Targeted level of study
BAC +5
ECTS
120 credits
Duration
2 years
Training structure
Faculty of Pharmacy, Faculty of Science, Faculty of Medicine
Language(s) of instruction
French, English
Presentation
The Biology-Health master's degree is organized into 12 courses covering a wide choice of training and opportunities (i) towards research in biology and health in public and private structures or (ii) towards technical and regulatory professions, in biotechnology for health, for drugs, in neuroprostheses and in clinical trials. This master's degree is supported by the faculties of Medicine, Pharmacy and Science of the University of Montpellier and provides a truly coherent and transdisciplinary training program.
4 courses in the Biology-Health master's program are more specifically oriented towards professionalization, while keeping the possibility of pursuing a doctorate at the end of the master's program:
- Therapeutic engineering and bioproduction in health biotechnology (IBIS)
- Management and Evaluation of Therapeutic Trials (TEP)
- Project Management and Innovation in Biotechnology (BIOTIN)
- Neuroprostheses
7 other courses are more focused on fundamental research with the possibility of pursuing studies at the doctoral level, while keeping the possibility of professional integration at the end of the Master's degree:
- Cancer biology
- Medicinal and translational chemistry
- Epigenetics, Genetics and Cell Biology (EpiGenBio)
- Infection Biology
- Experimental and Regenerative Medicine (ERM)
- Neuroscience
- Quantitative Biology (qBio)
The DYMAMEID course - Dynamic of Emergence of Infectious Diseases - is reserved for students enrolled in partner universities mainly in Asia.
The scientific environment of the Biology-Health master's degree at the University of Montpellier is exceptional. Indeed, this Master is very strongly linked to research, with the involvement of teacher-researchers and researchers who work in many institutes and laboratories in Montpellier and more widely in the region. The training offer of the Health Biology Master is in perfect adequacy with the scientific axes of the Health Biology research cluster of the I-SITE MUSE (Montpellier University of Excellence). This concordance between teaching and research offers students a wide choice of public or private laboratories for their internships (M1 and M2) but also allows them to attend conferences, workshops, thematic days that provide an undeniable scientific opening and interactions with the professional world.
The different courses of the Master's program share teaching units (common core courses). The transversality of these core courses in M1 and M2 is part of a desire for interaction between the courses in the Biology and Health field.
English language courses are gradually becoming more widespread.
The public is made up of students in science or health. Entry into the first year of the Master's program (M1) is selective. Applications are made via the e-Candidat platform generally in April and May. The exact opening and closing dates of the platform vary according to the course.
Program
Select a program
DYNAMEID Dynamic and Emergence of Infectious Diseases
The COVID-19 crisis has shown how dangerous, challenging and disruptive a pandemic can be to our societies. It has been shown that simply reacting to the disease does not stop the progression of a pandemic. We do not know when or where the next epidemic will occur. We don't know what kind it will be. However, one thing we can be sure of is that there will be a next epidemic. In the meantime, we are continuously observing the emergence of new pathogens and resistance to treatments. How should we prepare as a community to deal with it when it comes? The answer is not a one-size-fits-all one and certainly should not come after the disease has emerged. The answer lies in understanding the complex nature of an emerging infectious disease and managing the risk holistically. We must prevent the emergence of new diseases by organizing regulation and exchange in society in an appropriate manner. A new generation capable of managing risk with a new and more global vision is needed. DYNAMEID is designed to train this generation.
"The greatest victory is the one that requires no battle" Sun Tzu
Sensory and Motor Neuroprostheses
Initially created around auditory prostheses (middle ear implant, cochlear implants, brainstem implant), this course aims to broaden its training field to sensory (visual implants) and motor (stimulators) neuroprostheses. This course offers in-depth training in the fields of neurostimulation, implantable prostheses, prosthetic adaptation, and sensory and motor functional exploration. This training responds to a need recognized by all the actors, physicians, neuroprosthetists, and nursing staff, in search of a solid training in the field of neuroprosthesis. Such training requires knowledge that cannot be acquired in only 3 years. The development of implantable prostheses and the specificity of the populations to which they are addressed require additional professional training at Master's level (Bac+5), which can lead to doctoral studies.
Translational Medicinal Chemistry
This course lies at the interface between chemistry and biology, and is aimed at students in the biological sciences, the health sector or ENSCM. Based on structural, molecular and cellular biology, this course provides theoretical and methodological training in drug design and rational innovation, as well as nanotechnologies for vectorization and targeting. Training in pharmacokinetics, toxicological investigation and therapeutic pharmacology then enables students to understand the fate of a molecule within the body.
IBIS Therapeutic Engineering and Bioproduction in Biotechnology-Health
The IBIS program for Therapeutic Engineering and Bioproduction in Biotechnology and Health (Red Biotechnology) in the Biology and Health field is designed to train students to create and produce the therapies of tomorrow, using biotechnology tools. Scientific progress in the understanding of human diseases is leading to innovations in health, most of which are carried out by biotechnology companies. The French and global dynamism in the creation of highly specialized companies with specific know-how must coincide with an evolution of training leading to these new professions and skills.
These therapies are complex in their nature and their use
The IBIS program is designed to meet the needs of the pharmaceutical industry, which are listed in the report of the Leem (the professional organization for the pharmaceutical industry) entitled "Plan compétences, Biotech/innovations, santé2020" (skills plan, biotech/innovations, health2020). The IBIS course is based on the needs of the sector's industrialists, which are listed in the report of the Leem (the professional organization of drug companies) "Plan compétences, Biotech/innovations, santé2020".
The aspects developed concern:
- Biotechnological tools for the discovery of innovative therapeutic molecules, either biological (recombinant proteins and antibodies, cells) or chemical.
- The engineering of bioprocesses for the industrial production of these compounds will also be developed as well as their formulation and vectorization (nanobiotechnologies).
In addition, an opening towards agro-environmental (green and yellow), marine (blue) and industrial (white) biotechnologies will be offered through transversal teaching units with other Masters. Moreover, an agreement is planned with Polytech Montpellier in order to offer a double training validated by a double degree Engineer/Master:
- 2 students from Polytech Montpellier per year, Biological and Food Engineering GBA, to access the health biotechnology sector (pharmacy, cosmetics, etc.)
- to 2 students from the Biology-Health/IBIS Master's degree per year, to enter the field of agri-food and nutrition.
In summary, the IBIS program is an innovative training program in the field of health biotechnology, designed to meet the needs of the industry by offering applied, multidisciplinary, practical and integrated teaching for students in science, pharmacy, engineering or continuing education.
Epigenetics, Genetics and Cell Biology (EpiGenBio)
At the M1 level, a compulsory common base of knowledge allows the acquisition and consolidation of fundamental knowledge in genetics, genomics, cell and developmental biology. From this first year, an orientation towards a reinforcement of the knowledge in genetics is proposed by the possibility of choosing 3 UEs of genetics. It should be noted that the teaching in M1 is transversal since many UEs are common to different courses of the Biology-Health Master. This organization thus makes it possible to develop a personalized course of choice: molecular bases of hereditary diseases, signaling, structural biochemistry, biostatistics, physiopathology or R programming.
At the M2 level, the teaching is very directly associated with research laboratories. A compulsory elective course is completed by a thematic course.
This organization allows for a cross-disciplinary approach to training and an opening to the international scene.
Within the thematic framework, a workshop in Epigenetics is organized. This workshop offers the opportunity to bring together internationally renowned scientists and clinicians working on current topics in the field of genetics and epigenetics (evolutionary program). The objective of this workshop is twofold: to provide advanced training in the various fields of genetic research while giving the opportunity for an exchange between students and professionals on the development of their careers.
During the course, lectures are coupled with invited seminars given by researchers who have participated in major advances in the field.
These teaching sessions are then deepened through article analysis, methodological discussions and round tables with specialized researchers. Each student thus benefits from personalized supervision that gives him or her the opportunity for direct exchange with professionals. One day is also dedicated to the professional future.
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Each year, students will take theoretical and practical courses (internships). The program includes:
- 3 required core courses (15 credits), shared with the other specializations of the BioHealth Master's program:
- 3 courses (15 credits) to be chosen among optional courses
- A 5-credit English course
- Internships and personal research projects.
The aim of the first year (M1) of this specialization is to consolidate and acquire new fundamental knowledge in Genetics, Genomics, Cell and Developmental Biology. Building on three required common core courses, students will choose additional courses for 15 credits to create their own personalized curriculum. Optional courses cover various topics such as the Molecular Basis of Diseases, Cell Signaling, Structural Biology, Statistics, Physiopathology, or R programming.
During the second year (M2), a series of advanced courses exploring major topics in Genetics, Epigenetics, Cell and Developmental Biology will be taught by scientific and medical researchers from various research institutes and hospitals in Montpellier, as well as by selected international guest speakers.
In this context, a workshop in Epigenetics is organized every year with leaders in the field. The goal is to introduce various aspects of epigenetic research with a highly interactive approach. We also dedicate time to discuss critical issues linked to ethics in science and to the choice of both academic and private sector career paths.
During both years, students will be trained to analyze research articles and to discuss methodology, working with an academic advisor.
The second semester of each year will be largely devoted to internships in research laboratories. Thus, students will have the opportunity to select among research internship projects at one of the many local Institutes in Montpellier or elsewhere in France, or abroad.
Quantitative Biology (qBio)
At the crossroads of Biology, Physics, Chemistry and Bioinformatics, qbio is the graduate program intended for students interested in studying Biology with a quantitative perspective founded on transdisciplinary approaches.
The qbio curriculum has been designed to be highly innovative in pedagogical terms. Discussions animated by the teachers, together with the observation and manipulation of real material and concrete difficulties will help the students to make the different subjects their own.
Qbio bases its foundations on practical project-based teaching units in the first year. The second year is focused on internships, communication and scientific writing. The background of different disciplines will be refreshed during the Bootcamp, an intensive teaching unit held at the beginning of the master.
For more information and a detailed description of the different courses, check out our website https://qbio.umontpellier.fr
Cancer Biology
The program proposed in the "Cancer Biology" program allows students to understand the molecular basis of cancer and to explore the scientific rationale of anti-tumor therapies in a state-of-the-art scientific and medical environment. The training is supported by the Montpellier Cancer Integrated Research Center (SIRIC Montpellier Cancer), which brings together a cancer center (ICM, the Montpellier Cancer Institute), the Montpellier University Hospital and a hundred or so teams located in various research institutes in Montpellier and likely to host the students of the Cancer Biology Master's program for the Master's internships and eventually for the doctoral theses.
The curriculum offered in the "Cancer Biology" course will allow students to acquire understanding of the molecular and cellular basis of cancer and the rationale underlying cancer therapies, in a leading scientific and medical environment. This course is supported by the Montpellier comprehensive cancer center (SIRIC Montpellier Cancer) which is composed of the Regional Cancer Centre (ICM), Montpellier University hospital, and over a hundred research teams located in different Montpellier research institutes. These teams propose internships for Masters students and, for those who continue after the Masters, PhD.
Infection Biology
This course is devoted to microbiology in the broad sense, including the immune response to infection. It aims to provide a Master's level education on infectious processes and human pathogens (bacteria, viruses, unicellular parasites, etc.).
What characterizes this Master's program is the orientation of the teaching on the molecular and cellular aspects of infection. It is anchored in the community of research laboratories of Montpellier interested in these aspects of infectiology, university laboratories (faculties of Science, Medicine, Pharmacy), research institutes (CNRS, INSERM, IRD, CIRAD...) and university hospitals of Montpellier and Nîmes.
The laboratories likely to welcome students in the framework of this Master's program (as well as possibly for a subsequent doctorate) are for the vast majority associated with the major French research institutes and are particularly numerous (more than 70 HDR supervisors). They represent a great expertise in the field, as shown by their involvement in national or European projects, and their well established international visibility. The links with the COIMBRA group of European universities also give this Master's program an international outlook. The PACA-LR EuroBiomed interregional competitiveness cluster (one of whose major axes is "Diagnosis and therapy of infectious and tropical diseases") and the IHU "Méditerranée-Infection/Infectiopole Sud", with which many researchers involved in this program are associated, constitute levers of innovation and potentially of economic insertion.
The integrated teaching for the two years of the Master's program, although not exhaustive in the field, aims to give students a level of competence that will enable them to grasp any specific research or development topic in the fields of microbiology, under their molecular and cellular aspects. The teaching is given in English. The courses are given in the form of lectures covering the most recent research work and in the form of directed teaching with critical analysis of articles. Practical training is carried out mainly in research laboratories (2 internships in M1, 1 internship in M2) but also through practical work in immunology.
Experimental and Regenerative Medicine
This two-year training program covers the major physiological functions and the most advanced methods for normalizing homeostasis disturbed by pathologies. This translational approach is made possible by the numerous interactions between fundamentalists and clinicians.
Targeted approaches and especially modern therapeutic methods in humans are discussed.
It relies on the skills of specialists from research units in Montpellier and the national territory.
BIOTIN
The BIOTIN master's degree in biology and health is accredited by the universities of Montpellier and Nîmes and by the Institut Mines-Télécom. It also has an agreement with Polytech, the Kedge Business School of Marseille, the Etablissement Français du Sang and collaborates with Inserm-transfert. It is accredited by the Eurobiomed competitiveness cluster, which coordinates academic and industrial health activities in the PACA and Occitanie regions, i.e., in addition to research organizations and universities, some 300 biotechnology and pharmaceutical companies.
Neuroscience
This training addresses the major physio-pathological functions of the nervous system. It focuses on fundamental aspects of neurobiology and neurophysiology, and addresses molecular, cellular and integrated aspects of neuronal communication and the integration of synaptic signals at the basis of an individual's behavior. These different aspects are treated in the context of normal and pathological functioning of the nervous system. The courses will cover the latest conceptual and technological advances in neuroscience, as well as recent advances in the understanding and treatment of major neurological and psychiatric diseases. Particular attention will be given to explaining and presenting the crucial interconnections between basic, translational and clinical research in the development of innovative therapies.
IDIL- Sciences for human health
The multi-scale interdisciplinary research used in modern Bio-Health requires that people working in the field be trained in a wide range of disciplines. In this sense, the "Sciences for Human Health (SH2)" pathway provides a new training curriculum within a higher education institution for young scientists, ranging from Master to PhD, while bringing together people with different backgrounds.
Based on this observation, the program (SH2) implements a dual curriculum in medicine and biology, in order to train future leaders, scientists and health professionals in the field of Bio-health. The program provides a solid foundation in key disciplines and creates close links between education and research.
This training is intended for students from sciences and technologies closely related to the health field (physicians, pharmacists, odontologists).
Examples of teaching units:
- Cell biology
- Functional genomics
- Current research in immunology
Molecular basis of infectious diseases
Component
Faculty of Science
This UE is mainly composed of theoretical courses dealing with molecular aspects of infectious diseases (bacteriology, virology, parasitology)
Bacteriology: The nature of infectious agents. Methods of studying pathogenesis (in vivo in vitro, in silico and post-genomic study technologies) Strategies of pathogenic bacteria to survive in organisms: Bacterial adhesion to eukaryotic cells, antigenic variation and phase variation, invasion of non-phagocytic eukaryotic cells, mechanisms of resistance to phagocytosis, mechanisms of survival of bacteria in phagocytic cells, management of membrane permeability, bacterial secretion systems (type I, II, III, IV, V, and VI), mechanisms of iron acquisition, bacterial exotoxins, bacterial biofilms, examples of environmental regulations (Thermo-regulation, Quorum sensing...)).
Parasitology: Organization and cellular physiology of major pathogens in parasitic unicellular eukaryotes (invasion and modification of the host cell; metabolic characteristics and therapeutic targets); Genetics and molecular biology (genome organization, antigenic variation); Physiopathology and escape from the immune response
Virology: Molecular mechanisms of the viral cycle; Expression of viral genomes; Transformation by viruses; Viral replication strategy; Plasticity of viral genomes; Structural importance of viruses in host interaction;
Bibliographic survey
ECTS
2.5 credits
Component
Faculty of Pharmacy
Genomes and Evolution
ECTS
2.5 credits
Component
Faculty of Pharmacy
Infectious control policies
ECTS
2.5 credits
Component
Faculty of Pharmacy
Statistics applied to biology
ECTS
5 credits
Component
Faculty of Medicine
Cellular and Molecular Biology
ECTS
5 credits
Component
Faculty of Pharmacy
Environment, Geo, and Health
ECTS
2.5 credits
Component
Faculty of Pharmacy
Entomology and vector-borne diseases
ECTS
2.5 credits
Component
Faculty of Pharmacy
Bibliographic survey
ECTS
2.5 credits
Component
Faculty of Pharmacy
Integrated approach in Infectiology I
ECTS
5 credits
Component
Faculty of Pharmacy
Bioinformatic and OMICS
ECTS
2.5 credits
Component
Faculty of Pharmacy
Functional genomics
ECTS
5 credits
Component
Faculty of Science
The aim of this course is to introduce functional genomics technologies and to present examples of biological questions that can be asked using them.
This unit aims to present "omics" functional genomics technologies, and some biological questions that they can address.The lectures are given by both associate professors and researchers.
Introduction to functional genomics: approaches, concepts and methods
An introduction to functional Genomics: approaches, concepts and methods
V. Coulon, UM / IGMM
Genome organization / Organisation des génomes
Techniques de séquençage / DNA sequencing methodsL. Journot, IGF
3D genome organization J. Poli, UM / IGH
Genome topological organisation and replication-V. Coulon, UM / IGMM
Régulation spatio-temporelle de l'expression des génomes / Spatio-temporal regulation of gene expressionTranscriptionEpissage / Splicing-V. Coulon, UM / IGMM
Non-coding RNAsV. Coulon, UM / IGMM
Interactomics / InteractomiqueIan Robbins, UM / IGMM
Proteomics and Pharmacogenomics / Protéomique et pharmacogénomiqueC. Bécamel, UM / IGF
Animal Models / Modèles animaux
Using Mice in Functional Genomics F. Poulat, IGH
La Drosophile en génomique fonctionnelle / Using Drosophila in Functional Genomics -F. Juge and S. Chambeyron, IGH
Scientificarticles analysis and presentation(15min + 10 min discussion per group of 3 students)
CHOICE 1 Semester 1 M2 Dynameid
ECTS
2.5 credits
Component
Faculty of Pharmacy
Advanced Spatial Analysis
ECTS
2.5 credits
Component
Faculty of Pharmacy
Host pathogen interactions
ECTS
2.5 credits
Component
Faculty of Pharmacy
Computer modeling and databases
ECTS
5 credits
Component
Faculty of Pharmacy
International regulation and society
ECTS
2.5 credits
Component
Faculty of Pharmacy
CHOICE 2 Semester 1 M2 Dynameid
ECTS
2.5 credits
Component
Faculty of Pharmacy
Microbial genomics and metabolic diversity
ECTS
2.5 credits
Component
Faculty of Pharmacy
New generations of diagnostic technologies
ECTS
2.5 credits
Component
Faculty of Pharmacy
Integrated approach in Infectiology II
ECTS
5 credits
Component
Faculty of Pharmacy
Emerging diseases II
ECTS
2.5 credits
Component
Faculty of Pharmacy
Pathophysiology and hearing exploration
ECTS
5 credits
Component
Faculty of Pharmacy
Pathophysiology and exploration of hearing CC
Component
Faculty of Pharmacy
pathophysiology and CT hearing exploration
Component
Faculty of Pharmacy
Prolegomena of Electronics
ECTS
1 credits
Component
Faculty of Science
Prolegomena of Mathematics
ECTS
1 credits
Component
Faculty of Science
Signal Acquisition/Processing chain level 1
Component
Faculty of Science
Statistics applied to biology
ECTS
5 credits
Component
Faculty of Medicine
Introduction to biological signal processing
ECTS
5 credits
Component
Faculty of Pharmacy
Introduction to biological signal processing CC
Component
Faculty of Pharmacy
Introduction to CT biological signal processing
Component
Faculty of Pharmacy
Statistics applied to biology
ECTS
5 credits
Component
Faculty of Medicine
Data analysis and visualization
ECTS
2 credits
Component
Faculty of Pharmacy
Speech exploration and disorders
ECTS
5 credits
Component
Faculty of Pharmacy
Speech exploration and disorders CC
Component
Faculty of Pharmacy
CT speech exploration and disorders
Component
Faculty of Pharmacy
Deafness and child neuropsychology
ECTS
5 credits
Component
Faculty of Pharmacy
Balance and motor disorders
ECTS
3 credits
Component
Faculty of Pharmacy
Data acquisition and signal processing for biomedical applications
ECTS
5 credits
Component
Faculty of Science
Cochlear and retinal implants
ECTS
5 credits
Component
Faculty of Pharmacy
Toxicological investigation
ECTS
5 credits
Component
Faculty of Pharmacy
Cellular biology
ECTS
5 credits
Component
Faculty of Science
The program offers a refresher course and an in-depth study of the major concepts and methodologies of cell biology, organized around different themes:
Cytoskeleton:Introduction to the different types of cytoskeleton. Polymerization properties of actin and tubulin. Proteins associated with the cytoskeleton and regulating polymerization. Molecular motors. Principles of cell migration.
Cellular Adhesion & Signaling: Adhesive structures cell-cell and cell-extracellular matrix, their molecular organization and dynamics. Functions and regulations during development and pathogenesis. Regulation by signaling pathways. Mechanotransduction.
3. addressing and cell trafficking: Ubiquitination and proteasome. Addressing to subcellular compartments, endocytosis and secretion pathways. Molecular basis of vesicular transport, budding, fusion, molecular motors. Signaling in membrane trafficking, genetic diseases related to trafficking and detour by pathogens.
4.cell cycle:Historical introduction. Molecular regulation of the cell cycle. Mitotic spindle, microtubule dynamics and molecular motors, chromosome attachment mechanisms, checkpoints, regulation of mitosis exit and cytokinesis. Mitotic disorders associated with cancer cells.
5. stem cells: cell differentiation, toti-, pluri- and multipotency, embryonic, adult and cancer stem cells
6. programmed cell death: apoptosis, autophagy, necrosis. Stages and modalities of apoptosis, signaling pathways involved. Role in the maintenance of homeostasis. Pathophysiological consequences of deregulation of programmed cell death.
Different study models are presented, in order to introduce the importance of the contribution of biological diversity in the discovery of cellular and molecular mechanisms, as well as in the understanding of human pathologies.
The program offers a refresher of knowledge and an in-depth study of the major concepts and methodologies of cell biology, organized around different themes:
1. Cytoskeleton: Introduction to the different types of cytoskeleton. Polymerization properties of actin and tubulin. Proteins associated with the cytoskeleton and regulating polymerization. Molecular motors. Principles of cell migration.
2. Cellular Adhesion & Signaling: Cell-cell and extracellular cell-matrix adhesive structures, their molecular and dynamic organization. Functions and regulations during development and pathogenesis. Regulation by signaling channels. Mechanotransduction.
3. Addressing and cell traffic: Ubiquitination and proteasome. Addressing to subcellular compartments, endocytosis and secretion pathways. The molecular bases of vesicular transport, budding, fusion, molecular motors. Signaling in membrane trafficking, genetic diseases linked to trafficking and diversion by pathogens.
4. Cell cycle: Historical introduction. Molecular regulation of the cell cycle. The mitotic spindle, microtubule and molecular motor dynamics, chromosome attachment mechanisms, checkpoints, regulation of mitosis output and cytokinesis. Mitotic disorders associated with cancer cells.
5. Stem cells: cell differentiation, toti-, pluri-and multipotency, embryonic, adult and cancer stem cells.
6. Programmed cell death: Apoptosis, autophagy, necrosis. Stages and modalities of apoptosis, signaling pathways involved. Role in maintaining homeostasis. Physiopathological consequences of deregulation of programmed cell death.
Different study models are presented, in order to introduce the importance of the contribution of biological diversity in the discovery of cellular and molecular mechanisms, as well as in the understanding of human pathologies
Functional genomics
ECTS
5 credits
Component
Faculty of Science
The aim of this course is to introduce functional genomics technologies and to present examples of biological questions that can be asked using them.
This unit aims to present "omics" functional genomics technologies, and some biological questions that they can address.The lectures are given by both associate professors and researchers.
Introduction to functional genomics: approaches, concepts and methods
An introduction to functional Genomics: approaches, concepts and methods
V. Coulon, UM / IGMM
Genome organization / Organisation des génomes
Techniques de séquençage / DNA sequencing methodsL. Journot, IGF
3D genome organization J. Poli, UM / IGH
Genome topological organisation and replication-V. Coulon, UM / IGMM
Régulation spatio-temporelle de l'expression des génomes / Spatio-temporal regulation of gene expressionTranscriptionEpissage / Splicing-V. Coulon, UM / IGMM
Non-coding RNAsV. Coulon, UM / IGMM
Interactomics / InteractomiqueIan Robbins, UM / IGMM
Proteomics and Pharmacogenomics / Protéomique et pharmacogénomiqueC. Bécamel, UM / IGF
Animal Models / Modèles animaux
Using Mice in Functional Genomics F. Poulat, IGH
La Drosophile en génomique fonctionnelle / Using Drosophila in Functional Genomics -F. Juge and S. Chambeyron, IGH
Scientificarticles analysis and presentation(15min + 10 min discussion per group of 3 students)
Cellular pathophysiology and cancer
ECTS
5 credits
Component
Faculty of Science
The aim of the "Cellular Physiopathology and Cancer" course is to provide students with the knowledge necessary to follow the "Cancer Biology" course in M2. The course is organized in the form of a lecture with an introductory part followed by a part on current research in the laboratories. Students are required to present a scientific article orally (usually in pairs).
The aim of the cellular pathophysiology and cancer teaching unit is to provide the scientific background necessary to follow the cancer biology M2 program.Each lecture is organized as a conference starting with a general introduction of the field and followed by a more specialized emphasis on research done in laboratories. Students have to prepare an oral presentation based on the analysis of a scientific article (generally in pair).
Developmental genetics
ECTS
5 credits
Component
Faculty of Science
-A general introduction to developmental biology
How do cells build a multicellular animal organism from a single genome? Genotype/phenotype relationship.
-Genetic analysis reminders
Nature of mutations (loss-of-function; gain-of-function), notion of "master gene", clonal analysis (generation of somatic or germinal clones), notion of cell autonomy ....
-Genetic models and methods.
Study of regulatory regions, establishment of transgenic lines, enhancer trap, reporter genes (GFP, mCherry...), model organisms (drosophila, c.elegans, mice...).Use of FLP/FRT, CRE-LOX, UAS-GAL4-GAL80, AttpP/B-PhiC31, CRISPR etc.
-Positional information, maternal effect genes and the establishment of assymetry.
Models and mechanisms of positional information =induction, Spemann and Mangold experiment, organizing centers, notion of morphogen in invertebrates and vertebrates
-Establishment of the axes: antero-posterior, dorso-ventral.
Genetic screens: genes with maternal effects and genes with zygotic effects.Cellular communication and signaling pathways: in the establishment of the dorso-ventral axis, in the formation of limbs, in the establishment of cell fate (some examples: Nervous system: lateral inhibition process ...).
-Segmentation: the gap, pair rule and segmental polarity genes.
Segmentation in invertebrates and somitogenesis in vertebrates, dynamic aspects (establishment and maintenance).
-Signaling and transcriptional networks
Transcriptional regulations during development, regulatory sequences during evolution, concept of gene networks. Transcriptional coupling and signaling pathways in cell fate
-The memory of transcriptional programs by epigenetic mechanisms:
Hox homeotic genes and segmental identity.Evo-Devo concepts.Polycomb and Trithorax complexes.
Involvement of epigenetic mechanisms during cell differentiation
Neurobiology of behavior
ECTS
5 credits
Component
Faculty of Science
Behaviors, whether determined by conscious or unconscious processes, are based on complex neurobiological underpinnings, as they are underpinned by molecular and cellular modifications within the nervous system that modulate neural networks responsible for motor and emotional processes that are linked to the individual's memory. These processes are fundamental to allow the organism to elaborate an integrated behavioral response in close interaction with its environment, thus ensuring adaptation and survival of the individual and its species.
The topics covered in the Neurobiology of Behavior EU will include:
-Gene-Behavior
The relationship between genotype and phenotype -Impact of the environment -Attentional processes/Movement planning -Behavioral disorders (genetic and environmental aspects)
-Memory and synaptic plasticity
Methodological approaches to study synaptic plasticity: electrophysiology, optogenetics, animal models, behavioral tests-Regulatory factors of synaptic plasticity including genetics and epigenetics-Plasticity/memory relationship-Neurobiology of memory, forgetting and reconsolidation
-Neurobiology of emotions
Neurobiological substrates of emotions -Functions of emotions -Disadaptation: Pathological aspects: Emotional disorders
Neuropsychopharmacology
ECTS
5 credits
Component
Faculty of Science
The neuropsychopharmacology course deals with the molecular, cellular and integrated mechanisms underlying the mode of action of psychotropic drugs, using a few pathologies as examples (depression, schizophrenia, anxiety, ....). It aims to understand how the principles of pharmacology are specifically declined in the context of psychological disorders (e.g. pharmacodynamics, tolerance, physical and psychic dependence,...). Based on the advances in neurobiology research and their therapeutic applications in medication, the course aims to understand the concepts underlying the treatment of psychiatric disorders.
Molecular basis of infectious diseases
Component
Faculty of Science
This UE is mainly composed of theoretical courses dealing with molecular aspects of infectious diseases (bacteriology, virology, parasitology)
Bacteriology: The nature of infectious agents. Methods of studying pathogenesis (in vivo in vitro, in silico and post-genomic study technologies) Strategies of pathogenic bacteria to survive in organisms: Bacterial adhesion to eukaryotic cells, antigenic variation and phase variation, invasion of non-phagocytic eukaryotic cells, mechanisms of resistance to phagocytosis, mechanisms of survival of bacteria in phagocytic cells, management of membrane permeability, bacterial secretion systems (type I, II, III, IV, V, and VI), mechanisms of iron acquisition, bacterial exotoxins, bacterial biofilms, examples of environmental regulations (Thermo-regulation, Quorum sensing...)).
Parasitology: Organization and cellular physiology of major pathogens in parasitic unicellular eukaryotes (invasion and modification of the host cell; metabolic characteristics and therapeutic targets); Genetics and molecular biology (genome organization, antigenic variation); Physiopathology and escape from the immune response
Virology: Molecular mechanisms of the viral cycle; Expression of viral genomes; Transformation by viruses; Viral replication strategy; Plasticity of viral genomes; Structural importance of viruses in host interaction;
Developmental neurobiology
ECTS
5 credits
Component
Faculty of Science
1) What is the genetic program underlying the development of the nervous system? This course highlights the type of decisions that progressively specify the neural fate of cells and ensure their nervous function. The different steps considered are:
(i) the genesis of the nervous system
(ii) the specification of neurons
(iii) nerve function: axonal guidance and connectivity
(iv) neuronal remodeling
2) What are the molecular, cellular, and environmental interactions that control nervous system development?
-Synaptogenesis and major developmental milestones.
-Roles of neurotrophic factors
-Roles of electrical activity
-Critical periods
-Roles of neuron-glial cell interactions.
-Neuronal stem cells
3) Developmental pathologies
Current research in immunology
ECTS
5 credits
Component
Faculty of Science
Teaching is done by teachers and/or researchers at the Faculties of Medicine, Sciences or Pharmacy, or at local research institutes.Course contents will be adapted to current scientific advances.
Teaching is organized in topics (lectures/tutorials, 4 to 5:30 hrs each);each includes an introduction and a seminar. In addition, for each topic, a group of students is in charge of presenting one or two recent scientific research articles.
Examples of subjects treated:
Immune adaptive responses, vaccination
Immune tolerance
Aging of the immune system
Metabolic regulation of the immune response
Immune response regulation by microbiota
Immune system-central nervous system interactions
Immunotherapy, therapeutic antibodies
The Unit is complemented by practical work by groups on a mini-research project that includes design of experiments, realization and analysis. Training is available in the use of flow cytometry data analysis software.results are presented orally to the entire class.
Functional exploration and translational research
ECTS
5 credits
Component
Faculty of Science
Neuromuscular physiology:
Striated skeletal muscle: The neuromuscular junction; Contraction/muscle release; Myotypology; Plasticity; Muscle metabolism.
Neuromuscular diseases:Causes; symptoms; clinical diagnosis (clinical examinations; laboratory tests): EMG, blood assays, functional tests, etc.; Muscular dystrophies: Duchenne myopathy; Becker's myopathy; facioscapiohumeral muscular dystrophy (FSHD).Facioscapiohumeral muscular dystrophy FSHD: zebrafish model; mouse model; cell models; clinical trials.
Respiratory physiology:
Respiratory physiology: Anatomy of the respiratory system; mechanism of respiration; gas exchange; transport of respiratory gases by the blood; regulation of respiration
Respiratory exploration in small animals: Why explore respiratory function in small animals? Plethysmography; in vitro contractile force.
Respiratory Functional Explorations: performance and interpretation of respiratory explorations in human pathology; spirometry: Level 1 and Level 2; pulmonary diffusion capacity; arterial blood gas; specific exploration of respiratory muscles; 6-minute walk test; exercise test; explorations with stay at altitude.
Cardiovascular physiology:
Reminder of the anatomy of the heart: size, location and orientation; envelope of the heart; tunics of the heart wall; chambers and large vessels of the heart; blood flow in the heart; heart valves; blood supply to the heart: coronary circulation; properties of the cardiac muscle tissue.
Reminder of the physiology of the heart: regulation of the basic rhythm; conduction system of the heart; modification of the basic rhythm: extrinsic innervation of the heart; electrocardiography; mechanical phenomena: cardiac revolution; cardiac output; regulation of the systolic volume; regulation of the heart rate.
Reminder of vascular physiology: anatomy of the circulatory system; lymphatic system; vascular wall structure; blood pressure; vascular smooth muscle and vasomotricity; endothelial function.
Vascular function and dysfunction; functional exploration: Arterial Distensibility Measurement; arterial wave velocity measurement; pharmacological exploration of endothelium-dependent vasomotricity; ultrasonographic exploration; echotracking; ultrasound and echodoppler.
How to evaluate vascular function experimentally?isolated artery ring model Cardiac Doppler: a fabulous tool in clinical and experimental research; Ultrasound: anatomical and functional analysis"; Doppler: flow analysis; Application to animal models.
Translational research: example myocardial ischemia-reperfusion (myocardial infarction); animal models; isolated perfused heart (Langendorf); isolated cardiomyocytes; cardioprotective techniques.
Endocrinology: weight balance
Description of eating behavior; Energy balance; Central structures regulating food intake; Mechanisms regulating food intake; Factors modulating appetite and food intake; Nutritional assessment; Eating disorders; Functional exploration: impedancemetry; DEXA (X-ray photon absorption); MRI; Assessment of expenditure: calorimetry.
Molecular pharmacology and therapeutics
ECTS
5 credits
Component
Faculty of Pharmacy
Molecular and metabolic bases of inherited diseases
ECTS
5 credits
Component
Faculty of Science
Statistics applied to biology
ECTS
5 credits
Component
Faculty of Medicine
Cellular communications and signalling
ECTS
5 credits
Component
Faculty of Science
The main communication pathways between normal cells and intracellular transduction pathways, encountered in physiological and neurophysiological mechanisms, will be discussed, such as G protein coupled receptors (GPCRs), their structure, function and modulation by interacting proteins involved in the desensitization phenomenon. The main intracellular pathways activated by GPCRs will be discussed (MAPkinase, PI3kinase, etc...).
Secondly, an important part of the course will focus on calcium signaling and Ca2+ homeostasis; Ca2+ being a ubiquitous signal in cell signaling. Calcium homeostasis will be studied in particular during the response of lymphocytes after antigenic stimulation. Moreover, the production of oxygenated free radicals, at the origin of oxidative stress, is dependent on intracellular Ca2+. The physiological role of free radicals will be discussed, as well as their involvement in oxidative stress. In this context, the pathways of protection against oxidative stress will also be studied.The following chapter will address the endocannabinoid system which allows to recapitulate all the themes that will be evoked previously in the course. The endocannabinoid system is at the origin of multiple central and peripheral regulations.
Finally, two other themes will be addressed: the blood-brain barrier which allows to evoke the cellular communication in a very integrated way between two environments and the -pancreatic cell whose activity is crucial for the regulation of glycemia by the secretion of insulin.
UE Semestre 2 elective
ECTS
5 credits
Component
Faculty of Pharmacy
Long internship or abroad
ECTS
5 credits
Component
Faculty of Science
Internship of more than 4 months in a structure (research laboratory, company,...) in France or abroad
Practical work in Physiology
ECTS
5 credits
Component
Faculty of Science
The physiology laboratory course allows to carry out recordings of cardiac action potential on the frog heart by the intracellular microelectrode technique. This is a qualitative and quantitative method of measuring the electrical activity of the heart muscle.
Practical analysis of genomic data in R
ECTS
5 credits
Component
Faculty of Science
Cell culture
ECTS
5 credits
Component
Faculty of Science
Cell culture is a basic technique in the laboratory and is constantly evolving. It is important to know the basics of cell culture, which are often not well known, even though it is an essential methodology in research and also in industry.
Knowledge of the company and patent valuation
ECTS
5 credits
Component
Faculty of Science
You are a student of L3/M1 level in Languedoc-Roussillon? Would you like to work in small groups with students from other courses and in project mode, using a dormant scientific patent? To be accompanied and challenged by professional coaches of business creation? Register to PEPITE Patent Project to present a project of creation of innovative company based on the exploitation of a real patent provided by a local research team which will open its doors to you!
Why?
-Because you can create your own business whatever your field of study
To be selected by an incubator-type support structure
-To create a network in the field of entrepreneurship and innovation
PEPITE Patent Project, what is it? A Teaching Unit made up of strong times:
a 3-day "tool training" seminar
-regular meetings with the coaches
-Deliverables to be submitted: summary note, market study, business plan
a 10-minute final pitch to present your innovative company
Immunopathology
ECTS
5 credits
Component
Faculty of Science
The teaching is carried out by teacher-researchers from the UFRs of medicine, science and pharmacy. It is organized into 42 hours of classes and supervised work divided into 7 themes (see Syllabus) including 2 series of article presentations; the first series on articles proposed by the speakers of each theme. A second series on articles chosen by the students. The students organize a mini-colloquium at the end of the course where the articles are presented. They write short reports of these articles for the Medecine-Sciences magazine.
Medical genetics and genetic counseling
ECTS
5 credits
Component
Faculty of Science
Pharmacokinetics and Toxicology
ECTS
5 credits
Component
Faculty of Pharmacy
Bioinformatics and System Biology
ECTS
5 credits
Component
Faculty of Science
Integrative Pathophysiology
ECTS
5 credits
Component
Faculty of Science
Genetic information - Epigenetics - Mechanistic bases
ECTS
5 credits
Component
Faculty of Science
Signaling: Methods and Concepts
ECTS
5 credits
Component
Faculty of Science
Nanotechnologies and multifunctional systems for therapy
Component
Faculty of Pharmacy
Fictional research project_FDP
ECTS
10 credits
Component
Faculty of Pharmacy
Functional genomics
ECTS
5 credits
Component
Faculty of Science
The aim of this course is to introduce functional genomics technologies and to present examples of biological questions that can be asked using them.
This unit aims to present "omics" functional genomics technologies, and some biological questions that they can address.The lectures are given by both associate professors and researchers.
Introduction to functional genomics: approaches, concepts and methods
An introduction to functional Genomics: approaches, concepts and methods
V. Coulon, UM / IGMM
Genome organization / Organisation des génomes
Techniques de séquençage / DNA sequencing methodsL. Journot, IGF
3D genome organization J. Poli, UM / IGH
Genome topological organisation and replication-V. Coulon, UM / IGMM
Régulation spatio-temporelle de l'expression des génomes / Spatio-temporal regulation of gene expressionTranscriptionEpissage / Splicing-V. Coulon, UM / IGMM
Non-coding RNAsV. Coulon, UM / IGMM
Interactomics / InteractomiqueIan Robbins, UM / IGMM
Proteomics and Pharmacogenomics / Protéomique et pharmacogénomiqueC. Bécamel, UM / IGF
Animal Models / Modèles animaux
Using Mice in Functional Genomics F. Poulat, IGH
La Drosophile en génomique fonctionnelle / Using Drosophila in Functional Genomics -F. Juge and S. Chambeyron, IGH
Scientificarticles analysis and presentation(15min + 10 min discussion per group of 3 students)
Experimental models in biomedical research
ECTS
5 credits
Component
Faculty of Pharmacy
Protein engineering
ECTS
5 credits
Component
Faculty of Pharmacy
Proteins are now widely used as therapeutic tools in human and animal health. The knowledge of peptide and protein synthesis pathways, their folding, their possible post-translational modifications is essential before considering any therapeutic protein biosynthesis. Methods to better characterize these proteins are also essential to guarantee the quality of the proteins produced for therapeutic or industrial use. Protein engineering methods to improve their original properties will also be discussed.
The UE includes lectures and tutorials, conducted by teacher-researchers and researchers.
Statistics applied to biology
ECTS
5 credits
Component
Faculty of Medicine
Bioinformatics and Antibody Bioinformatics
ECTS
5 credits
Component
Faculty of Science
Bioinformatics is concerned with the creation and use of numerical and mathematical approaches applied to life sciences. The main applications concern the automatic processing of biological data and questions of modelling, analysis and integration of data in the field of life biology.This course aims to provide a solid foundation in sequence analysis using bioinformatics tools as well as in immunoinformatics. Theoretical aspects will be covered and these will be reinforced by practical aspects (exercises and project work). This course may or may not be conducted in English depending on the level of the students. The course includes lectures and practical work carried out by teacher-researchers.
Immunotechnology (UE PHARMACIE)
ECTS
5 credits
Component
Faculty of Pharmacy
Bioprocess Engineering - Metabolism and Bioproduction
ECTS
3 credits
Component
Faculty of Science
In the framework of bioprocess engineering, the knowledge of the metabolism of catalysts (cells, microorganisms) is essential. This course will be dedicated to the description of the diversity of microbial metabolites (primary and secondary metabolites) and of bioprocesses exploiting these microorganisms to produce these molecules.
This course includes interactive lectures, tutorials and practical work (practical work in the computer room + personal work in project mode in small groups)
Bioprocess Engineering - Batch
ECTS
2 credits
Component
Faculty of Science
Within biotechnologies, bioprocesses correspond to the industrial implementation of living tools (whether enzymes, microorganisms or cells from higher organisms) for the synthesis of products of interest. In this teaching unit (UE), the focus will be on the exploitation of microbial and cellular catalysts. The products of interest can be for example fermented foods (wine, beer, ...), energy molecules (bioethanol, methane, ...), chemical intermediates, or biomedicines (vaccines, monoclonal antibodies, growth factors...). The knowledge, know-how and skills acquired during this course will be transposable to any sector of activity in biotechnology. The examples that will be given will correspond to the outlets targeted by the two training courses (the Agrosciences and Health mentions).
The UE will be dedicated to bioprocesses and to the environment in which the biological reaction will be controlled (the bioreactor). The course will also address the issue of the description and modeling of a biological reaction, including the presentation of the approach applied in bioprocess engineering. The rest of the course will be devoted to the application of this approach to reactors operated in batch mode. The other operating modes will be covered by the M2 course HAV930V "Bioprocess engineering - continuous and fed-batch".
This course includes interactive lectures, tutorials and practical work (practical work in the computer room + personal work in small groups).
Bioproduction and valorization of microbial biodiversity
ECTS
3 credits
Component
Faculty of Science
A teaching module oriented towards the professional world, with general introductions on pre-defined themes targeting the biotechnological valorization of microorganisms (antimicrobials, microbiota, probiotics, applied virology, etc.) followed by presentations by industrialists who come to present their background, their company and/or the development of a project. This course covers both red biotechnologies (health applications) and the other colors of biotechnologies (green/agronomy, blue/marine, white/industrial, yellow/environmental).
Engineering of recombinant protein production
ECTS
3 credits
Component
Faculty of Science
Within biotechnology, the production of recombinant proteins in different prokaryotic and eukaryotic expression systems represents a mature and attractive technological field with a high employability. It is also a very important field of research in which many challenges remain. The bioproduction of biomedicines (recombinant proteins but also monoclonal antibodies) represents a major challenge in human therapeutics, but also in many fields of biotechnology (environmental, industrial, agronomic, marine...). Before designing any biological drug involving a biomanufacturing step, it is essential to know the different eukaryotic and prokaryotic expression systems used in biotechnologies as well as to have a complete overview of the biomanufacturing panorama and stakes in France, in Europe and in the world.
This UE includes interactive lectures. It is provided by various academic and industrial speakers involved in the field.
Multidisciplinary Lab project 1 (UE PHARMACIE)
ECTS
3 credits
Component
Faculty of Science
Bioethics and regulation (UE PHARMACIE)
ECTS
3 credits
Component
Faculty of Pharmacy
Bioprocess Engineering II, application specificities
ECTS
2 credits
Component
Faculty of Science
In this course, the specificities of health applications in the field of bioprocessing are presented. Thus, case studies on the production of biomedicines and advanced therapy drugs are proposed (e.g. clinical grade production of cell therapy products). The whole production chain is addressed with a particular focus on downstream processes (or DownStream Processing, DSP) which are particularly important for health products (separation, extraction, purification, and even formulation operations). Indeed, DSP represents a significant part of the production cost and the expectations and challenges associated with these technologies are numerous, especially with the development of single-use technologies. The UpStream Processing (USP) part is treated in depth in the complementary courses of the Bioproduction specialization (HAV930V and HAV911V).
This course includes lectures and conferences with numerous presentations by industrialists from the sector who will bring their expertise and vision of the field to the students. Beyond the technological aspects, these lectures will also be an opportunity to deal with Good Manufacturing Practices (GMP), quality control and the management of economic and environmental constraints.
Valorization of research and innovation
ECTS
5 credits
Component
Faculty of Science
The valorization of research work towards industrial applications will require strategies and actors at the interface between the scientific and socio-economic worlds. The identification and protection of the innovative character of a discovery will be followed by the search for funding and partners to transform this idea into an economic reality.
This course will focus on providing students with all the tools they need to develop their work with a view to discovering new therapeutic tools. This course includes lectures given by teacher-researchers who are lawyers and professionals in the field, as well as a tutored project that is followed throughout the course. Work will also be carried out in the Learning Lab: identification of innovative research, drafting of a patent, valorisation plan, creation of a company, business plan.
This course will involve teachers-researchers, industrialists and professionals in the field of patents and valorisation.
Continuous and fed-batch bioprocess engineering
ECTS
3 credits
Component
Faculty of Science
Within biotechnologies, bioprocesses correspond to the industrial implementation of living tools (whether enzymes, microorganisms or eukaryotic cells) for the synthesis of products of interest. This course will focus on the central step of the bioprocess: the biological reaction in a reactor. It will be more particularly devoted to the exploitation of microbial and cellular catalysts. The products of interest can be for example fermented foods (wine, beer, ...), energy molecules (bioethanol, methane, ...), chemical intermediates, or biomedicines (vaccines, monoclonal antibodies, growth factors...). The knowledge and skills acquired during this course will be transposable to any sector of activity. The examples will be given in the fields corresponding to the main outlets of the two courses concerned (Agrosciences and Health). This course is the direct continuation of the M1 course HAV811V "Bioprocess Engineering - Batch". It focuses on the UpStream Processing (USP) aspects of bioprocesses.
The first lectures will allow to resituate the bioprocesses and the approach applied in bioprocess engineering and to briefly recall the Batch mode (pre-requisite of M1). Then, the main part of the course will be devoted to the application of the bioprocess engineering approach to reactors operated in continuous and Fed-Batch mode (or semi-(dis)continuous culture).
Cross-cutting modules will also be offered:
-Transfer management (mixture management, heat transfer, gas transfer) with an important focus on gas transfer and how to ensure the oxygen needs of a culture (kLa, OUR, OTR) -Design of culture media
-Elementary balances (carbon balance and redox balance)
-Development of an indicator for monitoring the biological reaction: the Respiratory Quotient (RQ)
This course includes interactive lectures and tutorials.
An intensive practical application (1 month) carried out in the form of a project is planned for the students of the M2 Biology-Health / IBIS / Bioproduction specialization in the framework of the UEs "Multidisciplinary lab project: from gene to protein". For these students, a strong link is also foreseen with the specialization courses (HAV910V, HAV911V and HAA910V). See the descriptions of these courses for more information.
Project management and risk management
Component
Faculty of Pharmacy
Multidisciplinary Lab project 2
ECTS
6 credits
Component
Faculty of Science
The multidisciplinary lab project, also called "Gene to Protein project", will be a "learning by doing" project. The students will be in charge of the bioproduction of a protein using E. coli as a host. If they follow both parts of the project (1 & 2, like students from Biohealth master), they will start with strain construction and continue with pilot scale production and purification of the protein.Bioprocess engineering is a highly interdisciplinary fieldof study. The students (and future workers in the field), will benefit from project-based learning with an important practical part, where they can actively experience the interconnection between biology, engineering and physical sciences.
The part 2 of the project will be dedicated to the "production process design and pilot scale production" of the recombinant protein using a high-cell density fed-batch culture. It will be a multidisciplinary, hands-on training of Bioprocess Engineering and will be organized over three different periods:
-Week 1 : In Learning lab, students will participate in workshops to design and plan a production process in accordance with equipment and data available (scientific papers, reports, websites, previous results from UE "Multidisciplinary Lab Project 1"). Based on the bottlenecks identified for production of recombinant proteins in E. coli, the students will choose the culture process to be used, define the production objectives, simulate the culture (planning objective), design a sampling plan, design the culture medium...
-Week 2 :In practical training rooms on pilot-scale equipment (20L working volume bioreactor), students will prepare the bioreactor and all they need to perform the pilot-scale culture. They will be in charge of the monitoring of the culture and of real time data treatment in order to detect and correct deviations from the anticipated progress of the culture.
-Week 3: In learning labs, students will treat and analyze the data. They will be in charge of the interpretation and discussion of the results and of the writing of a professional report.
Bioproduction and valorization of microbial biodiversity
ECTS
3 credits
Component
Faculty of Science
A teaching module oriented towards the professional world, with general introductions on pre-defined themes targeting the biotechnological valorization of microorganisms (antimicrobials, microbiota, probiotics, applied virology, etc.) followed by presentations by industrialists who come to present their background, their company and/or the development of a project. This course covers both red biotechnologies (health applications) and the other colors of biotechnologies (green/agronomy, blue/marine, white/industrial, yellow/environmental).
Engineering of recombinant protein production
ECTS
3 credits
Component
Faculty of Science
Within biotechnology, the production of recombinant proteins in different prokaryotic and eukaryotic expression systems represents a mature and attractive technological field with a high employability. It is also a very important field of research in which many challenges remain. The bioproduction of biomedicines (recombinant proteins but also monoclonal antibodies) represents a major challenge in human therapeutics, but also in many fields of biotechnology (environmental, industrial, agronomic, marine...). Before designing any biological drug involving a biomanufacturing step, it is essential to know the different eukaryotic and prokaryotic expression systems used in biotechnologies as well as to have a complete overview of the biomanufacturing panorama and stakes in France, in Europe and in the world.
This UE includes interactive lectures. It is provided by various academic and industrial speakers involved in the field.
Multidisciplinary Lab project 1 (UE PHARMACIE)
ECTS
3 credits
Component
Faculty of Science
Bioethics and regulation (UE PHARMACIE)
ECTS
3 credits
Component
Faculty of Pharmacy
Bioprocess Engineering II, application specificities
ECTS
2 credits
Component
Faculty of Science
In this course, the specificities of health applications in the field of bioprocessing are presented. Thus, case studies on the production of biomedicines and advanced therapy drugs are proposed (e.g. clinical grade production of cell therapy products). The whole production chain is addressed with a particular focus on downstream processes (or DownStream Processing, DSP) which are particularly important for health products (separation, extraction, purification, and even formulation operations). Indeed, DSP represents a significant part of the production cost and the expectations and challenges associated with these technologies are numerous, especially with the development of single-use technologies. The UpStream Processing (USP) part is treated in depth in the complementary courses of the Bioproduction specialization (HAV930V and HAV911V).
This course includes lectures and conferences with numerous presentations by industrialists from the sector who will bring their expertise and vision of the field to the students. Beyond the technological aspects, these lectures will also be an opportunity to deal with Good Manufacturing Practices (GMP), quality control and the management of economic and environmental constraints.
Valorization of research and innovation
ECTS
5 credits
Component
Faculty of Science
The valorization of research work towards industrial applications will require strategies and actors at the interface between the scientific and socio-economic worlds. The identification and protection of the innovative character of a discovery will be followed by the search for funding and partners to transform this idea into an economic reality.
This course will focus on providing students with all the tools they need to develop their work with a view to discovering new therapeutic tools. This course includes lectures given by teacher-researchers who are lawyers and professionals in the field, as well as a tutored project that is followed throughout the course. Work will also be carried out in the Learning Lab: identification of innovative research, drafting of a patent, valorisation plan, creation of a company, business plan.
This course will involve teachers-researchers, industrialists and professionals in the field of patents and valorisation.
Continuous and fed-batch bioprocess engineering
ECTS
3 credits
Component
Faculty of Science
Within biotechnologies, bioprocesses correspond to the industrial implementation of living tools (whether enzymes, microorganisms or eukaryotic cells) for the synthesis of products of interest. This course will focus on the central step of the bioprocess: the biological reaction in a reactor. It will be more particularly devoted to the exploitation of microbial and cellular catalysts. The products of interest can be for example fermented foods (wine, beer, ...), energy molecules (bioethanol, methane, ...), chemical intermediates, or biomedicines (vaccines, monoclonal antibodies, growth factors...). The knowledge and skills acquired during this course will be transposable to any sector of activity. The examples will be given in the fields corresponding to the main outlets of the two courses concerned (Agrosciences and Health). This course is the direct continuation of the M1 course HAV811V "Bioprocess Engineering - Batch". It focuses on the UpStream Processing (USP) aspects of bioprocesses.
The first lectures will allow to resituate the bioprocesses and the approach applied in bioprocess engineering and to briefly recall the Batch mode (pre-requisite of M1). Then, the main part of the course will be devoted to the application of the bioprocess engineering approach to reactors operated in continuous and Fed-Batch mode (or semi-(dis)continuous culture).
Cross-cutting modules will also be offered:
-Transfer management (mixture management, heat transfer, gas transfer) with an important focus on gas transfer and how to ensure the oxygen needs of a culture (kLa, OUR, OTR) -Design of culture media
-Elementary balances (carbon balance and redox balance)
-Development of an indicator for monitoring the biological reaction: the Respiratory Quotient (RQ)
This course includes interactive lectures and tutorials.
An intensive practical application (1 month) carried out in the form of a project is planned for the students of the M2 Biology-Health / IBIS / Bioproduction specialization in the framework of the UEs "Multidisciplinary lab project: from gene to protein". For these students, a strong link is also foreseen with the specialization courses (HAV910V, HAV911V and HAA910V). See the descriptions of these courses for more information.
Project management and risk management
Component
Faculty of Pharmacy
Multidisciplinary Lab project 2
ECTS
6 credits
Component
Faculty of Science
The multidisciplinary lab project, also called "Gene to Protein project", will be a "learning by doing" project. The students will be in charge of the bioproduction of a protein using E. coli as a host. If they follow both parts of the project (1 & 2, like students from Biohealth master), they will start with strain construction and continue with pilot scale production and purification of the protein.Bioprocess engineering is a highly interdisciplinary fieldof study. The students (and future workers in the field), will benefit from project-based learning with an important practical part, where they can actively experience the interconnection between biology, engineering and physical sciences.
The part 2 of the project will be dedicated to the "production process design and pilot scale production" of the recombinant protein using a high-cell density fed-batch culture. It will be a multidisciplinary, hands-on training of Bioprocess Engineering and will be organized over three different periods:
-Week 1 : In Learning lab, students will participate in workshops to design and plan a production process in accordance with equipment and data available (scientific papers, reports, websites, previous results from UE "Multidisciplinary Lab Project 1"). Based on the bottlenecks identified for production of recombinant proteins in E. coli, the students will choose the culture process to be used, define the production objectives, simulate the culture (planning objective), design a sampling plan, design the culture medium...
-Week 2 :In practical training rooms on pilot-scale equipment (20L working volume bioreactor), students will prepare the bioreactor and all they need to perform the pilot-scale culture. They will be in charge of the monitoring of the culture and of real time data treatment in order to detect and correct deviations from the anticipated progress of the culture.
-Week 3: In learning labs, students will treat and analyze the data. They will be in charge of the interpretation and discussion of the results and of the writing of a professional report.
Statistics applied to biology
ECTS
5 credits
Component
Faculty of Medicine
Cellular communications and signalling
ECTS
5 credits
Component
Faculty of Science
The main communication pathways between normal cells and intracellular transduction pathways, encountered in physiological and neurophysiological mechanisms, will be discussed, such as G protein coupled receptors (GPCRs), their structure, function and modulation by interacting proteins involved in the desensitization phenomenon. The main intracellular pathways activated by GPCRs will be discussed (MAPkinase, PI3kinase, etc...).
Secondly, an important part of the course will focus on calcium signaling and Ca2+ homeostasis; Ca2+ being a ubiquitous signal in cell signaling. Calcium homeostasis will be studied in particular during the response of lymphocytes after antigenic stimulation. Moreover, the production of oxygenated free radicals, at the origin of oxidative stress, is dependent on intracellular Ca2+. The physiological role of free radicals will be discussed, as well as their involvement in oxidative stress. In this context, the pathways of protection against oxidative stress will also be studied.The following chapter will address the endocannabinoid system which allows to recapitulate all the themes that will be evoked previously in the course. The endocannabinoid system is at the origin of multiple central and peripheral regulations.
Finally, two other themes will be addressed: the blood-brain barrier which allows to evoke the cellular communication in a very integrated way between two environments and the -pancreatic cell whose activity is crucial for the regulation of glycemia by the secretion of insulin.
Functional genomics
ECTS
5 credits
Component
Faculty of Science
The aim of this course is to introduce functional genomics technologies and to present examples of biological questions that can be asked using them.
This unit aims to present "omics" functional genomics technologies, and some biological questions that they can address.The lectures are given by both associate professors and researchers.
Introduction to functional genomics: approaches, concepts and methods
An introduction to functional Genomics: approaches, concepts and methods
V. Coulon, UM / IGMM
Genome organization / Organisation des génomes
Techniques de séquençage / DNA sequencing methodsL. Journot, IGF
3D genome organization J. Poli, UM / IGH
Genome topological organisation and replication-V. Coulon, UM / IGMM
Régulation spatio-temporelle de l'expression des génomes / Spatio-temporal regulation of gene expressionTranscriptionEpissage / Splicing-V. Coulon, UM / IGMM
Non-coding RNAsV. Coulon, UM / IGMM
Interactomics / InteractomiqueIan Robbins, UM / IGMM
Proteomics and Pharmacogenomics / Protéomique et pharmacogénomiqueC. Bécamel, UM / IGF
Animal Models / Modèles animaux
Using Mice in Functional Genomics F. Poulat, IGH
La Drosophile en génomique fonctionnelle / Using Drosophila in Functional Genomics -F. Juge and S. Chambeyron, IGH
Scientificarticles analysis and presentation(15min + 10 min discussion per group of 3 students)
Cellular biology
ECTS
5 credits
Component
Faculty of Science
The program offers a refresher course and an in-depth study of the major concepts and methodologies of cell biology, organized around different themes:
Cytoskeleton:Introduction to the different types of cytoskeleton. Polymerization properties of actin and tubulin. Proteins associated with the cytoskeleton and regulating polymerization. Molecular motors. Principles of cell migration.
Cellular Adhesion & Signaling: Adhesive structures cell-cell and cell-extracellular matrix, their molecular organization and dynamics. Functions and regulations during development and pathogenesis. Regulation by signaling pathways. Mechanotransduction.
3. addressing and cell trafficking: Ubiquitination and proteasome. Addressing to subcellular compartments, endocytosis and secretion pathways. Molecular basis of vesicular transport, budding, fusion, molecular motors. Signaling in membrane trafficking, genetic diseases related to trafficking and detour by pathogens.
4.cell cycle:Historical introduction. Molecular regulation of the cell cycle. Mitotic spindle, microtubule dynamics and molecular motors, chromosome attachment mechanisms, checkpoints, regulation of mitosis exit and cytokinesis. Mitotic disorders associated with cancer cells.
5. stem cells: cell differentiation, toti-, pluri- and multipotency, embryonic, adult and cancer stem cells
6. programmed cell death: apoptosis, autophagy, necrosis. Stages and modalities of apoptosis, signaling pathways involved. Role in the maintenance of homeostasis. Pathophysiological consequences of deregulation of programmed cell death.
Different study models are presented, in order to introduce the importance of the contribution of biological diversity in the discovery of cellular and molecular mechanisms, as well as in the understanding of human pathologies.
The program offers a refresher of knowledge and an in-depth study of the major concepts and methodologies of cell biology, organized around different themes:
1. Cytoskeleton: Introduction to the different types of cytoskeleton. Polymerization properties of actin and tubulin. Proteins associated with the cytoskeleton and regulating polymerization. Molecular motors. Principles of cell migration.
2. Cellular Adhesion & Signaling: Cell-cell and extracellular cell-matrix adhesive structures, their molecular and dynamic organization. Functions and regulations during development and pathogenesis. Regulation by signaling channels. Mechanotransduction.
3. Addressing and cell traffic: Ubiquitination and proteasome. Addressing to subcellular compartments, endocytosis and secretion pathways. The molecular bases of vesicular transport, budding, fusion, molecular motors. Signaling in membrane trafficking, genetic diseases linked to trafficking and diversion by pathogens.
4. Cell cycle: Historical introduction. Molecular regulation of the cell cycle. The mitotic spindle, microtubule and molecular motor dynamics, chromosome attachment mechanisms, checkpoints, regulation of mitosis output and cytokinesis. Mitotic disorders associated with cancer cells.
5. Stem cells: cell differentiation, toti-, pluri-and multipotency, embryonic, adult and cancer stem cells.
6. Programmed cell death: Apoptosis, autophagy, necrosis. Stages and modalities of apoptosis, signaling pathways involved. Role in maintaining homeostasis. Physiopathological consequences of deregulation of programmed cell death.
Different study models are presented, in order to introduce the importance of the contribution of biological diversity in the discovery of cellular and molecular mechanisms, as well as in the understanding of human pathologies
Developmental genetics
ECTS
5 credits
Component
Faculty of Science
-A general introduction to developmental biology
How do cells build a multicellular animal organism from a single genome? Genotype/phenotype relationship.
-Genetic analysis reminders
Nature of mutations (loss-of-function; gain-of-function), notion of "master gene", clonal analysis (generation of somatic or germinal clones), notion of cell autonomy ....
-Genetic models and methods.
Study of regulatory regions, establishment of transgenic lines, enhancer trap, reporter genes (GFP, mCherry...), model organisms (drosophila, c.elegans, mice...).Use of FLP/FRT, CRE-LOX, UAS-GAL4-GAL80, AttpP/B-PhiC31, CRISPR etc.
-Positional information, maternal effect genes and the establishment of assymetry.
Models and mechanisms of positional information =induction, Spemann and Mangold experiment, organizing centers, notion of morphogen in invertebrates and vertebrates
-Establishment of the axes: antero-posterior, dorso-ventral.
Genetic screens: genes with maternal effects and genes with zygotic effects.Cellular communication and signaling pathways: in the establishment of the dorso-ventral axis, in the formation of limbs, in the establishment of cell fate (some examples: Nervous system: lateral inhibition process ...).
-Segmentation: the gap, pair rule and segmental polarity genes.
Segmentation in invertebrates and somitogenesis in vertebrates, dynamic aspects (establishment and maintenance).
-Signaling and transcriptional networks
Transcriptional regulations during development, regulatory sequences during evolution, concept of gene networks. Transcriptional coupling and signaling pathways in cell fate
-The memory of transcriptional programs by epigenetic mechanisms:
Hox homeotic genes and segmental identity.Evo-Devo concepts.Polycomb and Trithorax complexes.
Involvement of epigenetic mechanisms during cell differentiation
Internship_FDS
ECTS
15 credits
Component
Faculty of Science
Two to four month internship in a structure (research laboratory, company, etc.) in France or abroad
Long internship or abroad
ECTS
5 credits
Component
Faculty of Science
Internship of more than 4 months in a structure (research laboratory, company,...) in France or abroad
Cell culture
ECTS
5 credits
Component
Faculty of Science
Cell culture is a basic technique in the laboratory and is constantly evolving. It is important to know the basics of cell culture, which are often not well known, even though it is an essential methodology in research and also in industry.
Practical analysis of genomic data in R
ECTS
5 credits
Component
Faculty of Science
Medical genetics and genetic counseling
ECTS
5 credits
Component
Faculty of Science
TER_FDS
ECTS
5 credits
Component
Faculty of Science
The aim of the TER course is to prepare the student to organize and carry out an in-depth bibliographical analysis in order to approach the internship with a knowledge of the state of the art in the field and to produce a relevant and well thought-out introduction to his experimental work.
Genetic information - Epigenetics - Mechanistic bases
ECTS
5 credits
Component
Faculty of Science
Signaling: Methods and Concepts
ECTS
5 credits
Component
Faculty of Science
Bioinformatics and System Biology
ECTS
5 credits
Component
Faculty of Science
Integrative Pathophysiology
ECTS
5 credits
Component
Faculty of Science
Developmental Biology, Stem Cells and Biotherapy
ECTS
5 credits
Component
Faculty of Science
Workshop in Epigenetics
ECTS
5 credits
Component
Faculty of Science
Fictitious research project_FDS
ECTS
10 credits
Component
Faculty of Science
Internship_FDS
ECTS
20 credits
Component
Faculty of Science
Internship of at least 4 months in a structure (research laboratory, company,...) in France or abroad.
Bootcamp
ECTS
5 credits
Component
Faculty of Science
The Bootcamp is an intensive course at the beginning of the first semester, before the start of the courses characterizing the tracks. Its purpose is to refresh and/or bring students up to speed on the basics of mathematics, physics, computer science and biology.
The course will be adapted according to the students recruited, in order to achieve a more homogeneous start to the course. Students will be immersed in different role-playing games divided into small groups. They will have to solve enigmas using their knowledge in biology, physics/mathematics, chemistry and programming, like in an escape game over several days.
Statistics applied to biology
ECTS
5 credits
Component
Faculty of Medicine
Functional genomics
ECTS
5 credits
Component
Faculty of Science
The aim of this course is to introduce functional genomics technologies and to present examples of biological questions that can be asked using them.
This unit aims to present "omics" functional genomics technologies, and some biological questions that they can address.The lectures are given by both associate professors and researchers.
Introduction to functional genomics: approaches, concepts and methods
An introduction to functional Genomics: approaches, concepts and methods
V. Coulon, UM / IGMM
Genome organization / Organisation des génomes
Techniques de séquençage / DNA sequencing methodsL. Journot, IGF
3D genome organization J. Poli, UM / IGH
Genome topological organisation and replication-V. Coulon, UM / IGMM
Régulation spatio-temporelle de l'expression des génomes / Spatio-temporal regulation of gene expressionTranscriptionEpissage / Splicing-V. Coulon, UM / IGMM
Non-coding RNAsV. Coulon, UM / IGMM
Interactomics / InteractomiqueIan Robbins, UM / IGMM
Proteomics and Pharmacogenomics / Protéomique et pharmacogénomiqueC. Bécamel, UM / IGF
Animal Models / Modèles animaux
Using Mice in Functional Genomics F. Poulat, IGH
La Drosophile en génomique fonctionnelle / Using Drosophila in Functional Genomics -F. Juge and S. Chambeyron, IGH
Scientificarticles analysis and presentation(15min + 10 min discussion per group of 3 students)
Introduction to quantitative Biology
Component
Faculty of Science
This EU aims to provide a broad overview of emerging quantitative interdisciplinary fields in bioscience, ranging from advanced experimental techniques in microscopy and synthetic biology, to systems approaches.
In an innovative way, these methodological aspects will be presented in the context of biological and biophysical concepts such as robustness and optimality of biological systems, gene regulation and the fundamental principles underlying membrane and genome organization.
The main topics will be introduced first with traditional lectures and will be developed through individual or team projects where students will learn to apply specific techniques through examples, and see how these can be used to explore specific biological questions. These projects will involve literature reviews, use of existing code, or development of new code (depending on the student's experience) and will constitute half of the final assessment.
Synthetic Biology - Praticals
ECTS
5 credits
Component
Faculty of Science
In this (hands-on) teaching unit, we will first introduce the general concepts of synthetic biology, which will then be applied to student team projects (assessed). We will provide background knowledge to understand the set of fundamental concepts, approaches and current tools of synthetic biology that will be exploited throughout the course and practical sessions, ranging from gene design and synthesis to genetic library construction, from fluorescence measurements (e.g. plate readers. ) to flow cytometers.
Imaging Biologicals Systems - Praticals
ECTS
5 credits
Component
Faculty of Science
Students will acquire the fundamental basis and advanced microscopy techniques that allow them to push the limits of knowledge in biology. The teaching is progressive and modular, entirely built around practical projects: building a simple microscope, using advanced microscopes to study complex biological processes in bacteria and eukaryotes. Students will be immersed in a stimulating scientific environment. The training will rely on a significant personal investment through experimental projects, paper reviews and case studies. Communication skills will also be developed through oral presentations and written reports.
Internship_FDS
ECTS
15 credits
Component
Faculty of Science
Two to four month internship in a structure (research laboratory, company, etc.) in France or abroad
TER_FDS
ECTS
5 credits
Component
Faculty of Science
The aim of the TER course is to prepare the student to organize and carry out an in-depth bibliographical analysis in order to approach the internship with a knowledge of the state of the art in the field and to produce a relevant and well thought-out introduction to his experimental work.
Practical Modelling and Simulation of Biological Systems
ECTS
5 credits
Component
Faculty of Science
Applied Structural Biology
ECTS
5 credits
Component
Faculty of Science
This practical course is based on mini-projects involving the application of techniques for the structural study of biomolecules (X-ray crystallography, NMR, cryo-EM, mass spectrometry). In addition, students will learn the biophysical and biochemical techniques used to characterize the analyzed molecules and their interactions.
For each approach, students will learn the basic principles, sample preparation requirements, data acquisition and analysis.
Workshop
ECTS
5 credits
Component
Faculty of Science
The Workshop is a series of lectures given by external speakers.
The topic will change every year, with at least one leading speaker working in a given field. The topic will be decided a year in advance. We will encourage the speaker and participants to write notes from the lectures, which will contribute to the course evaluation.
Students in the qbio track have funds to organize a conference alongside the main conference (brainstorming on the topic with mentors, finding and inviting speakers, managing funding and advertising).
Genetic information - Epigenetics - Mechanistic bases
ECTS
5 credits
Component
Faculty of Science
Signaling: Methods and Concepts
ECTS
5 credits
Component
Faculty of Science
Bioinformatics and System Biology
ECTS
5 credits
Component
Faculty of Science
Integrative Pathophysiology
ECTS
5 credits
Component
Faculty of Science
Lab_2
ECTS
15 credits
Component
Faculty of Science
Lab2 is a short internship in a research laboratory (2 months).
Students are encouraged to work with different teams on interdisciplinary topics. Normally Lab2 takes place in a laboratory in Montpellier in order to be able to follow the other UE during semester 3 but exceptions are possible depending on the schedule.
Lab_3
ECTS
25 credits
Component
Faculty of Science
Lab3 is the end of Master internship (>= 5 months). Students must work on a research project in a French or international laboratory, different from the team with which they did their Lab2.
Scientific Writing
ECTS
5 credits
Component
Faculty of Science
This course is a workshop that will accompany students during semester 3 to learn how to write a scientific report. This workshop will take place throughout the semester in conjunction with their internship.
Students will learn how to approach, understand, and critique a scientific article.
Cellular biology
ECTS
5 credits
Component
Faculty of Science
The program offers a refresher course and an in-depth study of the major concepts and methodologies of cell biology, organized around different themes:
Cytoskeleton:Introduction to the different types of cytoskeleton. Polymerization properties of actin and tubulin. Proteins associated with the cytoskeleton and regulating polymerization. Molecular motors. Principles of cell migration.
Cellular Adhesion & Signaling: Adhesive structures cell-cell and cell-extracellular matrix, their molecular organization and dynamics. Functions and regulations during development and pathogenesis. Regulation by signaling pathways. Mechanotransduction.
3. addressing and cell trafficking: Ubiquitination and proteasome. Addressing to subcellular compartments, endocytosis and secretion pathways. Molecular basis of vesicular transport, budding, fusion, molecular motors. Signaling in membrane trafficking, genetic diseases related to trafficking and detour by pathogens.
4.cell cycle:Historical introduction. Molecular regulation of the cell cycle. Mitotic spindle, microtubule dynamics and molecular motors, chromosome attachment mechanisms, checkpoints, regulation of mitosis exit and cytokinesis. Mitotic disorders associated with cancer cells.
5. stem cells: cell differentiation, toti-, pluri- and multipotency, embryonic, adult and cancer stem cells
6. programmed cell death: apoptosis, autophagy, necrosis. Stages and modalities of apoptosis, signaling pathways involved. Role in the maintenance of homeostasis. Pathophysiological consequences of deregulation of programmed cell death.
Different study models are presented, in order to introduce the importance of the contribution of biological diversity in the discovery of cellular and molecular mechanisms, as well as in the understanding of human pathologies.
The program offers a refresher of knowledge and an in-depth study of the major concepts and methodologies of cell biology, organized around different themes:
1. Cytoskeleton: Introduction to the different types of cytoskeleton. Polymerization properties of actin and tubulin. Proteins associated with the cytoskeleton and regulating polymerization. Molecular motors. Principles of cell migration.
2. Cellular Adhesion & Signaling: Cell-cell and extracellular cell-matrix adhesive structures, their molecular and dynamic organization. Functions and regulations during development and pathogenesis. Regulation by signaling channels. Mechanotransduction.
3. Addressing and cell traffic: Ubiquitination and proteasome. Addressing to subcellular compartments, endocytosis and secretion pathways. The molecular bases of vesicular transport, budding, fusion, molecular motors. Signaling in membrane trafficking, genetic diseases linked to trafficking and diversion by pathogens.
4. Cell cycle: Historical introduction. Molecular regulation of the cell cycle. The mitotic spindle, microtubule and molecular motor dynamics, chromosome attachment mechanisms, checkpoints, regulation of mitosis output and cytokinesis. Mitotic disorders associated with cancer cells.
5. Stem cells: cell differentiation, toti-, pluri-and multipotency, embryonic, adult and cancer stem cells.
6. Programmed cell death: Apoptosis, autophagy, necrosis. Stages and modalities of apoptosis, signaling pathways involved. Role in maintaining homeostasis. Physiopathological consequences of deregulation of programmed cell death.
Different study models are presented, in order to introduce the importance of the contribution of biological diversity in the discovery of cellular and molecular mechanisms, as well as in the understanding of human pathologies
Cellular pathophysiology and cancer
ECTS
5 credits
Component
Faculty of Science
The aim of the "Cellular Physiopathology and Cancer" course is to provide students with the knowledge necessary to follow the "Cancer Biology" course in M2. The course is organized in the form of a lecture with an introductory part followed by a part on current research in the laboratories. Students are required to present a scientific article orally (usually in pairs).
The aim of the cellular pathophysiology and cancer teaching unit is to provide the scientific background necessary to follow the cancer biology M2 program.Each lecture is organized as a conference starting with a general introduction of the field and followed by a more specialized emphasis on research done in laboratories. Students have to prepare an oral presentation based on the analysis of a scientific article (generally in pair).
Functional genomics
ECTS
5 credits
Component
Faculty of Science
The aim of this course is to introduce functional genomics technologies and to present examples of biological questions that can be asked using them.
This unit aims to present "omics" functional genomics technologies, and some biological questions that they can address.The lectures are given by both associate professors and researchers.
Introduction to functional genomics: approaches, concepts and methods
An introduction to functional Genomics: approaches, concepts and methods
V. Coulon, UM / IGMM
Genome organization / Organisation des génomes
Techniques de séquençage / DNA sequencing methodsL. Journot, IGF
3D genome organization J. Poli, UM / IGH
Genome topological organisation and replication-V. Coulon, UM / IGMM
Régulation spatio-temporelle de l'expression des génomes / Spatio-temporal regulation of gene expressionTranscriptionEpissage / Splicing-V. Coulon, UM / IGMM
Non-coding RNAsV. Coulon, UM / IGMM
Interactomics / InteractomiqueIan Robbins, UM / IGMM
Proteomics and Pharmacogenomics / Protéomique et pharmacogénomiqueC. Bécamel, UM / IGF
Animal Models / Modèles animaux
Using Mice in Functional Genomics F. Poulat, IGH
La Drosophile en génomique fonctionnelle / Using Drosophila in Functional Genomics -F. Juge and S. Chambeyron, IGH
Scientificarticles analysis and presentation(15min + 10 min discussion per group of 3 students)
Toxicological investigation
ECTS
5 credits
Component
Faculty of Pharmacy
Developmental genetics
ECTS
5 credits
Component
Faculty of Science
-A general introduction to developmental biology
How do cells build a multicellular animal organism from a single genome? Genotype/phenotype relationship.
-Genetic analysis reminders
Nature of mutations (loss-of-function; gain-of-function), notion of "master gene", clonal analysis (generation of somatic or germinal clones), notion of cell autonomy ....
-Genetic models and methods.
Study of regulatory regions, establishment of transgenic lines, enhancer trap, reporter genes (GFP, mCherry...), model organisms (drosophila, c.elegans, mice...).Use of FLP/FRT, CRE-LOX, UAS-GAL4-GAL80, AttpP/B-PhiC31, CRISPR etc.
-Positional information, maternal effect genes and the establishment of assymetry.
Models and mechanisms of positional information =induction, Spemann and Mangold experiment, organizing centers, notion of morphogen in invertebrates and vertebrates
-Establishment of the axes: antero-posterior, dorso-ventral.
Genetic screens: genes with maternal effects and genes with zygotic effects.Cellular communication and signaling pathways: in the establishment of the dorso-ventral axis, in the formation of limbs, in the establishment of cell fate (some examples: Nervous system: lateral inhibition process ...).
-Segmentation: the gap, pair rule and segmental polarity genes.
Segmentation in invertebrates and somitogenesis in vertebrates, dynamic aspects (establishment and maintenance).
-Signaling and transcriptional networks
Transcriptional regulations during development, regulatory sequences during evolution, concept of gene networks. Transcriptional coupling and signaling pathways in cell fate
-The memory of transcriptional programs by epigenetic mechanisms:
Hox homeotic genes and segmental identity.Evo-Devo concepts.Polycomb and Trithorax complexes.
Involvement of epigenetic mechanisms during cell differentiation
Physiology and Integrated Homeostasis
ECTS
5 credits
Component
Faculty of Science
Three main themes are addressed:
-Study of weight and thermal homeostasis in relation to a model of dysfunction: obesity. For this purpose, the energy balance with food intake and energy expenditure composed of basic metabolism, physical activity and adaptive thermogenesis (AT) and their respective regulation will be addressed.
-Study of biological rhythms, through the description of the nature and properties of biological rhythms (ultradian, circadian and infradian), the description of endogenous circadian oscillators, and the detailed presentation of the molecular mechanisms of circadian clocks.
-Study of the different stages and physiological principles of breathing. Theoretical lessons will be complemented by tutorials. The tutorials are based on document studies and the analysis of scientific articles in English. The choice of the various scientific supports aims at showing the interaction of the various approached topics and thus the concept of integrative physiology.
Current research in immunology
ECTS
5 credits
Component
Faculty of Science
Teaching is done by teachers and/or researchers at the Faculties of Medicine, Sciences or Pharmacy, or at local research institutes.Course contents will be adapted to current scientific advances.
Teaching is organized in topics (lectures/tutorials, 4 to 5:30 hrs each);each includes an introduction and a seminar. In addition, for each topic, a group of students is in charge of presenting one or two recent scientific research articles.
Examples of subjects treated:
Immune adaptive responses, vaccination
Immune tolerance
Aging of the immune system
Metabolic regulation of the immune response
Immune response regulation by microbiota
Immune system-central nervous system interactions
Immunotherapy, therapeutic antibodies
The Unit is complemented by practical work by groups on a mini-research project that includes design of experiments, realization and analysis. Training is available in the use of flow cytometry data analysis software.results are presented orally to the entire class.
Functional exploration and translational research
ECTS
5 credits
Component
Faculty of Science
Neuromuscular physiology:
Striated skeletal muscle: The neuromuscular junction; Contraction/muscle release; Myotypology; Plasticity; Muscle metabolism.
Neuromuscular diseases:Causes; symptoms; clinical diagnosis (clinical examinations; laboratory tests): EMG, blood assays, functional tests, etc.; Muscular dystrophies: Duchenne myopathy; Becker's myopathy; facioscapiohumeral muscular dystrophy (FSHD).Facioscapiohumeral muscular dystrophy FSHD: zebrafish model; mouse model; cell models; clinical trials.
Respiratory physiology:
Respiratory physiology: Anatomy of the respiratory system; mechanism of respiration; gas exchange; transport of respiratory gases by the blood; regulation of respiration
Respiratory exploration in small animals: Why explore respiratory function in small animals? Plethysmography; in vitro contractile force.
Respiratory Functional Explorations: performance and interpretation of respiratory explorations in human pathology; spirometry: Level 1 and Level 2; pulmonary diffusion capacity; arterial blood gas; specific exploration of respiratory muscles; 6-minute walk test; exercise test; explorations with stay at altitude.
Cardiovascular physiology:
Reminder of the anatomy of the heart: size, location and orientation; envelope of the heart; tunics of the heart wall; chambers and large vessels of the heart; blood flow in the heart; heart valves; blood supply to the heart: coronary circulation; properties of the cardiac muscle tissue.
Reminder of the physiology of the heart: regulation of the basic rhythm; conduction system of the heart; modification of the basic rhythm: extrinsic innervation of the heart; electrocardiography; mechanical phenomena: cardiac revolution; cardiac output; regulation of the systolic volume; regulation of the heart rate.
Reminder of vascular physiology: anatomy of the circulatory system; lymphatic system; vascular wall structure; blood pressure; vascular smooth muscle and vasomotricity; endothelial function.
Vascular function and dysfunction; functional exploration: Arterial Distensibility Measurement; arterial wave velocity measurement; pharmacological exploration of endothelium-dependent vasomotricity; ultrasonographic exploration; echotracking; ultrasound and echodoppler.
How to evaluate vascular function experimentally?isolated artery ring model Cardiac Doppler: a fabulous tool in clinical and experimental research; Ultrasound: anatomical and functional analysis"; Doppler: flow analysis; Application to animal models.
Translational research: example myocardial ischemia-reperfusion (myocardial infarction); animal models; isolated perfused heart (Langendorf); isolated cardiomyocytes; cardioprotective techniques.
Endocrinology: weight balance
Description of eating behavior; Energy balance; Central structures regulating food intake; Mechanisms regulating food intake; Factors modulating appetite and food intake; Nutritional assessment; Eating disorders; Functional exploration: impedancemetry; DEXA (X-ray photon absorption); MRI; Assessment of expenditure: calorimetry.
Molecular pharmacology and therapeutics
ECTS
5 credits
Component
Faculty of Pharmacy
Molecular and metabolic bases of inherited diseases
ECTS
5 credits
Component
Faculty of Science
Introduction to quantitative Biology
Component
Faculty of Science
This EU aims to provide a broad overview of emerging quantitative interdisciplinary fields in bioscience, ranging from advanced experimental techniques in microscopy and synthetic biology, to systems approaches.
In an innovative way, these methodological aspects will be presented in the context of biological and biophysical concepts such as robustness and optimality of biological systems, gene regulation and the fundamental principles underlying membrane and genome organization.
The main topics will be introduced first with traditional lectures and will be developed through individual or team projects where students will learn to apply specific techniques through examples, and see how these can be used to explore specific biological questions. These projects will involve literature reviews, use of existing code, or development of new code (depending on the student's experience) and will constitute half of the final assessment.
Statistics applied to biology
ECTS
5 credits
Component
Faculty of Medicine
Cellular communications and signalling
ECTS
5 credits
Component
Faculty of Science
The main communication pathways between normal cells and intracellular transduction pathways, encountered in physiological and neurophysiological mechanisms, will be discussed, such as G protein coupled receptors (GPCRs), their structure, function and modulation by interacting proteins involved in the desensitization phenomenon. The main intracellular pathways activated by GPCRs will be discussed (MAPkinase, PI3kinase, etc...).
Secondly, an important part of the course will focus on calcium signaling and Ca2+ homeostasis; Ca2+ being a ubiquitous signal in cell signaling. Calcium homeostasis will be studied in particular during the response of lymphocytes after antigenic stimulation. Moreover, the production of oxygenated free radicals, at the origin of oxidative stress, is dependent on intracellular Ca2+. The physiological role of free radicals will be discussed, as well as their involvement in oxidative stress. In this context, the pathways of protection against oxidative stress will also be studied.The following chapter will address the endocannabinoid system which allows to recapitulate all the themes that will be evoked previously in the course. The endocannabinoid system is at the origin of multiple central and peripheral regulations.
Finally, two other themes will be addressed: the blood-brain barrier which allows to evoke the cellular communication in a very integrated way between two environments and the -pancreatic cell whose activity is crucial for the regulation of glycemia by the secretion of insulin.
Internship_FDS
ECTS
15 credits
Component
Faculty of Science
Two to four month internship in a structure (research laboratory, company, etc.) in France or abroad
TER_FDS
ECTS
5 credits
Component
Faculty of Science
The aim of the TER course is to prepare the student to organize and carry out an in-depth bibliographical analysis in order to approach the internship with a knowledge of the state of the art in the field and to produce a relevant and well thought-out introduction to his experimental work.
Long internship or abroad
ECTS
5 credits
Component
Faculty of Science
Internship of more than 4 months in a structure (research laboratory, company,...) in France or abroad
Cell culture
ECTS
5 credits
Component
Faculty of Science
Cell culture is a basic technique in the laboratory and is constantly evolving. It is important to know the basics of cell culture, which are often not well known, even though it is an essential methodology in research and also in industry.
Immunopathology
ECTS
5 credits
Component
Faculty of Science
The teaching is carried out by teacher-researchers from the UFRs of medicine, science and pharmacy. It is organized into 42 hours of classes and supervised work divided into 7 themes (see Syllabus) including 2 series of article presentations; the first series on articles proposed by the speakers of each theme. A second series on articles chosen by the students. The students organize a mini-colloquium at the end of the course where the articles are presented. They write short reports of these articles for the Medecine-Sciences magazine.
Practical analysis of genomic data in R
ECTS
5 credits
Component
Faculty of Science
Medical genetics and genetic counseling
ECTS
5 credits
Component
Faculty of Science
Knowledge of the company and patent valuation
ECTS
5 credits
Component
Faculty of Science
You are a student of L3/M1 level in Languedoc-Roussillon? Would you like to work in small groups with students from other courses and in project mode, using a dormant scientific patent? To be accompanied and challenged by professional coaches of business creation? Register to PEPITE Patent Project to present a project of creation of innovative company based on the exploitation of a real patent provided by a local research team which will open its doors to you!
Why?
-Because you can create your own business whatever your field of study
To be selected by an incubator-type support structure
-To create a network in the field of entrepreneurship and innovation
PEPITE Patent Project, what is it? A Teaching Unit made up of strong times:
a 3-day "tool training" seminar
-regular meetings with the coaches
-Deliverables to be submitted: summary note, market study, business plan
a 10-minute final pitch to present your innovative company
Genetic information - Epigenetics - Mechanistic bases
ECTS
5 credits
Component
Faculty of Science
Signaling: Methods and Concepts
ECTS
5 credits
Component
Faculty of Science
Bioinformatics and System Biology
ECTS
5 credits
Component
Faculty of Science
Integrative Pathophysiology
ECTS
5 credits
Component
Faculty of Science
Principles of Cancer Biology
ECTS
5 credits
Component
Faculty of Science
Genome Integrity and Cancer
ECTS
5 credits
Component
Faculty of Science
Fictitious research project_FDS
ECTS
10 credits
Component
Faculty of Science
Internship_FDS
ECTS
20 credits
Component
Faculty of Science
Internship of at least 4 months in a structure (research laboratory, company,...) in France or abroad.
Experimental approaches in Infection Biology
ECTS
5 credits
Component
Faculty of Science
This course aims to reinforce and illustrate the knowledge acquired in the "Molecular Bases of Infectious Diseases" course by analyzing scientific publications on infectious diseases. Publications using a variety of molecular and cellular approaches in Bacteriology, Parasitology and Virology (from the most classical to the most recent) are analyzed with the students.
Cellular biology
ECTS
5 credits
Component
Faculty of Science
The program offers a refresher course and an in-depth study of the major concepts and methodologies of cell biology, organized around different themes:
Cytoskeleton:Introduction to the different types of cytoskeleton. Polymerization properties of actin and tubulin. Proteins associated with the cytoskeleton and regulating polymerization. Molecular motors. Principles of cell migration.
Cellular Adhesion & Signaling: Adhesive structures cell-cell and cell-extracellular matrix, their molecular organization and dynamics. Functions and regulations during development and pathogenesis. Regulation by signaling pathways. Mechanotransduction.
3. addressing and cell trafficking: Ubiquitination and proteasome. Addressing to subcellular compartments, endocytosis and secretion pathways. Molecular basis of vesicular transport, budding, fusion, molecular motors. Signaling in membrane trafficking, genetic diseases related to trafficking and detour by pathogens.
4.cell cycle:Historical introduction. Molecular regulation of the cell cycle. Mitotic spindle, microtubule dynamics and molecular motors, chromosome attachment mechanisms, checkpoints, regulation of mitosis exit and cytokinesis. Mitotic disorders associated with cancer cells.
5. stem cells: cell differentiation, toti-, pluri- and multipotency, embryonic, adult and cancer stem cells
6. programmed cell death: apoptosis, autophagy, necrosis. Stages and modalities of apoptosis, signaling pathways involved. Role in the maintenance of homeostasis. Pathophysiological consequences of deregulation of programmed cell death.
Different study models are presented, in order to introduce the importance of the contribution of biological diversity in the discovery of cellular and molecular mechanisms, as well as in the understanding of human pathologies.
The program offers a refresher of knowledge and an in-depth study of the major concepts and methodologies of cell biology, organized around different themes:
1. Cytoskeleton: Introduction to the different types of cytoskeleton. Polymerization properties of actin and tubulin. Proteins associated with the cytoskeleton and regulating polymerization. Molecular motors. Principles of cell migration.
2. Cellular Adhesion & Signaling: Cell-cell and extracellular cell-matrix adhesive structures, their molecular and dynamic organization. Functions and regulations during development and pathogenesis. Regulation by signaling channels. Mechanotransduction.
3. Addressing and cell traffic: Ubiquitination and proteasome. Addressing to subcellular compartments, endocytosis and secretion pathways. The molecular bases of vesicular transport, budding, fusion, molecular motors. Signaling in membrane trafficking, genetic diseases linked to trafficking and diversion by pathogens.
4. Cell cycle: Historical introduction. Molecular regulation of the cell cycle. The mitotic spindle, microtubule and molecular motor dynamics, chromosome attachment mechanisms, checkpoints, regulation of mitosis output and cytokinesis. Mitotic disorders associated with cancer cells.
5. Stem cells: cell differentiation, toti-, pluri-and multipotency, embryonic, adult and cancer stem cells.
6. Programmed cell death: Apoptosis, autophagy, necrosis. Stages and modalities of apoptosis, signaling pathways involved. Role in maintaining homeostasis. Physiopathological consequences of deregulation of programmed cell death.
Different study models are presented, in order to introduce the importance of the contribution of biological diversity in the discovery of cellular and molecular mechanisms, as well as in the understanding of human pathologies
Functional genomics
ECTS
5 credits
Component
Faculty of Science
The aim of this course is to introduce functional genomics technologies and to present examples of biological questions that can be asked using them.
This unit aims to present "omics" functional genomics technologies, and some biological questions that they can address.The lectures are given by both associate professors and researchers.
Introduction to functional genomics: approaches, concepts and methods
An introduction to functional Genomics: approaches, concepts and methods
V. Coulon, UM / IGMM
Genome organization / Organisation des génomes
Techniques de séquençage / DNA sequencing methodsL. Journot, IGF
3D genome organization J. Poli, UM / IGH
Genome topological organisation and replication-V. Coulon, UM / IGMM
Régulation spatio-temporelle de l'expression des génomes / Spatio-temporal regulation of gene expressionTranscriptionEpissage / Splicing-V. Coulon, UM / IGMM
Non-coding RNAsV. Coulon, UM / IGMM
Interactomics / InteractomiqueIan Robbins, UM / IGMM
Proteomics and Pharmacogenomics / Protéomique et pharmacogénomiqueC. Bécamel, UM / IGF
Animal Models / Modèles animaux
Using Mice in Functional Genomics F. Poulat, IGH
La Drosophile en génomique fonctionnelle / Using Drosophila in Functional Genomics -F. Juge and S. Chambeyron, IGH
Scientificarticles analysis and presentation(15min + 10 min discussion per group of 3 students)
Molecular basis of infectious diseases
Component
Faculty of Science
This UE is mainly composed of theoretical courses dealing with molecular aspects of infectious diseases (bacteriology, virology, parasitology)
Bacteriology: The nature of infectious agents. Methods of studying pathogenesis (in vivo in vitro, in silico and post-genomic study technologies) Strategies of pathogenic bacteria to survive in organisms: Bacterial adhesion to eukaryotic cells, antigenic variation and phase variation, invasion of non-phagocytic eukaryotic cells, mechanisms of resistance to phagocytosis, mechanisms of survival of bacteria in phagocytic cells, management of membrane permeability, bacterial secretion systems (type I, II, III, IV, V, and VI), mechanisms of iron acquisition, bacterial exotoxins, bacterial biofilms, examples of environmental regulations (Thermo-regulation, Quorum sensing...)).
Parasitology: Organization and cellular physiology of major pathogens in parasitic unicellular eukaryotes (invasion and modification of the host cell; metabolic characteristics and therapeutic targets); Genetics and molecular biology (genome organization, antigenic variation); Physiopathology and escape from the immune response
Virology: Molecular mechanisms of the viral cycle; Expression of viral genomes; Transformation by viruses; Viral replication strategy; Plasticity of viral genomes; Structural importance of viruses in host interaction;
Current research in immunology
ECTS
5 credits
Component
Faculty of Science
Teaching is done by teachers and/or researchers at the Faculties of Medicine, Sciences or Pharmacy, or at local research institutes.Course contents will be adapted to current scientific advances.
Teaching is organized in topics (lectures/tutorials, 4 to 5:30 hrs each);each includes an introduction and a seminar. In addition, for each topic, a group of students is in charge of presenting one or two recent scientific research articles.
Examples of subjects treated:
Immune adaptive responses, vaccination
Immune tolerance
Aging of the immune system
Metabolic regulation of the immune response
Immune response regulation by microbiota
Immune system-central nervous system interactions
Immunotherapy, therapeutic antibodies
The Unit is complemented by practical work by groups on a mini-research project that includes design of experiments, realization and analysis. Training is available in the use of flow cytometry data analysis software.results are presented orally to the entire class.
Statistics applied to biology
ECTS
5 credits
Component
Faculty of Medicine
Immunopathology
ECTS
5 credits
Component
Faculty of Science
The teaching is carried out by teacher-researchers from the UFRs of medicine, science and pharmacy. It is organized into 42 hours of classes and supervised work divided into 7 themes (see Syllabus) including 2 series of article presentations; the first series on articles proposed by the speakers of each theme. A second series on articles chosen by the students. The students organize a mini-colloquium at the end of the course where the articles are presented. They write short reports of these articles for the Medecine-Sciences magazine.
TER_FDS
ECTS
5 credits
Component
Faculty of Science
The aim of the TER course is to prepare the student to organize and carry out an in-depth bibliographical analysis in order to approach the internship with a knowledge of the state of the art in the field and to produce a relevant and well thought-out introduction to his experimental work.
Immune responses to pathogens
ECTS
5 credits
Component
Faculty of Science
Molecular and Cellular Virology
ECTS
5 credits
Component
Faculty of Science
Genetic information - Epigenetics - Mechanistic bases
ECTS
5 credits
Component
Faculty of Science
Signaling: Methods and Concepts
ECTS
5 credits
Component
Faculty of Science
Bioinformatics and System Biology
ECTS
5 credits
Component
Faculty of Science
Integrative Pathophysiology
ECTS
5 credits
Component
Faculty of Science
Molecular and Cellular Parasitology
ECTS
5 credits
Component
Faculty of Science
Fictional research project + TER (Infectio)
ECTS
10 credits
Component
Faculty of Science
Internship_FDS
ECTS
20 credits
Component
Faculty of Science
Internship of at least 4 months in a structure (research laboratory, company,...) in France or abroad.
Toxicological investigation
ECTS
5 credits
Component
Faculty of Pharmacy
Bootcamp
ECTS
5 credits
Component
Faculty of Science
The Bootcamp is an intensive course at the beginning of the first semester, before the start of the courses characterizing the tracks. Its purpose is to refresh and/or bring students up to speed on the basics of mathematics, physics, computer science and biology.
The course will be adapted according to the students recruited, in order to achieve a more homogeneous start to the course. Students will be immersed in different role-playing games divided into small groups. They will have to solve enigmas using their knowledge in biology, physics/mathematics, chemistry and programming, like in an escape game over several days.
Introduction to quantitative Biology
Component
Faculty of Science
This EU aims to provide a broad overview of emerging quantitative interdisciplinary fields in bioscience, ranging from advanced experimental techniques in microscopy and synthetic biology, to systems approaches.
In an innovative way, these methodological aspects will be presented in the context of biological and biophysical concepts such as robustness and optimality of biological systems, gene regulation and the fundamental principles underlying membrane and genome organization.
The main topics will be introduced first with traditional lectures and will be developed through individual or team projects where students will learn to apply specific techniques through examples, and see how these can be used to explore specific biological questions. These projects will involve literature reviews, use of existing code, or development of new code (depending on the student's experience) and will constitute half of the final assessment.
Neurobiology of behavior
ECTS
5 credits
Component
Faculty of Science
Behaviors, whether determined by conscious or unconscious processes, are based on complex neurobiological underpinnings, as they are underpinned by molecular and cellular modifications within the nervous system that modulate neural networks responsible for motor and emotional processes that are linked to the individual's memory. These processes are fundamental to allow the organism to elaborate an integrated behavioral response in close interaction with its environment, thus ensuring adaptation and survival of the individual and its species.
The topics covered in the Neurobiology of Behavior EU will include:
-Gene-Behavior
The relationship between genotype and phenotype -Impact of the environment -Attentional processes/Movement planning -Behavioral disorders (genetic and environmental aspects)
-Memory and synaptic plasticity
Methodological approaches to study synaptic plasticity: electrophysiology, optogenetics, animal models, behavioral tests-Regulatory factors of synaptic plasticity including genetics and epigenetics-Plasticity/memory relationship-Neurobiology of memory, forgetting and reconsolidation
-Neurobiology of emotions
Neurobiological substrates of emotions -Functions of emotions -Disadaptation: Pathological aspects: Emotional disorders
Molecular and metabolic bases of inherited diseases
ECTS
5 credits
Component
Faculty of Science
The program covers the important basic notions of gene organization and different levels of gene regulation, as well as the essential notions of human population genetics that play an important role as risk factors.The molecular mechanisms involved in monogenic or polyfactorial diseases are presented using specific examples. The module also provides an overview of the new technological tools available (pan-genomic techniques, high-throughput genotyping, etc.), which have led to major advances in this field, as well as the impact of this research on medical practice through the development of cell therapy, gene therapy and pharmacogenomics.
Introduction to the clinical research profession
ECTS
5 credits
Component
Faculty of Medicine
Physiology and Integrated Homeostasis
ECTS
5 credits
Component
Faculty of Science
Three main themes are addressed:
-Study of weight and thermal homeostasis in relation to a model of dysfunction: obesity. For this purpose, the energy balance with food intake and energy expenditure composed of basic metabolism, physical activity and adaptive thermogenesis (AT) and their respective regulation will be addressed.
-Study of biological rhythms, through the description of the nature and properties of biological rhythms (ultradian, circadian and infradian), the description of endogenous circadian oscillators, and the detailed presentation of the molecular mechanisms of circadian clocks.
-Study of the different stages and physiological principles of breathing. Theoretical lessons will be complemented by tutorials. The tutorials are based on document studies and the analysis of scientific articles in English. The choice of the various scientific supports aims at showing the interaction of the various approached topics and thus the concept of integrative physiology.
Functional exploration and translational research
ECTS
5 credits
Component
Faculty of Science
Neuromuscular physiology:
Striated skeletal muscle: The neuromuscular junction; Contraction/muscle release; Myotypology; Plasticity; Muscle metabolism.
Neuromuscular diseases:Causes; symptoms; clinical diagnosis (clinical examinations; laboratory tests): EMG, blood assays, functional tests, etc.; Muscular dystrophies: Duchenne myopathy; Becker's myopathy; facioscapiohumeral muscular dystrophy (FSHD).Facioscapiohumeral muscular dystrophy FSHD: zebrafish model; mouse model; cell models; clinical trials.
Respiratory physiology:
Respiratory physiology: Anatomy of the respiratory system; mechanism of respiration; gas exchange; transport of respiratory gases by the blood; regulation of respiration
Respiratory exploration in small animals: Why explore respiratory function in small animals? Plethysmography; in vitro contractile force.
Respiratory Functional Explorations: performance and interpretation of respiratory explorations in human pathology; spirometry: Level 1 and Level 2; pulmonary diffusion capacity; arterial blood gas; specific exploration of respiratory muscles; 6-minute walk test; exercise test; explorations with stay at altitude.
Cardiovascular physiology:
Reminder of the anatomy of the heart: size, location and orientation; envelope of the heart; tunics of the heart wall; chambers and large vessels of the heart; blood flow in the heart; heart valves; blood supply to the heart: coronary circulation; properties of the cardiac muscle tissue.
Reminder of the physiology of the heart: regulation of the basic rhythm; conduction system of the heart; modification of the basic rhythm: extrinsic innervation of the heart; electrocardiography; mechanical phenomena: cardiac revolution; cardiac output; regulation of the systolic volume; regulation of the heart rate.
Reminder of vascular physiology: anatomy of the circulatory system; lymphatic system; vascular wall structure; blood pressure; vascular smooth muscle and vasomotricity; endothelial function.
Vascular function and dysfunction; functional exploration: Arterial Distensibility Measurement; arterial wave velocity measurement; pharmacological exploration of endothelium-dependent vasomotricity; ultrasonographic exploration; echotracking; ultrasound and echodoppler.
How to evaluate vascular function experimentally?isolated artery ring model Cardiac Doppler: a fabulous tool in clinical and experimental research; Ultrasound: anatomical and functional analysis"; Doppler: flow analysis; Application to animal models.
Translational research: example myocardial ischemia-reperfusion (myocardial infarction); animal models; isolated perfused heart (Langendorf); isolated cardiomyocytes; cardioprotective techniques.
Endocrinology: weight balance
Description of eating behavior; Energy balance; Central structures regulating food intake; Mechanisms regulating food intake; Factors modulating appetite and food intake; Nutritional assessment; Eating disorders; Functional exploration: impedancemetry; DEXA (X-ray photon absorption); MRI; Assessment of expenditure: calorimetry.
Current research in immunology
ECTS
5 credits
Component
Faculty of Science
Teaching is done by teachers and/or researchers at the Faculties of Medicine, Sciences or Pharmacy, or at local research institutes.Course contents will be adapted to current scientific advances.
Teaching is organized in topics (lectures/tutorials, 4 to 5:30 hrs each);each includes an introduction and a seminar. In addition, for each topic, a group of students is in charge of presenting one or two recent scientific research articles.
Examples of subjects treated:
Immune adaptive responses, vaccination
Immune tolerance
Aging of the immune system
Metabolic regulation of the immune response
Immune response regulation by microbiota
Immune system-central nervous system interactions
Immunotherapy, therapeutic antibodies
The Unit is complemented by practical work by groups on a mini-research project that includes design of experiments, realization and analysis. Training is available in the use of flow cytometry data analysis software.results are presented orally to the entire class.
Statistics applied to biology
ECTS
5 credits
Component
Faculty of Medicine
Cellular biology
ECTS
5 credits
Component
Faculty of Science
The program offers a refresher course and an in-depth study of the major concepts and methodologies of cell biology, organized around different themes:
Cytoskeleton:Introduction to the different types of cytoskeleton. Polymerization properties of actin and tubulin. Proteins associated with the cytoskeleton and regulating polymerization. Molecular motors. Principles of cell migration.
Cellular Adhesion & Signaling: Adhesive structures cell-cell and cell-extracellular matrix, their molecular organization and dynamics. Functions and regulations during development and pathogenesis. Regulation by signaling pathways. Mechanotransduction.
3. addressing and cell trafficking: Ubiquitination and proteasome. Addressing to subcellular compartments, endocytosis and secretion pathways. Molecular basis of vesicular transport, budding, fusion, molecular motors. Signaling in membrane trafficking, genetic diseases related to trafficking and detour by pathogens.
4.cell cycle:Historical introduction. Molecular regulation of the cell cycle. Mitotic spindle, microtubule dynamics and molecular motors, chromosome attachment mechanisms, checkpoints, regulation of mitosis exit and cytokinesis. Mitotic disorders associated with cancer cells.
5. stem cells: cell differentiation, toti-, pluri- and multipotency, embryonic, adult and cancer stem cells
6. programmed cell death: apoptosis, autophagy, necrosis. Stages and modalities of apoptosis, signaling pathways involved. Role in the maintenance of homeostasis. Pathophysiological consequences of deregulation of programmed cell death.
Different study models are presented, in order to introduce the importance of the contribution of biological diversity in the discovery of cellular and molecular mechanisms, as well as in the understanding of human pathologies.
The program offers a refresher of knowledge and an in-depth study of the major concepts and methodologies of cell biology, organized around different themes:
1. Cytoskeleton: Introduction to the different types of cytoskeleton. Polymerization properties of actin and tubulin. Proteins associated with the cytoskeleton and regulating polymerization. Molecular motors. Principles of cell migration.
2. Cellular Adhesion & Signaling: Cell-cell and extracellular cell-matrix adhesive structures, their molecular and dynamic organization. Functions and regulations during development and pathogenesis. Regulation by signaling channels. Mechanotransduction.
3. Addressing and cell traffic: Ubiquitination and proteasome. Addressing to subcellular compartments, endocytosis and secretion pathways. The molecular bases of vesicular transport, budding, fusion, molecular motors. Signaling in membrane trafficking, genetic diseases linked to trafficking and diversion by pathogens.
4. Cell cycle: Historical introduction. Molecular regulation of the cell cycle. The mitotic spindle, microtubule and molecular motor dynamics, chromosome attachment mechanisms, checkpoints, regulation of mitosis output and cytokinesis. Mitotic disorders associated with cancer cells.
5. Stem cells: cell differentiation, toti-, pluri-and multipotency, embryonic, adult and cancer stem cells.
6. Programmed cell death: Apoptosis, autophagy, necrosis. Stages and modalities of apoptosis, signaling pathways involved. Role in maintaining homeostasis. Physiopathological consequences of deregulation of programmed cell death.
Different study models are presented, in order to introduce the importance of the contribution of biological diversity in the discovery of cellular and molecular mechanisms, as well as in the understanding of human pathologies
Cellular communications and signalling
ECTS
5 credits
Component
Faculty of Science
The main communication pathways between normal cells and intracellular transduction pathways, encountered in physiological and neurophysiological mechanisms, will be discussed, such as G protein coupled receptors (GPCRs), their structure, function and modulation by interacting proteins involved in the desensitization phenomenon. The main intracellular pathways activated by GPCRs will be discussed (MAPkinase, PI3kinase, etc...).
Secondly, an important part of the course will focus on calcium signaling and Ca2+ homeostasis; Ca2+ being a ubiquitous signal in cell signaling. Calcium homeostasis will be studied in particular during the response of lymphocytes after antigenic stimulation. Moreover, the production of oxygenated free radicals, at the origin of oxidative stress, is dependent on intracellular Ca2+. The physiological role of free radicals will be discussed, as well as their involvement in oxidative stress. In this context, the pathways of protection against oxidative stress will also be studied.The following chapter will address the endocannabinoid system which allows to recapitulate all the themes that will be evoked previously in the course. The endocannabinoid system is at the origin of multiple central and peripheral regulations.
Finally, two other themes will be addressed: the blood-brain barrier which allows to evoke the cellular communication in a very integrated way between two environments and the -pancreatic cell whose activity is crucial for the regulation of glycemia by the secretion of insulin.
Internship_FDS
ECTS
15 credits
Component
Faculty of Science
Two to four month internship in a structure (research laboratory, company, etc.) in France or abroad
Long internship or abroad
ECTS
5 credits
Component
Faculty of Science
Internship of more than 4 months in a structure (research laboratory, company,...) in France or abroad
Practical work in Physiology
ECTS
5 credits
Component
Faculty of Science
The physiology laboratory course allows to carry out recordings of cardiac action potential on the frog heart by the intracellular microelectrode technique. This is a qualitative and quantitative method of measuring the electrical activity of the heart muscle.
Cell culture
ECTS
5 credits
Component
Faculty of Science
Cell culture is a basic technique in the laboratory and is constantly evolving. It is important to know the basics of cell culture, which are often not well known, even though it is an essential methodology in research and also in industry.
Knowledge of the company and patent valuation
ECTS
5 credits
Component
Faculty of Science
You are a student of L3/M1 level in Languedoc-Roussillon? Would you like to work in small groups with students from other courses and in project mode, using a dormant scientific patent? To be accompanied and challenged by professional coaches of business creation? Register to PEPITE Patent Project to present a project of creation of innovative company based on the exploitation of a real patent provided by a local research team which will open its doors to you!
Why?
-Because you can create your own business whatever your field of study
To be selected by an incubator-type support structure
-To create a network in the field of entrepreneurship and innovation
PEPITE Patent Project, what is it? A Teaching Unit made up of strong times:
a 3-day "tool training" seminar
-regular meetings with the coaches
-Deliverables to be submitted: summary note, market study, business plan
a 10-minute final pitch to present your innovative company
TER_FDS
ECTS
5 credits
Component
Faculty of Science
The aim of the TER course is to prepare the student to organize and carry out an in-depth bibliographical analysis in order to approach the internship with a knowledge of the state of the art in the field and to produce a relevant and well thought-out introduction to his experimental work.
Muscular and cardiac physiopathology
ECTS
5 credits
Component
Faculty of Science
Genetic information - Epigenetics - Mechanistic bases
ECTS
5 credits
Component
Faculty of Science
Signaling: Methods and Concepts
ECTS
5 credits
Component
Faculty of Science
Bioinformatics and System Biology
ECTS
5 credits
Component
Faculty of Science
Integrative Pathophysiology
ECTS
5 credits
Component
Faculty of Science
Gene and cell therapy
ECTS
5 credits
Component
Faculty of Medicine
Hourly volume
30h
Human nutrition (EU PHARMA)
ECTS
5 credits
Component
Faculty of Science
Fictitious research project_FDS
ECTS
10 credits
Component
Faculty of Science
Internship_FDS
ECTS
20 credits
Component
Faculty of Science
Internship of at least 4 months in a structure (research laboratory, company,...) in France or abroad.
Neurobiology of behavior
ECTS
5 credits
Component
Faculty of Science
Behaviors, whether determined by conscious or unconscious processes, are based on complex neurobiological underpinnings, as they are underpinned by molecular and cellular modifications within the nervous system that modulate neural networks responsible for motor and emotional processes that are linked to the individual's memory. These processes are fundamental to allow the organism to elaborate an integrated behavioral response in close interaction with its environment, thus ensuring adaptation and survival of the individual and its species.
The topics covered in the Neurobiology of Behavior EU will include:
-Gene-Behavior
The relationship between genotype and phenotype -Impact of the environment -Attentional processes/Movement planning -Behavioral disorders (genetic and environmental aspects)
-Memory and synaptic plasticity
Methodological approaches to study synaptic plasticity: electrophysiology, optogenetics, animal models, behavioral tests-Regulatory factors of synaptic plasticity including genetics and epigenetics-Plasticity/memory relationship-Neurobiology of memory, forgetting and reconsolidation
-Neurobiology of emotions
Neurobiological substrates of emotions -Functions of emotions -Disadaptation: Pathological aspects: Emotional disorders
Neuropsychopharmacology
ECTS
5 credits
Component
Faculty of Science
The neuropsychopharmacology course deals with the molecular, cellular and integrated mechanisms underlying the mode of action of psychotropic drugs, using a few pathologies as examples (depression, schizophrenia, anxiety, ....). It aims to understand how the principles of pharmacology are specifically declined in the context of psychological disorders (e.g. pharmacodynamics, tolerance, physical and psychic dependence,...). Based on the advances in neurobiology research and their therapeutic applications in medication, the course aims to understand the concepts underlying the treatment of psychiatric disorders.
Developmental neurobiology
ECTS
5 credits
Component
Faculty of Science
1) What is the genetic program underlying the development of the nervous system? This course highlights the type of decisions that progressively specify the neural fate of cells and ensure their nervous function. The different steps considered are:
(i) the genesis of the nervous system
(ii) the specification of neurons
(iii) nerve function: axonal guidance and connectivity
(iv) neuronal remodeling
2) What are the molecular, cellular, and environmental interactions that control nervous system development?
-Synaptogenesis and major developmental milestones.
-Roles of neurotrophic factors
-Roles of electrical activity
-Critical periods
-Roles of neuron-glial cell interactions.
-Neuronal stem cells
3) Developmental pathologies
Current research in immunology
ECTS
5 credits
Component
Faculty of Science
Teaching is done by teachers and/or researchers at the Faculties of Medicine, Sciences or Pharmacy, or at local research institutes.Course contents will be adapted to current scientific advances.
Teaching is organized in topics (lectures/tutorials, 4 to 5:30 hrs each);each includes an introduction and a seminar. In addition, for each topic, a group of students is in charge of presenting one or two recent scientific research articles.
Examples of subjects treated:
Immune adaptive responses, vaccination
Immune tolerance
Aging of the immune system
Metabolic regulation of the immune response
Immune response regulation by microbiota
Immune system-central nervous system interactions
Immunotherapy, therapeutic antibodies
The Unit is complemented by practical work by groups on a mini-research project that includes design of experiments, realization and analysis. Training is available in the use of flow cytometry data analysis software.results are presented orally to the entire class.
Statistics applied to biology
ECTS
5 credits
Component
Faculty of Medicine
Cellular biology
ECTS
5 credits
Component
Faculty of Science
The program offers a refresher course and an in-depth study of the major concepts and methodologies of cell biology, organized around different themes:
Cytoskeleton:Introduction to the different types of cytoskeleton. Polymerization properties of actin and tubulin. Proteins associated with the cytoskeleton and regulating polymerization. Molecular motors. Principles of cell migration.
Cellular Adhesion & Signaling: Adhesive structures cell-cell and cell-extracellular matrix, their molecular organization and dynamics. Functions and regulations during development and pathogenesis. Regulation by signaling pathways. Mechanotransduction.
3. addressing and cell trafficking: Ubiquitination and proteasome. Addressing to subcellular compartments, endocytosis and secretion pathways. Molecular basis of vesicular transport, budding, fusion, molecular motors. Signaling in membrane trafficking, genetic diseases related to trafficking and detour by pathogens.
4.cell cycle:Historical introduction. Molecular regulation of the cell cycle. Mitotic spindle, microtubule dynamics and molecular motors, chromosome attachment mechanisms, checkpoints, regulation of mitosis exit and cytokinesis. Mitotic disorders associated with cancer cells.
5. stem cells: cell differentiation, toti-, pluri- and multipotency, embryonic, adult and cancer stem cells
6. programmed cell death: apoptosis, autophagy, necrosis. Stages and modalities of apoptosis, signaling pathways involved. Role in the maintenance of homeostasis. Pathophysiological consequences of deregulation of programmed cell death.
Different study models are presented, in order to introduce the importance of the contribution of biological diversity in the discovery of cellular and molecular mechanisms, as well as in the understanding of human pathologies.
The program offers a refresher of knowledge and an in-depth study of the major concepts and methodologies of cell biology, organized around different themes:
1. Cytoskeleton: Introduction to the different types of cytoskeleton. Polymerization properties of actin and tubulin. Proteins associated with the cytoskeleton and regulating polymerization. Molecular motors. Principles of cell migration.
2. Cellular Adhesion & Signaling: Cell-cell and extracellular cell-matrix adhesive structures, their molecular and dynamic organization. Functions and regulations during development and pathogenesis. Regulation by signaling channels. Mechanotransduction.
3. Addressing and cell traffic: Ubiquitination and proteasome. Addressing to subcellular compartments, endocytosis and secretion pathways. The molecular bases of vesicular transport, budding, fusion, molecular motors. Signaling in membrane trafficking, genetic diseases linked to trafficking and diversion by pathogens.
4. Cell cycle: Historical introduction. Molecular regulation of the cell cycle. The mitotic spindle, microtubule and molecular motor dynamics, chromosome attachment mechanisms, checkpoints, regulation of mitosis output and cytokinesis. Mitotic disorders associated with cancer cells.
5. Stem cells: cell differentiation, toti-, pluri-and multipotency, embryonic, adult and cancer stem cells.
6. Programmed cell death: Apoptosis, autophagy, necrosis. Stages and modalities of apoptosis, signaling pathways involved. Role in maintaining homeostasis. Physiopathological consequences of deregulation of programmed cell death.
Different study models are presented, in order to introduce the importance of the contribution of biological diversity in the discovery of cellular and molecular mechanisms, as well as in the understanding of human pathologies
Cellular communications and signalling
ECTS
5 credits
Component
Faculty of Science
The main communication pathways between normal cells and intracellular transduction pathways, encountered in physiological and neurophysiological mechanisms, will be discussed, such as G protein coupled receptors (GPCRs), their structure, function and modulation by interacting proteins involved in the desensitization phenomenon. The main intracellular pathways activated by GPCRs will be discussed (MAPkinase, PI3kinase, etc...).
Secondly, an important part of the course will focus on calcium signaling and Ca2+ homeostasis; Ca2+ being a ubiquitous signal in cell signaling. Calcium homeostasis will be studied in particular during the response of lymphocytes after antigenic stimulation. Moreover, the production of oxygenated free radicals, at the origin of oxidative stress, is dependent on intracellular Ca2+. The physiological role of free radicals will be discussed, as well as their involvement in oxidative stress. In this context, the pathways of protection against oxidative stress will also be studied.The following chapter will address the endocannabinoid system which allows to recapitulate all the themes that will be evoked previously in the course. The endocannabinoid system is at the origin of multiple central and peripheral regulations.
Finally, two other themes will be addressed: the blood-brain barrier which allows to evoke the cellular communication in a very integrated way between two environments and the -pancreatic cell whose activity is crucial for the regulation of glycemia by the secretion of insulin.
Functional genomics
ECTS
5 credits
Component
Faculty of Science
The aim of this course is to introduce functional genomics technologies and to present examples of biological questions that can be asked using them.
This unit aims to present "omics" functional genomics technologies, and some biological questions that they can address.The lectures are given by both associate professors and researchers.
Introduction to functional genomics: approaches, concepts and methods
An introduction to functional Genomics: approaches, concepts and methods
V. Coulon, UM / IGMM
Genome organization / Organisation des génomes
Techniques de séquençage / DNA sequencing methodsL. Journot, IGF
3D genome organization J. Poli, UM / IGH
Genome topological organisation and replication-V. Coulon, UM / IGMM
Régulation spatio-temporelle de l'expression des génomes / Spatio-temporal regulation of gene expressionTranscriptionEpissage / Splicing-V. Coulon, UM / IGMM
Non-coding RNAsV. Coulon, UM / IGMM
Interactomics / InteractomiqueIan Robbins, UM / IGMM
Proteomics and Pharmacogenomics / Protéomique et pharmacogénomiqueC. Bécamel, UM / IGF
Animal Models / Modèles animaux
Using Mice in Functional Genomics F. Poulat, IGH
La Drosophile en génomique fonctionnelle / Using Drosophila in Functional Genomics -F. Juge and S. Chambeyron, IGH
Scientificarticles analysis and presentation(15min + 10 min discussion per group of 3 students)
Internship_FDS
ECTS
15 credits
Component
Faculty of Science
Two to four month internship in a structure (research laboratory, company, etc.) in France or abroad
Long internship or abroad
ECTS
5 credits
Component
Faculty of Science
Internship of more than 4 months in a structure (research laboratory, company,...) in France or abroad
Immunopathology
ECTS
5 credits
Component
Faculty of Science
The teaching is carried out by teacher-researchers from the UFRs of medicine, science and pharmacy. It is organized into 42 hours of classes and supervised work divided into 7 themes (see Syllabus) including 2 series of article presentations; the first series on articles proposed by the speakers of each theme. A second series on articles chosen by the students. The students organize a mini-colloquium at the end of the course where the articles are presented. They write short reports of these articles for the Medecine-Sciences magazine.
Practical work in Physiology
ECTS
5 credits
Component
Faculty of Science
The physiology laboratory course allows to carry out recordings of cardiac action potential on the frog heart by the intracellular microelectrode technique. This is a qualitative and quantitative method of measuring the electrical activity of the heart muscle.
Sensoriality
ECTS
5 credits
Component
Faculty of Pharmacy
Hourly volume
50h
TER_FDS
ECTS
5 credits
Component
Faculty of Science
The aim of the TER course is to prepare the student to organize and carry out an in-depth bibliographical analysis in order to approach the internship with a knowledge of the state of the art in the field and to produce a relevant and well thought-out introduction to his experimental work.
Integrated Neuropathology
ECTS
5 credits
Component
Faculty of Science
From the molecule to the cell
ECTS
5 credits
Component
Faculty of Science
Genetic information - Epigenetics - Mechanistic bases
ECTS
5 credits
Component
Faculty of Science
Signaling: Methods and Concepts
ECTS
5 credits
Component
Faculty of Science
Bioinformatics and System Biology
ECTS
5 credits
Component
Faculty of Science
Integrative Pathophysiology
ECTS
5 credits
Component
Faculty of Science
Fictitious research project_FDS
ECTS
10 credits
Component
Faculty of Science
Internship_FDS
ECTS
20 credits
Component
Faculty of Science
Internship of at least 4 months in a structure (research laboratory, company,...) in France or abroad.
Functional genomics
ECTS
5 credits
Component
Faculty of Science
The aim of this course is to introduce functional genomics technologies and to present examples of biological questions that can be asked using them.
This unit aims to present "omics" functional genomics technologies, and some biological questions that they can address.The lectures are given by both associate professors and researchers.
Introduction to functional genomics: approaches, concepts and methods
An introduction to functional Genomics: approaches, concepts and methods
V. Coulon, UM / IGMM
Genome organization / Organisation des génomes
Techniques de séquençage / DNA sequencing methodsL. Journot, IGF
3D genome organization J. Poli, UM / IGH
Genome topological organisation and replication-V. Coulon, UM / IGMM
Régulation spatio-temporelle de l'expression des génomes / Spatio-temporal regulation of gene expressionTranscriptionEpissage / Splicing-V. Coulon, UM / IGMM
Non-coding RNAsV. Coulon, UM / IGMM
Interactomics / InteractomiqueIan Robbins, UM / IGMM
Proteomics and Pharmacogenomics / Protéomique et pharmacogénomiqueC. Bécamel, UM / IGF
Animal Models / Modèles animaux
Using Mice in Functional Genomics F. Poulat, IGH
La Drosophile en génomique fonctionnelle / Using Drosophila in Functional Genomics -F. Juge and S. Chambeyron, IGH
Scientificarticles analysis and presentation(15min + 10 min discussion per group of 3 students)
CHOICE 1 Semester 1 M2 Dynameid
ECTS
2.5 credits
Component
Faculty of Pharmacy
Advanced Spatial Analysis
ECTS
2.5 credits
Component
Faculty of Pharmacy
Host pathogen interactions
ECTS
2.5 credits
Component
Faculty of Pharmacy
Computer modeling and databases
ECTS
5 credits
Component
Faculty of Pharmacy
International regulation and society
ECTS
2.5 credits
Component
Faculty of Pharmacy
CHOICE 2 Semester 1 M2 Dynameid
ECTS
2.5 credits
Component
Faculty of Pharmacy
Microbial genomics and metabolic diversity
ECTS
2.5 credits
Component
Faculty of Pharmacy
New generations of diagnostic technologies
ECTS
2.5 credits
Component
Faculty of Pharmacy
Integrated approach in Infectiology II
ECTS
5 credits
Component
Faculty of Pharmacy
Emerging diseases II
ECTS
2.5 credits
Component
Faculty of Pharmacy