Functional Genetics

Functional genetics aims to better understand the relationships between genotype and phenotype. This course covers various aspects of analyzing gene and genome function at the whole-genome level using in vivo approaches, as well as transcriptional regulation and the regulation of gene expression in eukaryotic genomes. The course is illustrated with concrete examples from developmental genetics in both physiological and pathological contexts.

-Knowledge:

Concepts and Methods for Understanding the Phenotype-Genotype Relationship

Gene Structure: Coding Versus Non-Coding Regions, Cis-Trans Effects

Regulation of Eukaryotic Gene Expression

Genetic screens and model organisms (forward genetics)

Techniques for Generating Genetically Modified Organisms (Reverse Genetics)

-Expertise:

Use of DNA manipulation techniques and the creation of genetically modified organisms

Interpretation of Genetic Test Results

-Interpersonal skills:

Ethical Conduct (use of model organisms, plagiarism, cheating in science, etc.)

Ability to methodically analyze the results of genetic testing

Being pragmatic

Be curious

MENDELIAN GENETICS, BASICS OF POPULATION AND HUMAN GENETICS