Biochemistry and molecular biology of the cell 1

The "Biochemistry and Molecular Biology of the Cell 1" course is the continuation of the S1 course "From Molecules to Cells" which will have laid the structural foundations of life. In this course, students will be introduced to the basics of biochemistry, replication, transcription, translation, intracellular movements and bioenergetics.

This UE will be completed by the UE HAV204V for the L1 SVSE.

It will be followed by the L1 TEE and the L1 Chemistry.

- Knowledge associated with biochemistry:

This part of the UE provides basic notions in biochemistry by presenting the 4 classes of biomolecules (proteins, nucleic acids, carbohydrates, lipids). For each family, the structure of elementary molecules (amino acids, nucleotides, simple sugars, fatty acids...) will be presented. Then this presentation will be extended to more complex structures (proteins, DNA or RNA, complex sugars, triglycerides, phospholipids, biological membranes...). The physico-chemical properties of elementary molecules and macromolecules will also be discussed.

- Knowledge associated with cell biology:

- Know the general processes of replication, transcription and translation in eukaryotes, prokaryotes and viruses.

- Understand cytotic movements, membrane transport as well as movements within the internal membrane system.

- Acquire the basics of bioenergetics (cellular respiration and photosynthesis)

- Know-how :

- Mobilize knowledge in cell biology, molecular biology, biochemistry and microbiology to address a problem in the field or analyze experimental data (including micrographs).

- Make height measurements using magnification or a scale bar

- Differentiate the different organelles with specific stains in light microscopy

- Differentiate the different organelles on electron micrographs

- Know how to recognize a cell in mitosis

- For all the molecules studied in the biochemistry part: to know how to recognize and write their formula, to know how to name them, to distinguish the different isomers, to recognize the different chemical groups and their physico-chemical properties, the zones of flexibility and rigidity, to make calculations concerning the state of charge of ionizable molecules

- Know how to recognize and write condensation and hydrolysis reactions

- know how to distinguish the main chain and the side chains of a peptide, know how to interpret a Ramachandran diagram, know how to calculate a percentage of identity between two protein sequences, know how to interpret images illustrating protein structures

- Synthesize knowledge for use in writing

Recommended prerequisites*:

High school programs, General Chemistry UE (S1), "From molecules to the cell" UE (S1) and Organic Chemistry UE (S2) : 1) Basic notions on the covalent structure of organic molecules and their non-covalent interactions. 2) Basic notions on isomerism. 3) Acid/base equilibria, pH, pKa, domains of predominance. 4) General basics of biological macromolecules.

Hourly volumes* :

            CM : 18h

            TD : 18h

            TP:

            Terrain: