Biochemistry in APA

The "Biochemistry and Molecular Biology of the Cell 1" course is the continuation of the S1 course "From Molecules to Cells" which will have laid the structural foundations of life. In this course, students will be introduced to the basics of biochemistry, replication, transcription, translation, intracellular movements and bioenergetics.

The program of this EU will be declined on :

• 2 sessions of 3 hours of tutoring 
• 2 TP of 3h
• 1 Scientific conferences

and it will integrate the organic chemistry program in APP (HAV226C) 4 ECTS :

• To understand the interest of catalyzing a reaction
• Know how to write a reaction equilibrium
• Anticipate the direction of the reactions according to the concentrations of the metabolites
• Know how to calculate the maximum speed of an enzymatic reaction
• Know how to calculate the affinity of an enzyme for a substrate
• Define the optimal operating conditions of an enzyme (pH and T°)
• Enzyme with inhibitors
• Structure/function of enzymes

• To know the basic concepts of Michael enzymology and cellular energetics in order to understand the regulation of metabolism.
• Basic knowledge of carbohydrate structure and metabolism, including glycolysis.
• To understand that the "spontaneity" of the reactions constituting a metabolic pathway in the cells is linked to a set of intracellular (variable concentrations of the various metabolites over time) and extracellular factors (concentration of secreted metabolites, hormonal signals, ...).
• Know how to recognize and write condensation and hydrolysis reactions
• Locate and measure an enzymatic activity, measure a reaction rate. To measure a metabolite.

100% continuous assessment

Recommended prerequisites*: High school programs (scientific field) strongly recommended