
Component
Faculty of Science
-A general introduction to Developmental Biology
How do cells build a multicellular animal organism from a single genome? Genotype/phenotype relationship.
-Genetic analysis reminders
Nature of mutations (loss-of-function; gain-of-function), notion of "master gene", clonal analysis (generation of somatic or germinal clones), notion of cell autonomy....
-Genetic models and methods.
Study of regulatory regions, establishment of transgenic lines, enhancer trap, reporter genes (GFP, mCherry...), model organisms (drosophila, c.elegans, mouse...).Use of FLP/FRT, CRE-LOX, UAS-GAL4-GAL80, AttpP/B-PhiC31, CRISPR systems etc.
-Positional information, maternal effect genes and the establishment of asymmetry.
Models and mechanisms of positional information =induction, Spemann and Mangold experiment, organizing centers, notion of morphogen in invertebrates and vertebrates
-Establishment of axes: antero-posterior, dorso-ventral.
Cell communication and signalling pathways: in the establishment of the dorso-ventral axis, in limb formation, in the establishment of cell fate (some examples: Nervous system: lateral inhibition processes ...).
-Segmentation: gap, pair rule and segment polarity genes.
Segmentation in invertebrates and somitogenesis in vertebrates, dynamic aspects (establishment and maintenance).
-Signaling and transcriptional networks
Transcriptional regulation during development, regulatory sequences during evolution, the concept of gene networks. Transcriptional coupling and signaling pathways in cell fate
-Epigenetic memory of transcriptional programs:
Hox homeotic genes and segmental identity.Evo-Devo concepts.Polycomb and Trithorax complexes.
Involvement of epigenetic mechanisms in cell differentiation
Neurobiology of behavior
ECTS
5 credits
Component
Faculty of Science
Behaviors, whether determined by conscious or unconscious processes, are based on complex neurobiological underpinnings: they are underpinned by molecular and cellular modifications within the nervous system, modulating neural networks at the origin of motor and emotional processes that are linked to the individual's memory. These processes are fundamental in enabling the organism to develop an integrated behavioral response in close interaction with its environment, ensuring adaptation and survival for the individual and its species.
The topics covered in the Neurobiology of Behavior course are as follows:
-Gene-behavior
The relationship between genotype and phenotype -Impact of the environment -Attentional processes/Movement planning -Behavioral disorders (genetic and environmental aspects)
-Memory and synaptic plasticity
Methodological approaches to studying synaptic plasticity: electrophysiology, optogenetics, animal models, behavioral tests-Factors regulating synaptic plasticity, including genetics and epigenetics-Plasticity/memory relationship-Neurobiology of memory, forgetting and reconsolidation
-Neurobiology of emotions
Neurobiological substrates of emotions -Emotional functions -Disadaptation: Pathological aspects: Emotional disorders
Neuropsychopharmacology
ECTS
5 credits
Component
Faculty of Science
The Neuropsychopharmacology UE covers the molecular, cellular and integrated mechanisms underlying the mode of action of psychotropic drugs, using a number of pathologies as examples (depression, schizophrenia, anxiety, ....). The aim is to understand how the principles of pharmacology are specifically applied to mental disorders (e.g. pharmacodynamics, tolerance, physical and psychological dependence, etc.). Based on advances in neurobiological research and their application to drug therapy, the course aims to understand the concepts underlying the treatment of psychiatric disorders.
Molecular basis of infectious diseases
Component
Faculty of Science
This UE consists mainly of theoretical courses dealing with the molecular aspects of infectious diseases (bacteriology, virology, parasitology).
Bacteriology: The nature of infectious agents. Methods for studying pathogenesis (in vivo, in vitro, in silico and post-genomic study technologies) Strategies of pathogenic bacteria to survive in organisms: Bacterial adhesion to eukaryotic cells, antigenic variation and phase variation, invasion of non-phagocytic eukaryotic cells, mechanisms of resistance to phagocytosis, mechanisms of bacterial survival in phagocytic cells, membrane permeability management, bacterial secretion systems (types I, II, III, IV, V and VI), iron acquisition mechanisms, bacterial exotoxins, bacterial biofilms, examples of environmental regulation (thermoregulation, quorum sensing, etc.).).
Parasitology: Organization and cellular physiology of major pathogens in unicellular eukaryotic parasites (invasion and modification of the host cell; metabolic particularities and therapeutic targets); Genetics and molecular biology (genome organization, antigenic variation); Physiopathology and escape from the immune response.
Virology: Molecular mechanisms of the viral cycle; Expression of viral genomes; Transformation by viruses; Viral replication strategy; Plasticity of viral genomes; Structural importance of viruses in host interaction;
Developmental neurobiology
ECTS
5 credits
Component
Faculty of Science
1) What is the genetic program underlying the development of the nervous system? This course highlights the type of decisions that gradually determine the neural destiny of cells and ensure their nervous function. The different stages considered are:
(i)the genesis of the nervous system
(ii)neuron specification
(iii)nerve function: axonal guidance and connectivity
(iv)neuronal remodeling
2) What molecular, cellular and environmental interactions control the development of the nervous system?
-Synaptogenesis and the major stages of development.
-The role of neurotrophic factors
-The role of electrical activity
-Critical periods
-The role of neuron-glial cell interactions.
-Neural stem cells
3) Developmental pathologies
Current research in immunology
ECTS
5 credits
Component
Faculty of Science
Teaching is done by teachers and/or researchers at the Faculties of Medicine, Sciences or Pharmacy, or at local research institutes.Course contents will be adapted to current scientific advances.
Teaching is organized in topics (lectures/tutorials, 4 to 5:30 hrs each);each includes an introduction and a seminar. In addition, for each topic, a group of students is in charge of presenting one or two recent scientific research articles.
Examples of subjects treated:
Immune adaptive responses, vaccination
Immune tolerance
Aging of the immune system
Metabolic regulation of the immune response
Immune response regulation by microbiota
Immune system-central nervous system interactions
Immunotherapy, therapeutic antibodies
The Unit is complemented by practical work by groups on a mini-research project that includes design of experiments, realization and analysis. Training is available in the use of flow cytometry data analysis software.Results are presented orally to the entire class.
Functional exploration and translational research
ECTS
5 credits
Component
Faculty of Science
Neuromuscular physiology:
Striated skeletal muscle: The neuromuscular junction; Muscle contraction/release; Myotypology; Plasticity; Muscle metabolism.
Neuromuscular diseases:Causes; symptoms; clinical diagnosis (clinical examinations; laboratory tests): EMG, blood assays, functional tests, etc.; muscular dystrophies: Duchenne myopathy; Becker myopathy; facioscapiohumeral muscular dystrophy (FSHD).FSHD facioscapiohumeral muscular dystrophy: zebrafish model; mouse model; cell models; clinical trials.
Respiratory physiology:
Respiratory physiology: Anatomy of the respiratory system; mechanism of respiration; gas exchange; transport of respiratory gases by the blood; regulation of respiration.
Respiratory exploration in small animals: Why explore respiratory function in small animals? Plethysmography; in vitro contractile force.
Functional Respiratory Explorations: performance and interpretation of respiratory explorations in human pathology; spirometry: Level 1 and Level 2; pulmonary diffusion capacity; arterial blood gas; specific explorations of respiratory muscles; 6-minute walk test; stress test; explorations at altitude.
Cardiovascular physiology:
Anatomy of the heart: size, location and orientation; heart envelope; tunics of the heart wall; chambers and large vessels of the heart; blood flow in the heart; heart valves; blood supply to the heart: coronary circulation; properties of cardiac muscle tissue.
Reminder of cardiac physiology: regulation of basic rhythm; cardiac conduction system; modification of basic rhythm: extrinsic innervation of the heart; electrocardiography; mechanical phenomena: cardiac revolution; cardiac output; regulation of stroke volume; regulation of heart rate.
Vascular physiology: anatomy of the circulatory system; lymphatic system; vascular wall structure; blood pressure; vascular smooth muscle and vasomotricity; endothelial function.
Vascular function and dysfunction; functional exploration: Arterial Distensibility Measurement; arterial wave velocity measurement; pharmacological exploration of endothelium-dependent vasomotricity; ultrasonographic exploration; echo-tracking; ultrasound and echodoppler.
How to assess vascular function experimentally: Isolated artery ring model Cardiac Doppler ultrasound: a fabulous tool for clinical and experimental research; Ultrasound: anatomical and functional analysis"; Doppler: flow analysis; Application to animal models.
Translational research: example of myocardial ischemia-reperfusion (myocardial infarction); animal models; isolated perfused heart (Langendorf); isolated cardiomyocytes; cardioprotective techniques.
Endocrinology: weight balance
Description of eating behavior; Energy balance; Central structures regulating food intake; Mechanisms regulating food intake; Factors modulating appetite and food intake; Nutritional assessment; Eating disorders; Functional exploration: impedancemetry; DEXA (X-ray photon absorption); MRI; Expenditure assessment: calorimetry.
Molecular pharmacology and therapeutics
ECTS
5 credits
Component
Faculty of Pharmacy
Molecular and metabolic bases of hereditary diseases
ECTS
5 credits
Component
Faculty of Science
Statistics applied to biology
ECTS
5 credits
Component
Faculty of Medicine
Cellular communications and signalling
ECTS
5 credits
Component
Faculty of Science
The main communication pathways between normal cells and the intracellular transduction pathways encountered in physiological and neurophysiological mechanisms will be covered, with a focus on G protein-coupled receptors (GPCRs) and their structure, function and modulation by interacting proteins, notably involved in desensitization. The main intracellular pathways activated by GPCRs will be discussed (MAPkinase, PI3kinase, etc.).
A major part of the course will then focus on calcium signaling and Ca2+ homeostasis, Ca2+ being a ubiquitous signal in cell signaling. Calcium homeostasis will be studied in particular during the lymphocyte response to antigenic stimulation. In addition, the production of oxygenated free radicals, at the origin of oxidative stress, is dependent on intracellular Ca2+. The physiological role of free radicals will be discussed, as well as their involvement in oxidative stress. The following chapter will focus on the endocannabinoid system, summarizing all the topics covered earlier in the course. The endocannabinoid system is at the origin of multiple central and peripheral regulations.
Finally, two other themes will be addressed: the blood-brain barrier, which evokes highly integrated cellular communication between two environments, and the -pancreatic cell, whose activity is crucial to the regulation of glycemia through insulin secretion.
UE Semestre 2 elective
ECTS
5 credits
Component
Faculty of Pharmacy
Long-term internship or abroad
ECTS
5 credits
Component
Faculty of Science
Internship of more than 4 months in a facility (research laboratory, company, etc.) in France or abroad.
Practical work in Physiology
ECTS
5 credits
Component
Faculty of Science
The physiology practical course enables you to record cardiac action potentials on frog hearts using the intracellular microelectrode technique. This is a qualitative and quantitative method for measuring the electrical activity of cardiac muscle.
Practical analysis of genomics data in R
ECTS
5 credits
Component
Faculty of Science
Cell culture
ECTS
5 credits
Component
Faculty of Science
Cell culture is a basic laboratory technique that is constantly evolving. It is important to know the basics, which are often poorly understood, even though it is an essential methodology in research and industry.
Corporate knowledge and patent valuation
ECTS
5 credits
Component
Faculty of Science
Are you an L3/M1 student in Languedoc-Roussillon? Would you like to work on a dormant scientific patent in small groups with students from other disciplines, in project mode? Be supported and challenged by professional business creation coaches? Sign up for the PEPITE Patent Project to present a project for the creation of an innovative company based on the exploitation of a real patent supplied by a local research team that will open its doors to you!
Why?
-Because you can start your own business whatever your field of study.
To be selected by an incubator-type support structure
-Build a network in the field of entrepreneurship and innovation
PEPITE Patent Project, what is it? A teaching unit made up of a number of key moments:
a 3-day "tool training" seminar
-regular meetings with coaches
-deliverables: briefing note, market study, business plan
a 10-minute final pitch to present your innovative company
Immunopathology
ECTS
5 credits
Component
Faculty of Science
Teaching is carried out by teacher-researchers from the UFRs of Medicine, Science and Pharmacy. It is organized into 42 hours of lectures and supervised work divided into 7 themes (see Syllabus) including 2 series of article presentations; 1 series on articles proposed by the lecturers in each theme. A second series on articles chosen by the students. At the end of the course, students organize a mini-colloquium at which the articles are presented. They write brief reviews of these articles for the journal Medecine-Sciences.
Medical genetics and genetic counseling
ECTS
5 credits
Component
Faculty of Science
Pharmacokinetics and Toxicology
ECTS
5 credits
Component
Faculty of Pharmacy
Bioinformatics and System Biology
ECTS
5 credits
Component
Faculty of Science
Integrative Pathophysiology
ECTS
5 credits
Component
Faculty of Science
Genetic information - Epigenetics - Mechanistic bases
ECTS
5 credits
Component
Faculty of Science
Signage: Methods and Concepts
ECTS
5 credits
Component
Faculty of Science
Nanotechnologies and multifunctional systems for therapy
Component
Faculty of Pharmacy
Fictional research project_FDP
ECTS
10 credits
Component
Faculty of Pharmacy
Experimental models in biomedical research
ECTS
5 credits
Component
Faculty of Pharmacy
Protein engineering
ECTS
5 credits
Component
Faculty of Pharmacy
Proteins are now widely used as therapeutic tools in human and animal health. Knowledge of peptide and protein synthesis pathways, folding and post-translational modifications is essential before any therapeutic protein biosynthesis can be envisaged. Methods to better characterize these proteins are also essential to guarantee the quality of the proteins produced for therapeutic or industrial use. Protein engineering methods designed to improve their original properties will also be discussed.
The course includes lectures and tutorials by teacher-researchers and researchers.
Statistics applied to biology
ECTS
5 credits
Component
Faculty of Medicine
Bioinformatics and Antibody Bioinformatics
ECTS
5 credits
Component
Faculty of Science
Bioinformatics is concerned with the creation and use of numerical and mathematical approaches applied to the life sciences. The main applications concern the automatic processing of biological data and questions of data modeling, analysis and integration in the field of life biology.This course aims to provide a solid grounding in sequence analysis using bioinformatics tools, as well as in immunoinformatics. Theoretical aspects will be covered, and these will be reinforced by practical aspects (exercises and project work). This course may or may not be taught in English, depending on the student's level. The course comprises lectures and practical work, carried out by research professors.
Immunotechnology (UE PHARMACIE)
ECTS
5 credits
Component
Faculty of Pharmacy
Bioprocess engineering - Metabolism and bioproduction
ECTS
3 credits
Component
Faculty of Science
In bioprocess engineering, knowledge of the metabolism of catalysts (cells, microorganisms) is essential. This course will focus on describing the diversity of microbial metabolites (primary and secondary metabolites) and the bioprocesses that use these microorganisms to produce these molecules.
This course includes interactive lectures, tutorials and practical exercises (practical work in the computer room + personal project work in small groups).
Bioprocess engineering - Batch
ECTS
2 credits
Component
Faculty of Science
Within biotechnology, bioprocesses correspond to the industrial application of living tools (whether enzymes, microorganisms or cells from higher organisms) for the synthesis of products of interest. This teaching unit will focus on the use of microbial and cellular catalysts. Products of interest may be, for example, fermented foods (wine, beer, etc.), energy molecules (bioethanol, methane, etc.), chemical intermediates, or biomedicines (vaccines, monoclonal antibodies, growth factors, etc.). The knowledge, know-how and skills acquired in this course can be transposed to any sector of biotechnology activity. The examples given will correspond to the outlets targeted by the two courses (Agrosciences and Health).
The course will focus on bioprocesses and the environment in which the biological reaction will be controlled (the bioreactor). The course will also cover the description and modeling of a biological reaction, with a presentation of the approach applied in bioprocess engineering. The remainder of the course will be devoted to the application of this approach to batch reactors. Other operating modes will be covered in the M2 course HAV930V "Bioprocess engineering - continuous and fed-batch".
This course includes interactive lectures, tutorials and practical exercises (practical work in the computer room + personal project work in small groups).
Bioproduction and valorization of microbial biodiversity
ECTS
3 credits
Component
Faculty of Science
A teaching module focused on the professional world, with general introductions to pre-defined themes targeting the biotechnological valorization of microorganisms (antimicrobials, microbiota, probiotics, applied virology, etc.), followed by presentations by industrialists on their background, their company and/or the development of a project. This course covers both red biotechnologies (health applications), and the other colors of biotechnologies (green/agronomy, blue/marine, white/industrial, yellow/environmental).
Recombinant protein production engineering
ECTS
3 credits
Component
Faculty of Science
Within biotechnologies, the production of recombinant proteins in various prokaryotic and eukaryotic expression systems represents a mature and attractive technological field with high employability. It is also a very important area of research in which many challenges remain to be met. The bioproduction of biomedicines (recombinant proteins and monoclonal antibodies) represents a major challenge for human therapeutics, but also for the many fields of biotechnology (environmental, industrial, agronomic, marine, etc.). Before designing any biological drug involving a biomanufacturing stage, it is essential to be familiar with the different eukaryotic and prokaryotic expression systems used in biotechnology, and to have a complete overview of the biomanufacturing panorama and challenges in France, Europe and the rest of the world.
This course includes interactive lectures. It is taught by various academic and industrial contributors involved in the field.
Multidisciplinary Lab project 1 (UE PHARMACIE)
ECTS
3 credits
Component
Faculty of Science
Bioethics and regulation (UE PHARMACIE)
ECTS
3 credits
Component
Faculty of Pharmacy
Bioprocess engineering II, specific applications
ECTS
2 credits
Component
Faculty of Science
This course focuses on the specificities of healthcare applications in the field of bioprocessing. Case studies of biomedical and advanced therapy drug production are presented (e.g. clinical grade production of cell therapy products). The entire production chain is covered, with a particular focus on downstream processes (or DownStream Processing, DSP), which are particularly important for healthcare products (separation, extraction, purification and even formulation operations). Indeed, DSP represents a significant proportion of production costs, and the expectations and challenges associated with these technologies are numerous, particularly with the development of single-use technologies. UpStream Processing (USP) is covered in depth in the complementary modules of the Biomanufacturing specialization (HAV930V and HAV911V).
This course includes lectures and conferences, with numerous contributions from industry experts who will share their expertise and vision of the field with the students. In addition to technological aspects, these presentations will also cover Good Manufacturing Practices (GMP), quality control and the management of economic and environmental constraints.
Promoting research and innovation
ECTS
5 credits
Component
Faculty of Science
Turning research into industrial applications will require strategies and players at the interface between the scientific and socio-economic worlds. Identifying and protecting the innovative nature of a discovery will be followed by the search for funding and partners to turn the idea into an economic reality.
This course is designed to give students all the tools they need to develop their work into new therapeutic tools. It includes lectures by legal professors and professionals in the field, as well as a tutored project that is followed throughout the course. Work will also be carried out in the Learning Lab: identification of innovative research, drafting of a patent, valorisation plan, company creation, business plan.
This course will involve teacher-researchers, industrialists and patent and development professionals.
Continuous and fed-batch bioprocess engineering
ECTS
3 credits
Component
Faculty of Science
Within biotechnologies, bioprocesses correspond to the industrial implementation of living tools (whether enzymes, microorganisms or eukaryotic cells) for the synthesis of products of interest. This course will focus on the central stage of the bioprocess: the biological reaction in the reactor. In particular, it will focus on the use of microbial and cellular catalysts. The products of interest may be fermented foods (wine, beer, etc.), energy molecules (bioethanol, methane, etc.), chemical intermediates or biomedicines (vaccines, monoclonal antibodies, growth factors, etc.). The knowledge and skills acquired in this course can be applied to any sector of activity. Examples will be given in fields corresponding to the main outlets of the two courses concerned (Agrosciences and Health). This course is a direct continuation of the M1 course HAV811V "Bioprocess Engineering -Batch". It focuses on the UpStream Processing (USP) aspects of bioprocessing.
The first lectures will provide an overview of bioprocesses and the approach applied in bioprocess engineering, as well as a brief reminder of the Batch mode (M1 prerequisite). The bulk of the course will then be devoted to applying the bioprocess engineering approach to reactors operating in continuous and Fed-Batch (or semi-(dis)continuous culture) modes.
Cross-disciplinary modules will also be offered:
-Transfer management (mixture management, heat transfer, gas transfer) with a focus on gas transfer and how to ensure a culture's oxygen requirements (kLa, OUR, OTR) -Design of culture media
-Elementary balances (carbon and redox balances)
-Development of a biological reaction monitoring indicator: the Respiratory Quotient (RQ)
This course includes interactive lectures and tutorials.
Students in the M2 Biology-Health / IBIS / Biomanufacturing specialization will be able to put their project into practice intensively (1 month) as part of the "Multidisciplinary lab project: from gene to protein" UEs. For these students, a strong link is also provided with the specialization courses (HAV910V, HAV911V and HAA910V). Please refer to the descriptions of these UEs for further information.
Multidisciplinary Lab project 2
ECTS
6 credits
Component
Faculty of Science
The multidisciplinary lab project, also called "Gene to Protein project", will be a "learning by doing" project. The students will be in charge of the bioproduction of a protein using E. coli as a host. If they follow both parts of the project (1 & 2, like students from Biohealth master), they will start with strain construction and continue with pilot scale production and purification of the protein.Bioprocess engineering is a highly interdisciplinary fieldof study. The students (and future workers in the field), will benefit from project-based learning with an important practical part, where they can actively experience the interconnection between biology, engineering and physical sciences.
The part 2 of the project will be dedicated to the "production process design and pilot scale production" of the recombinant protein using a high-cell density fed-batch culture. It will be a multidisciplinary, hands-on training of Bioprocess Engineering and will be organized over three different periods:
-Week 1 : In Learning lab, students will participate in workshops to design and plan a production process in accordance with equipment and data available (scientific papers, reports, websites, previous results from UE "Multidisciplinary Lab Project 1"). Based on the bottlenecks identified for production of recombinant proteins in E. coli, the students will choose the culture process to be used, define the production objectives, simulate the culture (planning objective), design a sampling plan, design the culture medium...
-Week 2 :In practical training rooms on pilot-scale equipment (20L working volume bioreactor), students will prepare the bioreactor and all they need to perform the pilot-scale culture. They will be in charge of the monitoring of the culture and of real time data treatment in order to detect and correct deviations from the anticipated progress of the culture.
-Week 3 : In learning labs, students will treat and analyze the data. They will be in charge of the interpretation and discussion of the results and of the writing of a professional report.
Bioproduction and valorization of microbial biodiversity
ECTS
3 credits
Component
Faculty of Science
A teaching module focused on the professional world, with general introductions to pre-defined themes targeting the biotechnological valorization of microorganisms (antimicrobials, microbiota, probiotics, applied virology, etc.), followed by presentations by industrialists on their background, their company and/or the development of a project. This course covers both red biotechnologies (health applications), and the other colors of biotechnologies (green/agronomy, blue/marine, white/industrial, yellow/environmental).
Recombinant protein production engineering
ECTS
3 credits
Component
Faculty of Science
Within biotechnologies, the production of recombinant proteins in various prokaryotic and eukaryotic expression systems represents a mature and attractive technological field with high employability. It is also a very important area of research in which many challenges remain to be met. The bioproduction of biomedicines (recombinant proteins and monoclonal antibodies) represents a major challenge for human therapeutics, but also for the many fields of biotechnology (environmental, industrial, agronomic, marine, etc.). Before designing any biological drug involving a biomanufacturing stage, it is essential to be familiar with the different eukaryotic and prokaryotic expression systems used in biotechnology, and to have a complete overview of the biomanufacturing panorama and challenges in France, Europe and the rest of the world.
This course includes interactive lectures. It is taught by various academic and industrial contributors involved in the field.
Multidisciplinary Lab project 1 (UE PHARMACIE)
ECTS
3 credits
Component
Faculty of Science
Bioethics and regulation (UE PHARMACIE)
ECTS
3 credits
Component
Faculty of Pharmacy
Bioprocess engineering II, specific applications
ECTS
2 credits
Component
Faculty of Science
This course focuses on the specificities of healthcare applications in the field of bioprocessing. Case studies of biomedical and advanced therapy drug production are presented (e.g. clinical grade production of cell therapy products). The entire production chain is covered, with a particular focus on downstream processes (or DownStream Processing, DSP), which are particularly important for healthcare products (separation, extraction, purification and even formulation operations). Indeed, DSP represents a significant proportion of production costs, and the expectations and challenges associated with these technologies are numerous, particularly with the development of single-use technologies. UpStream Processing (USP) is covered in depth in the complementary modules of the Biomanufacturing specialization (HAV930V and HAV911V).
This course includes lectures and conferences, with numerous contributions from industry experts who will share their expertise and vision of the field with the students. In addition to technological aspects, these presentations will also cover Good Manufacturing Practices (GMP), quality control and the management of economic and environmental constraints.
Promoting research and innovation
ECTS
5 credits
Component
Faculty of Science
Turning research into industrial applications will require strategies and players at the interface between the scientific and socio-economic worlds. Identifying and protecting the innovative nature of a discovery will be followed by the search for funding and partners to turn the idea into an economic reality.
This course is designed to give students all the tools they need to develop their work into new therapeutic tools. It includes lectures by legal professors and professionals in the field, as well as a tutored project that is followed throughout the course. Work will also be carried out in the Learning Lab: identification of innovative research, drafting of a patent, valorisation plan, company creation, business plan.
This course will involve teacher-researchers, industrialists and patent and development professionals.
Continuous and fed-batch bioprocess engineering
ECTS
3 credits
Component
Faculty of Science
Within biotechnologies, bioprocesses correspond to the industrial implementation of living tools (whether enzymes, microorganisms or eukaryotic cells) for the synthesis of products of interest. This course will focus on the central stage of the bioprocess: the biological reaction in the reactor. In particular, it will focus on the use of microbial and cellular catalysts. The products of interest may be fermented foods (wine, beer, etc.), energy molecules (bioethanol, methane, etc.), chemical intermediates or biomedicines (vaccines, monoclonal antibodies, growth factors, etc.). The knowledge and skills acquired in this course can be applied to any sector of activity. Examples will be given in fields corresponding to the main outlets of the two courses concerned (Agrosciences and Health). This course is a direct continuation of the M1 course HAV811V "Bioprocess Engineering -Batch". It focuses on the UpStream Processing (USP) aspects of bioprocessing.
The first lectures will provide an overview of bioprocesses and the approach applied in bioprocess engineering, as well as a brief reminder of the Batch mode (M1 prerequisite). The bulk of the course will then be devoted to applying the bioprocess engineering approach to reactors operating in continuous and Fed-Batch (or semi-(dis)continuous culture) modes.
Cross-disciplinary modules will also be offered:
-Transfer management (mixture management, heat transfer, gas transfer) with a focus on gas transfer and how to ensure a culture's oxygen requirements (kLa, OUR, OTR) -Design of culture media
-Elementary balances (carbon and redox balances)
-Development of a biological reaction monitoring indicator: the Respiratory Quotient (RQ)
This course includes interactive lectures and tutorials.
Students in the M2 Biology-Health / IBIS / Biomanufacturing specialization will be able to put their project into practice intensively (1 month) as part of the "Multidisciplinary lab project: from gene to protein" UEs. For these students, a strong link is also provided with the specialization courses (HAV910V, HAV911V and HAA910V). Please refer to the descriptions of these UEs for further information.
Multidisciplinary Lab project 2
ECTS
6 credits
Component
Faculty of Science
The multidisciplinary lab project, also called "Gene to Protein project", will be a "learning by doing" project. The students will be in charge of the bioproduction of a protein using E. coli as a host. If they follow both parts of the project (1 & 2, like students from Biohealth master), they will start with strain construction and continue with pilot scale production and purification of the protein.Bioprocess engineering is a highly interdisciplinary fieldof study. The students (and future workers in the field), will benefit from project-based learning with an important practical part, where they can actively experience the interconnection between biology, engineering and physical sciences.
The part 2 of the project will be dedicated to the "production process design and pilot scale production" of the recombinant protein using a high-cell density fed-batch culture. It will be a multidisciplinary, hands-on training of Bioprocess Engineering and will be organized over three different periods:
-Week 1 : In Learning lab, students will participate in workshops to design and plan a production process in accordance with equipment and data available (scientific papers, reports, websites, previous results from UE "Multidisciplinary Lab Project 1"). Based on the bottlenecks identified for production of recombinant proteins in E. coli, the students will choose the culture process to be used, define the production objectives, simulate the culture (planning objective), design a sampling plan, design the culture medium...
-Week 2 :In practical training rooms on pilot-scale equipment (20L working volume bioreactor), students will prepare the bioreactor and all they need to perform the pilot-scale culture. They will be in charge of the monitoring of the culture and of real time data treatment in order to detect and correct deviations from the anticipated progress of the culture.
-Week 3 : In learning labs, students will treat and analyze the data. They will be in charge of the interpretation and discussion of the results and of the writing of a professional report.
Statistics applied to biology
ECTS
5 credits
Component
Faculty of Medicine
Cellular communications and signalling
ECTS
5 credits
Component
Faculty of Science
The main communication pathways between normal cells and the intracellular transduction pathways encountered in physiological and neurophysiological mechanisms will be covered, with a focus on G protein-coupled receptors (GPCRs) and their structure, function and modulation by interacting proteins, notably involved in desensitization. The main intracellular pathways activated by GPCRs will be discussed (MAPkinase, PI3kinase, etc.).
A major part of the course will then focus on calcium signaling and Ca2+ homeostasis, Ca2+ being a ubiquitous signal in cell signaling. Calcium homeostasis will be studied in particular during the lymphocyte response to antigenic stimulation. In addition, the production of oxygenated free radicals, at the origin of oxidative stress, is dependent on intracellular Ca2+. The physiological role of free radicals will be discussed, as well as their involvement in oxidative stress. The following chapter will focus on the endocannabinoid system, summarizing all the topics covered earlier in the course. The endocannabinoid system is at the origin of multiple central and peripheral regulations.
Finally, two other themes will be addressed: the blood-brain barrier, which evokes highly integrated cellular communication between two environments, and the -pancreatic cell, whose activity is crucial to the regulation of glycemia through insulin secretion.
Cell Biology
ECTS
5 credits
Component
Faculty of Science
The program offers a refresher course and an in-depth study of the major concepts and methodologies of cell biology, organized around different themes:
1 Cytoskeleton:Introduction to the different types of cytoskeleton. Polymerization properties of actin and tubulin. Proteins associated with the cytoskeleton and regulating polymerization. Molecular motors. Principles of cell migration.
2.cell adhesion & signaling: cell-cell and cell-extracellular matrix adhesive structures, their molecular organization and dynamics. Functions and regulation during development and pathogenesis. Regulation by signaling pathways. Mechanotransduction.
3 Addressing and cell trafficking: Ubiquitination and proteasome. Addressing to subcellular compartments, endocytosis and secretion pathways. Molecular basis of vesicular transport, budding, fusion, molecular motors. Signaling in membrane trafficking, trafficking-related genetic diseases and pathogen detour.
4 Cell cycle: Historical introduction. Molecular regulation of the cell cycle. The mitotic spindle, microtubule dynamics and molecular motors, chromosome attachment mechanisms, checkpoints, regulation of mitosis exit and cytokinesis. Mitotic disorders associated with cancer cells.
5 Stem cells: cell differentiation, toti-, pluri- and multipotency, embryonic, adult and cancer stem cells.
6 Programmed cell death: Apoptosis, autophagy, necrosis. Stages and modalities of apoptosis, signaling pathways involved. Role in maintaining homeostasis. Pathophysiological consequences of deregulation of programmed cell death.
Different study models are presented, to introduce the importance of the contribution of biological diversity to the discovery of cellular and molecular mechanisms, and to the understanding of human pathologies.
The program offers a refresher of knowledge and an in-depth study of the major concepts and methodologies of cell biology, organized around different themes:
1. Cytoskeleton: Introduction to the different types of cytoskeleton. Polymerization properties of actin and tubulin. Proteins associated with the cytoskeleton and regulating polymerization. Molecular motors. Principles of cell migration.
2. Cellular Adhesion & Signaling: Cell-cell and extracellular cell-matrix adhesive structures, their molecular and dynamic organization. Functions and regulations during development and pathogenesis. Regulation by signaling channels. Mechanotransduction.
3. Addressing and cell traffic: Ubiquitination and proteasome. Addressing to subcellular compartments, endocytosis and secretion pathways. The molecular bases of vesicular transport, budding, fusion, molecular motors. Signaling in membrane trafficking, genetic diseases linked to trafficking and diversion by pathogens.
4. Cell cycle: Historical introduction. Molecular regulation of the cell cycle. The mitotic spindle, microtubule and molecular motor dynamics, chromosome attachment mechanisms, checkpoints, regulation of mitosis output and cytokinesis. Mitotic disorders associated with cancer cells.
5. Stem cells: cell differentiation, toti-, pluri-and multipotency, embryonic, adult and cancer stem cells.
6. Programmed cell death: Apoptosis, autophagy, necrosis. Stages and modalities of apoptosis, signaling pathways involved. Role in maintaining homeostasis. Physiopathological consequences of deregulation of programmed cell death.
Different study models are presented, in order to introduce the importance of the contribution of biological diversity in the discovery of cellular and molecular mechanisms, as well as in the understanding of human pathologies.
Developmental genetics
ECTS
5 credits
Component
Faculty of Science
-A general introduction to Developmental Biology
How do cells build a multicellular animal organism from a single genome? Genotype/phenotype relationship.
-Genetic analysis reminders
Nature of mutations (loss-of-function; gain-of-function), notion of "master gene", clonal analysis (generation of somatic or germinal clones), notion of cell autonomy....
-Genetic models and methods.
Study of regulatory regions, establishment of transgenic lines, enhancer trap, reporter genes (GFP, mCherry...), model organisms (drosophila, c.elegans, mouse...).Use of FLP/FRT, CRE-LOX, UAS-GAL4-GAL80, AttpP/B-PhiC31, CRISPR systems etc.
-Positional information, maternal effect genes and the establishment of asymmetry.
Models and mechanisms of positional information =induction, Spemann and Mangold experiment, organizing centers, notion of morphogen in invertebrates and vertebrates
-Establishment of axes: antero-posterior, dorso-ventral.
Cell communication and signalling pathways: in the establishment of the dorso-ventral axis, in limb formation, in the establishment of cell fate (some examples: Nervous system: lateral inhibition processes ...).
-Segmentation: gap, pair rule and segment polarity genes.
Segmentation in invertebrates and somitogenesis in vertebrates, dynamic aspects (establishment and maintenance).
-Signaling and transcriptional networks
Transcriptional regulation during development, regulatory sequences during evolution, the concept of gene networks. Transcriptional coupling and signaling pathways in cell fate
-Epigenetic memory of transcriptional programs:
Hox homeotic genes and segmental identity.Evo-Devo concepts.Polycomb and Trithorax complexes.
Involvement of epigenetic mechanisms in cell differentiation
Stage_FDS
ECTS
15 credits
Component
Faculty of Science
Two to 4-month internship in a research laboratory or company in France or abroad.
Long-term internship or abroad
ECTS
5 credits
Component
Faculty of Science
Internship of more than 4 months in a facility (research laboratory, company, etc.) in France or abroad.
Cell culture
ECTS
5 credits
Component
Faculty of Science
Cell culture is a basic laboratory technique that is constantly evolving. It is important to know the basics, which are often poorly understood, even though it is an essential methodology in research and industry.
Practical analysis of genomics data in R
ECTS
5 credits
Component
Faculty of Science
Medical genetics and genetic counseling
ECTS
5 credits
Component
Faculty of Science
TER_FDS
ECTS
5 credits
Component
Faculty of Science
The aim of the TER course is to prepare students to organize and carry out an in-depth bibliographical analysis, enabling them to approach their internship with a knowledge of the state of the art in the field, and in particular to produce a relevant and thoughtful introduction to their experimental work.
Genetic information - Epigenetics - Mechanistic bases
ECTS
5 credits
Component
Faculty of Science
Signage: Methods and Concepts
ECTS
5 credits
Component
Faculty of Science
Bioinformatics and System Biology
ECTS
5 credits
Component
Faculty of Science
Integrative Pathophysiology
ECTS
5 credits
Component
Faculty of Science
Developmental Biology, Stem Cells and Biotherapy
ECTS
5 credits
Component
Faculty of Science
Workshop in Epigenetics
ECTS
5 credits
Component
Faculty of Science
Fictional research project_FDS
ECTS
10 credits
Component
Faculty of Science
Stage_FDS
ECTS
20 credits
Component
Faculty of Science
Minimum 4-month internship in a research laboratory or company in France or abroad.
Bootcamp
ECTS
5 credits
Component
Faculty of Science
The Bootcamp is an intensive course at the beginning of the first semester, before the start of the courses that characterize the courses. Its aim is to refresh and/or bring students up to speed on the basics of mathematics, physics, computer science and biology.
The course will be adapted to suit the students recruited, with the aim of ensuring a more homogeneous start to the course. Students will be immersed in a variety of role-playing games, divided into small groups. They will have to solve enigmas using their knowledge of biology, physics/mathematics, chemistry and programming, as in an escape game over several days.
Statistics applied to biology
ECTS
5 credits
Component
Faculty of Medicine
Introduction to quantitative Biology
Component
Faculty of Science
This EU aims to provide a broad overview of emerging quantitative interdisciplinary fields in the biosciences, ranging from cutting-edge experimental techniques in microscopy and synthetic biology, to systems approaches.
In an innovative way, these methodological aspects will be presented in the context of biological and biophysical concepts such as the robustness and optimality of biological systems, gene regulation and the fundamental principles underlying membrane and genome organization.
The main topics will first be introduced with traditional lectures and will be developed through individual or team projects where students will learn to apply specific techniques through examples, and see how these can be used to explore specific biological questions. These projects will involve bibliographical studies, the use of existing code or the development of new code (depending on the student's experience) and will make up half of the final assessment.
Synthetic Biology - Praticals
ECTS
5 credits
Component
Faculty of Science
In this (practical) teaching unit, we will first introduce the general concepts of synthetic biology, which will then be applied to (assessed) student team projects. We will provide basic knowledge to understand the full range of fundamental concepts, approaches and current tools of synthetic biology that will be exploited throughout the course and practical sessions, ranging from gene design and synthesis to genetic library construction, from fluorescence measurements (e.g. plate readers. ) to flow cytometers.
Imaging Biologicals Systems - Praticals
ECTS
5 credits
Component
Faculty of Science
Students will acquire the fundamental basis and advanced microscopy techniques needed to push back the boundaries of knowledge in biology. Teaching is progressive and modular, built entirely around practical projects: building a simple microscope, using state-of-the-art microscopes to study complex biological processes in bacteria and eukaryotes. Students will be immersed in a stimulating scientific environment. Training will be based on significant personal investment through experimental projects, article reviews and case studies. Communication skills will also be developed through oral presentations and written reports.
Stage_FDS
ECTS
15 credits
Component
Faculty of Science
Two to 4-month internship in a research laboratory or company in France or abroad.
TER_FDS
ECTS
5 credits
Component
Faculty of Science
The aim of the TER course is to prepare students to organize and carry out an in-depth bibliographical analysis, enabling them to approach their internship with a knowledge of the state of the art in the field, and in particular to produce a relevant and thoughtful introduction to their experimental work.
Practical Modelling and Simulation of Biological Systems
ECTS
5 credits
Component
Faculty of Science
Applied Structural Biology
ECTS
5 credits
Component
Faculty of Science
This practical course is based on mini-projects involving the application of techniques for studying the structure of biomolecules (X-ray crystallography, NMR, cryo-EM, mass spectrometry). Students will also learn about the biophysical and biochemical techniques used to characterize the molecules analyzed and their interactions.
For each approach, students will learn the basic principles, sample preparation requirements, data acquisition and analysis.
Workshop
ECTS
5 credits
Component
Faculty of Science
The Workshop is a series of lectures given by external speakers.
The topic will change every year, with at least one leading speaker working in a given field. The topic will be decided a year in advance. We will encourage the speaker and participants to write notes from the lectures, which will contribute to the course evaluation.
Students on the qbio track have funding to organize a conference alongside the main conference (brainstorming on the topic with mentors, finding and inviting speakers, managing funding and advertising).
Genetic information - Epigenetics - Mechanistic bases
ECTS
5 credits
Component
Faculty of Science
Signage: Methods and Concepts
ECTS
5 credits
Component
Faculty of Science
Bioinformatics and System Biology
ECTS
5 credits
Component
Faculty of Science
Integrative Pathophysiology
ECTS
5 credits
Component
Faculty of Science
Lab_2
ECTS
15 credits
Component
Faculty of Science
Lab2 is a short internship in a research laboratory (2 months).
Students are encouraged to work with different teams on interdisciplinary topics. Lab2 is normally held in a laboratory in Montpellier to enable students to follow the other UEs during semester 3, but exceptions are possible depending on the timetable.
Lab_3
ECTS
25 credits
Component
Faculty of Science
Lab3 is the end-of-Master's internship (>= 5 months). Students must work on a research project in a French or international laboratory, different from the team with which they completed their Lab2.
Scientific Writing
ECTS
5 credits
Component
Faculty of Science
This course is a workshop that will accompany students during semester 3 to learn how to write a scientific report. This workshop will take place throughout the semester in parallel with their internship.
Students will learn how to approach, understand and critique a scientific article.
Cell Biology
ECTS
5 credits
Component
Faculty of Science
The program offers a refresher course and an in-depth study of the major concepts and methodologies of cell biology, organized around different themes:
1 Cytoskeleton:Introduction to the different types of cytoskeleton. Polymerization properties of actin and tubulin. Proteins associated with the cytoskeleton and regulating polymerization. Molecular motors. Principles of cell migration.
2.cell adhesion & signaling: cell-cell and cell-extracellular matrix adhesive structures, their molecular organization and dynamics. Functions and regulation during development and pathogenesis. Regulation by signaling pathways. Mechanotransduction.
3 Addressing and cell trafficking: Ubiquitination and proteasome. Addressing to subcellular compartments, endocytosis and secretion pathways. Molecular basis of vesicular transport, budding, fusion, molecular motors. Signaling in membrane trafficking, trafficking-related genetic diseases and pathogen detour.
4 Cell cycle: Historical introduction. Molecular regulation of the cell cycle. The mitotic spindle, microtubule dynamics and molecular motors, chromosome attachment mechanisms, checkpoints, regulation of mitosis exit and cytokinesis. Mitotic disorders associated with cancer cells.
5 Stem cells: cell differentiation, toti-, pluri- and multipotency, embryonic, adult and cancer stem cells.
6 Programmed cell death: Apoptosis, autophagy, necrosis. Stages and modalities of apoptosis, signaling pathways involved. Role in maintaining homeostasis. Pathophysiological consequences of deregulation of programmed cell death.
Different study models are presented, to introduce the importance of the contribution of biological diversity to the discovery of cellular and molecular mechanisms, and to the understanding of human pathologies.
The program offers a refresher of knowledge and an in-depth study of the major concepts and methodologies of cell biology, organized around different themes:
1. Cytoskeleton: Introduction to the different types of cytoskeleton. Polymerization properties of actin and tubulin. Proteins associated with the cytoskeleton and regulating polymerization. Molecular motors. Principles of cell migration.
2. Cellular Adhesion & Signaling: Cell-cell and extracellular cell-matrix adhesive structures, their molecular and dynamic organization. Functions and regulations during development and pathogenesis. Regulation by signaling channels. Mechanotransduction.
3. Addressing and cell traffic: Ubiquitination and proteasome. Addressing to subcellular compartments, endocytosis and secretion pathways. The molecular bases of vesicular transport, budding, fusion, molecular motors. Signaling in membrane trafficking, genetic diseases linked to trafficking and diversion by pathogens.
4. Cell cycle: Historical introduction. Molecular regulation of the cell cycle. The mitotic spindle, microtubule and molecular motor dynamics, chromosome attachment mechanisms, checkpoints, regulation of mitosis output and cytokinesis. Mitotic disorders associated with cancer cells.
5. Stem cells: cell differentiation, toti-, pluri-and multipotency, embryonic, adult and cancer stem cells.
6. Programmed cell death: Apoptosis, autophagy, necrosis. Stages and modalities of apoptosis, signaling pathways involved. Role in maintaining homeostasis. Physiopathological consequences of deregulation of programmed cell death.
Different study models are presented, in order to introduce the importance of the contribution of biological diversity in the discovery of cellular and molecular mechanisms, as well as in the understanding of human pathologies.
Cellular pathophysiology and cancer
ECTS
5 credits
Component
Faculty of Science
The aim of the "Cellular Physiopathology and Cancer" course is to provide students with the knowledge they need to follow the "Cancer Biology" pathway in M2. The course is organized in the form of a lecture, with an introductory section followed by a section on current laboratory research. Students are required to present a scientific article orally (usually in pairs).
The aim of the cellular pathophysiology and cancer teaching unit is to provide the scientific background necessary to follow the cancer biology M2 program.Each lecture is organized as a conference starting with a general introduction of the field and followed by a more specialized emphasis on research done in laboratories. Students have to prepare an oral presentation based on the analysis of a scientific article (generally in pair).
Toxicological investigation
ECTS
5 credits
Component
Faculty of Pharmacy
Developmental genetics
ECTS
5 credits
Component
Faculty of Science
-A general introduction to Developmental Biology
How do cells build a multicellular animal organism from a single genome? Genotype/phenotype relationship.
-Genetic analysis reminders
Nature of mutations (loss-of-function; gain-of-function), notion of "master gene", clonal analysis (generation of somatic or germinal clones), notion of cell autonomy....
-Genetic models and methods.
Study of regulatory regions, establishment of transgenic lines, enhancer trap, reporter genes (GFP, mCherry...), model organisms (drosophila, c.elegans, mouse...).Use of FLP/FRT, CRE-LOX, UAS-GAL4-GAL80, AttpP/B-PhiC31, CRISPR systems etc.
-Positional information, maternal effect genes and the establishment of asymmetry.
Models and mechanisms of positional information =induction, Spemann and Mangold experiment, organizing centers, notion of morphogen in invertebrates and vertebrates
-Establishment of axes: antero-posterior, dorso-ventral.
Cell communication and signalling pathways: in the establishment of the dorso-ventral axis, in limb formation, in the establishment of cell fate (some examples: Nervous system: lateral inhibition processes ...).
-Segmentation: gap, pair rule and segment polarity genes.
Segmentation in invertebrates and somitogenesis in vertebrates, dynamic aspects (establishment and maintenance).
-Signaling and transcriptional networks
Transcriptional regulation during development, regulatory sequences during evolution, the concept of gene networks. Transcriptional coupling and signaling pathways in cell fate
-Epigenetic memory of transcriptional programs:
Hox homeotic genes and segmental identity.Evo-Devo concepts.Polycomb and Trithorax complexes.
Involvement of epigenetic mechanisms in cell differentiation
Physiology and integrated homeostasis
ECTS
5 credits
Component
Faculty of Science
Three main themes are addressed:
-Study of weight and thermal homeostasis in relation to a dysfunctional model: obesity, by examining the energy balance with food intake and energy expenditure, comprising basic metabolism, physical activity and adaptive thermogenesis (AT), and their respective regulation.
-Study of biological rhythms, by describing the nature and properties of biological rhythms (ultradian, circadian and infradian), describing endogenous circadian oscillators, and detailing the molecular mechanisms of circadian clocks.
-Study of the different stages and physiological principles of breathing. Theoretical teaching will be complemented by tutorials (TD)TD sessions are based on document studies and analysis of scientific articles in English. The choice of scientific material is designed to demonstrate the interaction of the various themes covered, and hence the concept of integrative physiology.
Current research in immunology
ECTS
5 credits
Component
Faculty of Science
Teaching is done by teachers and/or researchers at the Faculties of Medicine, Sciences or Pharmacy, or at local research institutes.Course contents will be adapted to current scientific advances.
Teaching is organized in topics (lectures/tutorials, 4 to 5:30 hrs each);each includes an introduction and a seminar. In addition, for each topic, a group of students is in charge of presenting one or two recent scientific research articles.
Examples of subjects treated:
Immune adaptive responses, vaccination
Immune tolerance
Aging of the immune system
Metabolic regulation of the immune response
Immune response regulation by microbiota
Immune system-central nervous system interactions
Immunotherapy, therapeutic antibodies
The Unit is complemented by practical work by groups on a mini-research project that includes design of experiments, realization and analysis. Training is available in the use of flow cytometry data analysis software.Results are presented orally to the entire class.
Functional exploration and translational research
ECTS
5 credits
Component
Faculty of Science
Neuromuscular physiology:
Striated skeletal muscle: The neuromuscular junction; Muscle contraction/release; Myotypology; Plasticity; Muscle metabolism.
Neuromuscular diseases:Causes; symptoms; clinical diagnosis (clinical examinations; laboratory tests): EMG, blood assays, functional tests, etc.; muscular dystrophies: Duchenne myopathy; Becker myopathy; facioscapiohumeral muscular dystrophy (FSHD).FSHD facioscapiohumeral muscular dystrophy: zebrafish model; mouse model; cell models; clinical trials.
Respiratory physiology:
Respiratory physiology: Anatomy of the respiratory system; mechanism of respiration; gas exchange; transport of respiratory gases by the blood; regulation of respiration.
Respiratory exploration in small animals: Why explore respiratory function in small animals? Plethysmography; in vitro contractile force.
Functional Respiratory Explorations: performance and interpretation of respiratory explorations in human pathology; spirometry: Level 1 and Level 2; pulmonary diffusion capacity; arterial blood gas; specific explorations of respiratory muscles; 6-minute walk test; stress test; explorations at altitude.
Cardiovascular physiology:
Anatomy of the heart: size, location and orientation; heart envelope; tunics of the heart wall; chambers and large vessels of the heart; blood flow in the heart; heart valves; blood supply to the heart: coronary circulation; properties of cardiac muscle tissue.
Reminder of cardiac physiology: regulation of basic rhythm; cardiac conduction system; modification of basic rhythm: extrinsic innervation of the heart; electrocardiography; mechanical phenomena: cardiac revolution; cardiac output; regulation of stroke volume; regulation of heart rate.
Vascular physiology: anatomy of the circulatory system; lymphatic system; vascular wall structure; blood pressure; vascular smooth muscle and vasomotricity; endothelial function.
Vascular function and dysfunction; functional exploration: Arterial Distensibility Measurement; arterial wave velocity measurement; pharmacological exploration of endothelium-dependent vasomotricity; ultrasonographic exploration; echo-tracking; ultrasound and echodoppler.
How to assess vascular function experimentally: Isolated artery ring model Cardiac Doppler ultrasound: a fabulous tool for clinical and experimental research; Ultrasound: anatomical and functional analysis"; Doppler: flow analysis; Application to animal models.
Translational research: example of myocardial ischemia-reperfusion (myocardial infarction); animal models; isolated perfused heart (Langendorf); isolated cardiomyocytes; cardioprotective techniques.
Endocrinology: weight balance
Description of eating behavior; Energy balance; Central structures regulating food intake; Mechanisms regulating food intake; Factors modulating appetite and food intake; Nutritional assessment; Eating disorders; Functional exploration: impedancemetry; DEXA (X-ray photon absorption); MRI; Expenditure assessment: calorimetry.
Molecular pharmacology and therapeutics
ECTS
5 credits
Component
Faculty of Pharmacy
Molecular and metabolic bases of hereditary diseases
ECTS
5 credits
Component
Faculty of Science
Introduction to quantitative Biology
Component
Faculty of Science
This EU aims to provide a broad overview of emerging quantitative interdisciplinary fields in the biosciences, ranging from cutting-edge experimental techniques in microscopy and synthetic biology, to systems approaches.
In an innovative way, these methodological aspects will be presented in the context of biological and biophysical concepts such as the robustness and optimality of biological systems, gene regulation and the fundamental principles underlying membrane and genome organization.
The main topics will first be introduced with traditional lectures and will be developed through individual or team projects where students will learn to apply specific techniques through examples, and see how these can be used to explore specific biological questions. These projects will involve bibliographical studies, the use of existing code or the development of new code (depending on the student's experience) and will make up half of the final assessment.
Statistics applied to biology
ECTS
5 credits
Component
Faculty of Medicine
Cellular communications and signalling
ECTS
5 credits
Component
Faculty of Science
The main communication pathways between normal cells and the intracellular transduction pathways encountered in physiological and neurophysiological mechanisms will be covered, with a focus on G protein-coupled receptors (GPCRs) and their structure, function and modulation by interacting proteins, notably involved in desensitization. The main intracellular pathways activated by GPCRs will be discussed (MAPkinase, PI3kinase, etc.).
A major part of the course will then focus on calcium signaling and Ca2+ homeostasis, Ca2+ being a ubiquitous signal in cell signaling. Calcium homeostasis will be studied in particular during the lymphocyte response to antigenic stimulation. In addition, the production of oxygenated free radicals, at the origin of oxidative stress, is dependent on intracellular Ca2+. The physiological role of free radicals will be discussed, as well as their involvement in oxidative stress. The following chapter will focus on the endocannabinoid system, summarizing all the topics covered earlier in the course. The endocannabinoid system is at the origin of multiple central and peripheral regulations.
Finally, two other themes will be addressed: the blood-brain barrier, which evokes highly integrated cellular communication between two environments, and the -pancreatic cell, whose activity is crucial to the regulation of glycemia through insulin secretion.
Stage_FDS
ECTS
15 credits
Component
Faculty of Science
Two to 4-month internship in a research laboratory or company in France or abroad.
TER_FDS
ECTS
5 credits
Component
Faculty of Science
The aim of the TER course is to prepare students to organize and carry out an in-depth bibliographical analysis, enabling them to approach their internship with a knowledge of the state of the art in the field, and in particular to produce a relevant and thoughtful introduction to their experimental work.
Long-term internship or abroad
ECTS
5 credits
Component
Faculty of Science
Internship of more than 4 months in a facility (research laboratory, company, etc.) in France or abroad.
Cell culture
ECTS
5 credits
Component
Faculty of Science
Cell culture is a basic laboratory technique that is constantly evolving. It is important to know the basics, which are often poorly understood, even though it is an essential methodology in research and industry.
Immunopathology
ECTS
5 credits
Component
Faculty of Science
Teaching is carried out by teacher-researchers from the UFRs of Medicine, Science and Pharmacy. It is organized into 42 hours of lectures and supervised work divided into 7 themes (see Syllabus) including 2 series of article presentations; 1 series on articles proposed by the lecturers in each theme. A second series on articles chosen by the students. At the end of the course, students organize a mini-colloquium at which the articles are presented. They write brief reviews of these articles for the journal Medecine-Sciences.
Practical analysis of genomics data in R
ECTS
5 credits
Component
Faculty of Science
Medical genetics and genetic counseling
ECTS
5 credits
Component
Faculty of Science
Corporate knowledge and patent valuation
ECTS
5 credits
Component
Faculty of Science
Are you an L3/M1 student in Languedoc-Roussillon? Would you like to work on a dormant scientific patent in small groups with students from other disciplines, in project mode? Be supported and challenged by professional business creation coaches? Sign up for the PEPITE Patent Project to present a project for the creation of an innovative company based on the exploitation of a real patent supplied by a local research team that will open its doors to you!
Why?
-Because you can start your own business whatever your field of study.
To be selected by an incubator-type support structure
-Build a network in the field of entrepreneurship and innovation
PEPITE Patent Project, what is it? A teaching unit made up of a number of key moments:
a 3-day "tool training" seminar
-regular meetings with coaches
-deliverables: briefing note, market study, business plan
a 10-minute final pitch to present your innovative company
Genetic information - Epigenetics - Mechanistic bases
ECTS
5 credits
Component
Faculty of Science
Signage: Methods and Concepts
ECTS
5 credits
Component
Faculty of Science
Bioinformatics and System Biology
ECTS
5 credits
Component
Faculty of Science
Integrative Pathophysiology
ECTS
5 credits
Component
Faculty of Science
Principles of Cancer Biology
ECTS
5 credits
Component
Faculty of Science
Genome Integrity and Cancer
ECTS
5 credits
Component
Faculty of Science
Fictional research project_FDS
ECTS
10 credits
Component
Faculty of Science
Stage_FDS
ECTS
20 credits
Component
Faculty of Science
Minimum 4-month internship in a research laboratory or company in France or abroad.
Experimental approaches in Infection Biology
ECTS
5 credits
Component
Faculty of Science
This course aims to reinforce and illustrate the knowledge acquired in the "Molecular Bases of Infectious Diseases" course by analyzing scientific publications on infectious diseases. Publications using a variety of molecular and cellular approaches in Bacteriology, Parasitology and Virology (from the most classical to the most recent) are analyzed with the students.
Cell Biology
ECTS
5 credits
Component
Faculty of Science
The program offers a refresher course and an in-depth study of the major concepts and methodologies of cell biology, organized around different themes:
1 Cytoskeleton:Introduction to the different types of cytoskeleton. Polymerization properties of actin and tubulin. Proteins associated with the cytoskeleton and regulating polymerization. Molecular motors. Principles of cell migration.
2.cell adhesion & signaling: cell-cell and cell-extracellular matrix adhesive structures, their molecular organization and dynamics. Functions and regulation during development and pathogenesis. Regulation by signaling pathways. Mechanotransduction.
3 Addressing and cell trafficking: Ubiquitination and proteasome. Addressing to subcellular compartments, endocytosis and secretion pathways. Molecular basis of vesicular transport, budding, fusion, molecular motors. Signaling in membrane trafficking, trafficking-related genetic diseases and pathogen detour.
4 Cell cycle: Historical introduction. Molecular regulation of the cell cycle. The mitotic spindle, microtubule dynamics and molecular motors, chromosome attachment mechanisms, checkpoints, regulation of mitosis exit and cytokinesis. Mitotic disorders associated with cancer cells.
5 Stem cells: cell differentiation, toti-, pluri- and multipotency, embryonic, adult and cancer stem cells.
6 Programmed cell death: Apoptosis, autophagy, necrosis. Stages and modalities of apoptosis, signaling pathways involved. Role in maintaining homeostasis. Pathophysiological consequences of deregulation of programmed cell death.
Different study models are presented, to introduce the importance of the contribution of biological diversity to the discovery of cellular and molecular mechanisms, and to the understanding of human pathologies.
The program offers a refresher of knowledge and an in-depth study of the major concepts and methodologies of cell biology, organized around different themes:
1. Cytoskeleton: Introduction to the different types of cytoskeleton. Polymerization properties of actin and tubulin. Proteins associated with the cytoskeleton and regulating polymerization. Molecular motors. Principles of cell migration.
2. Cellular Adhesion & Signaling: Cell-cell and extracellular cell-matrix adhesive structures, their molecular and dynamic organization. Functions and regulations during development and pathogenesis. Regulation by signaling channels. Mechanotransduction.
3. Addressing and cell traffic: Ubiquitination and proteasome. Addressing to subcellular compartments, endocytosis and secretion pathways. The molecular bases of vesicular transport, budding, fusion, molecular motors. Signaling in membrane trafficking, genetic diseases linked to trafficking and diversion by pathogens.
4. Cell cycle: Historical introduction. Molecular regulation of the cell cycle. The mitotic spindle, microtubule and molecular motor dynamics, chromosome attachment mechanisms, checkpoints, regulation of mitosis output and cytokinesis. Mitotic disorders associated with cancer cells.
5. Stem cells: cell differentiation, toti-, pluri-and multipotency, embryonic, adult and cancer stem cells.
6. Programmed cell death: Apoptosis, autophagy, necrosis. Stages and modalities of apoptosis, signaling pathways involved. Role in maintaining homeostasis. Physiopathological consequences of deregulation of programmed cell death.
Different study models are presented, in order to introduce the importance of the contribution of biological diversity in the discovery of cellular and molecular mechanisms, as well as in the understanding of human pathologies.
Molecular basis of infectious diseases
Component
Faculty of Science
This UE consists mainly of theoretical courses dealing with the molecular aspects of infectious diseases (bacteriology, virology, parasitology).
Bacteriology: The nature of infectious agents. Methods for studying pathogenesis (in vivo, in vitro, in silico and post-genomic study technologies) Strategies of pathogenic bacteria to survive in organisms: Bacterial adhesion to eukaryotic cells, antigenic variation and phase variation, invasion of non-phagocytic eukaryotic cells, mechanisms of resistance to phagocytosis, mechanisms of bacterial survival in phagocytic cells, membrane permeability management, bacterial secretion systems (types I, II, III, IV, V and VI), iron acquisition mechanisms, bacterial exotoxins, bacterial biofilms, examples of environmental regulation (thermoregulation, quorum sensing, etc.).).
Parasitology: Organization and cellular physiology of major pathogens in unicellular eukaryotic parasites (invasion and modification of the host cell; metabolic particularities and therapeutic targets); Genetics and molecular biology (genome organization, antigenic variation); Physiopathology and escape from the immune response.
Virology: Molecular mechanisms of the viral cycle; Expression of viral genomes; Transformation by viruses; Viral replication strategy; Plasticity of viral genomes; Structural importance of viruses in host interaction;
Current research in immunology
ECTS
5 credits
Component
Faculty of Science
Teaching is done by teachers and/or researchers at the Faculties of Medicine, Sciences or Pharmacy, or at local research institutes.Course contents will be adapted to current scientific advances.
Teaching is organized in topics (lectures/tutorials, 4 to 5:30 hrs each);each includes an introduction and a seminar. In addition, for each topic, a group of students is in charge of presenting one or two recent scientific research articles.
Examples of subjects treated:
Immune adaptive responses, vaccination
Immune tolerance
Aging of the immune system
Metabolic regulation of the immune response
Immune response regulation by microbiota
Immune system-central nervous system interactions
Immunotherapy, therapeutic antibodies
The Unit is complemented by practical work by groups on a mini-research project that includes design of experiments, realization and analysis. Training is available in the use of flow cytometry data analysis software.Results are presented orally to the entire class.
Statistics applied to biology
ECTS
5 credits
Component
Faculty of Medicine
Immunopathology
ECTS
5 credits
Component
Faculty of Science
Teaching is carried out by teacher-researchers from the UFRs of Medicine, Science and Pharmacy. It is organized into 42 hours of lectures and supervised work divided into 7 themes (see Syllabus) including 2 series of article presentations; 1 series on articles proposed by the lecturers in each theme. A second series on articles chosen by the students. At the end of the course, students organize a mini-colloquium at which the articles are presented. They write brief reviews of these articles for the journal Medecine-Sciences.
TER_FDS
ECTS
5 credits
Component
Faculty of Science
The aim of the TER course is to prepare students to organize and carry out an in-depth bibliographical analysis, enabling them to approach their internship with a knowledge of the state of the art in the field, and in particular to produce a relevant and thoughtful introduction to their experimental work.
Immune responses to pathogens
ECTS
5 credits
Component
Faculty of Science
Molecular and Cellular Virology
ECTS
5 credits
Component
Faculty of Science
Genetic information - Epigenetics - Mechanistic bases
ECTS
5 credits
Component
Faculty of Science
Signage: Methods and Concepts
ECTS
5 credits
Component
Faculty of Science
Bioinformatics and System Biology
ECTS
5 credits
Component
Faculty of Science
Integrative Pathophysiology
ECTS
5 credits
Component
Faculty of Science
Molecular and Cellular Parasitology
ECTS
5 credits
Component
Faculty of Science
Fictional research project + TER (Infectio)
ECTS
10 credits
Component
Faculty of Science
Stage_FDS
ECTS
20 credits
Component
Faculty of Science
Minimum 4-month internship in a research laboratory or company in France or abroad.
Toxicological investigation
ECTS
5 credits
Component
Faculty of Pharmacy
Bootcamp
ECTS
5 credits
Component
Faculty of Science
The Bootcamp is an intensive course at the beginning of the first semester, before the start of the courses that characterize the courses. Its aim is to refresh and/or bring students up to speed on the basics of mathematics, physics, computer science and biology.
The course will be adapted to suit the students recruited, with the aim of ensuring a more homogeneous start to the course. Students will be immersed in a variety of role-playing games, divided into small groups. They will have to solve enigmas using their knowledge of biology, physics/mathematics, chemistry and programming, as in an escape game over several days.
Introduction to quantitative Biology
Component
Faculty of Science
This EU aims to provide a broad overview of emerging quantitative interdisciplinary fields in the biosciences, ranging from cutting-edge experimental techniques in microscopy and synthetic biology, to systems approaches.
In an innovative way, these methodological aspects will be presented in the context of biological and biophysical concepts such as the robustness and optimality of biological systems, gene regulation and the fundamental principles underlying membrane and genome organization.
The main topics will first be introduced with traditional lectures and will be developed through individual or team projects where students will learn to apply specific techniques through examples, and see how these can be used to explore specific biological questions. These projects will involve bibliographical studies, the use of existing code or the development of new code (depending on the student's experience) and will make up half of the final assessment.
Neurobiology of behavior
ECTS
5 credits
Component
Faculty of Science
Behaviors, whether determined by conscious or unconscious processes, are based on complex neurobiological underpinnings: they are underpinned by molecular and cellular modifications within the nervous system, modulating neural networks at the origin of motor and emotional processes that are linked to the individual's memory. These processes are fundamental in enabling the organism to develop an integrated behavioral response in close interaction with its environment, ensuring adaptation and survival for the individual and its species.
The topics covered in the Neurobiology of Behavior course are as follows:
-Gene-behavior
The relationship between genotype and phenotype -Impact of the environment -Attentional processes/Movement planning -Behavioral disorders (genetic and environmental aspects)
-Memory and synaptic plasticity
Methodological approaches to studying synaptic plasticity: electrophysiology, optogenetics, animal models, behavioral tests-Factors regulating synaptic plasticity, including genetics and epigenetics-Plasticity/memory relationship-Neurobiology of memory, forgetting and reconsolidation
-Neurobiology of emotions
Neurobiological substrates of emotions -Emotional functions -Disadaptation: Pathological aspects: Emotional disorders
Molecular and metabolic bases of hereditary diseases
ECTS
5 credits
Component
Faculty of Science
The program covers not only the basic notions of gene organization and the different levels of gene regulation, but also the essential notions of human population genetics, which play an important role as risk factors. Finally, the module provides an overview of the impact of this research on medical practice, through the development of cell therapy, gene therapy and pharmacogenomics.
Introduction to clinical research
ECTS
5 credits
Component
Faculty of Medicine
Physiology and integrated homeostasis
ECTS
5 credits
Component
Faculty of Science
Three main themes are addressed:
-Study of weight and thermal homeostasis in relation to a dysfunctional model: obesity, by examining the energy balance with food intake and energy expenditure, comprising basic metabolism, physical activity and adaptive thermogenesis (AT), and their respective regulation.
-Study of biological rhythms, by describing the nature and properties of biological rhythms (ultradian, circadian and infradian), describing endogenous circadian oscillators, and detailing the molecular mechanisms of circadian clocks.
-Study of the different stages and physiological principles of breathing. Theoretical teaching will be complemented by tutorials (TD)TD sessions are based on document studies and analysis of scientific articles in English. The choice of scientific material is designed to demonstrate the interaction of the various themes covered, and hence the concept of integrative physiology.
Functional exploration and translational research
ECTS
5 credits
Component
Faculty of Science
Neuromuscular physiology:
Striated skeletal muscle: The neuromuscular junction; Muscle contraction/release; Myotypology; Plasticity; Muscle metabolism.
Neuromuscular diseases:Causes; symptoms; clinical diagnosis (clinical examinations; laboratory tests): EMG, blood assays, functional tests, etc.; muscular dystrophies: Duchenne myopathy; Becker myopathy; facioscapiohumeral muscular dystrophy (FSHD).FSHD facioscapiohumeral muscular dystrophy: zebrafish model; mouse model; cell models; clinical trials.
Respiratory physiology:
Respiratory physiology: Anatomy of the respiratory system; mechanism of respiration; gas exchange; transport of respiratory gases by the blood; regulation of respiration.
Respiratory exploration in small animals: Why explore respiratory function in small animals? Plethysmography; in vitro contractile force.
Functional Respiratory Explorations: performance and interpretation of respiratory explorations in human pathology; spirometry: Level 1 and Level 2; pulmonary diffusion capacity; arterial blood gas; specific explorations of respiratory muscles; 6-minute walk test; stress test; explorations at altitude.
Cardiovascular physiology:
Anatomy of the heart: size, location and orientation; heart envelope; tunics of the heart wall; chambers and large vessels of the heart; blood flow in the heart; heart valves; blood supply to the heart: coronary circulation; properties of cardiac muscle tissue.
Reminder of cardiac physiology: regulation of basic rhythm; cardiac conduction system; modification of basic rhythm: extrinsic innervation of the heart; electrocardiography; mechanical phenomena: cardiac revolution; cardiac output; regulation of stroke volume; regulation of heart rate.
Vascular physiology: anatomy of the circulatory system; lymphatic system; vascular wall structure; blood pressure; vascular smooth muscle and vasomotricity; endothelial function.
Vascular function and dysfunction; functional exploration: Arterial Distensibility Measurement; arterial wave velocity measurement; pharmacological exploration of endothelium-dependent vasomotricity; ultrasonographic exploration; echo-tracking; ultrasound and echodoppler.
How to assess vascular function experimentally: Isolated artery ring model Cardiac Doppler ultrasound: a fabulous tool for clinical and experimental research; Ultrasound: anatomical and functional analysis"; Doppler: flow analysis; Application to animal models.
Translational research: example of myocardial ischemia-reperfusion (myocardial infarction); animal models; isolated perfused heart (Langendorf); isolated cardiomyocytes; cardioprotective techniques.
Endocrinology: weight balance
Description of eating behavior; Energy balance; Central structures regulating food intake; Mechanisms regulating food intake; Factors modulating appetite and food intake; Nutritional assessment; Eating disorders; Functional exploration: impedancemetry; DEXA (X-ray photon absorption); MRI; Expenditure assessment: calorimetry.
Current research in immunology
ECTS
5 credits
Component
Faculty of Science
Teaching is done by teachers and/or researchers at the Faculties of Medicine, Sciences or Pharmacy, or at local research institutes.Course contents will be adapted to current scientific advances.
Teaching is organized in topics (lectures/tutorials, 4 to 5:30 hrs each);each includes an introduction and a seminar. In addition, for each topic, a group of students is in charge of presenting one or two recent scientific research articles.
Examples of subjects treated:
Immune adaptive responses, vaccination
Immune tolerance
Aging of the immune system
Metabolic regulation of the immune response
Immune response regulation by microbiota
Immune system-central nervous system interactions
Immunotherapy, therapeutic antibodies
The Unit is complemented by practical work by groups on a mini-research project that includes design of experiments, realization and analysis. Training is available in the use of flow cytometry data analysis software.Results are presented orally to the entire class.
Statistics applied to biology
ECTS
5 credits
Component
Faculty of Medicine
Cell Biology
ECTS
5 credits
Component
Faculty of Science
The program offers a refresher course and an in-depth study of the major concepts and methodologies of cell biology, organized around different themes:
1 Cytoskeleton:Introduction to the different types of cytoskeleton. Polymerization properties of actin and tubulin. Proteins associated with the cytoskeleton and regulating polymerization. Molecular motors. Principles of cell migration.
2.cell adhesion & signaling: cell-cell and cell-extracellular matrix adhesive structures, their molecular organization and dynamics. Functions and regulation during development and pathogenesis. Regulation by signaling pathways. Mechanotransduction.
3 Addressing and cell trafficking: Ubiquitination and proteasome. Addressing to subcellular compartments, endocytosis and secretion pathways. Molecular basis of vesicular transport, budding, fusion, molecular motors. Signaling in membrane trafficking, trafficking-related genetic diseases and pathogen detour.
4 Cell cycle: Historical introduction. Molecular regulation of the cell cycle. The mitotic spindle, microtubule dynamics and molecular motors, chromosome attachment mechanisms, checkpoints, regulation of mitosis exit and cytokinesis. Mitotic disorders associated with cancer cells.
5 Stem cells: cell differentiation, toti-, pluri- and multipotency, embryonic, adult and cancer stem cells.
6 Programmed cell death: Apoptosis, autophagy, necrosis. Stages and modalities of apoptosis, signaling pathways involved. Role in maintaining homeostasis. Pathophysiological consequences of deregulation of programmed cell death.
Different study models are presented, to introduce the importance of the contribution of biological diversity to the discovery of cellular and molecular mechanisms, and to the understanding of human pathologies.
The program offers a refresher of knowledge and an in-depth study of the major concepts and methodologies of cell biology, organized around different themes:
1. Cytoskeleton: Introduction to the different types of cytoskeleton. Polymerization properties of actin and tubulin. Proteins associated with the cytoskeleton and regulating polymerization. Molecular motors. Principles of cell migration.
2. Cellular Adhesion & Signaling: Cell-cell and extracellular cell-matrix adhesive structures, their molecular and dynamic organization. Functions and regulations during development and pathogenesis. Regulation by signaling channels. Mechanotransduction.
3. Addressing and cell traffic: Ubiquitination and proteasome. Addressing to subcellular compartments, endocytosis and secretion pathways. The molecular bases of vesicular transport, budding, fusion, molecular motors. Signaling in membrane trafficking, genetic diseases linked to trafficking and diversion by pathogens.
4. Cell cycle: Historical introduction. Molecular regulation of the cell cycle. The mitotic spindle, microtubule and molecular motor dynamics, chromosome attachment mechanisms, checkpoints, regulation of mitosis output and cytokinesis. Mitotic disorders associated with cancer cells.
5. Stem cells: cell differentiation, toti-, pluri-and multipotency, embryonic, adult and cancer stem cells.
6. Programmed cell death: Apoptosis, autophagy, necrosis. Stages and modalities of apoptosis, signaling pathways involved. Role in maintaining homeostasis. Physiopathological consequences of deregulation of programmed cell death.
Different study models are presented, in order to introduce the importance of the contribution of biological diversity in the discovery of cellular and molecular mechanisms, as well as in the understanding of human pathologies.
Cellular communications and signalling
ECTS
5 credits
Component
Faculty of Science
The main communication pathways between normal cells and the intracellular transduction pathways encountered in physiological and neurophysiological mechanisms will be covered, with a focus on G protein-coupled receptors (GPCRs) and their structure, function and modulation by interacting proteins, notably involved in desensitization. The main intracellular pathways activated by GPCRs will be discussed (MAPkinase, PI3kinase, etc.).
A major part of the course will then focus on calcium signaling and Ca2+ homeostasis, Ca2+ being a ubiquitous signal in cell signaling. Calcium homeostasis will be studied in particular during the lymphocyte response to antigenic stimulation. In addition, the production of oxygenated free radicals, at the origin of oxidative stress, is dependent on intracellular Ca2+. The physiological role of free radicals will be discussed, as well as their involvement in oxidative stress. The following chapter will focus on the endocannabinoid system, summarizing all the topics covered earlier in the course. The endocannabinoid system is at the origin of multiple central and peripheral regulations.
Finally, two other themes will be addressed: the blood-brain barrier, which evokes highly integrated cellular communication between two environments, and the -pancreatic cell, whose activity is crucial to the regulation of glycemia through insulin secretion.
Stage_FDS
ECTS
15 credits
Component
Faculty of Science
Two to 4-month internship in a research laboratory or company in France or abroad.
Long-term internship or abroad
ECTS
5 credits
Component
Faculty of Science
Internship of more than 4 months in a facility (research laboratory, company, etc.) in France or abroad.
Practical work in Physiology
ECTS
5 credits
Component
Faculty of Science
The physiology practical course enables you to record cardiac action potentials on frog hearts using the intracellular microelectrode technique. This is a qualitative and quantitative method for measuring the electrical activity of cardiac muscle.
Cell culture
ECTS
5 credits
Component
Faculty of Science
Cell culture is a basic laboratory technique that is constantly evolving. It is important to know the basics, which are often poorly understood, even though it is an essential methodology in research and industry.
Corporate knowledge and patent valuation
ECTS
5 credits
Component
Faculty of Science
Are you an L3/M1 student in Languedoc-Roussillon? Would you like to work on a dormant scientific patent in small groups with students from other disciplines, in project mode? Be supported and challenged by professional business creation coaches? Sign up for the PEPITE Patent Project to present a project for the creation of an innovative company based on the exploitation of a real patent supplied by a local research team that will open its doors to you!
Why?
-Because you can start your own business whatever your field of study.
To be selected by an incubator-type support structure
-Build a network in the field of entrepreneurship and innovation
PEPITE Patent Project, what is it? A teaching unit made up of a number of key moments:
a 3-day "tool training" seminar
-regular meetings with coaches
-deliverables: briefing note, market study, business plan
a 10-minute final pitch to present your innovative company
TER_FDS
ECTS
5 credits
Component
Faculty of Science
The aim of the TER course is to prepare students to organize and carry out an in-depth bibliographical analysis, enabling them to approach their internship with a knowledge of the state of the art in the field, and in particular to produce a relevant and thoughtful introduction to their experimental work.
Muscular and cardiac pathophysiology
ECTS
5 credits
Component
Faculty of Science
Genetic information - Epigenetics - Mechanistic bases
ECTS
5 credits
Component
Faculty of Science
Signage: Methods and Concepts
ECTS
5 credits
Component
Faculty of Science
Bioinformatics and System Biology
ECTS
5 credits
Component
Faculty of Science
Integrative Pathophysiology
ECTS
5 credits
Component
Faculty of Science
Gene and cell therapy
ECTS
5 credits
Component
Faculty of Medicine
Hourly volume
30h
Human nutrition (UE PHARMA)
ECTS
5 credits
Component
Faculty of Science
Fictional research project_FDS
ECTS
10 credits
Component
Faculty of Science
Stage_FDS
ECTS
20 credits
Component
Faculty of Science
Minimum 4-month internship in a research laboratory or company in France or abroad.
Neurobiology of behavior
ECTS
5 credits
Component
Faculty of Science
Behaviors, whether determined by conscious or unconscious processes, are based on complex neurobiological underpinnings: they are underpinned by molecular and cellular modifications within the nervous system, modulating neural networks at the origin of motor and emotional processes that are linked to the individual's memory. These processes are fundamental in enabling the organism to develop an integrated behavioral response in close interaction with its environment, ensuring adaptation and survival for the individual and its species.
The topics covered in the Neurobiology of Behavior course are as follows:
-Gene-behavior
The relationship between genotype and phenotype -Impact of the environment -Attentional processes/Movement planning -Behavioral disorders (genetic and environmental aspects)
-Memory and synaptic plasticity
Methodological approaches to studying synaptic plasticity: electrophysiology, optogenetics, animal models, behavioral tests-Factors regulating synaptic plasticity, including genetics and epigenetics-Plasticity/memory relationship-Neurobiology of memory, forgetting and reconsolidation
-Neurobiology of emotions
Neurobiological substrates of emotions -Emotional functions -Disadaptation: Pathological aspects: Emotional disorders
Neuropsychopharmacology
ECTS
5 credits
Component
Faculty of Science
The Neuropsychopharmacology UE covers the molecular, cellular and integrated mechanisms underlying the mode of action of psychotropic drugs, using a number of pathologies as examples (depression, schizophrenia, anxiety, ....). The aim is to understand how the principles of pharmacology are specifically applied to mental disorders (e.g. pharmacodynamics, tolerance, physical and psychological dependence, etc.). Based on advances in neurobiological research and their application to drug therapy, the course aims to understand the concepts underlying the treatment of psychiatric disorders.
Developmental neurobiology
ECTS
5 credits
Component
Faculty of Science
1) What is the genetic program underlying the development of the nervous system? This course highlights the type of decisions that gradually determine the neural destiny of cells and ensure their nervous function. The different stages considered are:
(i)the genesis of the nervous system
(ii)neuron specification
(iii)nerve function: axonal guidance and connectivity
(iv)neuronal remodeling
2) What molecular, cellular and environmental interactions control the development of the nervous system?
-Synaptogenesis and the major stages of development.
-The role of neurotrophic factors
-The role of electrical activity
-Critical periods
-The role of neuron-glial cell interactions.
-Neural stem cells
3) Developmental pathologies
Current research in immunology
ECTS
5 credits
Component
Faculty of Science
Teaching is done by teachers and/or researchers at the Faculties of Medicine, Sciences or Pharmacy, or at local research institutes.Course contents will be adapted to current scientific advances.
Teaching is organized in topics (lectures/tutorials, 4 to 5:30 hrs each);each includes an introduction and a seminar. In addition, for each topic, a group of students is in charge of presenting one or two recent scientific research articles.
Examples of subjects treated:
Immune adaptive responses, vaccination
Immune tolerance
Aging of the immune system
Metabolic regulation of the immune response
Immune response regulation by microbiota
Immune system-central nervous system interactions
Immunotherapy, therapeutic antibodies
The Unit is complemented by practical work by groups on a mini-research project that includes design of experiments, realization and analysis. Training is available in the use of flow cytometry data analysis software.Results are presented orally to the entire class.
Statistics applied to biology
ECTS
5 credits
Component
Faculty of Medicine
Cell Biology
ECTS
5 credits
Component
Faculty of Science
The program offers a refresher course and an in-depth study of the major concepts and methodologies of cell biology, organized around different themes:
1 Cytoskeleton:Introduction to the different types of cytoskeleton. Polymerization properties of actin and tubulin. Proteins associated with the cytoskeleton and regulating polymerization. Molecular motors. Principles of cell migration.
2.cell adhesion & signaling: cell-cell and cell-extracellular matrix adhesive structures, their molecular organization and dynamics. Functions and regulation during development and pathogenesis. Regulation by signaling pathways. Mechanotransduction.
3 Addressing and cell trafficking: Ubiquitination and proteasome. Addressing to subcellular compartments, endocytosis and secretion pathways. Molecular basis of vesicular transport, budding, fusion, molecular motors. Signaling in membrane trafficking, trafficking-related genetic diseases and pathogen detour.
4 Cell cycle: Historical introduction. Molecular regulation of the cell cycle. The mitotic spindle, microtubule dynamics and molecular motors, chromosome attachment mechanisms, checkpoints, regulation of mitosis exit and cytokinesis. Mitotic disorders associated with cancer cells.
5 Stem cells: cell differentiation, toti-, pluri- and multipotency, embryonic, adult and cancer stem cells.
6 Programmed cell death: Apoptosis, autophagy, necrosis. Stages and modalities of apoptosis, signaling pathways involved. Role in maintaining homeostasis. Pathophysiological consequences of deregulation of programmed cell death.
Different study models are presented, to introduce the importance of the contribution of biological diversity to the discovery of cellular and molecular mechanisms, and to the understanding of human pathologies.
The program offers a refresher of knowledge and an in-depth study of the major concepts and methodologies of cell biology, organized around different themes:
1. Cytoskeleton: Introduction to the different types of cytoskeleton. Polymerization properties of actin and tubulin. Proteins associated with the cytoskeleton and regulating polymerization. Molecular motors. Principles of cell migration.
2. Cellular Adhesion & Signaling: Cell-cell and extracellular cell-matrix adhesive structures, their molecular and dynamic organization. Functions and regulations during development and pathogenesis. Regulation by signaling channels. Mechanotransduction.
3. Addressing and cell traffic: Ubiquitination and proteasome. Addressing to subcellular compartments, endocytosis and secretion pathways. The molecular bases of vesicular transport, budding, fusion, molecular motors. Signaling in membrane trafficking, genetic diseases linked to trafficking and diversion by pathogens.
4. Cell cycle: Historical introduction. Molecular regulation of the cell cycle. The mitotic spindle, microtubule and molecular motor dynamics, chromosome attachment mechanisms, checkpoints, regulation of mitosis output and cytokinesis. Mitotic disorders associated with cancer cells.
5. Stem cells: cell differentiation, toti-, pluri-and multipotency, embryonic, adult and cancer stem cells.
6. Programmed cell death: Apoptosis, autophagy, necrosis. Stages and modalities of apoptosis, signaling pathways involved. Role in maintaining homeostasis. Physiopathological consequences of deregulation of programmed cell death.
Different study models are presented, in order to introduce the importance of the contribution of biological diversity in the discovery of cellular and molecular mechanisms, as well as in the understanding of human pathologies.
Cellular communications and signalling
ECTS
5 credits
Component
Faculty of Science
The main communication pathways between normal cells and the intracellular transduction pathways encountered in physiological and neurophysiological mechanisms will be covered, with a focus on G protein-coupled receptors (GPCRs) and their structure, function and modulation by interacting proteins, notably involved in desensitization. The main intracellular pathways activated by GPCRs will be discussed (MAPkinase, PI3kinase, etc.).
A major part of the course will then focus on calcium signaling and Ca2+ homeostasis, Ca2+ being a ubiquitous signal in cell signaling. Calcium homeostasis will be studied in particular during the lymphocyte response to antigenic stimulation. In addition, the production of oxygenated free radicals, at the origin of oxidative stress, is dependent on intracellular Ca2+. The physiological role of free radicals will be discussed, as well as their involvement in oxidative stress. The following chapter will focus on the endocannabinoid system, summarizing all the topics covered earlier in the course. The endocannabinoid system is at the origin of multiple central and peripheral regulations.
Finally, two other themes will be addressed: the blood-brain barrier, which evokes highly integrated cellular communication between two environments, and the -pancreatic cell, whose activity is crucial to the regulation of glycemia through insulin secretion.
Stage_FDS
ECTS
15 credits
Component
Faculty of Science
Two to 4-month internship in a research laboratory or company in France or abroad.
Long-term internship or abroad
ECTS
5 credits
Component
Faculty of Science
Internship of more than 4 months in a facility (research laboratory, company, etc.) in France or abroad.
Immunopathology
ECTS
5 credits
Component
Faculty of Science
Teaching is carried out by teacher-researchers from the UFRs of Medicine, Science and Pharmacy. It is organized into 42 hours of lectures and supervised work divided into 7 themes (see Syllabus) including 2 series of article presentations; 1 series on articles proposed by the lecturers in each theme. A second series on articles chosen by the students. At the end of the course, students organize a mini-colloquium at which the articles are presented. They write brief reviews of these articles for the journal Medecine-Sciences.
Practical work in Physiology
ECTS
5 credits
Component
Faculty of Science
The physiology practical course enables you to record cardiac action potentials on frog hearts using the intracellular microelectrode technique. This is a qualitative and quantitative method for measuring the electrical activity of cardiac muscle.
Sensoriality
ECTS
5 credits
Component
Faculty of Pharmacy
Hourly volume
50h
TER_FDS
ECTS
5 credits
Component
Faculty of Science
The aim of the TER course is to prepare students to organize and carry out an in-depth bibliographical analysis, enabling them to approach their internship with a knowledge of the state of the art in the field, and in particular to produce a relevant and thoughtful introduction to their experimental work.
Integrated Neuropathology
ECTS
5 credits
Component
Faculty of Science
Genetic information - Epigenetics - Mechanistic bases
ECTS
5 credits
Component
Faculty of Science
Signage: Methods and Concepts
ECTS
5 credits
Component
Faculty of Science
Bioinformatics and System Biology
ECTS
5 credits
Component
Faculty of Science
Integrative Pathophysiology
ECTS
5 credits
Component
Faculty of Science
Fictional research project_FDS
ECTS
10 credits
Component
Faculty of Science
Stage_FDS
ECTS
20 credits
Component
Faculty of Science
Minimum 4-month internship in a research laboratory or company in France or abroad.
CHOICE 1 Semester 1 M2 Dynameid
ECTS
2.5 credits
Component
Faculty of Pharmacy
Advanced Spatial Analysis
ECTS
2.5 credits
Component
Faculty of Pharmacy
Host pathogen interactions
ECTS
2.5 credits
Component
Faculty of Pharmacy
Computer modeling and databases
ECTS
5 credits
Component
Faculty of Pharmacy
International regulation and society
ECTS
2.5 credits
Component
Faculty of Pharmacy
CHOICE 2 Semester 1 M2 Dynameid
ECTS
2.5 credits
Component
Faculty of Pharmacy
Microbial genomics and metabolic diversity
ECTS
2.5 credits
Component
Faculty of Pharmacy
New generations of diagnostic technologies
ECTS
2.5 credits
Component
Faculty of Pharmacy
Integrated approach in Infectiology II
ECTS
5 credits
Component
Faculty of Pharmacy
Emerging diseases II
ECTS
2.5 credits
Component
Faculty of Pharmacy