M1 IDIL - Quantitative Biology: Molecular Mechanisms of Living Systems (qBio)

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The Bootcamp is an intensive course at the beginning of the first semester, before the start of the courses that characterize the programs. Its purpose is to refresh and/or upgrade students' knowledge of the basics of mathematics, physics, computer science, and biology.

The course will be adapted to suit the students enrolled, with the aim of ensuring a more consistent start to the program. Students will be immersed in various role-playing activities in small groups. They will have to solve puzzles using their knowledge of biology, physics/mathematics, chemistry, and programming, as in an escape game lasting several days.

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This course unit aims to provide a broad overview of emerging quantitative interdisciplinary fields in biosciences, ranging from cutting-edge experimental techniques in microscopy and synthetic biology to systemic approaches.

In an innovative way, these methodological aspects will be presented in the context of biological and biophysical concepts such as the robustness and optimality of biological systems, gene regulation, and the fundamental principles underlying the organization of membranes and the genome.

The main topics will first be introduced through traditional lectures and then developed through individual or team projects, where students will learn to apply specific techniques through examples and see how these can be used to explore specific biological questions. These projects will involve bibliographic studies, the use of existing code, or the development of new code (depending on the student's experience) and will constitute half of the final assessment.

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In this teaching unit (practical), we will first present the general concepts of synthetic biology, which will then be applied to student team projects (assessed). We will provide basic knowledge to understand all the fundamental concepts, approaches, and current tools of synthetic biology that will be used throughout the course and practical sessions, ranging from gene design and synthesis to the construction of genetic libraries, from fluorescence measurements (e.g., plate readers) to flow cytometers.

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Students will acquire the fundamental knowledge and advanced techniques of microscopy that enable them to push the boundaries of knowledge in biology. The teaching is progressive and modular, built entirely around practical projects: constructing a simple microscope, using state-of-the-art microscopes to study complex biological processes in bacteria and eukaryotes. Students will be immersed in a stimulating scientific environment. The program will require significant personal investment through experimental projects, article analysis, and case studies. Communication skills will also be developed through oral presentations and written reports.

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Two- to four-month internship in an organization (research laboratory, company, etc.) in France or abroad

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The TER aims to prepare students to organize and carry out an in-depth bibliographic analysis that will enable them to approach their internship with knowledge of the state of the art in the field, in particular in order to produce a relevant and thoughtful introduction to their experimental work.

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This practical course is based on mini-projects applying structural study techniques for biomolecules (X-ray crystallography, NMR, cryo-EM, mass spectrometry). In addition, students will learn the biophysical and biochemical techniques used to characterize the molecules analyzed and their interactions.

For each approach, students will learn the basic principles, sample preparation requirements, data acquisition, and data analysis.

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