Master 1 IBIS Therapeutic Engineering and Bioproduction in Biotechnology-Health

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Proteins are now widely used as therapeutic tools in human and animal health. Knowledge of the synthesis pathways of peptides and proteins, their folding, and their possible post-translational modifications is essential before considering any biosynthesis of therapeutic proteins. Methods for better characterizing these proteins are also essential to guarantee the quality of proteins produced for therapeutic or industrial use. Protein engineering methods designed to improve their original properties will also be discussed.

The EU comprises lectures and tutorials, delivered by faculty members and researchers.

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Bioinformatics focuses on the creation and use of digital and mathematical approaches applied to life sciences. The main applications concern the automatic processing of biological data and issues of modeling, analysis, and data integration in the field of life sciences. This course unit aims to provide a solid foundation in sequence analysis using bioinformatics tools and in immunoinformatics. Theoretical aspects will be covered and reinforced by practical aspects (exercises and project work). This course unit may or may not be taught in English, depending on the level of the students. The course unit includes lectures and practical work, carried out by teacher-researchers.

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In the field of bioprocess engineering, knowledge of the metabolism of catalysts (cells, microorganisms) is essential. The EU will be dedicated to describing the diversity of valuable microbial metabolites (primary and secondary metabolites) and the bioprocesses that exploit these microorganisms to produce these molecules.

This course unit includes interactive lectures, tutorials, and practical work (practical work in the computer lab + individual project work in small groups).

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Within biotechnology, bioprocesses correspond to the industrial implementation of living tools (whether enzymes, microorganisms, or cells from higher organisms) for the synthesis of products of interest. In this teaching unit (TU), the focus will be on the use of microbial and cellular catalysts. Products of interest may include fermented foods (wine, beer, etc.), energy molecules (bioethanol, methane, etc.), chemical intermediates, and biomedicines (vaccines, monoclonal antibodies, growth factors, etc.). The knowledge, skills, and expertise acquired in this teaching unit will be transferable to any sector of biotechnology. The examples given will correspond to the career opportunities targeted by the two programs (Agrosciences and Health).

The EU will focus on bioprocesses and the environment in which the biological reaction will be controlled (the bioreactor). The course will also address the issue of describing and modeling a biological reaction, including a presentation of the approach applied in bioprocess engineering. The rest of the course will be devoted to the application of this approach to reactors operated in batch mode (or discontinuous culture). Other operating modes will be covered by the M2 HAV930V course "Bioprocess Engineering - Continuous and Fed-Batch."

This course unit includes interactive lectures, tutorials, and practical work (practical work in the computer lab + individual project work in small groups).

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