Orientation 3

Description of the latest mass spectrometry techniques for analysis in the pharmaceutical industry (drug development: drug discovery and preclinical analysis).

Instrumentation and acquisition modes in mass spectrometry in the pharmaceutical industry for the following applications:

• Analyses at various stages of drug development,
• Qualitative analyses in metabolism,
• Quantitative pharmacokinetic analyses.

Hourly volumes*:

            CM: 3 p.m.

           Land: 5 H

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This course will cover techniques for extracting biomolecules (protein precipitation, SPE) and techniques for separating biomolecules (chromatography, electrophoresis).

Hourly volumes:

            CM: 9 a.m.

            Field: 11 a.m.

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Peptides and proteins are made up of chains of amino acid residues that give them specific properties. Their functionality depends on their sequence and therefore on the chemical functions they carry, and is also greatly modulated by their structure. In addition to conventional peptide synthesis, advanced options for functional modification, structures, and properties that can significantly alter or improve the properties of the resulting peptide will be developed. Significant biotechnological developments in both the chemical and biological fields will be addressed, leading to a wide range of applications in which peptides and proteins are used successfully.

Hourly volumes*:

CM: 15

TD: 5

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The EU themes are as follows:

A theoretical section dedicated to chemoinformatics

A theoretical section dedicated more specifically to modeling tools for drug design

Hourly volumes*:

CM: 3 p.m. 

Tutorial: 5 hours

A section dedicated to practical skills with computer work

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Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and siRNA oligonucleotides, and DNA arrays.

Hourly volumes*:

            CM: 3 p.m.  

            Tutorial: 5 hours

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Knowledge of LC/MS and LC/MS/MS techniques for characterizing organic molecules and biomolecules in complex environments. 

Description of the instruments and acquisition methods that will be used in practical work.

1) Chromatography techniques in analytical mode coupled with mass spectrometry with ambient ionization:

• LC/MS instruments,
• LC/MS/MS instrumentation.

2) Coupled spectral data acquisition devices.

Hourly volumes*:

CM: 9 H

Field: 11 a.m.

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 In-depth study of NMR ^1H, ^13C, ^19F, ^29Si, ^31P, as well as two-dimensional methods. RPE concepts will also be covered (principles and applications).

Hourly volumes*:

CM: 3 p.m.

Tutorial: 5 hours

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The objective of this course unit is to provide students with theoretical and practical training in the fundamental techniques of biomolecule separation and purification.

Hours per week*:
CM: 9 hours
Field: 11 hours

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Understanding of screening techniques for bioactive molecules, and more generally in vitro tests used to measure a biological event in the context of drug discovery or diagnosis.

1) Pharmacological and biophysical fundamentals describing a biological event, target of biological tests:

2) Biological tests for the development of medicines or diagnostics

3) Applications, case studies, critical analyses.

Hourly volumes*:

CM: 3 p.m.

Tutorial: 5 hours

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Knowledge of the latest mass spectrometry techniques for the detection, identification, and structural characterization of organic molecules and biomolecules.

Applications in chemistry (pharmaceutical industry) and biology (Omics approaches).

1) Structural elucidation (ion characterization technologies):

• LC/MS/MS and accurate mass measurements 
• Isotopic labeling, H/D exchange
• Ionic mobility

2) Surface analysis and imaging (molecular mapping)

3) Application in chemistry and biology: characterization of small organic molecules and biomolecules.

Hourly volumes*:

CM: 3 p.m.

Tutorial: 5 hours

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The following topics will be covered:

- Triglycerides

- Phospholipids and sphingolipids

- Glycolipids

- Fat-soluble vitamins

- Steroid hormones

- Bile salts

- Structure and synthesis of prostaglandins and leukotrienes

Hourly volumes*:

CM: 15

TD: 5

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The following topics will be covered:

- General mechanism of glycosylation

- Summary of glycosyl donors

- Methods for activating glycosyl donors

- Stereoselective synthesis of some natural oligosaccharides

Hourly volumes*:

CM: 15

TD: 5

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A 5- to 6-month internship must be completed in a research or research and development laboratory specializing in organic chemistry, biomolecular chemistry, life sciences, analytical instrumentation, or analytical analysis/development. Students will therefore have the opportunity to complete this end-of-study internship in academic or private research laboratories. Subject to prior approval by the teaching team (internship topic related to the master's program and adequate environment/resources), students may seek a host team in an academic setting at the institutes of the Chemistry Cluster of the University of Montpellier (IBMM, ICGM, IEM, etc.), in academic laboratories outside the University of Montpellier (in France or abroad), or in the private sector (chemical, pharmaceutical, agri-food, and cosmetics industries, biotechnology laboratories, etc.), as well as in research structures such as proteomics/metabolomics/fluxomics platforms.

The research project assigned to students must be related to the skills and expertise acquired during previous semesters and courses taken, particularly in semester 9, depending on the chosen specialization.

This internship, lasting 5 to 6 months, may begin in mid-January after the exam session and may not exceed 6 months for a period in semester 10 included during the validity of university enrollment. The teaching team of the Master's in Biomolecular Chemistry will advise students on finding an internship that matches their aspirations and abilities.

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Scientific information: This course aims to familiarize students with scientific information research and management. In this context, the latest bibliographic research tools will be explained and used during lectures/tutorials (Electronic documentation: Scifinder/Isis/Belstein). Training in the features of the Zotero tool and the use of the electronic laboratory notebook will also be provided. The writing and use of scientific publications will be discussed.

Bibliographic project: Scientific information research tools will be applied to a specific case. The teaching team will propose a bibliographic topic to the student related to their chosen field of study. Where appropriate, this bibliographic topic may be defined in agreement with the host organization where the internship will take place.

For this personal project, students will have access to all bibliographic sources at the university or company hosting them. The bibliographic work may be combined with the English teaching unit in order to prepare for an oral defense similar to an oral presentation at an international conference.

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