CHOICE 2

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The Bootcamp is an intensive course at the beginning of the first semester, before the start of the courses characterizing the tracks. Its purpose is to refresh and/or bring students up to speed on the basics of mathematics, physics, computer science and biology.

The course will be adapted according to the students recruited, in order to achieve a more homogeneous start to the course. Students will be immersed in different role-playing games divided into small groups. They will have to solve enigmas using their knowledge in biology, physics/mathematics, chemistry and programming, like in an escape game over several days.

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This EU aims to provide a broad overview of emerging quantitative interdisciplinary fields in bioscience, ranging from advanced experimental techniques in microscopy and synthetic biology, to systems approaches.

In an innovative way, these methodological aspects will be presented in the context of biological and biophysical concepts such as robustness and optimality of biological systems, gene regulation and the fundamental principles underlying membrane and genome organization.

The main topics will be introduced first with traditional lectures and will be developed through individual or team projects where students will learn to apply specific techniques through examples, and see how these can be used to explore specific biological questions. These projects will involve literature reviews, use of existing code, or development of new code (depending on the student's experience) and will constitute half of the final assessment.

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Behaviors, whether determined by conscious or unconscious processes, are based on complex neurobiological underpinnings, as they are underpinned by molecular and cellular modifications within the nervous system that modulate neural networks responsible for motor and emotional processes that are linked to the individual's memory. These processes are fundamental to allow the organism to elaborate an integrated behavioral response in close interaction with its environment, thus ensuring adaptation and survival of the individual and its species.

The topics covered in the Neurobiology of Behavior EU will include:

-Gene-Behavior

The relationship between genotype and phenotype -Impact of the environment -Attentional processes/Movement planning -Behavioral disorders (genetic and environmental aspects)

-Memory and synaptic plasticity

Methodological approaches to study synaptic plasticity: electrophysiology, optogenetics, animal models, behavioral tests-Regulatory factors of synaptic plasticity including genetics and epigenetics-Plasticity/memory relationship-Neurobiology of memory, forgetting and reconsolidation

-Neurobiology of emotions

Neurobiological substrates of emotions -Functions of emotions -Disadaptation: Pathological aspects: Emotional disorders

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The program covers the important basic notions of gene organization and different levels of gene regulation, as well as the essential notions of human population genetics that play an important role as risk factors.The molecular mechanisms involved in monogenic or polyfactorial diseases are presented using specific examples. The module also provides an overview of the new technological tools available (pan-genomic techniques, high-throughput genotyping, etc.), which have led to major advances in this field, as well as the impact of this research on medical practice through the development of cell therapy, gene therapy and pharmacogenomics.

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