Functional genetics

Functional genetics aims to better understand the relationships between genotype and phenotype. This course integrates the various aspects of gene and genome function analysis at the whole-genome level using in vivo approaches, as well as transcriptional regulation and regulation of eukaryotic genome expression. The course is illustrated with concrete examples in developmental genetics in physiological and pathological contexts.

-Knowledge:

Concepts and methods for understanding the phenotype-genotype relationship

Gene structure: coding versus non-coding regions, Cis-Trans effects

Regulation of eukaryotic gene expression

Genetic screens and model organisms (forward genetics)

Techniques for generating genetically modified organisms (reverse genetics)

-Expertise:

Use of DNA manipulation techniques and generation of genetically modified organisms

Interpretation of genetic test results

-Interpersonal skills:

Ethical conduct (use of model organisms, plagiarism, scientific misconduct, etc.)

Ability to methodically analyze genetic test results

Be pragmatic

Be curious

MENDELIAN GENETICS, BASIC CONCEPTS IN POPULATION AND HUMAN GENETICS