ECTS
120 credits
Duration
2 years
Training structure
Faculty of Pharmacy, Faculty of Science
Language(s) of instruction
French
Presentation
This course lies at the interface between chemistry and biology, and is aimed at students in the biological sciences, the health sector or ENSCM. Based on structural, molecular and cellular biology, this course provides theoretical and methodological training in drug design and rational innovation, as well as nanotechnologies for vectorization and targeting. Training in pharmacokinetics, toxicological investigation and therapeutic pharmacology then enables students to understand the fate of a molecule within the body.
Objectives
The internships affiliated with the Master II program enable students to go on to complete a thesis at a French or international university in the field of the chemistry-biology interface. The Translational Medicinal Chemistry program helps train professionals for the pharmaceutical, cosmetics, agri-food and biotech industries.
Program
Select a program
Master 1Translational Medicinal Chemistry
Master 1 Translational Medicinal Chemistry
Toxicological investigation
5 creditsCell Biology
5 creditsS1 elective courses
Choice of 3 from 13
Functional genomics
5 creditsStructural Biology
5 creditsCellular pathophysiology and cancer
5 creditsDevelopmental genetics
5 creditsNeurobiology of behavior
5 creditsNeuropsychopharmacology
5 creditsMolecular basis of infectious diseases
Developmental neurobiology
5 creditsCurrent research in immunology
5 creditsFunctional exploration and translational research
5 creditsMolecular pharmacology and therapeutics
5 creditsMolecular and metabolic bases of hereditary diseases
5 creditsStatistics applied to biology
5 credits
Cellular communications and signalling
5 credits
TER FDP
5 creditsUE Semestre 2 elective
5 creditsYour choice: 1 of 7
Long-term internship or abroad
5 creditsPractical work in Physiology
5 creditsPractical analysis of genomics data in R
5 creditsCell culture
5 creditsCorporate knowledge and patent valuation
5 creditsImmunopathology
5 creditsMedical genetics and genetic counseling
5 credits
FDP internship
15 creditsEnglish
Master 2 Translational Medicinal Chemistry
This course lies at the interface between chemistry and biology, and is aimed at students from the biological sciences, the health sector or ENSCM. It will develop interdisciplinary skills to meet the needs of research and innovation in the fields of health, biotechnology, cosmetics and agri-food.
From target to drug
5 creditsTER FDP
5 creditsPharmacokinetics and Toxicology
5 creditsSemester 1 Elective UE
Choice of 2 out of 5
Nanotechnologies and multifunctional systems for therapy
FPD Internship
20 creditsFictional research project_FDP
10 credits
Toxicological investigation
ECTS
5 credits
Component
Faculty of Pharmacy
Cell Biology
ECTS
5 credits
Component
Faculty of Science
The program offers a refresher course and an in-depth study of the major concepts and methodologies of cell biology, organized around different themes:
1 Cytoskeleton:Introduction to the different types of cytoskeleton. Polymerization properties of actin and tubulin. Proteins associated with the cytoskeleton and regulating polymerization. Molecular motors. Principles of cell migration.
2.cell adhesion & signaling: cell-cell and cell-extracellular matrix adhesive structures, their molecular organization and dynamics. Functions and regulation during development and pathogenesis. Regulation by signaling pathways. Mechanotransduction.
3 Addressing and cell trafficking: Ubiquitination and proteasome. Addressing to subcellular compartments, endocytosis and secretion pathways. Molecular basis of vesicular transport, budding, fusion, molecular motors. Signaling in membrane trafficking, trafficking-related genetic diseases and pathogen detour.
4 Cell cycle: Historical introduction. Molecular regulation of the cell cycle. The mitotic spindle, microtubule dynamics and molecular motors, chromosome attachment mechanisms, checkpoints, regulation of mitosis exit and cytokinesis. Mitotic disorders associated with cancer cells.
5 Stem cells: cell differentiation, toti-, pluri- and multipotency, embryonic, adult and cancer stem cells.
6 Programmed cell death: Apoptosis, autophagy, necrosis. Stages and modalities of apoptosis, signaling pathways involved. Role in maintaining homeostasis. Pathophysiological consequences of deregulation of programmed cell death.
Different study models are presented, to introduce the importance of the contribution of biological diversity to the discovery of cellular and molecular mechanisms, and to the understanding of human pathologies.
The program offers a refresher of knowledge and an in-depth study of the major concepts and methodologies of cell biology, organized around different themes:
1. Cytoskeleton: Introduction to the different types of cytoskeleton. Polymerization properties of actin and tubulin. Proteins associated with the cytoskeleton and regulating polymerization. Molecular motors. Principles of cell migration.
2. Cellular Adhesion & Signaling: Cell-cell and extracellular cell-matrix adhesive structures, their molecular and dynamic organization. Functions and regulations during development and pathogenesis. Regulation by signaling channels. Mechanotransduction.
3. Addressing and cell traffic: Ubiquitination and proteasome. Addressing to subcellular compartments, endocytosis and secretion pathways. The molecular bases of vesicular transport, budding, fusion, molecular motors. Signaling in membrane trafficking, genetic diseases linked to trafficking and diversion by pathogens.
4. Cell cycle: Historical introduction. Molecular regulation of the cell cycle. The mitotic spindle, microtubule and molecular motor dynamics, chromosome attachment mechanisms, checkpoints, regulation of mitosis output and cytokinesis. Mitotic disorders associated with cancer cells.
5. Stem cells: cell differentiation, toti-, pluri-and multipotency, embryonic, adult and cancer stem cells.
6. Programmed cell death: Apoptosis, autophagy, necrosis. Stages and modalities of apoptosis, signaling pathways involved. Role in maintaining homeostasis. Physiopathological consequences of deregulation of programmed cell death.
Different study models are presented, in order to introduce the importance of the contribution of biological diversity in the discovery of cellular and molecular mechanisms, as well as in the understanding of human pathologies.
Functional genomics
ECTS
5 credits
Component
Faculty of Science
The aim of this course is to introduce functional genomics technologies in -omics, and to present examples of biological questions that can be answered using these technologies.
This unit aims to present "omics" functional genomics technologies, and some biological questions that they can address.The lectures are given by both associate professors and researchers.
Introduction to functional genomics: approaches, concepts and methods
An introduction to functional Genomics: approaches, concepts and methods
V. Coulon, UM / IGMM
Organisation des génomes / Genome organization
Techniques de séquençage / DNA sequencing methodsL. Journot, IGF
Organisation 3D des génomes / 3D genome organisation J. Poli, UM / IGH
Genome topological organization and replication / Organisation topologique et réplication des génomes-V. Coulon, UM / IGMM
Régulation spatio-temporelle de l'expression des génomes / Spatio-temporal regulation of gene expressionTranscriptionEpissage / Splicing-V. Coulon, UM / IGMM
ARN non-codants / non-coding RNAsV. Coulon, UM / IGMM
Interactomique / InteractomicsIan Robbins, UM / IGMM
Proteomics and Pharmacogenomics / Protéomique et pharmacogénomiqueC. Bécamel, UM / IGF
Animal Models / Modèles animaux
Using Mice in Functional Genomics / Utilisation de la souris en génomique fonctionnelle F. Poulat, IGH
La Drosophile en génomique fonctionnelle / Using Drosophila in Functional Genomics -F. Juge and S. Chambeyron, IGH
Analyse et présentation d'articles scientifiques/ Scientificarticles analysis and presentation(15min + 10 min discussion per group of 3 students)
Cellular pathophysiology and cancer
ECTS
5 credits
Component
Faculty of Science
The aim of the "Cellular Physiopathology and Cancer" course is to provide students with the knowledge they need to follow the "Cancer Biology" pathway in M2. The course is organized in the form of a lecture, with an introductory section followed by a section on current laboratory research. Students are required to present a scientific article orally (usually in pairs).
The aim of the cellular pathophysiology and cancer teaching unit is to provide the scientific background necessary to follow the cancer biology M2 program.Each lecture is organized as a conference starting with a general introduction of the field and followed by a more specialized emphasis on research done in laboratories. Students have to prepare an oral presentation based on the analysis of a scientific article (generally in pair).
Developmental genetics
ECTS
5 credits
Component
Faculty of Science
-A general introduction to Developmental Biology
How do cells build a multicellular animal organism from a single genome? Genotype/phenotype relationship.
-Genetic analysis reminders
Nature of mutations (loss-of-function; gain-of-function), notion of "master gene", clonal analysis (generation of somatic or germinal clones), notion of cell autonomy....
-Genetic models and methods.
Study of regulatory regions, establishment of transgenic lines, enhancer trap, reporter genes (GFP, mCherry...), model organisms (drosophila, c.elegans, mouse...).Use of FLP/FRT, CRE-LOX, UAS-GAL4-GAL80, AttpP/B-PhiC31, CRISPR systems etc.
-Positional information, maternal effect genes and the establishment of asymmetry.
Models and mechanisms of positional information =induction, Spemann and Mangold experiment, organizing centers, notion of morphogen in invertebrates and vertebrates
-Establishment of axes: antero-posterior, dorso-ventral.
Cell communication and signalling pathways: in the establishment of the dorso-ventral axis, in limb formation, in the establishment of cell fate (some examples: Nervous system: lateral inhibition processes ...).
-Segmentation: gap, pair rule and segment polarity genes.
Segmentation in invertebrates and somitogenesis in vertebrates, dynamic aspects (establishment and maintenance).
-Signaling and transcriptional networks
Transcriptional regulation during development, regulatory sequences during evolution, the concept of gene networks. Transcriptional coupling and signaling pathways in cell fate
-Epigenetic memory of transcriptional programs:
Hox homeotic genes and segmental identity.Evo-Devo concepts.Polycomb and Trithorax complexes.
Involvement of epigenetic mechanisms in cell differentiation
Neurobiology of behavior
ECTS
5 credits
Component
Faculty of Science
Behaviors, whether determined by conscious or unconscious processes, are based on complex neurobiological underpinnings: they are underpinned by molecular and cellular modifications within the nervous system, modulating neural networks at the origin of motor and emotional processes that are linked to the individual's memory. These processes are fundamental in enabling the organism to develop an integrated behavioral response in close interaction with its environment, ensuring adaptation and survival for the individual and its species.
The topics covered in the Neurobiology of Behavior course are as follows:
-Gene-behavior
The relationship between genotype and phenotype -Impact of the environment -Attentional processes/Movement planning -Behavioral disorders (genetic and environmental aspects)
-Memory and synaptic plasticity
Methodological approaches to studying synaptic plasticity: electrophysiology, optogenetics, animal models, behavioral tests-Factors regulating synaptic plasticity, including genetics and epigenetics-Plasticity/memory relationship-Neurobiology of memory, forgetting and reconsolidation
-Neurobiology of emotions
Neurobiological substrates of emotions -Emotional functions -Disadaptation: Pathological aspects: Emotional disorders
Neuropsychopharmacology
ECTS
5 credits
Component
Faculty of Science
The Neuropsychopharmacology UE covers the molecular, cellular and integrated mechanisms underlying the mode of action of psychotropic drugs, using a number of pathologies as examples (depression, schizophrenia, anxiety, ....). The aim is to understand how the principles of pharmacology are specifically applied to mental disorders (e.g. pharmacodynamics, tolerance, physical and psychological dependence, etc.). Based on advances in neurobiological research and their application to drug therapy, the course aims to understand the concepts underlying the treatment of psychiatric disorders.
Molecular basis of infectious diseases
Component
Faculty of Science
This UE consists mainly of theoretical courses dealing with the molecular aspects of infectious diseases (bacteriology, virology, parasitology).
Bacteriology: The nature of infectious agents. Methods for studying pathogenesis (in vivo, in vitro, in silico and post-genomic study technologies) Strategies of pathogenic bacteria to survive in organisms: Bacterial adhesion to eukaryotic cells, antigenic variation and phase variation, invasion of non-phagocytic eukaryotic cells, mechanisms of resistance to phagocytosis, mechanisms of bacterial survival in phagocytic cells, membrane permeability management, bacterial secretion systems (types I, II, III, IV, V and VI), iron acquisition mechanisms, bacterial exotoxins, bacterial biofilms, examples of environmental regulation (thermoregulation, quorum sensing, etc.).).
Parasitology: Organization and cellular physiology of major pathogens in unicellular eukaryotic parasites (invasion and modification of the host cell; metabolic particularities and therapeutic targets); Genetics and molecular biology (genome organization, antigenic variation); Physiopathology and escape from the immune response.
Virology: Molecular mechanisms of the viral cycle; Expression of viral genomes; Transformation by viruses; Viral replication strategy; Plasticity of viral genomes; Structural importance of viruses in host interaction;
Developmental neurobiology
ECTS
5 credits
Component
Faculty of Science
1) What is the genetic program underlying the development of the nervous system? This course highlights the type of decisions that gradually determine the neural destiny of cells and ensure their nervous function. The different stages considered are:
(i)the genesis of the nervous system
(ii)neuron specification
(iii)nerve function: axonal guidance and connectivity
(iv)neuronal remodeling
2) What molecular, cellular and environmental interactions control the development of the nervous system?
-Synaptogenesis and the major stages of development.
-The role of neurotrophic factors
-The role of electrical activity
-Critical periods
-The role of neuron-glial cell interactions.
-Neural stem cells
3) Developmental pathologies
Current research in immunology
ECTS
5 credits
Component
Faculty of Science
Teaching is done by teachers and/or researchers at the Faculties of Medicine, Sciences or Pharmacy, or at local research institutes.Course contents will be adapted to current scientific advances.
Teaching is organized in topics (lectures/tutorials, 4 to 5:30 hrs each);each includes an introduction and a seminar. In addition, for each topic, a group of students is in charge of presenting one or two recent scientific research articles.
Examples of subjects treated:
Immune adaptive responses, vaccination
Immune tolerance
Aging of the immune system
Metabolic regulation of the immune response
Immune response regulation by microbiota
Immune system-central nervous system interactions
Immunotherapy, therapeutic antibodies
The Unit is complemented by practical work by groups on a mini-research project that includes design of experiments, realization and analysis. Training is available in the use of flow cytometry data analysis software.Results are presented orally to the entire class.
Functional exploration and translational research
ECTS
5 credits
Component
Faculty of Science
Neuromuscular physiology:
Striated skeletal muscle: The neuromuscular junction; Muscle contraction/release; Myotypology; Plasticity; Muscle metabolism.
Neuromuscular diseases:Causes; symptoms; clinical diagnosis (clinical examinations; laboratory tests): EMG, blood assays, functional tests, etc.; muscular dystrophies: Duchenne myopathy; Becker myopathy; facioscapiohumeral muscular dystrophy (FSHD).FSHD facioscapiohumeral muscular dystrophy: zebrafish model; mouse model; cell models; clinical trials.
Respiratory physiology:
Respiratory physiology: Anatomy of the respiratory system; mechanism of respiration; gas exchange; transport of respiratory gases by the blood; regulation of respiration.
Respiratory exploration in small animals: Why explore respiratory function in small animals? Plethysmography; in vitro contractile force.
Functional Respiratory Explorations: performance and interpretation of respiratory explorations in human pathology; spirometry: Level 1 and Level 2; pulmonary diffusion capacity; arterial blood gas; specific explorations of respiratory muscles; 6-minute walk test; stress test; explorations at altitude.
Cardiovascular physiology:
Anatomy of the heart: size, location and orientation; heart envelope; tunics of the heart wall; chambers and large vessels of the heart; blood flow in the heart; heart valves; blood supply to the heart: coronary circulation; properties of cardiac muscle tissue.
Reminder of cardiac physiology: regulation of basic rhythm; cardiac conduction system; modification of basic rhythm: extrinsic innervation of the heart; electrocardiography; mechanical phenomena: cardiac revolution; cardiac output; regulation of stroke volume; regulation of heart rate.
Vascular physiology: anatomy of the circulatory system; lymphatic system; vascular wall structure; blood pressure; vascular smooth muscle and vasomotricity; endothelial function.
Vascular function and dysfunction; functional exploration: Arterial Distensibility Measurement; arterial wave velocity measurement; pharmacological exploration of endothelium-dependent vasomotricity; ultrasonographic exploration; echo-tracking; ultrasound and echodoppler.
How to assess vascular function experimentally: Isolated artery ring model Cardiac Doppler ultrasound: a fabulous tool for clinical and experimental research; Ultrasound: anatomical and functional analysis"; Doppler: flow analysis; Application to animal models.
Translational research: example of myocardial ischemia-reperfusion (myocardial infarction); animal models; isolated perfused heart (Langendorf); isolated cardiomyocytes; cardioprotective techniques.
Endocrinology: weight balance
Description of eating behavior; Energy balance; Central structures regulating food intake; Mechanisms regulating food intake; Factors modulating appetite and food intake; Nutritional assessment; Eating disorders; Functional exploration: impedancemetry; DEXA (X-ray photon absorption); MRI; Expenditure assessment: calorimetry.
Molecular pharmacology and therapeutics
ECTS
5 credits
Component
Faculty of Pharmacy
Molecular and metabolic bases of hereditary diseases
ECTS
5 credits
Component
Faculty of Science
Statistics applied to biology
ECTS
5 credits
Component
Faculty of Medicine
Cellular communications and signalling
ECTS
5 credits
Component
Faculty of Science
The main communication pathways between normal cells and the intracellular transduction pathways encountered in physiological and neurophysiological mechanisms will be covered, with a focus on G protein-coupled receptors (GPCRs) and their structure, function and modulation by interacting proteins, notably involved in desensitization. The main intracellular pathways activated by GPCRs will be discussed (MAPkinase, PI3kinase, etc.).
A major part of the course will then focus on calcium signaling and Ca2+ homeostasis, Ca2+ being a ubiquitous signal in cell signaling. Calcium homeostasis will be studied in particular during the lymphocyte response to antigenic stimulation. In addition, the production of oxygenated free radicals, at the origin of oxidative stress, is dependent on intracellular Ca2+. The physiological role of free radicals will be discussed, as well as their involvement in oxidative stress. The following chapter will focus on the endocannabinoid system, summarizing all the topics covered earlier in the course. The endocannabinoid system is at the origin of multiple central and peripheral regulations.
Finally, two other themes will be addressed: the blood-brain barrier, which evokes highly integrated cellular communication between two environments, and the -pancreatic cell, whose activity is crucial to the regulation of glycemia through insulin secretion.
UE Semestre 2 elective
ECTS
5 credits
Component
Faculty of Pharmacy
Long-term internship or abroad
ECTS
5 credits
Component
Faculty of Science
Internship of more than 4 months in a facility (research laboratory, company, etc.) in France or abroad.
Practical work in Physiology
ECTS
5 credits
Component
Faculty of Science
The physiology practical course enables you to record cardiac action potentials on frog hearts using the intracellular microelectrode technique. This is a qualitative and quantitative method for measuring the electrical activity of cardiac muscle.
Practical analysis of genomics data in R
ECTS
5 credits
Component
Faculty of Science
Cell culture
ECTS
5 credits
Component
Faculty of Science
Cell culture is a basic laboratory technique that is constantly evolving. It is important to know the basics, which are often poorly understood, even though it is an essential methodology in research and industry.
Corporate knowledge and patent valuation
ECTS
5 credits
Component
Faculty of Science
Are you an L3/M1 student in Languedoc-Roussillon? Would you like to work on a dormant scientific patent in small groups with students from other disciplines, in project mode? Be supported and challenged by professional business creation coaches? Sign up for the PEPITE Patent Project to present a project for the creation of an innovative company based on the exploitation of a real patent supplied by a local research team that will open its doors to you!
Why?
-Because you can start your own business whatever your field of study.
To be selected by an incubator-type support structure
-Build a network in the field of entrepreneurship and innovation
PEPITE Patent Project, what is it? A teaching unit made up of a number of key moments:
a 3-day "tool training" seminar
-regular meetings with coaches
-deliverables: briefing note, market study, business plan
a 10-minute final pitch to present your innovative company
Immunopathology
ECTS
5 credits
Component
Faculty of Science
Teaching is carried out by teacher-researchers from the UFRs of Medicine, Science and Pharmacy. It is organized into 42 hours of lectures and supervised work divided into 7 themes (see Syllabus) including 2 series of article presentations; 1 series on articles proposed by the lecturers in each theme. A second series on articles chosen by the students. At the end of the course, students organize a mini-colloquium at which the articles are presented. They write brief reviews of these articles for the journal Medecine-Sciences.
Medical genetics and genetic counseling
ECTS
5 credits
Component
Faculty of Science
Pharmacokinetics and Toxicology
ECTS
5 credits
Component
Faculty of Pharmacy
Bioinformatics and System Biology
ECTS
5 credits
Component
Faculty of Science
Integrative Pathophysiology
ECTS
5 credits
Component
Faculty of Science
Genetic information - Epigenetics - Mechanistic bases
ECTS
5 credits
Component
Faculty of Science
Signage: Methods and Concepts
ECTS
5 credits
Component
Faculty of Science
Nanotechnologies and multifunctional systems for therapy
Component
Faculty of Pharmacy
Fictional research project_FDP
ECTS
10 credits
Component
Faculty of Pharmacy
Admission
Access conditions
Applications for M1 must be made on the following platform:
- French & European students: follow the "My Master" procedure on the website: https: //www.monmaster.gouv.fr/
- For M2 courses, students must submit their application via the e-candidat application https://candidature.umontpellier.fr/candidature