Bioprocess Engineering II, Specific Applications

This EU presents the specific features of healthcare applications in the field of bioprocesses. Case studies on the production of biopharmaceuticals and innovative therapeutic drugs are provided (e.g., clinical-grade production of cell therapy products). The entire production chain is covered, with a particular focus on downstream processes (or DownStream Processing, DSP), which are particularly important for healthcare products (separation, extraction, purification, and even formulation operations). DSP represents a significant portion of production costs, and there are many expectations and challenges associated with these technologies, particularly with the development of single-use technologies. Upstream processing (USP) is covered in depth in the complementary teaching units of the Bioproduction specialization (HAV930V and HAV911V).

This course unit includes lectures and conferences with numerous presentations by industry professionals who will share their expertise and vision of the field with students. Beyond the technological aspects, these presentations will also provide an opportunity to discuss Good Manufacturing Practices (GMP), quality control, and the management of economic and environmental constraints.

At the end of this course, students will have a comprehensive and integrated understanding of pharmaceutical bioprocesses and will be able to integrate the economic and environmental constraints of bioprocesses in this field. They will be able to choose the best process to implement for each bioproduction, while being aware of the properties and limitations of each system.

Fundamentals of Bioprocess Engineering (Master's level course HAV811V "Bioprocess Engineering - BATCH" or equivalent)

Recommended prerequisites: Bioprocess engineering and recombinant protein production (M2 level UE HAV930V "Bioprocess engineering - Fed-Batch and continuous" or equivalent, and UE HAV911V "Recombinant protein production engineering")Basics in Immunotechnology and Protein Engineering (M1 level UEs PAM1IIMM and PAM1IIPR or equivalent).

Knowledge is assessed through continuous assessment (CCI).