Evolutionary Genomics

This learning unit has three objectives:

1) To deepen understanding of concepts in evolutionary genetics and genomics, such as linkage disequilibrium, selection, coalescence theory, the detection of natural selection, and the evolutionary forces acting on genome evolution and the process of genomic speciation.

2) Provide an overview of research topics in evolutionary genomics through educational seminars: molecular evolution, evolutionary genomics of endosymbiosis, chromosomal evolution, and molecular evolution.

3) Finally, the EU is proposing a bioanalysis project based on an empirical dataset to gain an understanding of evolutionary genomics and to tackle the increasingly sophisticated bioinformatics aspects of the discipline.

"Understand microevolutionary mechanisms and their quantitative effects (mutation, genetic drift, selection, migration), and know how to formalize them mathematically.

Population structure: the processes that generate it and the indicators that describe it; conservation genetics (diversity, gene flow, corridors).

Inference of evolutionary forces based on molecular data (equilibria between migration, selection, and drift: Fst, Qst, Ne, etc.).

- Understanding of the main concepts in evolutionary genomics and molecular evolution.

- Understanding existing methods for detecting natural selection in genomic data: the codon model for divergence data and the effect of linked selection for genetic diversity data. .

- Recognition of the importance of confounding factors in detecting adaptation at the molecular level: mutational bias, genetic conversion bias toward GC, and demography. .

- Basic concepts of bioinformatics analysis (Linux Bash + R) of genomic data...

 - "Knowing how to read a scientific article and extract the relevant information" - "

Skills acquired in the EU as part of the core curriculum for the M1 BEE program.

Comprehensive ongoing assessment: 100%

Hourly volumes:

            CM: 12:00 a.m.

            TD: 2:00 p.m.

            Practical Training: 0 hours

            Land: 0 h

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            SPS: 12:00 a.m.

            Seminars: 4:00 p.m.

            Excluding UM: 0 h