Master 1 IBIS Therapeutic Engineering and Bioproduction in Biotechnology-Health

The aim of this course is to introduce functional genomics technologies and to present examples of biological questions that can be asked using them.

This unit aims to present "omics" functional genomics technologies, and some biological questions that they can address.The lectures are given by both associate professors and researchers.

Introduction to functional genomics: approaches, concepts and methods

An introduction to functional Genomics: approaches, concepts and methods

V. Coulon, UM / IGMM

Genome organization / Organisation des génomes

Techniques de séquençage / DNA sequencing methodsL. Journot, IGF

3D genome organization J. Poli, UM / IGH

Genome topological organisation and replication-V. Coulon, UM / IGMM

Régulation spatio-temporelle de l'expression des génomes / Spatio-temporal regulation of gene expressionTranscriptionEpissage / Splicing-V. Coulon, UM / IGMM

Non-coding RNAsV. Coulon, UM / IGMM

Interactomics / InteractomiqueIan Robbins, UM / IGMM

Proteomics and Pharmacogenomics / Protéomique et pharmacogénomiqueC. Bécamel, UM / IGF

Animal Models / Modèles animaux

Using Mice in Functional Genomics F. Poulat, IGH

La Drosophile en génomique fonctionnelle / Using Drosophila in Functional Genomics -F. Juge and S. Chambeyron, IGH

Scientificarticles analysis and presentation(15min + 10 min discussion per group of 3 students)

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Proteins are now widely used as therapeutic tools in human and animal health. The knowledge of peptide and protein synthesis pathways, their folding, their possible post-translational modifications is essential before considering any therapeutic protein biosynthesis. Methods to better characterize these proteins are also essential to guarantee the quality of the proteins produced for therapeutic or industrial use. Protein engineering methods to improve their original properties will also be discussed.

The UE includes lectures and tutorials, conducted by teacher-researchers and researchers.

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Bioinformatics is concerned with the creation and use of numerical and mathematical approaches applied to life sciences. The main applications concern the automatic processing of biological data and questions of modelling, analysis and integration of data in the field of life biology.This course aims to provide a solid foundation in sequence analysis using bioinformatics tools as well as in immunoinformatics. Theoretical aspects will be covered and these will be reinforced by practical aspects (exercises and project work). This course may or may not be conducted in English depending on the level of the students. The course includes lectures and practical work carried out by teacher-researchers.

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In the framework of bioprocess engineering, the knowledge of the metabolism of catalysts (cells, microorganisms) is essential. This course will be dedicated to the description of the diversity of microbial metabolites (primary and secondary metabolites) and of bioprocesses exploiting these microorganisms to produce these molecules.

This course includes interactive lectures, tutorials and practical work (practical work in the computer room + personal work in project mode in small groups)

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Within biotechnologies, bioprocesses correspond to the industrial implementation of living tools (whether enzymes, microorganisms or cells from higher organisms) for the synthesis of products of interest. In this teaching unit (UE), the focus will be on the exploitation of microbial and cellular catalysts. The products of interest can be for example fermented foods (wine, beer, ...), energy molecules (bioethanol, methane, ...), chemical intermediates, or biomedicines (vaccines, monoclonal antibodies, growth factors...). The knowledge, know-how and skills acquired during this course will be transposable to any sector of activity in biotechnology. The examples that will be given will correspond to the outlets targeted by the two training courses (the Agrosciences and Health mentions).

The UE will be dedicated to bioprocesses and to the environment in which the biological reaction will be controlled (the bioreactor). The course will also address the issue of the description and modeling of a biological reaction, including the presentation of the approach applied in bioprocess engineering. The rest of the course will be devoted to the application of this approach to reactors operated in batch mode. The other operating modes will be covered by the M2 course HAV930V "Bioprocess engineering - continuous and fed-batch".

This course includes interactive lectures, tutorials and practical work (practical work in the computer room + personal work in small groups).

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