Master 2 - IDIL Chemistry for healthcare, protection and nutrition applications

- Reminder of thermodynamics of single component systems.

- Basic notions of thermodynamics of multicomponent systems. Chemical potential, Gibbs-Duhem relation, variance.

- Knowledge of thermal analysis techniques that allow the construction of binary/ternary diagrams: TGA, DTA and DSC

- Construction and interpretation of binary phase diagrams from thermodynamic quantities. Diagrams of Gibbs free enthalpy, pressure and temperature as a function of the composition of the binary mixture. Liquid-liquid, liquid-vapor, solid-liquid mixtures.

- Phase transformation: first and second order transitions, critical points. Examples.

- The supercritical state: definition, thermodynamic properties, most extensive industrial applications.

- Construction and interpretation of ternary phase diagrams: variance, definitions of ternary eutectic, first and second order peritectic, isothermal section, study of cooling of alloys.

Hourly volumes* :

CM :13

TD :7

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The substitution of materials of petroleum origin is an increasingly important issue from both a technological and economic point of view. This module provides skills in the field of agropolymers, biosourced polymers, degradable materials and biocomposites. New and more environmentally friendly synthesis routes will be presented in order to prepare synthetic degradable polymers

Degradation, biodegradation and recyclability of polymers will also be addressed

Hourly volumes* :

            CM : 11CM

            TD : 9 TD

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The themes of the EU are the following:

A theoretical part dedicated to chemoinformatics

A theoretical part dedicated more specifically to modeling tools for drug design

Hourly volumes* :

CM : 15 H 

TD : 5 H

A part dedicated to the practical aspect with work on computers

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The elaboration of materials involves many coupled phenomena, some of which are related to the nature of materials and their intrinsic properties, others to the processes implemented during the operations of transformation of matter and/or energy. Morphogenesis is thus the result of interdependent, coupled mechanisms, whose relative kinetics will lead to one structure or another. The control of these coupled mechanisms requires a good knowledge of the dynamics of transformation of the materials themselves as well as a precise description of the transfer and transport phenomena implemented in the process. The integration in the reactive environment will be addressed at the end of the course.

Hourly volumes* :

            CM : 11

            TD : 9

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Peptides and proteins are composed of a sequence of amino acid residues that give them specific properties. Their functionality depends on their sequence and thus on the chemical functions they carry, and is also greatly modulated by their structure. In addition to conventional peptide synthesis, advanced functional modification options, structures, and properties that can significantly modify or improve the properties of the resulting peptide will be developed. Significant biotechnological developments in both the chemical and biological fields will be discussed leading to a wide range of applications in which peptides and proteins are successfully used.

Hourly volumes*:

CM :15

TD :5

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One of the major issues related to the use of different materials in our daily life is their durability and therefore their degradation. In this course, we will address the issues related to the durability of materials (resources, reserves, criticality of materials, ...) as well as the methodologies for studying durability (types of aging surface / volume, temporal extrapolation, multi-scale, combination of effects, experimental representation and industrial validation). This will then allow to model the aging kinetics from different models.

The different types of degradation affecting polymers will then be analyzed.

Finally, the aging of different types of materials will be illustrated by different concrete case studies (concrete, ceramic, metals and elastomers).

Hourly volume* : 11h CM :

                                    9h TD

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Knowledge of the main families of polymers used in the biomedical field.

1) Specificity of polymers for biomedical applications and main families of polymers used

2) Description of the application families

3) Discussion on the notion of synthesis and the structure/property/software relationship

Hourly volumes* :

CM : 15 H

TD : 5 H

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This teaching unit is dedicated to the presentation of materials and nanomaterials for use in the biomedical field (imaging, therapy, implants, etc.). The aim is to give a representative image of the health issues where materials and nanomaterials play an indispensable role in diagnosis, therapy and well-being. Strategies for developing the materials and nanomaterials of the future will also be discussed.

The prerequisites for the development of materials for health and their behavior/interaction with a living organism will be explained. Examples of inorganic (inorganic nanoparticles, various materials for implants...), organic (polymers, liposomes, etc.) and biologically derived materials used as contrast agents for various types of imaging, as therapeutic agents, or as implants will be presented.

The UE includes lessons given in lectures and tutorials. 

Hourly volumes* :

            CM : 11

            TD : 9

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This teaching unit is dedicated to the presentation of inorganic materials and nanomaterials for use in the biomedical field (imaging, therapy, implants). This UE is the deepening of the knowledge acquired in the UE HAC930C (Development of materials for health). The aim is to develop health issues and inorganic materials and nanomaterials in diagnosis, therapy and well-being. Strategies for the development of future inorganic materials and nanomaterials based on therapeutics and multifunctionality, and smart materials will also be addressed.

The UE includes lectures and tutorials. A group project on the (theoretical) study of an inorganic material or nanomaterials for health will be proposed to the students

Hourly volumes* :

            CM : 11

            TD : 9

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Membrane materials are usually divided into two families: polymeric membranes and inorganic (or ceramic) membranes. Each of these families will constitute a part of this course. The first part will be devoted to the design of polymeric membranes. In this part, we will mainly deal with the techniques of preparation by phase inversion (NIPS, VIPS, TIPS) with an opening on research and innovation (SNIPS, aquaporin...). In addition, the additives (especially pore-forming and hydrophilizing agents), which play an important role in the phase inversion approaches, will be described and the different chemical modification routes of the post-synthesis membranes will be presented. The second part will be devoted to the design of inorganic membranes. In this part, we will present on the one hand the wet processes, i.e. the main methods of deposition of liquid films (dip-coating, spin-coating, sputtering, tape-casting, silk-screening) and of deposition from solutions (electrolytic or chemical processes) or suspensions (electrophoresis, Langmuir-Blodgett), and on the other hand the dry processes (PVD techniques (evap. and spray), CVD techniques (thermal, PECVD and ALD), MBE, surface treatment). Finally, as an illustration of the two families of membranes, we will deal with case studies on membrane applications, in particular in the field of packaging.

Hourly volumes* :

            CM : 11h

            TD : 9h

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Understanding of screening techniques for bioactive molecules, and more generally in vitro tests used to measure a biological event in the perspective of drug discovery or diagnosis.

1) Pharmacological and biophysical fundamentals describing a biological event, target of biological tests:

2) Biological tests for the development of medicines or diagnostics

3) Applications, case studies, critical analyses.

Hourly volumes* :

CM : 15 H

TD : 5 H

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This course will cover the main conventional membrane technologies in liquid and gas media. Concerning the liquid medium, baromembrane technologies such as microfiltration, ultrafiltration, nanofiltration and reverse osmosis will be mainly described, but also those based on electrochemical potential gradients (electrodeionization) or temperature (membrane distillation). In addition, gas permeation and pervaporation for the separation of gases and/or vapors will also be presented. For all the technologies, the question of the choice of the adapted membrane materials will be addressed and representative examples of appropriate fields of use (in connection with the current environmental and energy problems) will be given.

Hourly volumes* :

            CM : 11h

            TD : 9h

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This teaching unit is dedicated to the deepening of the bases of organic chemistry and coordination chemistry seen in L3 and to the acquisition of notions related to molecular engineering and molecular chemistry. The UE includes lectures and tutorials. The students will work before some lectures and tutorials with course documents provided so that the lectures and tutorials can allow them to be fully involved in the training, to understand the concepts presented and the skills to be acquired. The progression program and activities will be proposed. For those students who have not seen the basics of coordination chemistry and organic chemistry, the documents will be made available.

Coordination chemistry: The teaching will cover the different aspects of transition metal and lanthanide complexes, molecular materials (polynuclear complexes and coordination polymers with extended structures (MOFs, etc.)) and their properties and applications. Structural aspects, bonding description, properties, as well as stability and reactivity aspects will be discussed. Emphasis will be put on the complexation effect and on the stability of metal, lanthanide and actinide complexes with certain ligands for applications in the biomedical field (imaging and therapy), decontamination (nuclear field), etc. The electronic (relaxivity, magnetism) and optical (absorption, luminescence) properties of these complexes will be discussed and put in the context of applications in various fields, such as imaging, electronics, sensors, etc.

Organic Chemistry: The teaching is based on the knowledge acquired in the Bachelor's degree and will approach through a reasoned study the main reaction mechanisms of organic chemistry and will allow to give a common base to all the students of the Master Chemistry. The main processes (substitution, addition, elimination, transposition...) and their essential characteristics and applications to mechanistic sequences will be examined. This course should provide the student with general tools for the analysis of mechanisms (ionic, radical, concerted) in order to understand these mechanisms in their variety.

Hourly volumes* :

CM : 13 H

TD : 7 H

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Today, it is essential to design products that are environmentally friendly throughout their life cycle. It is commonly accepted that as the manufacturing process of a product progresses, the technical choices become narrower and the possibilities to reduce environmental impacts become less and less. It is therefore from the start, i.e. at the product design stage, that the environment must be integrated.

The method is based on the life cycle analysis of a product. It takes into account factors such as :

• The choice of materials and raw materials
• The technologies implemented during the manufacture, use, maintenance of the product and during its treatment as waste.
• The life span of the product and the possibility of recovering materials at the end of its life (recycling, etc.).
• User behavior analysis.

Hourly volumes* :

            CM : 11h

            TD :9h

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Knowledge of the limitations associated with the administration of an active ingredient (solubility, bioavailability, etc.).

General description of the enzymatic systems involved in the biotransformation of nutrients and exogenous compounds.

Description of the main modes of membrane passage and transport systems of fundamental biomolecules (sugars, amino acids, nucleosides...).

Examples of prodrug(s) and bioprecursor(s) design.

Hourly volumes* :

CM : 15 H

TD : 5 H

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