Master 1 IBIS Therapeutic Engineering and Bioproduction in Biotechnology-Health

The aim of this course is to introduce functional genomics technologies in -omics, and to present examples of biological questions that can be answered using these technologies.

This unit aims to present "omics" functional genomics technologies, and some biological questions that they can address.The lectures are given by both associate professors and researchers.

Introduction to functional genomics: approaches, concepts and methods

An introduction to functional Genomics: approaches, concepts and methods

V. Coulon, UM / IGMM

Organisation des génomes / Genome organization

Techniques de séquençage / DNA sequencing methodsL. Journot, IGF

Organisation 3D des génomes / 3D genome organisation J. Poli, UM / IGH

Genome topological organization and replication / Organisation topologique et réplication des génomes-V. Coulon, UM / IGMM

Régulation spatio-temporelle de l'expression des génomes / Spatio-temporal regulation of gene expressionTranscriptionEpissage / Splicing-V. Coulon, UM / IGMM

ARN non-codants / non-coding RNAsV. Coulon, UM / IGMM

Interactomique / InteractomicsIan Robbins, UM / IGMM

Proteomics and Pharmacogenomics / Protéomique et pharmacogénomiqueC. Bécamel, UM / IGF

Animal Models / Modèles animaux

Using Mice in Functional Genomics / Utilisation de la souris en génomique fonctionnelle F. Poulat, IGH

La Drosophile en génomique fonctionnelle / Using Drosophila in Functional Genomics -F. Juge and S. Chambeyron, IGH

Analyse et présentation d'articles scientifiques/ Scientificarticles analysis and presentation(15min + 10 min discussion per group of 3 students)

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Proteins are now widely used as therapeutic tools in human and animal health. Knowledge of peptide and protein synthesis pathways, folding and post-translational modifications is essential before any therapeutic protein biosynthesis can be envisaged. Methods to better characterize these proteins are also essential to guarantee the quality of the proteins produced for therapeutic or industrial use. Protein engineering methods designed to improve their original properties will also be discussed.

The course includes lectures and tutorials by teacher-researchers and researchers.

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Bioinformatics is concerned with the creation and use of numerical and mathematical approaches applied to the life sciences. The main applications concern the automatic processing of biological data and questions of data modeling, analysis and integration in the field of life biology.This course aims to provide a solid grounding in sequence analysis using bioinformatics tools, as well as in immunoinformatics. Theoretical aspects will be covered, and these will be reinforced by practical aspects (exercises and project work). This course may or may not be taught in English, depending on the student's level. The course comprises lectures and practical work, carried out by research professors.

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In bioprocess engineering, knowledge of the metabolism of catalysts (cells, microorganisms) is essential. This course will focus on describing the diversity of microbial metabolites (primary and secondary metabolites) and the bioprocesses that use these microorganisms to produce these molecules.

This course includes interactive lectures, tutorials and practical exercises (practical work in the computer room + personal project work in small groups).

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Within biotechnology, bioprocesses correspond to the industrial application of living tools (whether enzymes, microorganisms or cells from higher organisms) for the synthesis of products of interest. This teaching unit will focus on the use of microbial and cellular catalysts. Products of interest may be, for example, fermented foods (wine, beer, etc.), energy molecules (bioethanol, methane, etc.), chemical intermediates, or biomedicines (vaccines, monoclonal antibodies, growth factors, etc.). The knowledge, know-how and skills acquired in this course can be transposed to any sector of biotechnology activity. The examples given will correspond to the outlets targeted by the two courses (Agrosciences and Health).

The course will focus on bioprocesses and the environment in which the biological reaction will be controlled (the bioreactor). The course will also cover the description and modeling of a biological reaction, with a presentation of the approach applied in bioprocess engineering. The remainder of the course will be devoted to the application of this approach to batch reactors. Other operating modes will be covered in the M2 course HAV930V "Bioprocess engineering - continuous and fed-batch".

This course includes interactive lectures, tutorials and practical exercises (practical work in the computer room + personal project work in small groups).

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