Biochemistry in APP

The "Biochemistry and Molecular Biology of the Cell 1" course follows on from the S1 "From Molecules to Cells" course, which laid the structural foundations of living organisms. In this course, students will be introduced to the basics of biochemistry, replication, transcription, translation, intracellular movements and bioenergetics.

The program of this UE will be declined on :

• 2 x 3-hour tutorials 
• 2 x 3-hour practical sessions
• 1 Scientific conferences

and will integrate the organic chemistry program in APP (HAV226C) 4 ECTS :

• Understand the benefits of catalyzing a reaction
• Write down a reaction equilibrium
• Anticipate reaction directions based on metabolite concentrations
• Calculate the maximum speed of an enzymatic reaction
• Calculate the affinity of an enzyme for a substrate
• Define the optimum operating conditions for an enzyme (pH and T°)
• Enzyme with inhibitors
• Enzyme structure/function

• Know the basic notions and concepts of Michael enzymology and cellular energetics to understand metabolic regulation.
• Basic knowledge of carbohydrate structure and metabolism, particularly glycolysis.
• Understand that the "spontaneity" of reactions constituting a metabolic pathway in cells is linked to a set of intracellular factors (varying concentrations of different metabolites over time) and extracellular factors (secreted metabolite concentrations, hormonal signals, etc.).
• Recognize and write down condensation and hydrolysis reactions
• Locate and measure enzymatic activity, measure reaction rate. Determine a metabolite.

100% continuous assessment

Recommended prerequisites*:High school curriculum (scientific stream) strongly recommended