Orientation 2

This course aims to highlight biological processes at the cellular level or even in living subjects. Different approaches to molecular imaging will be discussed (fluorescent probes, radiolabeling).

Hourly volumes*:

            CM: 9 a.m.

           Field: 11 a.m.

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The principles of green chemistry provide a basis for evaluating and designing new chemical products and processes that minimize negative impacts on human health and the environment. In this teaching unit, offered to M2 students in the Master's program in Biomolecular Chemistry (BM), Orientation 2 (O2), the basic principles and concepts of green chemistry will be addressed, along with their applications in the field of unconventional activation methods and the use of alternative media in organic synthesis.

Hourly volumes*:

CM: 9 a.m.

Field: 11 a.m.

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This course will cover techniques for extracting biomolecules (protein precipitation, SPE) and techniques for separating biomolecules (chromatography, electrophoresis).

Hourly volumes:

            CM: 9 a.m.

            Field: 11 a.m.

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Peptides and proteins are made up of chains of amino acid residues that give them specific properties. Their functionality depends on their sequence and therefore on the chemical functions they carry, and is also greatly modulated by their structure. In addition to conventional peptide synthesis, advanced options for functional modification, structures, and properties that can significantly alter or improve the properties of the resulting peptide will be developed. Significant biotechnological developments in both the chemical and biological fields will be addressed, leading to a wide range of applications in which peptides and proteins are used successfully.

Hourly volumes*:

CM: 15

TD: 5

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In chemistry, solid-phase synthesis is a method in which molecules are covalently bound to a solid support and synthesized step by step using selective protective groups. This applied course aims to provide a comprehensive understanding of this field and to examine the supported strategies that enable the practical preparation of polypeptides and oligonucleotides.

Hourly volumes*:

CM: 9 H 

Field: 11 a.m.

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Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and siRNA oligonucleotides, and DNA arrays.

Hourly volumes*:

            CM: 3 p.m.  

            Tutorial: 5 hours

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This course covers the various molecular and supramolecular tools used for vectorization and delivery of active ingredients according to the type of cells or intracellular organelles targeted. Ligand-receptor interactions will be discussed, as well as methods for preparing and activating conjugates. Examples of drugs will be presented.

Hourly volumes*:

CM: 3 p.m.

Tutorial: 5 hours

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The course will focus on organic chemistry and post-functionalization of biomolecules applied to peptides, proteins, and nucleic acids (DNA and RNA) with applications in gene therapy, biosensing, and design of probes for biological studies.

Hourly volumes*:

CM: 3 p.m. 

Tutorial: 5 hours

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 In-depth study of NMR ^1H, ^13C, ^19F, ^29Si, ^31P, as well as two-dimensional methods. RPE concepts will also be covered (principles and applications).

Hourly volumes*:

CM: 3 p.m.

Tutorial: 5 hours

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This course aims to describe the synthesis tools applied to complex and polyfunctional molecules. Retrosynthetic and stereocontrolled approaches will be discussed, as well as the judicious use of protective groups.

Hourly volumes*:

CM: 9 a.m.

Field: 11 a.m.

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Bioconjugation reactions are of major interest in biomedical sciences and enable chemists to modify biomolecules in order to give them new functions or properties. This course will cover bioconjugation and biomolecule labeling strategies that enable the exploration of complex biological systems. Practical sessions will illustrate these concepts through examples of bioconjugation of osidic and nucleotide platforms.

Hourly volumes*:

CM: 9 H 

Field: 11 a.m.

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Knowledge of the latest mass spectrometry techniques for the detection, identification, and structural characterization of organic molecules and biomolecules.

Applications in chemistry (pharmaceutical industry) and biology (Omics approaches).

1) Structural elucidation (ion characterization technologies):

• LC/MS/MS and accurate mass measurements 
• Isotopic labeling, H/D exchange
• Ionic mobility

2) Surface analysis and imaging (molecular mapping)

3) Application in chemistry and biology: characterization of small organic molecules and biomolecules.

Hourly volumes*:

CM: 3 p.m.

Tutorial: 5 hours

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The following topics will be covered:

- Triglycerides

- Phospholipids and sphingolipids

- Glycolipids

- Fat-soluble vitamins

- Steroid hormones

- Bile salts

- Structure and synthesis of prostaglandins and leukotrienes

Hourly volumes*:

CM: 15

TD: 5

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The following topics will be covered:

- General mechanism of glycosylation

- Summary of glycosyl donors

- Methods for activating glycosyl donors

- Stereoselective synthesis of some natural oligosaccharides

Hourly volumes*:

CM: 15

TD: 5

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A 5- to 6-month internship must be completed in a research or research and development laboratory specializing in organic chemistry, biomolecular chemistry, life sciences, analytical instrumentation, or analytical analysis/development. Students will therefore have the opportunity to complete this end-of-study internship in academic or private research laboratories. Subject to prior approval by the teaching team (internship topic related to the master's program and adequate environment/resources), students may seek a host team in an academic setting at the institutes of the Chemistry Cluster of the University of Montpellier (IBMM, ICGM, IEM, etc.), in academic laboratories outside the University of Montpellier (in France or abroad), or in the private sector (chemical, pharmaceutical, agri-food, and cosmetics industries, biotechnology laboratories, etc.), as well as in research structures such as proteomics/metabolomics/fluxomics platforms.

The research project assigned to students must be related to the skills and expertise acquired during previous semesters and courses taken, particularly in semester 9, depending on the chosen specialization.

This internship, lasting 5 to 6 months, may begin in mid-January after the exam session and may not exceed 6 months for a period in semester 10 included during the validity of university enrollment. The teaching team of the Master's in Biomolecular Chemistry will advise students on finding an internship that matches their aspirations and abilities.

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Scientific information: This course aims to familiarize students with scientific information research and management. In this context, the latest bibliographic research tools will be explained and used during lectures/tutorials (Electronic documentation: Scifinder/Isis/Belstein). Training in the features of the Zotero tool and the use of the electronic laboratory notebook will also be provided. The writing and use of scientific publications will be discussed.

Bibliographic project: Scientific information research tools will be applied to a specific case. The teaching team will propose a bibliographic topic to the student related to their chosen field of study. Where appropriate, this bibliographic topic may be defined in agreement with the host organization where the internship will take place.

For this personal project, students will have access to all bibliographic sources at the university or company hosting them. The bibliographic work may be combined with the English teaching unit in order to prepare for an oral defense similar to an oral presentation at an international conference.

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