Medicinal chemistry

The aim of teaching medicinal chemistry is to introduce students to the key stages in the process of developing molecules with biological activities. In particular, a description of the interactions involved, the concept of pharmacophores, bioisosterism, etc., as well as structure-activity relationship studies will be covered, enabling students to consider appropriate strategies and structural modifications.

Hourly volumes:

CM: 3 p.m.

Tutorial: 5 hours

The aim of this course is to understand the issues involved in medicinal chemistry research.

Organic Chemistry L3

Biomolecule Chemistry, M1 level:

Knowledge of various families (structures, properties)

2-hour final written exam:

• Authorized documents: no
• Internet access: no

Course: Inductive (problem-based) and deductive teaching methods. Materials available on the digital workspace (Moodle): Course documents, tutorial documents, past exam papers, and reference publications.

1. Molecular interactions of biomolecules with their targets (1.5 hours)
2. Pharmacophore and pharmacophore analogues (3 hours)
3. Concepts of bioisosterism/homologation/function inversion (4.5 hours)
4. Structure-activity relationships (4.5 hours)
5. Physicochemical Properties (1.5 hours)

TD (5 hours): Individual work, exercises to be prepared before and during the session.

Teaching staff :

Christophe Mathé

christophe.mathe@umontpellier.fr

Administrative contact(s):

Master's Program in Chemistry Secretariat

https://master-chimie.edu.umontpellier.fr/