Bioprocess engineering - Batch

Within biotechnology, bioprocesses correspond to the industrial application of living tools (whether enzymes, microorganisms or cells from higher organisms) for the synthesis of products of interest. This teaching unit will focus on the use of microbial and cellular catalysts. Products of interest may be, for example, fermented foods (wine, beer, etc.), energy molecules (bioethanol, methane, etc.), chemical intermediates, or biomedicines (vaccines, monoclonal antibodies, growth factors, etc.). The knowledge, know-how and skills acquired in this course can be transposed to any sector of biotechnology activity. The examples given will correspond to the outlets targeted by the two courses (Agrosciences and Health).

The course will focus on bioprocesses and the environment in which the biological reaction will be controlled (the bioreactor). The course will also cover the description and modeling of a biological reaction, with a presentation of the approach applied in bioprocess engineering. The remainder of the course will be devoted to the application of this approach to batch reactors. Other operating modes will be covered in the M2 course HAV930V "Bioprocess engineering - continuous and fed-batch".

This course includes interactive lectures, tutorials and practical exercises (practical work in the computer room + personal project work in small groups).

Given the importance of the interaction between biology and engineering sciences in biomanufacturing, this course will introduce students to the vocabulary used in biomanufacturing and the parameters that are important on an industrial scale. As a result, students will be able to interact effectively with the various players involved in bioproduction, whether engineers or biologists, in R&D or production, etc.

At the end of this course, students will have acquired basic knowledge of bioprocesses (understanding and implementation of a biological reaction, applied bioprocess engineering approach), bioreactors, different operating modes, choice of operating mode, modeling of a biological reaction.

Students will also have acquired the bioprocess engineering approach (applied in M1 to the BATCH operating mode) applicable to any bioprocess, including mastery of the following three points:

-Processing of experimental data (calculation of yields, net speeds, specific speeds, etc.) using standard business tools (Excel spreadsheet or free equivalent), interpretation of results obtained.

-Structuring the data obtained in the form of models

-Based on the information obtained (from experiments or bibliography), simulate/plan a crop/production (i.e. size a simple batch process).

By the end of this course, students will also be able to write an activity report. For this writing, they will have been made aware of the aspects of communication and synthesis (choice of relevant information, choice of ways of representing information in line with the message, etc.).

Basics of microbiology, metabolism and cell biology (L3 biology degree or eq. level)Basics of differential and integral calculus (high school level: 1st general and technological mathematics program, applications in common scientific teaching...)

Recommended prerequisites :

Knowledge of catalyst metabolism, applied to bioproduction, is essential. This course is therefore closely linked with course HAV812V "Bioprocess Engineering - Metabolism and Bioproduction" for the M1 Biology-Health / IBIS, and with course HAA710V "Biological Catalysis and Microbiology" for the M1 Biology-Agrosciences / ICOA.

Assessment of knowledge is based on continuous assessment (CCI) (personal assignments, practical work and final test).