Orientation 1

The EU themes are as follows:

A theoretical section dedicated to chemoinformatics

A theoretical section devoted more specifically to modeling tools for drug design

Hourly volumes* :

CM: 15 H 

TD: 5 H

A practical section with computer work

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Peptides and proteins are made up of a sequence of amino acid residues, giving them specific properties. Their functionality depends on their sequence and thus on the chemical functions they carry, and is also greatly modulated by their structure. In addition to conventional peptide synthesis, advanced functional modification options, structures and properties that can significantly modify or enhance the properties of the resulting peptide will be developed. Significant biotechnological developments in both the chemical and biological fields will be discussed, leading to a wide range of applications in which peptides and proteins are successfully used.

Hourly volumes*:

CM :15

TD :5

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Receptors are of major interest in medicinal chemistry and represent over 40% of current therapeutic targets. This teaching unit provides an interdisciplinary approach to the basic concepts and notions of receptology required by students pursuing their training in biomolecular chemistry at the chemistry-biology interface.

Hourly volumes* :

CM: 15 H 

TD: 5 H

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Discusses nucleic acid structure and function. Reviews methods used to synthesize DNA and RNA-based oligonucleotides, and chemical reactions that lead to modifications of nucleic acids for therapeutic and diagnostic applications. Additional topics include: nucleic acid molecular beacons, antisense and SiRNA oligonucleotides and DNA arrays.

Hourly volumes* :

            CM: 15 H  

            TD: 5 H

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 In-depth knowledge of ^1H, ^13C, ^19F, ^29Siand ^31PNMR, as well as two-dimensional methods. Notions of EPR will also be covered (principle and applications).

Hourly volumes* :

CM: 15 H

TD: 5 H

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This course covers the various molecular and supramolecular tools available for the vectorization and delivery of active ingredients, depending on the type of cells or intracellular organelles targeted. Ligand-receptor interactions are covered, as are methods for preparing and activating conjugates. Examples of drugs will be presented.

Hourly volumes* :

CM: 15 H

TD: 5 H

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Knowledge of the latest mass spectrometry techniques for the detection, identification and structural characterization of organic molecules and biomolecules.

Applications in chemistry (pharmaceutical industry) and biology (omic approaches).

1) Structural elucidation (Ion characterization technologies) :

• LC/MS/MS and exact mass measurements 
• Isotope marking, H/D exchange
• Ion mobility

2) Surface analysis and imaging (molecular mapping)

3) Applications in chemistry and biology: characterization of small organic molecules and biomolecules.

Hourly volumes* :

CM: 15 H

TD: 5 H

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The course will focus on organic chemistry and post-functionalization of biomolecules applied to peptides, proteins and nucleic acids (DNA and RNA) with applications in gene therapy, biosensing and design of probes for biological studies.

Hourly volumes* :

CM: 15 H 

TD: 5 H

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The following topics will be covered:

- Triglycerides

- Phospholipids and sphingolipids

- Glycolipids

- Fat-soluble vitamins

- Steroid hormones

- Bile salts

- Structure and synthesis of prostaglandins and leukotrienes

Hourly volumes* :

CM: 15

TD : 5

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The following topics will be covered:

- General mechanism of glycosylation

- Glycosyl donor synthesis

- Glycosyl donor activation methods

- Stereoselective synthesis of some natural oligosaccharides

Hourly volumes* :

CM: 15

TD : 5

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Knowledge of the limitations associated with the administration of an active ingredient (solubility, bioavailability, etc.).

General description of the enzymatic systems involved in the biotransformation of nutrients and exogenous compounds.

Description of the main membrane passageways and transport systems for fundamental biomolecules (sugars, amino acids, nucleosides, etc.).

Examples of prodrug and bioprecursor design.

Hourly volumes* :

CM: 15 H

TD: 5 H

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This teaching unit is dedicated to the presentation of inorganic materials and nanomaterials for use in the biomedical field (imaging, therapy, implants). It builds on the knowledge acquired in UE HAC930C (Development of materials for health). The aim is to develop health issues and inorganic materials and nanomaterials in diagnostics, therapy and wellness. Strategies for developing the inorganic materials and nanomaterials of the future based on therapeutics and multifunctionality, and intelligent materials will also be addressed.

The course comprises lectures and tutorials. A group project on the (theoretical) study of an inorganic material or nanomaterials for health will be proposed to students.

Hourly volumes* :

            CM: 11

            TD : 9

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An internship lasting 5 to 6 months must be carried out in a research or R&D laboratory specializing in organic chemistry, biomolecule chemistry, life chemistry, analytical instrumentation or analytical analysis/development. Students will have the opportunity to carry out this end-of-study internship in academic or private research laboratories. Subject to prior approval by the teaching staff (internship subject in line with the Master's courses and suitable environment/means), students can look for a host team in an academic environment in the institutes of the Chemistry Pole of the University of Montpellier (IBMM, ICGM, IEM....), in academic laboratories outside the University of Montpellier (in France or abroad) or in the private sector (chemical, pharmaceutical, agri-food and cosmetics industries, biotechnology laboratories, etc.), as well as in research structures such as proteomics / metabolomics / fluxomics platforms.

The research project entrusted to students must be linked to the skills and expertise acquired in previous semesters and teaching units, particularly in semester 9, depending on the direction chosen.

This 5 to 6 month internship may start in mid-January after the exam session, and may not exceed 6 months for a period in semester 10 within the validity of the university registration. The teaching staff of the Chemistry of Biomolecules master's program will advise students on finding an internship that matches their aspirations and abilities.

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Scientific information: The aim of this course is to familiarize students with the search for and management of scientific information. Recent bibliographic research tools will be explained and used in lectures and practical work (electronic documentation: Scifinder / Isis / Belstein). Training in the functionalities of the Zotero tool and in the use of the electronic laboratory notebook will also be provided. The writing and use of scientific publications will also be covered.

Bibliographic project: Scientific information research tools will be applied to a concrete case. The pedagogical team will propose a bibliographical subject related to the student's chosen field of study. This bibliographical subject may, where appropriate, be defined in agreement with the host organization where the internship is to be carried out.

For this personal project, students will have access to all the bibliographic sources of the university or company hosting them. Bibliographic work may be combined with the English teaching unit to prepare an oral presentation at an international conference.

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