Biochemistry in APP

The "Biochemistry and Molecular Biology of the Cell 1" course is a continuation of the S1 course "From Molecules to Cells," which laid the structural foundations of life. In this course, students will learn the basics of biochemistry, replication, transcription, translation, intracellular movements, and bioenergetics.

The program for this EU will be divided into:

• 2 three-hour tutoring sessions 
• 2 three-hour practical sessions
• 1 Scientific conferences

and it will be included in the organic chemistry program in APP (HAV226C) 4 ECTS:

• Understanding the importance of catalyzing a reaction
• Knowing how to write a balanced reaction equation
• Anticipate the nature of reactions based on metabolite concentrations
• Knowing how to calculate the maximum speed of an enzyme reaction
• Knowing how to calculate the affinity of an enzyme for a substrate
• Define the optimal conditions for enzyme activity (pH and temperature).
• Enzymo with inhibitors
• Enzyme structure/function

• Know the basic notions and concepts of Michaelian enzymology and cellular energetics in order to understand metabolic regulation.
• Basic knowledge of the structure and metabolism of carbohydrates, particularly glycolysis.
• Understanding that the "spontaneity" of reactions constituting a metabolic pathway in cells is linked to a set of intracellular factors (variable concentrations of different metabolites over time) and extracellular factors (concentration of secreted metabolites, hormonal signals, etc.).
• Know how to recognize and write condensation and hydrolysis reactions
• Locate and measure enzyme activity, measure reaction speed. Measure a metabolite.

100% continuous assessment

Recommended prerequisites*: High school programs (science track) strongly recommended