Biochemistry and Molecular Biology of the Cell 1

The "Biochemistry and Molecular Biology of the Cell 1" course is a continuation of the S1 course "From Molecules to Cells," which laid the structural foundations of life. In this course, students will learn the basics of biochemistry, replication, transcription, translation, intracellular movements, and bioenergetics.

This EU will be supplemented by EU HAV204V for L1 SVSE.

It will be followed by L1 TEE and L1 Chemistry.

- Knowledge related to biochemistry:

This part of the EU provides basic concepts in biochemistry by presenting the four classes of biomolecules (proteins, nucleic acids, carbohydrates, lipids). For each family, a presentation of the structure of elementary molecules (amino acids, nucleotides, simple sugars, fatty acids, etc.) will be given. This presentation will then be extended to more complex structures (proteins, DNA or RNA, complex sugars, triglycerides, phospholipids, biological membranes, etc.). The physicochemical properties of elementary molecules and macromolecules will also begin to be addressed.

- Knowledge related to cell biology:

- Understand the general processes of replication, transcription, and translation in eukaryotes, prokaryotes, and viruses.

- Understand cytotic movements, membrane transport, and movements within the internal membrane system.

- Acquire the basics of bioenergetics (cellular respiration and photosynthesis)

- Expertise:

- Apply knowledge of cell biology, molecular biology, biochemistry, and microbiology to address issues in the field or analyze experimental data (including micrographs).

- Take measurements using magnification or a scale bar.

- Differentiate between different organelles using specific stains in photon microscopy

- Differentiate between different organelles in electron micrographs

- Know how to recognize a cell in mitosis

- For all molecules studied in the biochemistry section: know how to recognize and write their formulas, know how to name them, distinguish between different isomers, recognize different chemical groups and their physicochemical properties, areas of flexibility and rigidity, and perform calculations concerning the charge state of ionizable molecules.

- Know how to recognize and write condensation and hydrolysis reactions

- know how to distinguish between the main chain and side chains of a peptide, know how to interpret a Ramachandran diagram, know how to calculate the percentage of identity between two protein sequences, know how to interpret images illustrating protein structures

- Synthesize knowledge for use in writing

Recommended prerequisites:

High school programs, General Chemistry course (S1), "From Molecules to Cells" course (S1), and Organic Chemistry course (S2): 1) Basic concepts of the covalent structure of organic molecules and their non-covalent interactions. 2) Basic concepts of isomerism. 3) Acid/base equilibria, pH, pKa, domains of predominance. 4) General basic concepts of biological macromolecules.

Hourly volumes:

            CM: 6 p.m.

            TD: 6 p.m.

            TP:

            Land: