ECTS
5 credits
Component
Faculty of Science
Description
1) What is the genetic program underlying the development of the nervous system? This course highlights the type of decisions that progressively specify the neural fate of cells and ensure their nervous function. The different steps considered are:
(i) the genesis of the nervous system
(ii) the specification of neurons
(iii) nerve function: axonal guidance and connectivity
(iv) neuronal remodeling
2) What are the molecular, cellular, and environmental interactions that control nervous system development?
-Synaptogenesis and major developmental milestones.
-Roles of neurotrophic factors
-Roles of electrical activity
-Critical periods
-Roles of neuron-glial cell interactions.
-Neuronal stem cells
3) Developmental pathologies
Objectives
The objectives of this module are:
-to acquire knowledge on the mechanisms of nervous system development (from the earliest to the latest stages), based on the study of different model organisms and considering different experimental approaches (particularly the genetic approach).
-To be able to critically approach experimental results in this field To be aware of the conservation of developmental mechanisms between different organisms (e.g., from insects to humans) and of the impact of development in neurological and psychiatric pathologies in children and adults
-To become aware of the conservation of developmental mechanisms between different organisms (e.g., from insects to humans) and of the impact of development in neurological and psychiatric pathologies in children and adults.
Necessary pre-requisites
Obtaining a Bachelor's degree with UE in neurosciences: basic knowledge in Neurobiology/Neurophysiology, Sensoriality and Motricity or its equivalence for medical schools, pharmacists, engineers, etc...
Recommended prerequisites: Knowledge of the major physiological and neurobiological functions.
Knowledge control
Written in first and second session
Syllabus
The speakers are all researchers and research teachers: Agnès Fichard-Carroll, Marie-Laure Parmentier, Jean-Maurice Dura, Patrick Carroll and Jean Valmier.