• ECTS

    2 credits

  • Component

    Faculty of Science

Description

In this course, the specificities of health applications in the field of bioprocessing are presented. Thus, case studies on the production of biomedicines and advanced therapy drugs are proposed (e.g. clinical grade production of cell therapy products). The whole production chain is addressed with a particular focus on downstream processes (or DownStream Processing, DSP) which are particularly important for health products (separation, extraction, purification, and even formulation operations). Indeed, DSP represents a significant part of the production cost and the expectations and challenges associated with these technologies are numerous, especially with the development of single-use technologies. The UpStream Processing (USP) part is treated in depth in the complementary courses of the Bioproduction specialization (HAV930V and HAV911V).

This course includes lectures and conferences with numerous presentations by industrialists from the sector who will bring their expertise and vision of the field to the students. Beyond the technological aspects, these lectures will also be an opportunity to deal with Good Manufacturing Practices (GMP), quality control and the management of economic and environmental constraints.

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Objectives

At the end of this course, students will have a global and integrated vision of pharmaceutical bioprocesses and will be able to integrate the economic and environmental constraints of bioprocesses in this field. They will know how to choose the best process to implement, for each bioproduction, being aware of the properties and limits of each system.

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Necessary pre-requisites

Basics of Bioprocess Engineering (M1 level UE HAV811V "Bioprocess Engineering -BATCH" or eq.)

Recommended prerequisites: Bioprocess engineering and recombinant protein production (M2 level UE HAV930V "Bioprocess engineering -Fed-Batch and continuous" or eq. and UE HAV911V "Recombinant protein production engineering"). Basics in Immunotechnology and Protein Engineering (M1 level UEs PAM1IIMM and PAM1IIPR or eq.).

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Knowledge control

The control of knowledge is done in continuous integral control (CCI).

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