Bioprocess Engineering - Batch

Within biotechnology, bioprocesses correspond to the industrial implementation of living tools (whether enzymes, microorganisms, or cells from higher organisms) for the synthesis of products of interest. In this teaching unit (TU), the focus will be on the use of microbial and cellular catalysts. Products of interest may include fermented foods (wine, beer, etc.), energy molecules (bioethanol, methane, etc.), chemical intermediates, and biomedicines (vaccines, monoclonal antibodies, growth factors, etc.). The knowledge, skills, and expertise acquired in this teaching unit will be transferable to any sector of biotechnology. The examples given will correspond to the career opportunities targeted by the two programs (Agrosciences and Health).

The EU will focus on bioprocesses and the environment in which the biological reaction will be controlled (the bioreactor). The course will also address the issue of describing and modeling a biological reaction, including a presentation of the approach applied in bioprocess engineering. The rest of the course will be devoted to the application of this approach to reactors operated in batch mode (or discontinuous culture). Other operating modes will be covered by the M2 HAV930V course "Bioprocess Engineering - Continuous and Fed-Batch."

This course unit includes interactive lectures, tutorials, and practical work (practical work in the computer lab + individual project work in small groups).

Given the importance of the interaction between biology and engineering sciences in bioproduction, this course unit will provide students with an understanding of the vocabulary used in bioproduction and the key parameters at industrial scale. Students will thus be able to interact effectively with the various stakeholders involved in bioproduction, whether engineers or biologists, in R&D or production, etc.

At the end of this course, students will have acquired basic knowledge of bioprocesses (understanding and implementation of a biological reaction, applied approach in bioprocess engineering), bioreactors, different operating modes, choice of operating mode, and modeling of a biological reaction.

Students will also have acquired the bioprocess engineering approach (applied in M1 to the BATCH operating mode) applicable to any bioprocess, with particular emphasis on mastering the following three points:

-Use of experimental data (calculation of yields, net speeds, specific speeds, etc.) using standard business tools (Excel-type spreadsheets or equivalent free software), interpretation of results obtained

-Structuring of data obtained in the form of models

-Based on the information gathered (from experiments or the bibliography), simulation/planning of a crop/production (i.e., designing a simple batch process)

With the practical exercises proposed, students will also be able, at the end of this course unit, to write an activity report. For this report, they will have been made aware of the aspects of communication and synthesis (choice of relevant information, choice of methods of presenting information in accordance with the message, etc.).

Basics of microbiology, metabolism, and cell biology (level L3 biology degree or equivalent) Basics of differential and integral calculus (high school level: general and technological mathematics program for 11th grade, applications in common science education, etc.)

Recommended prerequisites:

Knowledge of catalyst metabolism, applied to bioproduction, is essential. This course is therefore closely linked to course HAV812V "Bioprocess Engineering - Metabolism and Bioproduction" for the M1 Biology-Health / IBIS program, and to course HAA710V "Biological Catalysis and Microbiology" for the M1 Biology-Agrosciences / ICOA program.

Knowledge is assessed through continuous assessment (CCI) (individual assignments, practical work, and final exam).