ECTS
5 credits
Component
Faculty of Science
Description
The aim of this course is to introduce functional genomics technologies in -omics, and to present examples of biological questions that can be answered using these technologies.
This unit aims to present "omics" functional genomics technologies, and some biological questions that they can address.The lectures are given by both associate professors and researchers.
Introduction to functional genomics: approaches, concepts and methods
An introduction to functional Genomics: approaches, concepts and methods
V. Coulon, UM / IGMM
Organisation des génomes / Genome organization
Techniques de séquençage / DNA sequencing methodsL. Journot, IGF
Organisation 3D des génomes / 3D genome organisation J. Poli, UM / IGH
Genome topological organization and replication / Organisation topologique et réplication des génomes-V. Coulon, UM / IGMM
Régulation spatio-temporelle de l'expression des génomes / Spatio-temporal regulation of gene expressionTranscriptionEpissage / Splicing-V. Coulon, UM / IGMM
ARN non-codants / non-coding RNAsV. Coulon, UM / IGMM
Interactomique / InteractomicsIan Robbins, UM / IGMM
Proteomics and Pharmacogenomics / Protéomique et pharmacogénomiqueC. Bécamel, UM / IGF
Animal Models / Modèles animaux
Using Mice in Functional Genomics / Utilisation de la souris en génomique fonctionnelle F. Poulat, IGH
La Drosophile en génomique fonctionnelle / Using Drosophila in Functional Genomics -F. Juge and S. Chambeyron, IGH
Analyse et présentation d'articles scientifiques/ Scientificarticles analysis and presentation(15min + 10 min discussion per group of 3 students)
Objectives
-Deepen your understanding of the molecular basis of major functional genomics/epigenomics mechanisms: replication, transcription, post-transcriptional regulation, etc.
-Introduction to functional genomics: approaches, tools, conceptsand limits
-Animal models (mouse, drosophila) and transgenesis techniques
-Critical analysis of functional genomics results
Necessary prerequisites
1. BSc level in cellular and molecular biology
2. Good English language skills, as most of the lectures and all of the articles are in this language.
Recommended prerequisites:
-Bon niveau en biologie moléculaire Good knowledge of molecularbiology
Knowledge control
Final exam: 70% (or 100%) of the grade . Analysis of figures, course summary questions or choice of techniques to answer a given biological question...
Final exam : 70% (or 100%) of your mark. Figure analysis, synthesis questions or pairing techniques with biological questions...
Article presentation: 30% of your mark if above the final one. Article analysis and presentation : 30% of your mark if above the final one.