Orientation 2

The aim of this course is to highlight biological processes at the cellular level or even in living subjects. Different molecular imaging approaches will be discussed (fluorescent probes, radiolabeling).

Hourly volumes* :

            CM : 9 H

           Field : 11 H

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The principles of Green Chemistry provide a basis for the evaluation and design of new chemical products and processes that minimize negative impacts on human health and the environment. In this teaching unit, offered to M2 students of the Master of Biomolecular Chemistry (BM), Orientation 2 (O2), the basic principles and concepts of Green Chemistry will be discussed, and their applications in the field of non-conventional activation methods and the use of alternative media in organic synthesis.

Hourly volumes* :

CM : 9 H

Field: 11 a.m.

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This course will teach techniques for the extraction of biomolecules (protein precipitation, SPE), as well as techniques for the separation of biomolecules (chromatography, electrophoresis).

Hourly volumes* :

            CM : 9 h

            Field: 11 a.m.

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Peptides and proteins are composed of a sequence of amino acid residues that give them specific properties. Their functionality depends on their sequence and thus on the chemical functions they carry, and is also greatly modulated by their structure. In addition to conventional peptide synthesis, advanced functional modification options, structures, and properties that can significantly modify or improve the properties of the resulting peptide will be developed. Significant biotechnological developments in both the chemical and biological fields will be discussed leading to a wide range of applications in which peptides and proteins are successfully used.

Hourly volumes*:

CM :15

TD :5

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In chemistry, solid phase synthesis is a method in which molecules are covalently bonded to a solid support and synthesized step by step using selective protecting groups. The purpose of this applied course is to provide a comprehensive understanding of this field and to examine supported strategies for the practical preparation of polypeptides and oligonucleotides.

Hourly volumes* :

CM : 9 H 

Field : 11 H

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Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.

Hourly volumes* :

            CM : 15 H  

            TD : 5 H

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In this course, the different molecular or supramolecular tools for the delivery of active ingredients according to the type of cells or intracellular organelles targeted are discussed. Ligand-receptor interactions will be discussed as well as the methods of preparation and activation of conjugates. Examples of drugs will be presented.

Hourly volumes* :

CM : 15 H

TD : 5 H

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The course will focus on organic chemistry and post-functionalization of biomolecules applied to peptides, proteins and nucleic acids (DNA and RNA) with applications in gene therapy, biosensing and design of probes for biological studies.

Hourly volumes* :

CM : 15 H 

TD : 5 H

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 Deepening of knowledge in ^1H, ^13C, ^19F, ^29Si, ^31PNMR, as well as two-dimensional methods. Notions of EPR will also be covered (principle and applications).

Hourly volumes* :

CM : 15 H

TD : 5 H

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This course aims at describing the synthesis tools applied to complex and polyfunctional molecules. Retrosynthetic and stereocontrolled approaches will be discussed as well as the rational use of protective groups.

Hourly volumes* :

CM : 9 H

Field : 11 H

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Bioconjugation reactions are of major interest in the biomedical sciences and allow chemists to modify biomolecules to confer new functions or properties. In this course, bioconjugation and biomolecule labeling strategies will be discussed in order to explore complex biological systems. The practical sessions will illustrate these concepts through examples of bioconjugation of osidic and nucleotidic platforms.

Hourly volumes* :

CM : 9 H 

Field : 11 H

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Knowledge of the latest mass spectrometry techniques for the detection, identification and structural characterization of organic molecules and biomolecules.

Applications in chemistry (pharmaceutical industry) and biology (Omics approaches).

1) Structural elucidation (Ion characterization technologies):

• LC/MS/MS and exact mass measurements 
• Isotopic labelling, H/D exchange
• Ionic mobility

2) Surface analysis and imaging (molecular mapping)

3) Application in chemistry and biology: characterization of small organic molecules and biomolecules.

Hourly volumes* :

CM : 15 H

TD : 5 H

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The following topics will be covered:

- Triglycerides

- Phospholipids and sphingolipids

- Glycolipids

- Fat-soluble vitamins

- Steroid hormones

- Bile salts

- Structure and synthesis of prostaglandins and leukotrienes

Hourly volumes* :

CM : 15

TD : 5

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The following topics will be covered:

- General mechanism of glycosylation

- Synthesis of glycosyl donors

- Methods of activation of glycosyl donors

- Stereoselective synthesis of some natural oligosaccharides

Hourly volumes* :

CM : 15

TD : 5

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An internship of 5 to 6 months duration must be carried out in a research or research and development laboratory specialized in organic chemistry, biomolecular chemistry, life chemistry, analytical instrumentation or analytical analysis/development. Thus, students will have the opportunity to carry out this end-of-study internship in academic or private research laboratories. Subject to the prior acceptance of the teaching staff (internship subject in connection with the master's courses and adequate environment/means), the student will be able to look for a host team in the academic environment in the institutes of the Chemistry Pole of the University of Montpellier (IBMM, ICGM, IEM...), in academic laboratories outside the University of Montpellier (in France or abroad) or in the private sector (chemical, pharmaceutical, agri-food, cosmetic industries, biotechnology laboratories, etc.) as well as in research structures such as proteomic/metabolomic/flowomic platforms.

The research project that will be entrusted to the students will have to be linked to the skills and expertise acquired during the previous semesters and the teaching units followed, in particular in semester 9 according to the chosen orientation.

This internship of 5 to 6 months can start from mid-January after the exam session and cannot exceed 6 months for a period in semester 10 included during the validity of the university registration. The pedagogical team of the master Chemistry of Biomolecules will advise the students to find an internship corresponding to their aspirations and capacities.

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Scientific information: The aim of this course is to familiarize students with the search and management of scientific information. In this context, recent tools for bibliographic research will be explained and used during courses/DD (Electronic documentation: Scifinder / Isis / Belstein). Training in the functionalities of the Zotero tool and in the use of the electronic laboratory notebook will also be provided. The writing and use of scientific publications will be addressed.

Bibliographic project: The tools of scientific information research will be applied to a concrete case. The pedagogical team will propose a bibliographic subject to the student in relation with the chosen orientation. This bibliographic subject may, if necessary, be defined in agreement with the host organization where the internship will be carried out.

For this personal project, the student will have access to all the bibliographic sources of the university or the company that hosts him/her. The bibliographic work may be combined with the English teaching unit in order to prepare an oral presentation at an international conference.

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