Cellular pathophysiology and cancer

The aim of the "Cellular Physiopathology and Cancer" course is to provide students with the knowledge they need to follow the "Cancer Biology" pathway in M2. The course is organized in the form of a lecture, with an introductory section followed by a section on current laboratory research. Students are required to present a scientific article orally (usually in pairs).

The aim of the cellular pathophysiology and cancer teaching unit is to provide the scientific background necessary to follow the cancer biology M2 program.Each lecture is organized as a conference starting with a general introduction of the field and followed by a more specialized emphasis on research done in laboratories. Students have to prepare an oral presentation based on the analysis of a scientific article (generally in pair).

Topics will include the link between oncogenic transformation and the neoplastic functioning of different cell types (epithelial, stem, hematopoietic, etc.), with particular emphasis on the molecular mechanisms associated with DNA metabolism.

Several topics related to cancer cell pathophysiology will be explored including oncogenic transformation events in different physiological contexts. During the course, we will investigate both molecular processes promoting and preventing cell transformation, focusing in particular on DNA replication and repair. In a second part, you will be introduced to state-of-the art concepts that are redefining the cancer biology field (metabolism, microenvironment, angiogenesis and cancer stem cells).

Bases de biologie cellulaire et moléculaire / Molecular and cellular biology basis

Recommended prerequisites: Scientific article analysis and oral presentation / Analyse et présentation orale d'article scientifique

Session 1: 80% written - 20% oral

Session 2: written

1.hallmarks of cancer / Historical snapshots and the hallmarks of cancer

2 DNA replication and cancer/ Réplication de l'ADN et cancer

3.epigenetic mechanisms in cancer/ Epigenetics and cancer

4 DNA damage and repair mechanisms

5 Cell metabolism and cancer/ Cell metabolism and cancer

6 Microenvironment and cancer/ Microenvironment et cancer

7 Normal and pathological angiogenesis/ Angiogenesis in cancer

8.stem cells and solid tumors/ Cancer stem cells

9.Mechanisms of cancer drug resistance/ Principes de la résistance aux traitements des cellules cancéreuses

10 Hematopoiesis and hematological malignancies/ Hématopoièse et oncohématologie