MICRO CERTIFICATION | Metal-Free Synthesis Methods for Biomolecules*

  • Duration

    3 days

  • Training structure

    Continuing Education Department, Faculty of Science

Presentation

This course offers an advanced program on the synthesis of monovalent and multivalent biomolecules of biological or pharmacological interest that are free of toxic metals. The course will cover various “click” reactions that do not require copper or other metal catalysts, such as thiol-ene and thiol-yne radical coupling reactions, as well as the SuFEx reaction.

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*Subject to approval by the Board of Trustees of the University of Montpellier on Monday, September 28, 2026

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The advantages of the training program

Next training session: May 31–June 2, 2027

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Know-how and skills

  • Finding an alternative reaction to metal-catalyzed conjugation methods
  • Be able to define a modern synthesis strategy for ligation partners
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Program

16 hours of training spread over 3 days of in-person sessions— Training available as an in-house program

PROGRAM

  • CYCLOADDITION COUPLING REACTION: FORMATION OF TRIAZOLES AND TETRAZOLES
  • 1,4-CONJUGATED ADDITION LIGATION METHODS: ADDITION OF THIOLS TO ACRYLAMIDES AND MALEIMIDES
  • RADICAL ADDITION OF THIOLS TO ALKENES 
  • COUPLING REACTIONS OF ALDEHYDES: FORMATION OF OXIMES AND HYDRAZONES 
  • SUFEX (SULFUR(VI) FLUORIDE EXCHANGE) LIGATION: FORMATION OF SULFONAMIDES
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Admission

Target audience

Senior Technicians and Managers in the Chemical and Pharmaceutical Industries

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Tuition fees

Training fees: 

  • €1,350 (including tax)
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Mandatory prerequisites

Organic chemistry; minimum of a bachelor's degree (BAC + 3)

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