Health

Structural Biology and Rational Design of Bioactive Molecules

  • ECTS

    120 credits

  • Duration

    2 years

  • Training structure

    Faculty of Pharmacy

  • Language(s) of instruction

    French

Presentation

The course, based at the Montpellier Structural Biology Center, leads to the mastery of approaches used for the structural analysis of biomolecules and their complexes for the in vitro analysis of interactions between biomolecules and their ligands.

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Objectives

Rational design of new bioactive molecules through the mastery of structural biology tools

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Know-how and skills

  • Mastery of major biophysical techniques or methods of structural analysis applicable to the rational design of bioactive molecules.
  • Mastering the strategies of structural analysis of biological macromolecules, their pharmacological ligands, and macromolecule/ligand complexes
  • Design and implement a rational screening protocol on a given target biomolecule (adaptation of tools, adaptation of types of experiments, etc.)
  • Synthesize data from different biophysical analysis methods.
  • Ensure effective communication at the interface of chemistry and biology in a laboratory / R&D department.
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Organization

Knowledge control

Program

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M2 Structural Biology and Rational Design of Bioactive Molecules

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  • Drug design: case studies

    2 credits
  • Biological NMR: structure, interactions, molecule screening

    6 credits
  • Biocrystallography: protein structure and screening

    4.5 credits
    • Biocrystallography: struturing and screening CC proteins

    • Biocrystallography: structure and screening of CT proteins

  • Preparative and analytical biochemistry

    5 credits
    • Preparative and analytical biochemistry CC

    • Preparative biochemistry CT

  • Core syllabus

    • News and recent advances in drug science

      4 credits
    • Comnunication - Application of English

      3 credits
    • Project management and risk management

  • Specific courses

    • Drug design: case studies

      2 credits
    • Biological NMR: structure, interactions, molecule screening

      6 credits
    • Biocrystallography: protein structure and screening

      4.5 credits
      • Biocrystallography: struturing and screening CC proteins

      • Biocrystallography: structure and screening of CT proteins

    • Preparative and analytical biochemistry

      5 credits
      • Preparative and analytical biochemistry CC

      • Preparative biochemistry CT

    • Structural bioinformatics

      2.5 credits
  • Structural bioinformatics

    2.5 credits
  • Tutored project in structural biology

    10 credits
    • Oral project tut. P4

    • Project tut. P4

  • Structural Biology Internship

    20 credits
    • P4 internship assessment

    • P4 internship report