• ECTS

    4 credits

  • Component

    Faculty of Science

Description

This EU has three objectives:

1) deepen knowledge of concepts in genetics and evolutionary genomics such as linkage disequilibrium, selection, coalescent theory, detection of natural selection and evolutionary forces acting on genome evolution and the process of genomic speciation.

2) To propose a panorama of research themes in evolutionary genomics in the form of pedagogical seminars: molecular evolution, evolutionary genomics of endosymbioses, chromosomal evolution and molecular evolution.

3) Finally, the EU proposes a project of bioanalysis of an empirical dataset to understand the analysis in evolutionary genomics and to rub shoulders with the bioinformatics aspects increasingly developed in the discipline.

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Objectives

"Know the micro-evolutionary mechanisms and their quantitative effects (mutation, drift, selection, migration), and know how to formalize them mathematically.

Population structuring: processes that generate it and indices that describe it; conservation genetics (diversity, flows, corridors).

Inference of evolutionary forces on the basis of molecular data (migration/selection/drift equilibrium: Fst, Qst, Ne ...).

- Understanding of key concepts in evolutionary genomics and molecular evolution.

- Understanding of existing methods for detecting natural selection in genomic data: codon model for divergence data and linkage selection effect for genetic diversity data. .

- Awareness of the importance of confounding factors in the detection of adaptation at the molecular level: mutational bias, genetic to GC conversion bias, demographics .

- Basic knowledge of bioinformatics analysis (Bash linux + R) of genomics data.

 - Know how to read a scientific article and extract relevant information from it'-"

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Necessary pre-requisites

Competences acquired in the UE of evolution of the common core of the M1 BEE.

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Knowledge control

Continuous assessment : 100%.

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Additional information

Hourly volumes:

            CM : 0 h

            TD : 14 h

            TP : 0 h

            Field : 0 h

            **********

            SPS : 0 h

            Seminars: 16 h

            Outside UM : 0 h

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