M1 IDIL - Quantitative Biology: Molecular Mechanisms of Living Systems (qBio)

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The Bootcamp is an intensive course at the beginning of the first semester, before the start of the courses that characterize the courses. Its aim is to refresh and/or bring students up to speed on the basics of mathematics, physics, computer science and biology.

The course will be adapted to suit the students recruited, with the aim of ensuring a more homogeneous start to the course. Students will be immersed in a variety of role-playing games, divided into small groups. They will have to solve enigmas using their knowledge of biology, physics/mathematics, chemistry and programming, as in an escape game over several days.

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This EU aims to provide a broad overview of emerging quantitative interdisciplinary fields in the biosciences, ranging from cutting-edge experimental techniques in microscopy and synthetic biology, to systems approaches.

In an innovative way, these methodological aspects will be presented in the context of biological and biophysical concepts such as the robustness and optimality of biological systems, gene regulation and the fundamental principles underlying membrane and genome organization.

The main topics will first be introduced with traditional lectures and will be developed through individual or team projects where students will learn to apply specific techniques through examples, and see how these can be used to explore specific biological questions. These projects will involve bibliographical studies, the use of existing code or the development of new code (depending on the student's experience) and will make up half of the final assessment.

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In this (practical) teaching unit, we will first introduce the general concepts of synthetic biology, which will then be applied to (assessed) student team projects. We will provide basic knowledge to understand the full range of fundamental concepts, approaches and current tools of synthetic biology that will be exploited throughout the course and practical sessions, ranging from gene design and synthesis to genetic library construction, from fluorescence measurements (e.g. plate readers. ) to flow cytometers.

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Students will acquire the fundamental basis and advanced microscopy techniques needed to push back the boundaries of knowledge in biology. Teaching is progressive and modular, built entirely around practical projects: building a simple microscope, using state-of-the-art microscopes to study complex biological processes in bacteria and eukaryotes. Students will be immersed in a stimulating scientific environment. Training will be based on significant personal investment through experimental projects, article reviews and case studies. Communication skills will also be developed through oral presentations and written reports.

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Two to 4-month internship in a research laboratory or company in France or abroad.

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The aim of the TER course is to prepare students to organize and carry out an in-depth bibliographical analysis, enabling them to approach their internship with a knowledge of the state of the art in the field, and in particular to produce a relevant and thoughtful introduction to their experimental work.

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This practical course is based on mini-projects involving the application of techniques for studying the structure of biomolecules (X-ray crystallography, NMR, cryo-EM, mass spectrometry). Students will also learn about the biophysical and biochemical techniques used to characterize the molecules analyzed and their interactions.

For each approach, students will learn the basic principles, sample preparation requirements, data acquisition and analysis.

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