Integrated Cellular Metabolism

This course enables students to deepen their knowledge of metabolism. This course provides a global vision of human metabolism. It will emphasize the links between the different metabolic pathways. It will also show how different tissues communicate to maintain overall energy homeostasis. Dysregulation of this metabolism, at the origin of certain pathologies, will be presented.

• In-depth knowledge of integrated metabolism and its different levels of control in the cell.
• Integration of metabolic regulation systems throughout the body (e.g. blood sugar levels).
• Metabolism of nitrogen compounds (biological nitrogen cycle, amino acid anabolism, nucleotide anabolism)
• Lipid synthesis pathways (glycerophospholipids, sphingolipids, cholesterol)
• Understand the close links between lipid and carbohydrate metabolism.
• Understand the different cellular and physiological roles of molecules derived from lipid metabolism, including steroidal compounds and lipid second messengers.
• Understanding the links between metabolism, signaling and vesicular/membrane trafficking (autophagy, insulin signaling, mTOR pathways)
• Metabolic pathologies (lysosomal and mitochondrial diseases, cancer, diabetes, etc.)
• Understand the types of metabolisms found in various cell types (cancer cells, neurons, liver cells, etc.) in relation to their environment, functions and energy requirements (and any abnormalities).
• Introduction to the metabolism of free radicals and the dangers they represent for cells. Demonstrate the mechanisms that protect against free radicals.
• Food intake control and metabolism

Know-how

• Analyze experimental metabolic data, formulate hypotheses and propose ways of testing them.
• Know the techniques used to study metabolism, their scope, cost, advantages and limitations.
• Synthesize and extract important information from a simple scientific article on metabolism.

How to be

• Demonstrate autonomy and determination to synthesize metabolic pathways and integrate them into an organ

Demonstrate intellectual curiosity to be able to predict a metabolic pathology by the metabolic defects described.

Biochemistry S3, HLVA403V (Biochemistry S4)