Health

Structural Biology and Rational Design of Bioactive Molecules

  • ECTS

    120 credits

  • Duration

    2 years

  • Training structure

    Faculty of Pharmacy

  • Language(s) of instruction

    French

Presentation

The program, based at the Centre de Biologie Structurale de Montpellier (Montpellier structural biology center), will enable you to master the approaches used for the structural analysis of biomolecules and their complexes, and for the in vitro analysis of interactions between biomolecules and their ligands.

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Objectives

Train managers to design new bioactive molecules by mastering structural biology tools.

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Know-how and skills

  • Master biophysical structural analysis techniques or methods applicable to the rational design of bioactive molecules.
  • Master structural analysis strategies (crystallography & X-rays, mass spectroscopy and NMR, electron microscopy, bioinformatics, etc.) for biological macromolecules, their pharmacological ligands and macromolecule/ligand complexes.
  • Design and implement a rational screening protocol for a given target biomolecule
  • Synthesize data from different biophysical analysis methods.
  • Ensure effective communication at the interface of chemistry and biology in a laboratory / R&D department.
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Organization

Knowledge control

Open on a sandwich basis

Contract type

Apprenticeship contract, Professionalization contract

Internships, tutored projects

Internship

Mandatory

  • In Master 1, supervised research work to familiarize students with the specific features of the course followed. Preferably a 2-month internship (minimum one month, long internship of 4/5 months possible depending on the course), starting in April. The minimum one-month Master 1 internship provides an introduction to research and development in the field of health products.
  • Master 2 :
    • Tutored project related to the professional environment.
    • A minimum 5-month internship enables you to integrate into the professional world on the basis of solid theoretical and methodological knowledge.
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Program

The program is divided into two years: a first year of Master 1 and a second year of Master 2, comprising six specialization courses. Master 1 offers a core curriculum and specific teaching units, enabling students to acquire fundamental knowledge of drugs and healthcare products. The specific teaching units prepare students for future specialization in Master 2.

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Select a program

M2 Structural Biology and Rational Design of Bioactive Molecules

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  • Drug design: case studies

    2 credits
  • Biological NMR: structure, interactions, molecule screening

    6 credits
  • Biocrystallography: protein structure and screening

    4.5 credits
    • Biocrystallography: struturing and screening CC proteins

    • Biocrystallography: structure and screening of CT proteins

  • Preparative and analytical biochemistry

    5 credits
    • Preparative and analytical biochemistry CC

    • Preparative biochemistry CT

  • Core syllabus

    • News and recent advances in drug science

      4 credits
    • Comnunication - Application of English

      3 credits
    • Project and risk management

  • Specific courses

    • Drug design: case studies

      2 credits
    • Biological NMR: structure, interactions, molecule screening

      6 credits
    • Biocrystallography: protein structure and screening

      4.5 credits
      • Biocrystallography: struturing and screening CC proteins

      • Biocrystallography: structure and screening of CT proteins

    • Preparative and analytical biochemistry

      5 credits
      • Preparative and analytical biochemistry CC

      • Preparative biochemistry CT

    • Structural bioinformatics

      2.5 credits
  • Structural bioinformatics

    2.5 credits
  • Tutored project in structural biology

    10 credits
    • Oral project tut. P4

    • Project tut. P4

  • Structural Biology Internship

    20 credits
    • P4 internship assessment

    • P4 internship report

Admission

Access conditions

Master 1 is open to students with a scientific L3 degree who have a solid grounding in life sciences, biology or chemistry (including physical-chemical sciences), a curriculum consistent with the chosen course and a suitable career plan.

Master 2 is open to

  • Holders of a Master 1 in Pharmaceutical Sciences
  • Students who have completed DFASP2 or DFASM3, interns in Pharmacy or Medicine
  • Holders of a diploma in pharmacy, medicine or veterinary medicine.
  • Candidates benefiting from validation of prior learning
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How to register

Master 1

Master 2

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Target audience

For M1: L3 or BUT in Life Sciences, Biology or Chemistry for students graduating from an EU country. M1, M2, pharmacy for non-EU students.    

For M2: holders of a Master 1 in drug sciences or health products, DFASP2 or DFASM3 students, pharmacy or medical interns.

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And then

Further studies

This pathway enables students to enroll in the Doctoral Schools in Biology - Chemistry - Physics, or to obtain another Master's degree to acquire dual skills.

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Bridges and reorientation

At the end of Master 1, you can transfer to a Master 2 in the same field of training, in Biology, Health and Health Engineering.

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Professional integration

  • Project managers
  • Design engineers
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