Physiology and integrated homeostasis

Three main themes are addressed:

-Study of weight and thermal homeostasis in relation to a dysfunctional model: obesity, by examining the energy balance with food intake and energy expenditure, comprising basic metabolism, physical activity and adaptive thermogenesis (AT), and their respective regulation.

-Study of biological rhythms, by describing the nature and properties of biological rhythms (ultradian, circadian and infradian), describing endogenous circadian oscillators, and detailing the molecular mechanisms of circadian clocks.

-Study of the different stages and physiological principles of breathing. Theoretical teaching will be complemented by tutorials (TD)TD sessions are based on document studies and analysis of scientific articles in English. The choice of scientific material is designed to demonstrate the interaction of the various themes covered, and hence the concept of integrative physiology.

-Understand the cellular and molecular mechanisms that regulate energy balance.

-Discover how deregulations of these mechanisms are involved in metabolic diseases such as obesity.

-Understand that circadian rhythms enable the body to anticipate and respond to periodic variations in the environment, thus ensuring relative constancy of the internal environment (predictive homeostasis).

-Address the adaptive value of circadian rhythms on the functioning of the organism, a concept which forms the basis of chronopharmacology.

-Trace oxygen from ventilation to tissue consumption

Basic knowledge of physiology of major functions, nerve communication and endocrine communication.

-Final exam 80% written

-Continuous assessment 20