Orientation 3

Description of the latest mass spectrometry techniques for analyses in the pharmaceutical industry (drug development : Drug discovery and pre-clinical analysis).

Mass spectrometry instrumentation and acquisition in the pharmaceutical industry for the following applications:

• Analysis in the various stages of drug development,
• Qualitative metabolic analysis,
• Quantitative pharmacokinetic analyses.

Hourly volumes* :

            CM: 15 H

           Field : 5 H

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This course covers techniques for extracting biomolecules (protein precipitation, SPE), as well as techniques for separating biomolecules (chromatography, electrophoresis).

Hourly volumes* :

            CM: 9 h

            Field: 11 a.m.

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Peptides and proteins are made up of a sequence of amino acid residues, giving them specific properties. Their functionality depends on their sequence and thus on the chemical functions they carry, and is also greatly modulated by their structure. In addition to conventional peptide synthesis, advanced functional modification options, structures and properties that can significantly modify or enhance the properties of the resulting peptide will be developed. Significant biotechnological developments in both the chemical and biological fields will be discussed, leading to a wide range of applications in which peptides and proteins are successfully used.

Hourly volumes*:

CM :15

TD :5

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The EU themes are as follows:

A theoretical section dedicated to chemoinformatics

A theoretical section devoted more specifically to modeling tools for drug design

Hourly volumes* :

CM: 15 H 

TD: 5 H

A practical section with computer work

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Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.

Hourly volumes* :

            CM: 15 H  

            TD: 5 H

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Knowledge of LC/MS and LC/MS/MS techniques for characterizing organic molecules and biomolecules in complex media. 

Description of the instruments and acquisition modes to be used in practical work.

1) Analytical chromatography-mass spectrometry techniques with ambient ionization:

• LC/MS instrumentation,
• LC/MS/MS instrumentation.

2) Coupled spectral data acquisition devices.

Hourly volumes* :

CM: 9 H

Field : 11 H

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 In-depth knowledge of ^1H, ^13C, ^19F, ^29Siand ^31PNMR, as well as two-dimensional methods. Notions of EPR will also be covered (principle and applications).

Hourly volumes* :

CM: 15 H

TD: 5 H

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The aim of this course is to provide students with theoretical and practical training in fundamental techniques for the separation and purification of biomolecules.

Timetable*:
CM: 9h
Field: 11h

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Understanding of screening techniques for bioactive molecules, and more generally in vitro tests used to measure a biological event in the perspective of drug discovery or diagnosis.

1) Pharmacological and biophysical fundamentals describing a biological event, target of biological tests:

2) Biological tests for the development of medicines or diagnostics

3) Applications, case studies, critical analyses.

Hourly volumes* :

CM: 15 H

TD: 5 H

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Knowledge of the latest mass spectrometry techniques for the detection, identification and structural characterization of organic molecules and biomolecules.

Applications in chemistry (pharmaceutical industry) and biology (omic approaches).

1) Structural elucidation (Ion characterization technologies) :

• LC/MS/MS and exact mass measurements 
• Isotope marking, H/D exchange
• Ion mobility

2) Surface analysis and imaging (molecular mapping)

3) Applications in chemistry and biology: characterization of small organic molecules and biomolecules.

Hourly volumes* :

CM: 15 H

TD: 5 H

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The following topics will be covered:

- Triglycerides

- Phospholipids and sphingolipids

- Glycolipids

- Fat-soluble vitamins

- Steroid hormones

- Bile salts

- Structure and synthesis of prostaglandins and leukotrienes

Hourly volumes* :

CM: 15

TD : 5

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The following topics will be covered:

- General mechanism of glycosylation

- Glycosyl donor synthesis

- Glycosyl donor activation methods

- Stereoselective synthesis of some natural oligosaccharides

Hourly volumes* :

CM: 15

TD : 5

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An internship lasting 5 to 6 months must be carried out in a research or R&D laboratory specializing in organic chemistry, biomolecule chemistry, life chemistry, analytical instrumentation or analytical analysis/development. Students will have the opportunity to carry out this end-of-study internship in academic or private research laboratories. Subject to prior approval by the teaching staff (internship subject in line with the Master's courses and suitable environment/means), students can look for a host team in an academic environment in the institutes of the Chemistry Pole of the University of Montpellier (IBMM, ICGM, IEM....), in academic laboratories outside the University of Montpellier (in France or abroad) or in the private sector (chemical, pharmaceutical, agri-food and cosmetics industries, biotechnology laboratories, etc.), as well as in research structures such as proteomics / metabolomics / fluxomics platforms.

The research project entrusted to students must be linked to the skills and expertise acquired in previous semesters and teaching units, particularly in semester 9, depending on the direction chosen.

This 5 to 6 month internship may start in mid-January after the exam session, and may not exceed 6 months for a period in semester 10 within the validity of the university registration. The teaching staff of the Chemistry of Biomolecules master's program will advise students on finding an internship that matches their aspirations and abilities.

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Scientific information: The aim of this course is to familiarize students with the search for and management of scientific information. Recent bibliographic research tools will be explained and used in lectures and practical work (electronic documentation: Scifinder / Isis / Belstein). Training in the functionalities of the Zotero tool and in the use of the electronic laboratory notebook will also be provided. The writing and use of scientific publications will also be covered.

Bibliographic project: Scientific information research tools will be applied to a concrete case. The pedagogical team will propose a bibliographical subject related to the student's chosen field of study. This bibliographical subject may, where appropriate, be defined in agreement with the host organization where the internship is to be carried out.

For this personal project, students will have access to all the bibliographic sources of the university or company hosting them. Bibliographic work may be combined with the English teaching unit to prepare an oral presentation at an international conference.

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