M1 - Quantitative Biology (qBio)

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The Bootcamp is an intensive course at the beginning of the first semester, before the start of the courses characterizing the tracks. Its purpose is to refresh and/or bring students up to speed on the basics of mathematics, physics, computer science and biology.

The course will be adapted according to the students recruited, in order to achieve a more homogeneous start to the course. Students will be immersed in different role-playing games divided into small groups. They will have to solve enigmas using their knowledge in biology, physics/mathematics, chemistry and programming, like in an escape game over several days.

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The aim of this course is to introduce functional genomics technologies and to present examples of biological questions that can be asked using them.

This unit aims to present "omics" functional genomics technologies, and some biological questions that they can address.The lectures are given by both associate professors and researchers.

Introduction to functional genomics: approaches, concepts and methods

An introduction to functional Genomics: approaches, concepts and methods

V. Coulon, UM / IGMM

Genome organization / Organisation des génomes

Techniques de séquençage / DNA sequencing methodsL. Journot, IGF

3D genome organization J. Poli, UM / IGH

Genome topological organisation and replication-V. Coulon, UM / IGMM

Régulation spatio-temporelle de l'expression des génomes / Spatio-temporal regulation of gene expressionTranscriptionEpissage / Splicing-V. Coulon, UM / IGMM

Non-coding RNAsV. Coulon, UM / IGMM

Interactomics / InteractomiqueIan Robbins, UM / IGMM

Proteomics and Pharmacogenomics / Protéomique et pharmacogénomiqueC. Bécamel, UM / IGF

Animal Models / Modèles animaux

Using Mice in Functional Genomics F. Poulat, IGH

La Drosophile en génomique fonctionnelle / Using Drosophila in Functional Genomics -F. Juge and S. Chambeyron, IGH

Scientificarticles analysis and presentation(15min + 10 min discussion per group of 3 students)

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This EU aims to provide a broad overview of emerging quantitative interdisciplinary fields in bioscience, ranging from advanced experimental techniques in microscopy and synthetic biology, to systems approaches.

In an innovative way, these methodological aspects will be presented in the context of biological and biophysical concepts such as robustness and optimality of biological systems, gene regulation and the fundamental principles underlying membrane and genome organization.

The main topics will be introduced first with traditional lectures and will be developed through individual or team projects where students will learn to apply specific techniques through examples, and see how these can be used to explore specific biological questions. These projects will involve literature reviews, use of existing code, or development of new code (depending on the student's experience) and will constitute half of the final assessment.

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In this (hands-on) teaching unit, we will first introduce the general concepts of synthetic biology, which will then be applied to student team projects (assessed). We will provide background knowledge to understand the set of fundamental concepts, approaches and current tools of synthetic biology that will be exploited throughout the course and practical sessions, ranging from gene design and synthesis to genetic library construction, from fluorescence measurements (e.g. plate readers. ) to flow cytometers.

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Students will acquire the fundamental basis and advanced microscopy techniques that allow them to push the limits of knowledge in biology. The teaching is progressive and modular, entirely built around practical projects: building a simple microscope, using advanced microscopes to study complex biological processes in bacteria and eukaryotes. Students will be immersed in a stimulating scientific environment. The training will rely on a significant personal investment through experimental projects, paper reviews and case studies. Communication skills will also be developed through oral presentations and written reports.

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Two to four month internship in a structure (research laboratory, company, etc.) in France or abroad

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The aim of the TER course is to prepare the student to organize and carry out an in-depth bibliographical analysis in order to approach the internship with a knowledge of the state of the art in the field and to produce a relevant and well thought-out introduction to his experimental work.

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This practical course is based on mini-projects involving the application of techniques for the structural study of biomolecules (X-ray crystallography, NMR, cryo-EM, mass spectrometry). In addition, students will learn the biophysical and biochemical techniques used to characterize the analyzed molecules and their interactions.

For each approach, students will learn the basic principles, sample preparation requirements, data acquisition and analysis.

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