Orientation 2

The aim of this course is to highlight biological processes at the cellular level or even in living subjects. Various molecular imaging approaches will be discussed (fluorescent probes, radiolabeling).

Hourly volumes* :

            CM: 9 H

           Field : 11 H

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The principles of Green Chemistry provide a basis for the evaluation and design of new chemical products and processes that minimize negative impacts on human health and the environment. In this teaching unit, offered to M2 students in the Master of Biomolecular Chemistry (BM), Orientation 2 (O2), the basic principles and concepts of Green Chemistry will be covered, and their applications in the field of non-conventional activation methods and the use of alternative media in organic synthesis.

Hourly volumes* :

CM: 9 H

Field: 11 a.m.

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This course covers techniques for extracting biomolecules (protein precipitation, SPE), as well as techniques for separating biomolecules (chromatography, electrophoresis).

Hourly volumes* :

            CM: 9 h

            Field: 11 a.m.

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Peptides and proteins are made up of a sequence of amino acid residues, giving them specific properties. Their functionality depends on their sequence and thus on the chemical functions they carry, and is also greatly modulated by their structure. In addition to conventional peptide synthesis, advanced functional modification options, structures and properties that can significantly modify or enhance the properties of the resulting peptide will be developed. Significant biotechnological developments in both the chemical and biological fields will be discussed, leading to a wide range of applications in which peptides and proteins are successfully used.

Hourly volumes*:

CM :15

TD :5

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In chemistry, solid-phase synthesis is a method in which molecules are covalently bonded to a solid support and synthesized step by step using selective protecting groups. The aim of this applied course is to provide a comprehensive understanding of this field and to examine supported strategies for the practical preparation of polypeptides and oligonucleotides.

Hourly volumes* :

CM: 9 H 

Field : 11 H

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Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.

Hourly volumes* :

            CM: 15 H  

            TD: 5 H

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This course covers the various molecular and supramolecular tools available for the vectorization and delivery of active ingredients, depending on the type of cells or intracellular organelles targeted. Ligand-receptor interactions are covered, as are methods for preparing and activating conjugates. Examples of drugs will be presented.

Hourly volumes* :

CM: 15 H

TD: 5 H

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The course will focus on organic chemistry and post-functionalization of biomolecules applied to peptides, proteins and nucleic acids (DNA and RNA) with applications in gene therapy, biosensing and design of probes for biological studies.

Hourly volumes* :

CM: 15 H 

TD: 5 H

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 In-depth knowledge of ^1H, ^13C, ^19F, ^29Siand ^31PNMR, as well as two-dimensional methods. Notions of EPR will also be covered (principle and applications).

Hourly volumes* :

CM: 15 H

TD: 5 H

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The aim of this course is to describe synthesis tools applied to complex, polyfunctional molecules. Retrosynthetic and stereocontrolled approaches will be covered, as well as the rational use of protecting groups.

Hourly volumes* :

CM: 9 H

Field : 11 H

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Bioconjugation reactions are of major interest in the biomedical sciences, enabling chemists to modify biomolecules to confer new functions or properties. This course covers bioconjugation and biomolecule labeling strategies for exploring complex biological systems. Practical sessions will illustrate these concepts through examples of bioconjugation of osidic and nucleotide platforms.

Hourly volumes* :

CM: 9 H 

Field : 11 H

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Knowledge of the latest mass spectrometry techniques for the detection, identification and structural characterization of organic molecules and biomolecules.

Applications in chemistry (pharmaceutical industry) and biology (omic approaches).

1) Structural elucidation (Ion characterization technologies) :

• LC/MS/MS and exact mass measurements 
• Isotope marking, H/D exchange
• Ion mobility

2) Surface analysis and imaging (molecular mapping)

3) Applications in chemistry and biology: characterization of small organic molecules and biomolecules.

Hourly volumes* :

CM: 15 H

TD: 5 H

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The following topics will be covered:

- Triglycerides

- Phospholipids and sphingolipids

- Glycolipids

- Fat-soluble vitamins

- Steroid hormones

- Bile salts

- Structure and synthesis of prostaglandins and leukotrienes

Hourly volumes* :

CM: 15

TD : 5

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The following topics will be covered:

- General mechanism of glycosylation

- Glycosyl donor synthesis

- Glycosyl donor activation methods

- Stereoselective synthesis of some natural oligosaccharides

Hourly volumes* :

CM: 15

TD : 5

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An internship lasting 5 to 6 months must be carried out in a research or R&D laboratory specializing in organic chemistry, biomolecule chemistry, life chemistry, analytical instrumentation or analytical analysis/development. Students will have the opportunity to carry out this end-of-study internship in academic or private research laboratories. Subject to prior approval by the teaching staff (internship subject in line with the Master's courses and suitable environment/means), students can look for a host team in an academic environment in the institutes of the Chemistry Pole of the University of Montpellier (IBMM, ICGM, IEM....), in academic laboratories outside the University of Montpellier (in France or abroad) or in the private sector (chemical, pharmaceutical, agri-food and cosmetics industries, biotechnology laboratories, etc.), as well as in research structures such as proteomics / metabolomics / fluxomics platforms.

The research project entrusted to students must be linked to the skills and expertise acquired in previous semesters and teaching units, particularly in semester 9, depending on the direction chosen.

This 5 to 6 month internship may start in mid-January after the exam session, and may not exceed 6 months for a period in semester 10 within the validity of the university registration. The teaching staff of the Chemistry of Biomolecules master's program will advise students on finding an internship that matches their aspirations and abilities.

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Scientific information: The aim of this course is to familiarize students with the search for and management of scientific information. Recent bibliographic research tools will be explained and used in lectures and practical work (electronic documentation: Scifinder / Isis / Belstein). Training in the functionalities of the Zotero tool and in the use of the electronic laboratory notebook will also be provided. The writing and use of scientific publications will also be covered.

Bibliographic project: Scientific information research tools will be applied to a concrete case. The pedagogical team will propose a bibliographical subject related to the student's chosen field of study. This bibliographical subject may, where appropriate, be defined in agreement with the host organization where the internship is to be carried out.

For this personal project, students will have access to all the bibliographic sources of the university or company hosting them. Bibliographic work may be combined with the English teaching unit to prepare an oral presentation at an international conference.

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