Licence 2 CPES Modeling and Numerics in Life Sciences

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This UE is a transversal UE of L2 SV aiming at giving to the students in Biology a basic knowledge on the functioning of plants allowing to understand the current stakes of the plant Agro-sciences.

The following basic Plant Physiology/Functional Biology will be studied: 

essential experimental approaches: plant transgenesis, direct and reverse genetics

basics of autotrophy

mechanisms underlying the major stages of angiosperm development: meristem function, floral transition, fertilization.

auxin, a major hormone for the development of plants and their response to the abiotic environment

The practical sessions will allow students to manipulate the regulation of water nutrition in plants and to analyze their mineral nutrition using different biochemical assays (flame photometry, spectrophotometry). 

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This course is an introduction to the general concepts of scientific ecology: levels of organization, measurement and conservation of biodiversity, biogeography, biotic and abiotic factors of distribution and dynamics of biodiversity. It also provides an understanding of the methods used in scientific ecology: the importance of experimentation, reflection on the construction of a protocol, data analysis, oral and written reports of an experiment

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This module should enable students to acquire:

Basic notions in Physiology : Concept of homeostasis; levels of organization of the human body; compartments of the Internal Environment; study of the endocrine system; acid-base and hydro-mineral balance; anatomical and functional studies of the central and peripheral nervous system.

Basic concepts in Immunology:

General presentation of the immune system; study of T and B lymphocytes, antigen presenting cells; study of antimicrobial immunity and complement.

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This course is designed to deepen in small groups the fundamental molecular and cellular processes seen in the BMC2 and BMC3 courses by approaching them through more concrete notions. The lessons will be based on real data (experimental results, scientific articles) to simply explain the main scientific approaches and to learn how to analyze and interpret the results (Example 1: show an interaction in cellulo by expression of tagged proteins in cell lines followed by immunoprecipitation and western-blot. Example 2: principle of immunofluorescence, intracellular distribution of an antigen. Example 3: transcription and translation in vitro and study of interaction by GST-pull down). The practical exercises will illustrate some of these basic approaches: cell culture, construction of expression vectors, transfection, immunolabeling, fluorescence microscopy.   

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This course aims to broaden the knowledge acquired previously in different areas of microbiology, particularly in microbial ecology.

It will deal with pathogenic relationships, but will also present examples of symbiotic associations. It will address the applications of microorganisms in biotechnology. It will describe the mode of action of antibiotics and the associated resistance phenomena and their impact.

The EU will approach the notion of viral ecology by presenting the place and role of viruses in ecosystems. The case of bacteriophages will be treated more specifically and the mechanisms of resistance of bacteria to phagic infection will be detailed. The different types of viral infections in animals will be presented (acute and persistent infections) and illustrated through the study of the pathogenesis of selected viral infections.

The knowledge on microorganisms will be extended by the study of Archaea and a model eukaryotic organism, the yeast.

The practical work will focus on the realization of an antibiogram and its interpretation, and on the titration of bacteriophages.

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The objective of this course is to understand evolutionary processes, both at the micro- and macro-evolutionary scales.

Based on examples, manipulations and accessible modeling, the lessons will aim at presenting in a concrete and quantitative way the effects of the 4 evolutionary forces operating at the scale of individuals and populations (mutation, migration, selection and drift). The integration of these micro-evolutionary processes at larger time scales (e.g. differentiation between lineages, speciation) will then be addressed. Finally, the course will include an introduction to the tools of phylogeny (reading and construction of trees) allowing the study of macro-evolutionary events (diversification, extinction) and the tracing of changes in character states, notably by integrating fossil data.

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This compulsory course will allow students to deepen their skills acquired in "S3 biochemistry". It will allow them to understand cellular metabolism through:

-The understanding of bioenergetics in order to study the processes by which living cells carry, transmit, use, store and release energy;
-the study of catabolism and anabolism of carbohydrates, lipids, nucleotides, amino acids and the metabolic interactions between these pathways.

- description of metabolic pathologies.

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In this introductory course to genetic analysis, the objectives are to learn the terms, principles, concepts and methods used in formal genetics, as well as their application in human and medical genetics. This course covers the genetics of transmission (Mendelian or non-Mendelian), quantitative genetics and notions of population genetics. Throughout the course, close links are established between classical and molecular genetics.

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