Orientation 3

Description of the most recent mass spectrometry techniques for analyses in the pharmaceutical industry (drug development : Drug discovery and pre-clinical analysis).

Mass spectrometry instrumentation and acquisition modes in the pharmaceutical industry for the following applications:

• Analyses in the various stages of drug development,
• Qualitative analysis in metabolism,
• Quantitative analyses in pharmacokinetics.

Hourly volumes* :

            CM : 15 H

           Field : 5 H

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This course will teach techniques for the extraction of biomolecules (protein precipitation, SPE), as well as techniques for the separation of biomolecules (chromatography, electrophoresis).

Hourly volumes* :

            CM : 9 h

            Field: 11 a.m.

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Peptides and proteins are composed of a sequence of amino acid residues that give them specific properties. Their functionality depends on their sequence and thus on the chemical functions they carry, and is also greatly modulated by their structure. In addition to conventional peptide synthesis, advanced functional modification options, structures, and properties that can significantly modify or improve the properties of the resulting peptide will be developed. Significant biotechnological developments in both the chemical and biological fields will be discussed leading to a wide range of applications in which peptides and proteins are successfully used.

Hourly volumes*:

CM :15

TD :5

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The themes of the EU are the following:

A theoretical part dedicated to chemoinformatics

A theoretical part dedicated more specifically to modeling tools for drug design

Hourly volumes* :

CM : 15 H 

TD : 5 H

A part dedicated to the practical aspect with work on computers

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Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.

Hourly volumes* :

            CM : 15 H  

            TD : 5 H

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Knowledge of LC/MS and LC/MS/MS techniques for the characterization of organic molecules and biomolecules in complex media. 

Description of the instruments and acquisition modes that will be used in the lab.

1) Analytical Chromatography techniques coupled to mass spectrometry with ambient ionization:

• LC/MS type instrumentation,
• LC/MS/MS type instrumentation.

2) Coupled spectral data acquisition devices.

Hourly volumes* :

CM : 9 H

Field : 11 H

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 Deepening of knowledge in ^1H, ^13C, ^19F, ^29Si, ^31PNMR, as well as two-dimensional methods. Notions of EPR will also be covered (principle and applications).

Hourly volumes* :

CM : 15 H

TD : 5 H

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The objective of this course is to give students a theoretical and practical training in the fundamental techniques of separation and purification of biomolecules

Hourly volumes* :
CM : 9h
Field : 11h

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Understanding of screening techniques for bioactive molecules, and more generally in vitro tests used to measure a biological event in the perspective of drug discovery or diagnosis.

1) Pharmacological and biophysical fundamentals describing a biological event, target of biological tests:

2) Biological tests for the development of medicines or diagnostics

3) Applications, case studies, critical analyses.

Hourly volumes* :

CM : 15 H

TD : 5 H

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Knowledge of the latest mass spectrometry techniques for the detection, identification and structural characterization of organic molecules and biomolecules.

Applications in chemistry (pharmaceutical industry) and biology (Omics approaches).

1) Structural elucidation (Ion characterization technologies):

• LC/MS/MS and exact mass measurements 
• Isotopic labelling, H/D exchange
• Ionic mobility

2) Surface analysis and imaging (molecular mapping)

3) Application in chemistry and biology: characterization of small organic molecules and biomolecules.

Hourly volumes* :

CM : 15 H

TD : 5 H

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The following topics will be covered:

- Triglycerides

- Phospholipids and sphingolipids

- Glycolipids

- Fat-soluble vitamins

- Steroid hormones

- Bile salts

- Structure and synthesis of prostaglandins and leukotrienes

Hourly volumes* :

CM : 15

TD : 5

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The following topics will be covered:

- General mechanism of glycosylation

- Synthesis of glycosyl donors

- Methods of activation of glycosyl donors

- Stereoselective synthesis of some natural oligosaccharides

Hourly volumes* :

CM : 15

TD : 5

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An internship of 5 to 6 months duration must be carried out in a research or research and development laboratory specialized in organic chemistry, biomolecular chemistry, life chemistry, analytical instrumentation or analytical analysis/development. Thus, students will have the opportunity to carry out this end-of-study internship in academic or private research laboratories. Subject to the prior acceptance of the teaching staff (internship subject in connection with the master's courses and adequate environment/means), the student will be able to look for a host team in the academic environment in the institutes of the Chemistry Pole of the University of Montpellier (IBMM, ICGM, IEM...), in academic laboratories outside the University of Montpellier (in France or abroad) or in the private sector (chemical, pharmaceutical, agri-food, cosmetic industries, biotechnology laboratories, etc.) as well as in research structures such as proteomic/metabolomic/flowomic platforms.

The research project that will be entrusted to the students will have to be linked to the skills and expertise acquired during the previous semesters and the teaching units followed, in particular in semester 9 according to the chosen orientation.

This internship of 5 to 6 months can start from mid-January after the exam session and cannot exceed 6 months for a period in semester 10 included during the validity of the university registration. The pedagogical team of the master Chemistry of Biomolecules will advise the students to find an internship corresponding to their aspirations and capacities.

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Scientific information: The aim of this course is to familiarize students with the search and management of scientific information. In this context, recent tools for bibliographic research will be explained and used during courses/DD (Electronic documentation: Scifinder / Isis / Belstein). Training in the functionalities of the Zotero tool and in the use of the electronic laboratory notebook will also be provided. The writing and use of scientific publications will be addressed.

Bibliographic project: The tools of scientific information research will be applied to a concrete case. The pedagogical team will propose a bibliographic subject to the student in relation with the chosen orientation. This bibliographic subject may, if necessary, be defined in agreement with the host organization where the internship will be carried out.

For this personal project, the student will have access to all the bibliographic sources of the university or the company that hosts him/her. The bibliographic work may be combined with the English teaching unit in order to prepare an oral presentation at an international conference.

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